Bulnesene oxide (CAS 33784-90-6) is a sesquiterpene oxide of natural origin (notably associated with patchouli oil) used primarily in fragrance applications to impart warm woody–earthy, slightly amber nuances, enhancing depth and longevity in woody, chypre, fougère, and woody-amber accords; it is incorporated into fine fragrances, personal-care cosmetics, soaps, detergents, home-care products, candles, and deodorizers, where it helps fix, round off, and modulate patchouli facets or reconstruct the natural impression of the oil; in analytics and QC, bulnesene oxide is employed as a GC–MS reference/standard for identification and quantification in essential oils and botanical extracts, supporting origin assessment and adulteration screening; in fragrance R&D, it serves as a reference for sesquiterpene oxidation studies, olfactory characterization, and matrix interactions, and occasionally as an intermediate toward related odorants; usage should follow applicable safety and regulatory frameworks (e.g., IFRA, allergen considerations) with application-specific recommended levels.
