Caffeic Acid Phenethyl Ester

Overview IFRA Request a quote

  • Identifiers

    CAS number
    104594-70-9

    Molecular formula
    C17H16O4

    SMILES
    C1=CC=C(C=C1)CCOC(=O)/C=C/C2=CC(=C(C=C2)O)O

    Safety labels

    Irritant
    Irritant

  • Properties

    XLogP3-AA
    4.2

    Molecular weight
    284.31 g/mol

  • Synonyms

    • Caffeic acid phenethyl ester
    • 104594-70-9
    • Phenethyl caffeate
    • CAPE
    • Capeee
    • 2-phenylethyl (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate
    • G960R9S5SK
    • 2-phenylethyl 3-(3,4-dihydroxyphenyl)-2-propenoate
    • CHEBI:8062
    • DTXSID8040987
    • CAPE compound
    • RefChem:573319
    • DTXCID40810387
    • 3-(3,4-Dihydroxyphenyl)-2-propenoic Acid, 2-Phenylethyl Ester
    • caffeic acid phenyl ester
    • phenethyl 3-(3,4-dihydroxyphenyl)acrylate
    • 115610-29-2
    • Phenylethyl caffeate
    • 100981-80-4
    • caffeic acid phenylethyl ester
    • PHENETHYL CAFFEATE (CAPE)
    • 2-Phenylethyl (2e)-3-(3,4-Dihydroxyphenyl)prop-2-Enoate
    • 2-Propenoic acid, 3-(3,4-dihydroxyphenyl)-, 2-phenylethyl ester
    • (E)-phenethyl 3-(3,4-dihydroxyphenyl)acrylate
    • MFCD00866470
    • 2-phenylethyl caffeate
    • CHEMBL319244
    • SMR000326751
    • Phenethyl (E)-caffeate
    • SR-01000075785
    • UNII-G960R9S5SK
    • phenylethylcaffeate
    • Caffeic acid ester
    • QAP
    • caffeic acidphenethylester
    • caffeic acid phenethylester
    • caffeic-acid-phenethyl-ester
    • caffeic acid phenylethylester
    • Lopac0_000269
    • Phenylethyl caffeate, (E)-
    • BSPBio_001560
    • BSPBio_003586
    • MLS000859889
    • MLS002207297
    • Caffeic acid-phenylethyl ester
    • SCHEMBL490546
    • SPECTRUM1502209
    • 2-phenylethyl (2E)-3-(3,4-dihydroxyphenyl)acrylate
    • orb1300776
    • phenethyl (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate
    • SCHEMBL30070826
    • CHEBI:93478
    • DTXSID80861176
    • FR102
    • GLXC-08018
    • HMS1361N22
    • HMS1791N22
    • HMS1989N22
    • HMS2233J04
    • HMS3260F20
    • HMS3402N22
    • HMS3413D22
    • HMS3649C16
    • HMS3677D22
    • Phenylethyl 3,4-dihydroxycinnamate
    • Caffeic acid beta-phenylethyl ester
    • Caffeic acid phenethyl ester(CAPE)
    • HY-N0274
    • MSK14259
    • Tox21_500269
    • BDBM50029207
    • CCG-39542
    • s7414
    • 2-Propenoic acid, 3-(3,4-dihydroxyphenyl)-, 2-phenylethyl ester, (E)-
    • AKOS015888207
    • AC-8896
    • EBC-459091
    • FC19630
    • LP00269
    • SDCCGSBI-0050257.P002
    • IDI1_034030
    • QTL1_000016
    • NCGC00093727-01
    • NCGC00093727-02
    • NCGC00093727-03
    • NCGC00093727-04
    • NCGC00093727-05
    • NCGC00093727-06
    • NCGC00093727-07
    • NCGC00093727-08
    • NCGC00093727-09
    • NCGC00093727-16
    • NCGC00260954-01
    • AS-14021
    • LS-14562
    • SY032957
    • SY271989
    • CS-0008774
    • EU-0100269
    • SW219156-1
    • (E)-phenethyl3-(3,4-dihydroxyphenyl)acrylate
    • C 8221
    • Phenethyl (E)-3-(3,4-Dihydroxyphenyl)acrylate
    • F814395
    • SR-01000075785-1
    • SR-01000075785-6
    • SR-01000075785-9
    • BRD-K84709232-001-02-6
    • BRD-K96188950-001-02-9
    • BRD-K96188950-001-04-5
    • BRD-K96188950-001-15-1
    • BRD-K96188950-001-16-9
    • Caffeic acid phenethyl ester, >=97% (HPLC), powder
    • Caffeic acid phenethyl esterCAPE; Phenylethyl caffeate
    • Q15410860
    • 3-(3,4-Dihydroxy-phenyl)-acrylic acid phenethyl ester
    • (E)-3-(3,4-Dihydroxy-phenyl)-acrylic acid phenethyl ester
    • 3-(3,4-Dihydroxyphenyl)-2-propenoic acid 2-phenylethyl ester;CAPE;Phenethyl caffeate
    • 115610-29-2

  • Applications

    Caffeic acid phenethyl ester (CAPE, CAS 104594-70-9) is used as an antioxidant and radical scavenger in cosmetic and personal care formulations, helping improve the oxidative stability of products. In the plastics, polymer and coatings industries, CAPE is regarded as an antioxidant and photostabilizing additive, enhancing durability of materials exposed to air and heat. It is also employed as an intermediate in organic synthesis and as a precursor for polyphenol derivatives for the development of fine chemicals. In the fragrance and perfumery sector, CAPE may be considered as a fragrance-related ingredient or aroma component in some formulations. Additionally, CAPE is studied in biological research as a compound with potential activity, but health-related claims should comply with local regulations.

    gpt-5-nano

1 3

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction