Butyl 2-pyridyl ether

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  • Identifiers

    CAS number
    27361-16-6

    Molecular formula
    C9H13NO

    SMILES
    CCCCOC1=CC=CC=N1

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Green 61.42%
    Sweet 48.73%
    Earthy 43.1%
    Herbal 38.21%
    Nutty 36.35%
    Spicy 34.68%
    Aromatic 34.26%
    Vegetable 32.91%
    Burnt 31.62%
    Roasted 31.55%

     

    Flavor
    Sweet 53.9%
    Fruity 50.45%
    Earthy 41.59%
    Green 41.1%
    Spicy 32.74%
    Floral 32.09%
    Nutty 31.82%
    Musty 30.53%
    Balsam 30.2%
    Chocolate 25.94%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    2.7

    pKa est.
    5.71 (weak acid)

    Molecular weight
    151.21 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderate

    Boiling point est.
    227°C

    Flash point

    • 87.65 ˚C est.

  • Synonyms

    • 2-Butoxypyridine
    • 27361-16-6
    • Butyl 2-pyridyl ether
    • EINECS 248-428-9
    • DTXSID10181793
    • NSC 30253
    • RefChem:571658
    • DTXCID50104284
    • 248-428-9
    • InChI=1/C9H13NO/c1-2-3-8-11-9-6-4-5-7-10-9/h4-7H,2-3,8H2,1H
    • 2-N-BUTOXYPYRIDINE
    • Pyridine, 2-butoxy-
    • MFCD00006267
    • NSC-30253
    • NSC30253
    • SCHEMBL6803
    • 9UDE6RUH68
    • SCHEMBL128336
    • SCHEMBL128601
    • SCHEMBL128641
    • SCHEMBL131537
    • SCHEMBL447717
    • SCHEMBL9078610
    • 2-BUTOXYPYRIDINE, TECH.
    • SCHEMBL29379587
    • CBA36116
    • AKOS009031429
    • SB53791
    • AS-56769
    • SY049107
    • DB-047209
    • CS-0214825
    • NS00028288
    • ST50409747
    • EN300-19703
    • D88876
    • 27361-16-6

  • Applications

    Butyl 2-pyridyl ether (CAS 27361-16-6) is used primarily as an organic solvent and reaction medium in industrial manufacturing, particularly for organic syntheses involving pyridyl-containing intermediates. It is commonly employed as an intermediate in the preparation of active pharmaceutical ingredients and agrochemical compounds. It can function as a co-solvent in coatings and ink formulations, and is suitable as a cleaning/degreasing solvent in industrial maintenance. Depending on formulation requirements and regulatory constraints, it may also be evaluated for use in electronics-related surface treatments and other specialty cleaning or processing applications.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 3523.5
    methanol 3845.09
    isopropanol 1934.61
    water 0.95
    ethyl acetate 2533.0
    n-propanol 2346.37
    acetone 3129.96
    n-butanol 2261.26
    acetonitrile 2648.52
    DMF 2472.28
    toluene 1002.83
    isobutanol 1707.32
    1,4-dioxane 2655.31
    methyl acetate 1603.79
    THF 2687.21
    2-butanone 1954.78
    n-pentanol 1556.19
    sec-butanol 1687.34
    n-hexane 387.22
    ethylene glycol 391.6
    NMP 1448.67
    cyclohexane 637.08
    DMSO 3497.27
    n-butyl acetate 2331.1
    n-octanol 588.55
    chloroform 7253.07
    n-propyl acetate 1427.47
    acetic acid 3850.17
    dichloromethane 7038.22
    cyclohexanone 2795.94
    propylene glycol 537.27
    isopropyl acetate 1172.66
    DMAc 1500.99
    2-ethoxyethanol 1295.19
    isopentanol 1628.46
    n-heptane 217.98
    ethyl formate 1548.68
    1,2-dichloroethane 4050.08
    n-hexanol 1631.86
    2-methoxyethanol 2498.76
    isobutyl acetate 790.3
    tetrachloromethane 772.59
    n-pentyl acetate 874.85
    transcutol 4116.26
    n-heptanol 513.33
    ethylbenzene 485.17
    MIBK 814.38
    2-propoxyethanol 1602.43
    tert-butanol 1827.15
    MTBE 1543.59
    2-butoxyethanol 786.41
    propionic acid 1716.61
    o-xylene 448.83
    formic acid 768.48
    diethyl ether 2308.23
    m-xylene 514.59
    p-xylene 641.59
    chlorobenzene 1711.66
    dimethyl carbonate 508.31
    n-octane 79.68
    formamide 1055.89
    cyclopentanone 2132.81
    2-pentanone 1705.82
    anisole 913.71
    cyclopentyl methyl ether 1337.09
    gamma-butyrolactone 2254.07
    1-methoxy-2-propanol 1534.61
    pyridine 3251.04
    3-pentanone 1127.34
    furfural 2119.67
    n-dodecane 67.69
    diethylene glycol 945.97
    diisopropyl ether 461.28
    tert-amyl alcohol 1451.41
    acetylacetone 1507.96
    n-hexadecane 76.22
    acetophenone 806.48
    methyl propionate 1353.29
    isopentyl acetate 1520.85
    trichloroethylene 6627.19
    n-nonanol 479.88
    cyclohexanol 1651.93
    benzyl alcohol 814.97
    2-ethylhexanol 870.93
    isooctanol 398.05
    dipropyl ether 1094.6
    1,2-dichlorobenzene 1312.95
    ethyl lactate 425.98
    propylene carbonate 1561.94
    n-methylformamide 1403.28
    2-pentanol 1334.75
    n-pentane 339.66
    1-propoxy-2-propanol 1262.84
    1-methoxy-2-propyl acetate 1010.25
    2-(2-methoxypropoxy) propanol 678.8
    mesitylene 289.23
    ε-caprolactone 2029.17
    p-cymene 298.5
    epichlorohydrin 3009.17
    1,1,1-trichloroethane 2910.4
    2-aminoethanol 871.69
    morpholine-4-carbaldehyde 1523.77
    sulfolane 2229.19
    2,2,4-trimethylpentane 123.77
    2-methyltetrahydrofuran 2154.86
    n-hexyl acetate 1172.52
    isooctane 87.72
    2-(2-butoxyethoxy)ethanol 1014.61
    sec-butyl acetate 772.42
    tert-butyl acetate 889.51
    decalin 191.21
    glycerin 629.4
    diglyme 1800.24
    acrylic acid 1421.58
    isopropyl myristate 384.03
    n-butyric acid 3164.07
    acetyl acetate 1252.8
    di(2-ethylhexyl) phthalate 324.81
    ethyl propionate 981.31
    nitromethane 3657.19
    1,2-diethoxyethane 1702.02
    benzonitrile 1516.71
    trioctyl phosphate 251.13
    1-bromopropane 2610.53
    gamma-valerolactone 2338.22
    n-decanol 350.5
    triethyl phosphate 350.23
    4-methyl-2-pentanol 531.82
    propionitrile 2143.65
    vinylene carbonate 1430.34
    1,1,2-trichlorotrifluoroethane 1973.29
    DMS 686.55
    cumene 297.65
    2-octanol 366.33
    2-hexanone 1278.89
    octyl acetate 507.23
    limonene 505.53
    1,2-dimethoxyethane 2197.05
    ethyl orthosilicate 357.86
    tributyl phosphate 358.73
    diacetone alcohol 785.97
    N,N-dimethylaniline 506.9
    acrylonitrile 2192.55
    aniline 1326.39
    1,3-propanediol 1406.36
    bromobenzene 1895.44
    dibromomethane 4881.37
    1,1,2,2-tetrachloroethane 4648.18
    2-methyl-cyclohexyl acetate 633.05
    tetrabutyl urea 448.26
    diisobutyl methanol 394.07
    2-phenylethanol 843.83
    styrene 784.41
    dioctyl adipate 544.95
    dimethyl sulfate 609.38
    ethyl butyrate 1202.1
    methyl lactate 507.05
    butyl lactate 587.93
    diethyl carbonate 723.62
    propanediol butyl ether 782.23
    triethyl orthoformate 661.65
    p-tert-butyltoluene 254.22
    methyl 4-tert-butylbenzoate 522.55
    morpholine 3056.92
    tert-butylamine 1274.38
    n-dodecanol 275.12
    dimethoxymethane 1547.83
    ethylene carbonate 1329.68
    cyrene 438.62
    2-ethoxyethyl acetate 975.72
    2-ethylhexyl acetate 1110.8
    1,2,4-trichlorobenzene 1340.63
    4-methylpyridine 2749.32
    dibutyl ether 976.58
    2,6-dimethyl-4-heptanol 394.07
    DEF 1893.9
    dimethyl isosorbide 878.92
    tetrachloroethylene 3243.11
    eugenol 576.54
    triacetin 717.37
    span 80 683.51
    1,4-butanediol 536.6
    1,1-dichloroethane 3737.28
    2-methyl-1-pentanol 1180.42
    methyl formate 1064.17
    2-methyl-1-butanol 1653.89
    n-decane 114.52
    butyronitrile 2567.38
    3,7-dimethyl-1-octanol 550.71
    1-chlorooctane 452.62
    1-chlorotetradecane 173.29
    n-nonane 116.73
    undecane 85.11
    tert-butylcyclohexane 160.14
    cyclooctane 138.49
    cyclopentanol 1310.89
    tetrahydropyran 3192.73
    tert-amyl methyl ether 909.86
    2,5,8-trioxanonane 1099.08
    1-hexene 1320.42
    2-isopropoxyethanol 808.83
    2,2,2-trifluoroethanol 657.23
    methyl butyrate 1610.21

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction