Butyramide

Overview IFRA Request a quote

  • Identifiers

    CAS number
    541-35-5

    Molecular formula
    C4H9NO

    SMILES
    CCCC(=O)N

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Cheesy 51.28%
    Nutty 37.55%
    Fishy 32.18%
    Pungent 31.08%
    Meaty 28.75%
    Roasted 28.16%
    Buttery 26.72%
    Sweet 26.19%
    Fruity 25.57%
    Savory 25.51%

     

    Flavor
    Cheese 44.09%
    Sweat 32.4%
    Acidic 31.95%
    Sour 31.34%
    Pungent 29.98%
    Rancid 29.14%
    Animal 25.85%
    Cheesy 25.5%
    Fishy 25.26%
    Butter 25.0%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -0.2

    pKa est.
    7.33 (neutral)

    Molecular weight
    87.12 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Slow

    Melting point expt.

    • 114.8 °C
    • 115-116 °C
    • 115 - 116 °C

    Boiling point

    • 216 °C
    • 216.00 to 217.00 °C. @ 760.00 mm Hg

    Flash point

    • 74.03 ˚C est.

    Solubility expt.

    • 163000 mg/L (at 15 °C)
    • Sol in alcohol; slightly sol in ether
    • INSOL IN BENZENE
    • In water, 163,000 mg/l @ 15 °C
    • 163 mg/mL at 15 °C
    • Soluble in water
    • Soluble (in ethanol)

  • Synonyms

    • Butyramide
    • Butanamide
    • 541-35-5
    • n-Butyramide
    • Butanimidic acid
    • N-BUTYLAMIDE
    • Butanoic acid, amide
    • UNII-9J6OR937VR
    • MFCD00041894
    • CHEBI:50724
    • HSDB 5684
    • NSC 8424
    • NSC-8424
    • EINECS 208-776-4
    • BUTYRAMIDE [FHFI]
    • N-BUTYLAMIDE [HSDB]
    • n-C3H7C(O)NH2
    • AI3-24199
    • 9J6OR937VR
    • DTXSID8060248
    • FEMA NO. 4252
    • DNSISZSEWVHGLH-UHFFFAOYSA-
    • butyrylamide
    • Butanimidic Acid; NSC 8424; n-Butylamide; n-Butyramide;
    • nButyramide
    • Butyramid
    • n-butanamide
    • Butanoate, amide
    • Amide C4
    • propane, 1-carbamoyl-
    • N-BUTYRAMIDE [MI]
    • C3H7C(O)NH2
    • CHEMBL1231396
    • DTXCID2041595
    • Butyramide, >=98.0% (T)
    • NSC8424
    • LMFA08010018
    • AKOS008937485
    • DB02121
    • HY-W088319
    • SY038223
    • B0809
    • CS-0130522
    • NS00022341
    • EN300-61108
    • D70204
    • Q5003189
    • Z33546461

  • Applications

    Butyramide (CAS 541-35-5) is primarily used as an organic synthesis intermediate, providing a simple amide building block for preparing amide derivatives in pharmaceutical and agrochemical research. It can serve as a precursor in polymer and materials chemistry, including the synthesis of amide-containing monomers or additives for specialty polymers and resins. In process development it may be employed as a solvent or reaction medium in laboratory-scale work. It is also evaluated for niche formulation roles in coatings, inks, and some cosmetic or personal care formulations as a processing aid, subject to regulatory and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 270.86
    methanol 613.44
    isopropanol 142.65
    water 199.98
    ethyl acetate 46.84
    n-propanol 141.51
    acetone 111.7
    n-butanol 108.0
    acetonitrile 83.95
    DMF 181.46
    toluene 5.59
    isobutanol 91.04
    1,4-dioxane 91.66
    methyl acetate 53.88
    THF 176.45
    2-butanone 59.87
    n-pentanol 68.86
    sec-butanol 92.17
    n-hexane 5.29
    ethylene glycol 202.25
    NMP 225.68
    cyclohexane 3.2
    DMSO 192.15
    n-butyl acetate 40.0
    n-octanol 38.59
    chloroform 36.59
    n-propyl acetate 27.8
    acetic acid 593.38
    dichloromethane 28.77
    cyclohexanone 84.49
    propylene glycol 185.14
    isopropyl acetate 29.19
    DMAc 142.31
    2-ethoxyethanol 106.09
    isopentanol 68.52
    n-heptane 4.01
    ethyl formate 54.19
    1,2-dichloroethane 16.7
    n-hexanol 77.82
    2-methoxyethanol 214.82
    isobutyl acetate 21.49
    tetrachloromethane 8.53
    n-pentyl acetate 30.55
    transcutol 238.31
    n-heptanol 38.52
    ethylbenzene 3.83
    MIBK 28.34
    2-propoxyethanol 132.84
    tert-butanol 112.93
    MTBE 37.85
    2-butoxyethanol 73.55
    propionic acid 205.53
    o-xylene 6.79
    formic acid 424.87
    diethyl ether 26.58
    m-xylene 7.52
    p-xylene 7.02
    chlorobenzene 14.62
    dimethyl carbonate 16.31
    n-octane 1.89
    formamide 207.56
    cyclopentanone 133.13
    2-pentanone 44.13
    anisole 16.62
    cyclopentyl methyl ether 47.67
    gamma-butyrolactone 180.23
    1-methoxy-2-propanol 122.2
    pyridine 41.19
    3-pentanone 30.49
    furfural 136.78
    n-dodecane 1.88
    diethylene glycol 154.04
    diisopropyl ether 8.42
    tert-amyl alcohol 84.07
    acetylacetone 57.28
    n-hexadecane 1.93
    acetophenone 24.01
    methyl propionate 39.87
    isopentyl acetate 33.64
    trichloroethylene 37.43
    n-nonanol 32.07
    cyclohexanol 60.62
    benzyl alcohol 30.52
    2-ethylhexanol 30.99
    isooctanol 26.84
    dipropyl ether 19.97
    1,2-dichlorobenzene 15.44
    ethyl lactate 29.26
    propylene carbonate 82.77
    n-methylformamide 140.92
    2-pentanol 53.18
    n-pentane 4.36
    1-propoxy-2-propanol 81.63
    1-methoxy-2-propyl acetate 42.82
    2-(2-methoxypropoxy) propanol 64.54
    mesitylene 6.01
    ε-caprolactone 84.89
    p-cymene 7.19
    epichlorohydrin 79.08
    1,1,1-trichloroethane 16.42
    2-aminoethanol 230.51
    morpholine-4-carbaldehyde 159.31
    sulfolane 189.96
    2,2,4-trimethylpentane 3.18
    2-methyltetrahydrofuran 96.56
    n-hexyl acetate 48.22
    isooctane 2.4
    2-(2-butoxyethoxy)ethanol 91.55
    sec-butyl acetate 17.19
    tert-butyl acetate 31.23
    decalin 2.37
    glycerin 238.22
    diglyme 111.45
    acrylic acid 213.39
    isopropyl myristate 17.71
    n-butyric acid 162.8
    acetyl acetate 41.43
    di(2-ethylhexyl) phthalate 30.1
    ethyl propionate 22.16
    nitromethane 277.44
    1,2-diethoxyethane 39.54
    benzonitrile 31.9
    trioctyl phosphate 22.09
    1-bromopropane 10.05
    gamma-valerolactone 162.81
    n-decanol 23.04
    triethyl phosphate 16.33
    4-methyl-2-pentanol 28.22
    propionitrile 46.49
    vinylene carbonate 70.51
    1,1,2-trichlorotrifluoroethane 111.65
    DMS 34.35
    cumene 5.04
    2-octanol 24.0
    2-hexanone 33.01
    octyl acetate 26.9
    limonene 10.92
    1,2-dimethoxyethane 89.52
    ethyl orthosilicate 15.74
    tributyl phosphate 26.19
    diacetone alcohol 61.85
    N,N-dimethylaniline 15.75
    acrylonitrile 61.13
    aniline 27.48
    1,3-propanediol 189.79
    bromobenzene 8.58
    dibromomethane 17.15
    1,1,2,2-tetrachloroethane 31.73
    2-methyl-cyclohexyl acetate 25.93
    tetrabutyl urea 32.65
    diisobutyl methanol 15.33
    2-phenylethanol 36.09
    styrene 4.64
    dioctyl adipate 29.2
    dimethyl sulfate 35.42
    ethyl butyrate 23.43
    methyl lactate 52.75
    butyl lactate 39.78
    diethyl carbonate 16.55
    propanediol butyl ether 92.61
    triethyl orthoformate 19.82
    p-tert-butyltoluene 7.29
    methyl 4-tert-butylbenzoate 40.84
    morpholine 109.74
    tert-butylamine 52.56
    n-dodecanol 17.29
    dimethoxymethane 52.86
    ethylene carbonate 55.56
    cyrene 60.78
    2-ethoxyethyl acetate 42.54
    2-ethylhexyl acetate 24.2
    1,2,4-trichlorobenzene 21.59
    4-methylpyridine 37.68
    dibutyl ether 19.67
    2,6-dimethyl-4-heptanol 15.33
    DEF 60.1
    dimethyl isosorbide 82.12
    tetrachloroethylene 27.98
    eugenol 47.47
    triacetin 51.84
    span 80 70.59
    1,4-butanediol 87.18
    1,1-dichloroethane 16.97
    2-methyl-1-pentanol 50.14
    methyl formate 87.57
    2-methyl-1-butanol 70.18
    n-decane 2.86
    butyronitrile 46.69
    3,7-dimethyl-1-octanol 30.52
    1-chlorooctane 10.69
    1-chlorotetradecane 4.77
    n-nonane 2.73
    undecane 2.19
    tert-butylcyclohexane 3.13
    cyclooctane 1.31
    cyclopentanol 109.29
    tetrahydropyran 55.09
    tert-amyl methyl ether 29.38
    2,5,8-trioxanonane 93.88
    1-hexene 12.43
    2-isopropoxyethanol 66.04
    2,2,2-trifluoroethanol 166.47
    methyl butyrate 33.36

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction