Butylparaben

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  • Identifiers

    CAS number
    94-26-8

    Molecular formula
    C11H14O3

    SMILES
    CCCCOC(=O)C1=CC=C(C=C1)O

    Safety labels

    Corrosive
    Corrosive

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Sweet 59.87%
    Phenolic 52.5%
    Balsamic 51.35%
    Floral 44.91%
    Vanilla 42.87%
    Herbal 42.09%
    Aromatic 38.52%
    Spicy 38.05%
    Woody 35.86%
    Anisic 32.85%

     

    Flavor
    Balsam 50.23%
    Floral 39.45%
    Sweet 34.92%
    Wintergreen 31.15%
    Herbal 30.4%
    Fruity 29.83%
    Balsamic 29.14%
    Powdery 28.9%
    Faint 28.72%
    Spicy 27.75%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    3.6

    pKa est.
    7.87 (neutral)

    Molecular weight
    194.23 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Melting point expt.

    • 154 to 156 °F (NTP, 1992)
    • 68.5 °C
    • 68 - 69 °C

    Boiling point

    • 156.00 to 157.00 °C. @ 3.50 mm Hg

    Flash point

    • 143.21 ˚C est.
    • 181 °C

    Solubility expt.

    • less than 1 mg/mL at 63 °F (NTP, 1992)
    • Crystalline powder; solubility in water: approx 1:125 /Butylparaben calcium salt/
    • Crystalline powder; solubility in water: approx 1:110 /Butylparaben magnesium salt/
    • In water, 2.07X10+2 mg/L at 20 °C
    • Very slightly soluble in water
    • SOLUBILITY IN WATER: 0.15 G/100 G @ 80 °C
    • Slightly soluble in carbon tetrachloride; soluble in ethanol
    • For more Solubility (Complete) data for BUTYLPARABEN (7 total), please visit the HSDB record page.
    • 0.207 mg/mL at 20 °C
    • insoluble in water; soluble in ether, acetone and propylene glycol, slightly soluble in oils
    • soluble (in ethanol)

  • Synonyms

    • BUTYLPARABEN
    • Butyl 4-hydroxybenzoate
    • 94-26-8
    • Butyl paraben
    • Butyl p-hydroxybenzoate
    • Butoben
    • Butyl parahydroxybenzoate
    • Nipabutyl
    • Butyl chemosept
    • Butyl parasept
    • Tegosept B
    • n-Butyl p-hydroxybenzoate
    • Butyl tegosept
    • Butyl butex
    • Butyl-Parasept
    • Tegosept Butyl
    • Aseptoform butyl
    • Preserval B
    • Solbrol B
    • Benzoic acid, 4-hydroxy-, butyl ester
    • butyl p-hydroxy benzoate
    • 4-(Butoxycarbonyl)phenol
    • n-Butyl paraben
    • n-Butyl hydroxybenzoate
    • FEMA No. 2203
    • n-Butyl-p-hydroxybenzoate
    • n-butyl 4-hydroxybenzoate
    • n-Butyl parahydroxybenzoate
    • Parasept
    • butyl-p-hydroxybenzoate
    • n-Butyl-paraben
    • Butyl Par asept
    • Caswell No. 130A
    • Lexgard B
    • FEMA Number 2203
    • n-Butyl-4-hydroxybenzoate
    • Butylparaben (NF)
    • Butylparaben (TN)
    • Butylparaben [NF]
    • 4-Hydroxybenzoic acid butyl ester
    • Butyl hydroxybenzoate
    • NSC 8475
    • CCRIS 2462
    • HSDB 286
    • Benzoic acid, p-hydroxy-, butyl ester
    • p-Hydroxy butyl benzoate
    • p-Hydroxybenzoic acid butyl ester
    • p-Hydroxybenzoic acid, butyl ester
    • 4-Hydroxybenzoic acid, butyl ester
    • UNII-3QPI1U3FV8
    • p-Hydroxybenzoic acid n-butyl ester
    • EINECS 202-318-7
    • p-Hydroxybenzoic butyl ester
    • 3QPI1U3FV8
    • MFCD00016478
    • EPA Pesticide Chemical Code 061205
    • BRN 1103741
    • Butyl parahydroxybenzoate (TN)
    • DTXSID3020209
    • SPF
    • AI3-02930
    • BUTYLPARABEN [II]
    • BUTYLPARABEN [MI]
    • NSC-13164
    • BUTYLPARABEN [HSDB]
    • BUTYLPARABEN [VANDF]
    • Butyl //p//-Hydroxybenzoate
    • BUTYLPARABEN [USP-RS]
    • DTXCID90209
    • CHEBI:88542
    • FEMA 2203
    • NSC8475
    • Butyl parahydroxybenzoate (JP15)
    • Butyl parahydroxybenzoate (JP17)
    • 4-10-00-00375 (Beilstein Handbook Reference)
    • 4-Hydroxybenzoic acid-n-butyl ester
    • p-Hydroxybenzoic acid, n-butyl ester
    • BUTYL HYDROXYBENZOATE [MART.]
    • BUTYL HYDROXYBENZOATE [WHO-DD]
    • BUTYL PARAHYDROXYBENZOATE [JAN]
    • BUTYL P-HYDROXY BENZOATE [FHFI]
    • CAS-94-26-8
    • Butyl 4-?Hydroxybenzoate(Butyl Paraben)
    • NCGC00016354-03
    • n-butylparaben
    • BUTYLPARABEN (II)
    • BUTYL PARAHYDROXYBENZOATE [EP IMPURITY]
    • BUTYL PARAHYDROXYBENZOATE [EP MONOGRAPH]
    • BUTYLPARABEN (USP-RS)
    • PROPYL HYDROXYBENZOATE IMPURITY D [EP IMPURITY]
    • Butylparaben [USAN]
    • METHYL PARAHYDROXYBENZOATE IMPURITY D [EP IMPURITY]
    • butyl-paraben
    • 4-Hydroxybenzoic acid-n-butyl ester 1000 microg/mL in Acetonitrile
    • BUTYL HYDROXYBENZOATE (MART.)
    • SMR000462402
    • BUTYL PARAHYDROXYBENZOATE (EP IMPURITY)
    • BUTYL PARAHYDROXYBENZOATE (EP MONOGRAPH)
    • SR-01000389296
    • PROPYL HYDROXYBENZOATE IMPURITY D (EP IMPURITY)
    • METHYL PARAHYDROXYBENZOATE IMPURITY D (EP IMPURITY)
    • ButylParasept
    • 27K
    • Butyl phydroxybenzoate
    • nButyl hydroxybenzoate
    • Butyl 4hydroxybenzoate
    • nButyl phydroxybenzoate
    • MEKKINGS B
    • 4(Butoxycarbonyl)phenol
    • 4mg9
    • Butylparaben (Standard)
    • nButyl parahydroxybenzoate
    • Prestwick0_000894
    • Prestwick1_000894
    • Prestwick2_000894
    • Prestwick3_000894
    • WLN: QR DVO4
    • BUTYLPARABEN [INCI]
    • cid_7184
    • SCHEMBL3647
    • BSPBio_000708
    • MLS000575004
    • MLS002154054
    • MLS002303045
    • BIDD:ER0231
    • SPBio_002917
    • BPBio1_000780
    • CHEMBL459008

  • Applications

    Butyl 4-hydroxybenzoate, also known as butylparaben (CAS 94-26-8), is a widely used paraben preservative valued for its broad-spectrum antimicrobial action against bacteria, yeasts and molds; it is incorporated into skin creams, lotions, shampoos, makeup, deodorants, wet wipes and many other personal-care items, as well as oral and topical pharmaceutical formulations such as syrups, non-aqueous injections, ophthalmic solutions, gels, ointments and lubricants; the compound is further applied in baked goods, sauces, low-alcohol beverages, condiments and food packaging to prolong shelf life, and in industrial metalworking fluids, paints, adhesives, printing inks and lubricating oils to prevent microbial spoilage; it shows optimum efficacy between pH 4-8 and is often blended with methyl- or propylparaben to take advantage of synergistic effects and lower total dosage, typical use levels being 0.02-0.4 %; its low cost, thermal stability and minimal color or odor make it attractive, yet endocrine-disruption concerns have led to concentration limits in the EU, Japan and other markets, requiring manufacturers to comply with current regulations and labeling rules.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 3631.16
    methanol 7143.36
    isopropanol 1470.24
    water 0.24
    ethyl acetate 2338.96
    n-propanol 2290.02
    acetone 4671.99
    n-butanol 1578.57
    acetonitrile 2704.46
    DMF 4935.44
    toluene 241.86
    isobutanol 1144.71
    1,4-dioxane 1738.46
    methyl acetate 1709.72
    THF 2283.57
    2-butanone 2137.21
    n-pentanol 757.22
    sec-butanol 1339.93
    n-hexane 10.48
    ethylene glycol 310.29
    NMP 1679.19
    cyclohexane 16.86
    DMSO 4929.88
    n-butyl acetate 903.71
    n-octanol 176.01
    chloroform 1106.42
    n-propyl acetate 857.66
    acetic acid 2236.81
    dichloromethane 1433.95
    cyclohexanone 1614.6
    propylene glycol 551.75
    isopropyl acetate 969.69
    DMAc 2162.75
    2-ethoxyethanol 1282.7
    isopentanol 1004.16
    n-heptane 5.39
    ethyl formate 909.68
    1,2-dichloroethane 1378.3
    n-hexanol 524.49
    2-methoxyethanol 2917.31
    isobutyl acetate 430.4
    tetrachloromethane 47.23
    n-pentyl acetate 333.01
    transcutol 4294.5
    n-heptanol 171.13
    ethylbenzene 117.73
    MIBK 740.44
    2-propoxyethanol 983.9
    tert-butanol 1688.95
    MTBE 1174.58
    2-butoxyethanol 417.04
    propionic acid 1188.17
    o-xylene 137.13
    formic acid 706.06
    diethyl ether 1521.4
    m-xylene 158.74
    p-xylene 155.84
    chlorobenzene 451.23
    dimethyl carbonate 467.46
    n-octane 3.62
    formamide 1986.16
    cyclopentanone 2187.77
    2-pentanone 1840.61
    anisole 476.62
    cyclopentyl methyl ether 839.68
    gamma-butyrolactone 2163.26
    1-methoxy-2-propanol 1890.01
    pyridine 1355.36
    3-pentanone 908.83
    furfural 1291.95
    n-dodecane 6.24
    diethylene glycol 801.2
    diisopropyl ether 207.36
    tert-amyl alcohol 1243.12
    acetylacetone 1741.67
    n-hexadecane 7.42
    acetophenone 473.07
    methyl propionate 1498.75
    isopentyl acetate 678.86
    trichloroethylene 2330.1
    n-nonanol 157.14
    cyclohexanol 662.46
    benzyl alcohol 459.79
    2-ethylhexanol 217.0
    isooctanol 140.21
    dipropyl ether 223.69
    1,2-dichlorobenzene 327.67
    ethyl lactate 280.6
    propylene carbonate 892.68
    n-methylformamide 2330.42
    2-pentanol 851.37
    n-pentane 10.35
    1-propoxy-2-propanol 619.26
    1-methoxy-2-propyl acetate 699.75
    2-(2-methoxypropoxy) propanol 449.53
    mesitylene 87.59
    ε-caprolactone 1225.59
    p-cymene 64.14
    epichlorohydrin 2367.76
    1,1,1-trichloroethane 563.91
    2-aminoethanol 978.15
    morpholine-4-carbaldehyde 1553.39
    sulfolane 1888.46
    2,2,4-trimethylpentane 14.3
    2-methyltetrahydrofuran 1564.47
    n-hexyl acetate 482.11
    isooctane 12.48
    2-(2-butoxyethoxy)ethanol 767.46
    sec-butyl acetate 489.79
    tert-butyl acetate 802.3
    decalin 16.31
    glycerin 607.45
    diglyme 1397.07
    acrylic acid 924.77
    isopropyl myristate 152.46
    n-butyric acid 1650.76
    acetyl acetate 817.82
    di(2-ethylhexyl) phthalate 130.64
    ethyl propionate 610.29
    nitromethane 4490.05
    1,2-diethoxyethane 828.75
    benzonitrile 568.78
    trioctyl phosphate 100.32
    1-bromopropane 470.32
    gamma-valerolactone 2149.39
    n-decanol 115.23
    triethyl phosphate 142.23
    4-methyl-2-pentanol 319.54
    propionitrile 1144.08
    vinylene carbonate 784.87
    1,1,2-trichlorotrifluoroethane 1105.39
    DMS 438.5
    cumene 77.11
    2-octanol 119.0
    2-hexanone 803.86
    octyl acetate 201.65
    limonene 104.96
    1,2-dimethoxyethane 1662.2
    ethyl orthosilicate 131.95
    tributyl phosphate 144.51
    diacetone alcohol 985.07
    N,N-dimethylaniline 227.14
    acrylonitrile 1576.24
    aniline 568.62
    1,3-propanediol 1390.93
    bromobenzene 388.86
    dibromomethane 710.63
    1,1,2,2-tetrachloroethane 1593.25
    2-methyl-cyclohexyl acetate 255.22
    tetrabutyl urea 183.95
    diisobutyl methanol 119.91
    2-phenylethanol 339.26
    styrene 186.94
    dioctyl adipate 233.66
    dimethyl sulfate 648.62
    ethyl butyrate 428.36
    methyl lactate 513.65
    butyl lactate 280.35
    diethyl carbonate 277.73
    propanediol butyl ether 518.76
    triethyl orthoformate 231.68
    p-tert-butyltoluene 65.62
    methyl 4-tert-butylbenzoate 280.11
    morpholine 2705.87
    tert-butylamine 691.98
    n-dodecanol 81.73
    dimethoxymethane 1978.02
    ethylene carbonate 674.32
    cyrene 333.97
    2-ethoxyethyl acetate 572.04
    2-ethylhexyl acetate 430.6
    1,2,4-trichlorobenzene 419.94
    4-methylpyridine 1337.81
    dibutyl ether 241.97
    2,6-dimethyl-4-heptanol 119.91
    DEF 1824.37
    dimethyl isosorbide 569.73
    tetrachloroethylene 750.56
    eugenol 302.09
    triacetin 434.58
    span 80 331.47
    1,4-butanediol 355.44
    1,1-dichloroethane 1093.76
    2-methyl-1-pentanol 560.47
    methyl formate 1297.99
    2-methyl-1-butanol 936.48
    n-decane 9.08
    butyronitrile 1154.19
    3,7-dimethyl-1-octanol 197.94
    1-chlorooctane 80.28
    1-chlorotetradecane 32.43
    n-nonane 7.17
    undecane 7.45
    tert-butylcyclohexane 17.28
    cyclooctane 4.67
    cyclopentanol 716.27
    tetrahydropyran 1699.28
    tert-amyl methyl ether 656.14
    2,5,8-trioxanonane 790.17
    1-hexene 130.08
    2-isopropoxyethanol 720.73
    2,2,2-trifluoroethanol 417.57
    methyl butyrate 912.86

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction