Butylated hydroxymethylphenol

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  • Identifiers

    CAS number
    88-26-6

    Molecular formula
    C15H24O2

    SMILES
    CC(C)(C)C1=CC(=CC(=C1O)C(C)(C)C)CO

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Woody 53.2%
    Phenolic 50.1%
    Leathery 46.07%
    Dry 39.61%
    Camphoreous 38.63%
    Musk 36.31%
    Amber 31.56%
    Animal 30.09%
    Medicinal 28.86%
    Spicy 28.84%

     

    Flavor
    Phenolic 47.84%
    Camphor 42.06%
    Musty 38.07%
    Mild 35.29%
    Woody 34.55%
    Medicinal 26.29%
    Herbal 25.91%
    Leather 25.66%
    Spice 24.9%
    Earthy 24.45%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    4.0

    pKa est.
    8.9 (weak base)

    Molecular weight
    236.35 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    319°C

    Melting point expt.

    • 141 °C

    Flash point

    • 154.29 ˚C est.

  • Synonyms

    • 2,6-Di-tert-butyl-4-(hydroxymethyl)phenol
    • 2,6-Di-tert-butyl-4-hydroxymethylphenol
    • DTXSID7020211
    • 4-hydroxymethyl-2,6-di-tert-butylphenol
    • BENZYL ALCOHOL, 3,5-DI-tert-BUTYL-4-HYDROXY-
    • 46ND6GQI48
    • NSC-159133
    • DTXCID70211
    • BHTBzOH
    • 4-HMDBP
    • RefChem:83102
    • 201-815-6
    • 88-26-6
    • 3,5-Di-tert-butyl-4-hydroxybenzyl alcohol
    • Ionox 100
    • Ionox 100 antioxidant
    • BHT alcohol
    • Antioxidant 754
    • Benzenemethanol, 3,5-bis(1,1-dimethylethyl)-4-hydroxy-
    • 2,6-ditert-butyl-4-(hydroxymethyl)phenol
    • 3,5-Di-t-butyl-4-hydroxybenzyl alcohol
    • AO 754
    • di-tert-Butyl-4-hydroxymethyl phenol
    • MFCD00017254
    • 2,6-Di-t-butyl-4-hydroxymethylphenol
    • 3,5-Bis(1,1-dimethylethyl)-4-hydroxybenzenemethanol
    • NSC 159133
    • alpha-Hydroxy-2,6-di-tert-butyl-p-cresol
    • 2,6-bis(tert-butyl)-4-(hydroxymethyl)phenol
    • 2,6-bis(1,1-dimethylethyl)-4-(hydroxymethyl)phenol
    • 4-hydroxymethyl-2,6-di-t-butylphenol
    • 2,6-di-tert-Butyl-4-hydroxymethyl phenol
    • CCRIS 7069
    • EINECS 201-815-6
    • 4-hydroxymethyl-2,6-di-tertbutylphenol
    • BRN 2052291
    • UNII-46ND6GQI48
    • SCHEMBL42656
    • 4-06-00-06080 (Beilstein Handbook Reference)
    • CHEMBL225220
    • SCHEMBL2298328
    • SCHEMBL5609769
    • MSK2323
    • CHEBI:173703
    • Tox21_200631
    • NSC159133
    • SBB008243
    • AKOS000249317
    • FD70466
    • CAS-88-26-6
    • 2,6-di-tert.butyl-4-hydroxymethylphenol
    • NCGC00248772-01
    • NCGC00258185-01
    • 3,5-ditert.butyl-4-hydroxybenzyl alcohol
    • AS-69598
    • MSK2323-1000
    • SY048590
    • 2, 6-Di-tert-butyl-4-hydroxymethylphenol
    • 4-hydroxymethyl-2,6-di-tert-butyl phenol
    • Benzyl alcohol,5-di-tert-butyl-4-hydroxy-
    • DB-057052
    • 2, 6-Di-tert-butyl-4-(hydroxymethyl)phenol
    • 3,5-Di-tert-butyl-4-hydroxy-Benzyl alcohol
    • 4-hydroxy-3,5-di-tert-butyl-benzyl alcohol
    • CS-0204438
    • D1480
    • NS00015217
    • ST50825857
    • Benzenemethanol, 4-hydroxy-3,5-di-tert-butyl
    • Benzenemethanol, 4-hydroxy-3,5-di-tert.-butyl
    • 3,5-Di-tert-butyl-4-hydroxybenzyl alcohol, 8CI
    • 3,5-Di-tert-butyl-4-hydroxybenzyl alcohol, 97%
    • F242221
    • 3,5-bis(1,1-dimethylethyl)-4-hydroxy-benzenemethanol
    • Benzenemethanol,5-bis(1,1-dimethylethyl)-4-hydroxy-
    • Q27258951
    • 3,5-Bis(1,1-dimethylethyl)-4-hydroxybenzenemethanol, 9CI
    • 3,5-Di-tert-butyl-4-hydroxybenzyl alcohol Solution in Methanol, 1000?g/mL
    • InChI=1/C15H24O2/c1-14(2,3)11-7-10(9-16)8-12(13(11)17)15(4,5)6/h7-8,16-17H,9H2,1-6H
    • 88-26-6

  • Applications

    Butylated hydroxymethylphenol (CAS 88-26-6) is primarily used as an antioxidant and stabilizer in polymer and plastics formulations to retard thermal and oxidative degradation; it is also applied as a processing stabilizer in coatings and inks, and in adhesive systems to improve oxidative stability of resin matrices. In cosmetics and personal care, it may function as an antioxidant additive in certain formulations, subject to regulatory compliance; in household products and cleaning formulations, it can serve as a stabilizer/additive to extend shelf life and preserve fragrance and color integrity.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 98.44
    methanol 73.22
    isopropanol 114.04
    water 0.43
    ethyl acetate 84.46
    n-propanol 111.14
    acetone 156.66
    n-butanol 100.62
    acetonitrile 86.14
    DMF 286.58
    toluene 80.7
    isobutanol 98.34
    1,4-dioxane 226.03
    methyl acetate 102.03
    THF 561.01
    2-butanone 149.63
    n-pentanol 89.45
    sec-butanol 110.01
    n-hexane 24.54
    ethylene glycol 28.24
    NMP 384.79
    cyclohexane 32.27
    DMSO 178.56
    n-butyl acetate 131.47
    n-octanol 85.48
    chloroform 296.54
    n-propyl acetate 94.07
    acetic acid 91.24
    dichloromethane 204.66
    cyclohexanone 265.73
    propylene glycol 79.29
    isopropyl acetate 69.67
    DMAc 229.48
    2-ethoxyethanol 87.59
    isopentanol 89.51
    n-heptane 33.53
    ethyl formate 93.75
    1,2-dichloroethane 122.18
    n-hexanol 158.48
    2-methoxyethanol 137.99
    isobutyl acetate 84.68
    tetrachloromethane 47.26
    n-pentyl acetate 97.95
    transcutol 111.83
    n-heptanol 106.1
    ethylbenzene 72.42
    MIBK 87.73
    2-propoxyethanol 181.74
    tert-butanol 150.78
    MTBE 101.38
    2-butoxyethanol 123.51
    propionic acid 95.3
    o-xylene 65.96
    formic acid 27.26
    diethyl ether 71.89
    m-xylene 72.24
    p-xylene 103.4
    chlorobenzene 107.34
    dimethyl carbonate 53.61
    n-octane 16.15
    formamide 46.38
    cyclopentanone 417.3
    2-pentanone 114.06
    anisole 112.95
    cyclopentyl methyl ether 189.45
    gamma-butyrolactone 404.62
    1-methoxy-2-propanol 147.41
    pyridine 188.53
    3-pentanone 86.02
    furfural 270.06
    n-dodecane 12.31
    diethylene glycol 93.59
    diisopropyl ether 35.95
    tert-amyl alcohol 127.22
    acetylacetone 120.9
    n-hexadecane 13.64
    acetophenone 122.29
    methyl propionate 96.95
    isopentyl acetate 131.81
    trichloroethylene 243.66
    n-nonanol 81.17
    cyclohexanol 134.5
    benzyl alcohol 99.07
    2-ethylhexanol 112.55
    isooctanol 89.26
    dipropyl ether 104.88
    1,2-dichlorobenzene 103.47
    ethyl lactate 71.38
    propylene carbonate 242.81
    n-methylformamide 108.18
    2-pentanol 79.69
    n-pentane 20.29
    1-propoxy-2-propanol 156.7
    1-methoxy-2-propyl acetate 124.48
    2-(2-methoxypropoxy) propanol 104.92
    mesitylene 51.16
    ε-caprolactone 228.69
    p-cymene 76.57
    epichlorohydrin 312.55
    1,1,1-trichloroethane 139.15
    2-aminoethanol 64.7
    morpholine-4-carbaldehyde 276.78
    sulfolane 489.4
    2,2,4-trimethylpentane 16.91
    2-methyltetrahydrofuran 293.14
    n-hexyl acetate 126.01
    isooctane 13.27
    2-(2-butoxyethoxy)ethanol 110.93
    sec-butyl acetate 69.17
    tert-butyl acetate 96.95
    decalin 27.05
    glycerin 80.02
    diglyme 169.57
    acrylic acid 82.51
    isopropyl myristate 70.01
    n-butyric acid 119.22
    acetyl acetate 59.15
    di(2-ethylhexyl) phthalate 75.22
    ethyl propionate 82.41
    nitromethane 141.64
    1,2-diethoxyethane 72.32
    benzonitrile 111.1
    trioctyl phosphate 67.44
    1-bromopropane 93.65
    gamma-valerolactone 393.93
    n-decanol 68.04
    triethyl phosphate 66.03
    4-methyl-2-pentanol 59.98
    propionitrile 95.84
    vinylene carbonate 175.14
    1,1,2-trichlorotrifluoroethane 179.65
    DMS 78.32
    cumene 63.54
    2-octanol 77.51
    2-hexanone 108.83
    octyl acetate 90.1
    limonene 101.14
    1,2-dimethoxyethane 178.5
    ethyl orthosilicate 64.52
    tributyl phosphate 58.24
    diacetone alcohol 133.3
    N,N-dimethylaniline 109.14
    acrylonitrile 104.37
    aniline 96.82
    1,3-propanediol 81.42
    bromobenzene 109.75
    dibromomethane 152.53
    1,1,2,2-tetrachloroethane 226.18
    2-methyl-cyclohexyl acetate 138.8
    tetrabutyl urea 85.5
    diisobutyl methanol 68.66
    2-phenylethanol 130.19
    styrene 69.9
    dioctyl adipate 100.22
    dimethyl sulfate 105.79
    ethyl butyrate 104.42
    methyl lactate 80.51
    butyl lactate 91.64
    diethyl carbonate 71.67
    propanediol butyl ether 111.78
    triethyl orthoformate 86.42
    p-tert-butyltoluene 86.2
    methyl 4-tert-butylbenzoate 148.4
    morpholine 262.73
    tert-butylamine 103.38
    n-dodecanol 56.62
    dimethoxymethane 149.95
    ethylene carbonate 140.69
    cyrene 184.64
    2-ethoxyethyl acetate 84.09
    2-ethylhexyl acetate 110.51
    1,2,4-trichlorobenzene 126.08
    4-methylpyridine 177.52
    dibutyl ether 71.39
    2,6-dimethyl-4-heptanol 68.66
    DEF 116.95
    dimethyl isosorbide 240.38
    tetrachloroethylene 116.08
    eugenol 133.64
    triacetin 98.58
    span 80 139.75
    1,4-butanediol 49.17
    1,1-dichloroethane 142.16
    2-methyl-1-pentanol 79.05
    methyl formate 98.12
    2-methyl-1-butanol 89.02
    n-decane 19.97
    butyronitrile 111.51
    3,7-dimethyl-1-octanol 75.58
    1-chlorooctane 63.26
    1-chlorotetradecane 29.42
    n-nonane 19.44
    undecane 15.28
    tert-butylcyclohexane 28.93
    cyclooctane 14.7
    cyclopentanol 198.96
    tetrahydropyran 228.8
    tert-amyl methyl ether 85.71
    2,5,8-trioxanonane 134.5
    1-hexene 63.94
    2-isopropoxyethanol 79.86
    2,2,2-trifluoroethanol 40.23
    methyl butyrate 116.61

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction