Bulnesol

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  • Identifiers

    CAS number
    22451-73-6

    Molecular formula
    C15H26O

    SMILES
    C[C@H]1CCC2=C(CC[C@H](C[C@@H]12)C(C)(C)O)C

    Retention indicies (RI)

    • DB5: 1666.14
    • Carbowax: 2212.67

  • Odor profile

    Woody 73.0%
    Sweet 55.88%
    Floral 50.61%
    Spicy 46.59%
    Balsamic 42.45%
    Amber 34.35%
    Sandalwood 33.94%
    Dry 33.41%
    Clean 33.23%
    Herbal 31.87%

    Scent© AI

  • Properties

    XLogP3-AA
    2.9

    pKa est.
    10.16 (weak base)

    Molecular weight
    222.37 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    320°C

    Flash point est.
    96.7 ˚C

  • Synonyms

    • Bulnesol
    • 22451-73-6
    • 2-[(3S,3aS,5R)-3,8-Dimethyl-1,2,3,3a,4,5,6,7-octahydroazulen-5-yl]propan-2-ol
    • SCHEMBL2696394
    • DTXSID4051873
    • CHEBI:167421
    • LGOFSGDSFQNIAT-SCRDCRAPSA-N
    • HY-N10014
    • AKOS040763769
    • DA-61943
    • CS-0253685
    • NS00095836

  • Applications

    Bulnesol (CAS 22451-73-6) is a natural sesquiterpene alcohol with a warm woody–earthy tonality, widely used in perfumery as a base-note odorant and fixative for fine fragrances, diffusers, candles, soaps, shampoos and detergents, where it enhances longevity, rounds patchouli/amber/woody accords and improves odor stability in surfactant-rich matrices; in home and fabric care it is incorporated into air fresheners, wax melts and softeners for long-lasting warmth; analytically, Bulnesol serves as a marker for qualitative/quantitative GC–MS profiling and quality control of patchouli oil and as a reference standard in aroma research; in R&D it is employed as a sesquiterpene scaffold for semi-synthesis and is investigated for potential antimicrobial, antifungal and insect-repellent activities (research context, not a product claim), and it can be microencapsulated to enable slow release in laundry powders or fragrance tablets; use should follow IFRA and local regulatory guidance, with dosage tailored to the product matrix and desired sensory impact.

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 852.01
    methanol 827.24
    isopropanol 849.25
    water 2.11
    ethyl acetate 717.11
    n-propanol 765.22
    acetone 850.64
    n-butanol 747.5
    acetonitrile 746.3
    DMF 690.78
    toluene 670.1
    isobutanol 550.18
    1,4-dioxane 2037.56
    methyl acetate 640.73
    THF 2570.14
    2-butanone 751.39
    n-pentanol 372.49
    sec-butanol 492.75
    n-hexane 85.6
    ethylene glycol 77.35
    NMP 461.31
    cyclohexane 250.79
    DMSO 446.85
    n-butyl acetate 687.4
    n-octanol 302.45
    chloroform 2155.04
    n-propyl acetate 412.94
    acetic acid 353.98
    dichloromethane 1591.23
    cyclohexanone 971.07
    propylene glycol 162.02
    isopropyl acetate 504.98
    DMAc 509.68
    2-ethoxyethanol 398.38
    isopentanol 582.41
    n-heptane 124.13
    ethyl formate 461.06
    1,2-dichloroethane 720.13
    n-hexanol 666.74
    2-methoxyethanol 781.66
    isobutyl acetate 354.01
    tetrachloromethane 364.39
    n-pentyl acetate 411.63
    transcutol 1460.08
    n-heptanol 316.9
    ethylbenzene 284.67
    MIBK 418.6
    2-propoxyethanol 828.45
    tert-butanol 863.65
    MTBE 804.79
    2-butoxyethanol 490.44
    propionic acid 353.17
    o-xylene 326.28
    formic acid 92.51
    diethyl ether 806.48
    m-xylene 386.07
    p-xylene 407.15
    chlorobenzene 607.19
    dimethyl carbonate 197.24
    n-octane 48.96
    formamide 178.08
    cyclopentanone 1035.83
    2-pentanone 605.64
    anisole 501.63
    cyclopentyl methyl ether 730.12
    gamma-butyrolactone 940.43
    1-methoxy-2-propanol 702.16
    pyridine 1155.79
    3-pentanone 401.38
    furfural 704.08
    n-dodecane 39.3
    diethylene glycol 417.66
    diisopropyl ether 260.37
    tert-amyl alcohol 452.12
    acetylacetone 615.43
    n-hexadecane 45.5
    acetophenone 385.24
    methyl propionate 424.04
    isopentyl acetate 642.64
    trichloroethylene 1227.71
    n-nonanol 272.0
    cyclohexanol 569.16
    benzyl alcohol 364.19
    2-ethylhexanol 374.93
    isooctanol 250.86
    dipropyl ether 579.22
    1,2-dichlorobenzene 458.78
    ethyl lactate 160.52
    propylene carbonate 537.26
    n-methylformamide 363.36
    2-pentanol 400.03
    n-pentane 109.24
    1-propoxy-2-propanol 638.18
    1-methoxy-2-propyl acetate 592.87
    2-(2-methoxypropoxy) propanol 403.91
    mesitylene 237.05
    ε-caprolactone 749.23
    p-cymene 232.42
    epichlorohydrin 1003.88
    1,1,1-trichloroethane 845.57
    2-aminoethanol 237.81
    morpholine-4-carbaldehyde 785.93
    sulfolane 629.47
    2,2,4-trimethylpentane 54.05
    2-methyltetrahydrofuran 1317.08
    n-hexyl acetate 544.62
    isooctane 55.79
    2-(2-butoxyethoxy)ethanol 591.72
    sec-butyl acetate 304.8
    tert-butyl acetate 504.34
    decalin 84.51
    glycerin 184.86
    diglyme 1081.92
    acrylic acid 248.43
    isopropyl myristate 231.05
    n-butyric acid 665.73
    acetyl acetate 455.17
    di(2-ethylhexyl) phthalate 221.19
    ethyl propionate 338.29
    nitromethane 619.83
    1,2-diethoxyethane 730.1
    benzonitrile 595.51
    trioctyl phosphate 165.1
    1-bromopropane 662.63
    gamma-valerolactone 1215.02
    n-decanol 197.98
    triethyl phosphate 183.92
    4-methyl-2-pentanol 272.64
    propionitrile 743.6
    vinylene carbonate 567.98
    1,1,2-trichlorotrifluoroethane 473.23
    DMS 336.48
    cumene 191.64
    2-octanol 215.01
    2-hexanone 385.33
    octyl acetate 277.08
    limonene 301.65
    1,2-dimethoxyethane 936.37
    ethyl orthosilicate 191.81
    tributyl phosphate 189.26
    diacetone alcohol 426.22
    N,N-dimethylaniline 298.44
    acrylonitrile 635.78
    aniline 572.06
    1,3-propanediol 440.27
    bromobenzene 666.66
    dibromomethane 1047.12
    1,1,2,2-tetrachloroethane 939.83
    2-methyl-cyclohexyl acetate 369.49
    tetrabutyl urea 231.74
    diisobutyl methanol 234.93
    2-phenylethanol 457.15
    styrene 350.36
    dioctyl adipate 287.49
    dimethyl sulfate 211.79
    ethyl butyrate 466.21
    methyl lactate 193.14
    butyl lactate 299.2
    diethyl carbonate 292.35
    propanediol butyl ether 391.32
    triethyl orthoformate 331.05
    p-tert-butyltoluene 242.31
    methyl 4-tert-butylbenzoate 353.81
    morpholine 1815.49
    tert-butylamine 602.92
    n-dodecanol 153.51
    dimethoxymethane 694.96
    ethylene carbonate 525.74
    cyrene 306.2
    2-ethoxyethyl acetate 519.72
    2-ethylhexyl acetate 495.04
    1,2,4-trichlorobenzene 511.81
    4-methylpyridine 1073.69
    dibutyl ether 411.56
    2,6-dimethyl-4-heptanol 234.93
    DEF 455.84
    dimethyl isosorbide 666.28
    tetrachloroethylene 588.55
    eugenol 331.07
    triacetin 421.99
    span 80 418.44
    1,4-butanediol 129.02
    1,1-dichloroethane 908.06
    2-methyl-1-pentanol 312.05
    methyl formate 282.68
    2-methyl-1-butanol 452.02
    n-decane 70.3
    butyronitrile 839.13
    3,7-dimethyl-1-octanol 295.71
    1-chlorooctane 209.62
    1-chlorotetradecane 90.28
    n-nonane 66.91
    undecane 50.79
    tert-butylcyclohexane 77.16
    cyclooctane 79.82
    cyclopentanol 571.16
    tetrahydropyran 1855.13
    tert-amyl methyl ether 384.46
    2,5,8-trioxanonane 687.78
    1-hexene 271.28
    2-isopropoxyethanol 311.56
    2,2,2-trifluoroethanol 127.83
    methyl butyrate 432.26

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction

Botanical

Name CAS Botanical Proportion
Basil 2 8015-73-4 Ocimum basilicum L., fam. Lamiaceae (Labiatae) 0.45%
Galbanum 2 9000-24-2 Ferula galbaniflua Boiss. et Buhse, fam. Apiaceae (Umbelliferae) 0.5%
Cajuput (Vietnam) 2 8008-98-8 Melaleuca cajuputi Powell, var. cajuputi, fam. Myrtaceae 0.01%
Guaiacwood 2 8016-23-7 Bulnesia sarmienti Lorentz ex Griseb, fam. Zygophyllaceae 41.3%
Guaiacwood 1 8016-23-7 Bulnesia sarmienti Lorentz ex Griseb, fam. Zygophyllaceae 45.0%
Patchouli (India) 1 8014-09-3 Pogostemon cablin Benth., fam. Lamiaceae (Labiatae) 5.32%
Eucalyptus globulus (Portugal) 1 8016-26-0 Eucalyptus globulus Labill., fam. Myrtaceae 0.01%
Aristolochia impudica leaf Aristolochia impudica J. Ortega, fam. Aristolochiaceae 1.73%
Leptospermum javanicum (Malaysia) Leptospermum javanicum Blume, fam. Myrtaceae 1.8%
Helichrysum italicum 1a 8023-95-8 Helichrysum italicum (Roth) G. Don ssp. italicum, fam. Asteraceae 0.81%
Aristolochia brevipes Aristolochia brevipes Benth., fam. Aristolochiaceae 0.4%
Bixa orellana (Cameroon) Bixa orellana L., fam. Bixaceae 2.3%
Bupleurum gibraltarium (Spain) Bupleurum gibraltarium Lam., fam. Apiaceae (Umbelliferae) 2.1%
Piper plurinervosum Piper plurinervosum Yuncker, fam. Piperaceae 0.8%
Cajuput (Vietnam) 1 8008-98-8 Melaleuca cajuputi Powell, var. cajuputi, fam. Myrtaceae 0.2%
Salvia aramiensis (Turkey) Salvia aramiensis Rech. fil., fam. Lamiaceae (Labiatae) 0.5%
Helichrysum italicum (France-Corsica) 8025-95-8 Helichyrsum italicum (Roth) G. Don ssp.italicum, fam. Asteraceae (Compos.) 0.5%
Licaria salicifolia Licaria salicifolia (Sw.) Kosterm., fam. Lauraceae 0.5%
Cassinia laevis flower Cassinia laevis R.Br., fam. Asteraceae (Compositae) 0.7%
Cassinia laevis leaf Cassinia laevis R.Br., fam. Asteraceae (Compositae) 0.4%
Myrtle leaf (Turkey) 2 8008-46-6 Myrtus communis L., fam. Myrtaceae 0.05%
Prostanthera staurophylla Prostanthera staurophylla F. Muell., fam. Lamiaceae (Labiatae) 0.6%
Hedychium coccineum rhizome (Mauritius) Hedychium coccineum, fam. Zingiberaceae 0.4%
Hedychium coronarium rhizome (Mauritius) Hedychium coronarium Koenig, fam. Zingiberaceae 0.3%