(+-)-Brompheniramine maleate

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  • Identifiers

    CAS number
    980-71-2

    Molecular formula
    C20H23BrN2O4

    SMILES
    CN(C)CCC(C1=CC=C(C=C1)Br)C2=CC=CC=N2.C(=C\C(=O)O)\C(=O)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Animal 38.81%
    Floral 32.4%
    Sweet 31.23%
    Fishy 28.72%
    Citrus 27.06%
    Grapefruit 25.42%
    Fresh 24.67%
    Roasted 23.25%
    Burnt 22.55%
    Grape 22.06%

     

    Flavor
    Bitter 33.16%
    Mild 25.34%
    Green 21.83%
    Syrup 20.2%
    Tomato leaf 20.14%
    Green pepper 19.93%
    Herbal 19.87%
    Cedarleaf 19.78%
    Nitrile 19.65%
    Carrot 19.49%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    6.6 (neutral)

    Molecular weight
    435.3 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    407°C

    Flash point

    • 170.93 ˚C est.

  • Synonyms

    • Brompheniramine maleate
    • 980-71-2
    • Brompheniramine hydrogen maleate
    • Dimotane
    • Allent
    • Drauxin
    • Nagemid
    • Veltane
    • Ilvin
    • Parabromdylamine maleate
    • IXA7C9ZN03
    • Brompheniramine maleate [USP]
    • NSC-758652
    • Brompheniramine maleate (USP)
    • CHEBI:3184
    • DTXSID2052657
    • 2-(p-Bromo-alpha-(2-(dimethylamino)ethyl)benzyl)pyridine maleate
    • 2-Pyridinepropanamine, gamma-(4-bromophenyl)-N,N-dimethyl-, (Z)-butenedioate (1:1)
    • 2-Pyridinepropanamine, gamma-(4-bromophenyl)-N,N-dimethyl-, (2Z)-2-butenedioate (1:1)
    • Dimegan
    • 2-[p-Bromo-alpha-[2-(dimethylamino)ethyl]benzyl]pyridine Maleate
    • Dimotane l.a.
    • Brompheniramine fumarate
    • Maleate, Brompheniramine
    • RefChem:390697
    • Dimetapp Cold and Allergy
    • (+-)-Brompheniramine maleate
    • Brompheniramine Maleate (1:1)
    • DTXCID3031230
    • CVS PHARMACY Childrens Cold and Allergy
    • 2-Pyridinepropanamine, gamma-(4-Bromophenyl)-N,N-dimethyl-,(Z)-butenedioate(1:1)
    • 213-562-9
    • Dimetane
    • (+/-)-Brompheniramine maleate
    • Dimetane-ten
    • MFCD00057367
    • Lodrane
    • MLS000028423
    • Brompheniramine (maleate)
    • (+/-)-Brompheniramine maleate salt
    • C20H23BrN2O4
    • Rolabromophen
    • Gammistin
    • SMR000058417
    • Spentane
    • Ebalin
    • 3-(4-bromophenyl)-N,N-dimethyl-3-(pyridin-2-yl)propan-1-amine maleate
    • MFCD00865691
    • gamma-(4-Bromophenyl)-N,N-dimethyl-2-pyridinepropanamine Maleate
    • Dimetane Extentabs
    • 3-(4-bromophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine;(Z)-but-2-enedioic acid
    • SR-01000003057
    • EINECS 213-562-9
    • UNII-IXA7C9ZN03
    • Halin;
    • Dimetane (TN)
    • Prestwick_913
    • 3-(p-bromophenyl)-3-(2-pyridyl)-N,N-dimethylpropylamine maleate
    • Opera_ID_399
    • 2-(p-Bromo-alpha-(2-(dimethylamino)ethyl)benzyl)pyridine maleate (1:1)
    • Dexbrompheniramine maleate;
    • Brompheniramine maleate CRS
    • (y)-Brompheniramine maleate
    • (?)-Brompheniramine maleate
    • 2-Pyridinepropanamine, gamma-(4-bromophenyl)-N,N-dimethyl-, (+-)-, (Z)-2-butenedioate (1:1)
    • SCHEMBL41913
    • MLS001148196
    • SPECTRUM1503985
    • orb1310837
    • CHEMBL1200961
    • (A+/-)-Brompheniramine maleate
    • HY-B0480R
    • SRGKFVAASLQVBO-BTJKTKAUSA-N
    • HMS1569O12
    • HMS1922O16
    • HMS2093O07
    • HMS2096O12
    • HMS2230I21
    • HMS2234D14
    • HMS3260J03
    • HMS3713O12
    • HMS3884J10
    • HMS5081J07
    • Pharmakon1600-01503985
    • HY-B0480
    • MSK10144
    • Tox21_500201
    • Brompheniramine (maleate) (Standard)
    • CCG-39068
    • EBC-80064
    • NSC758652
    • s2585
    • (+-)-2-p-Bromo-alpha-2-(dimethylamino)ethylbenzylpyridine maleate (1:1)
    • AKOS015855858
    • Pyridine, 2-(p-bromo-alpha-(2-(dimethylamino)ethyl)benzyl)-, maleate (1:1)
    • AC-1311
    • BROMPHENIRAMINE MALEATE [MART.]
    • BROMPHENIRAMINE MALEATE [VANDF]
    • FB19341
    • LP00201
    • NSC 758652
    • 2-Pyridinepropanamine, gamma-(4-bromophenyl)-N,N-dimethyl-, (+-)-, (Z)-butenedioate (1:1)
    • BROMPHENIRAMINE MALEATE [USP-RS]
    • BROMPHENIRAMINE MALEATE [WHO-DD]
    • NCGC00093676-01
    • NCGC00093676-02
    • NCGC00093676-03
    • NCGC00093676-04
    • NCGC00093676-05
    • NCGC00260886-01
    • AS-14101
    • DA-61905
    • SMR000653459
    • SY066720
    • BROMPHENIRAMINE MALEATE [EP IMPURITY]
    • BROMPHENIRAMINE MALEATE [ORANGE BOOK]
    • EU-0100201
    • NS00076241
    • SW197031-3
    • BROMPHENIRAMINE MALEATE [EP MONOGRAPH]
    • B 2390
    • BROMPHENIRAMINE MALEATE [USP MONOGRAPH]
    • C77353
    • D00663
    • ( inverted question mark)-Brompheniramine maleate
    • BIPHETAP COMPONENT BROMPHENIRAMINE MALEATE
    • DIMETAPP COMPONENT BROMPHENIRAMINE MALEATE
    • 980-71-2

  • Applications

    Primarily, (+-)-Brompheniramine maleate serves as an active pharmaceutical ingredient (API) in antihistamine formulations for allergy relief and upper respiratory symptoms. It is commonly found in over-the-counter medicines, including combination products with decongestants to treat cold symptoms. It is formulated in a range of oral dosage forms, such as tablets, capsules, and syrups, for consumer health care. In research and development, brompheniramine maleate may be encountered as a reference compound or intermediate in medicinal chemistry studies related to antihistaminic agents.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 129.14
    methanol 119.99
    isopropanol 61.24
    water 1.77
    ethyl acetate 168.04
    n-propanol 121.35
    acetone 237.04
    n-butanol 112.58
    acetonitrile 72.95
    DMF 333.33
    toluene 112.87
    isobutanol 96.84
    1,4-dioxane 322.48
    methyl acetate 173.96
    THF 375.34
    2-butanone 219.12
    n-pentanol 102.47
    sec-butanol 70.6
    n-hexane 2.39
    ethylene glycol 75.6
    NMP 340.03
    cyclohexane 9.23
    DMSO 388.75
    n-butyl acetate 131.17
    n-octanol 31.27
    chloroform 654.41
    n-propyl acetate 127.35
    acetic acid 233.42
    dichloromethane 616.54
    cyclohexanone 302.8
    propylene glycol 97.13
    isopropyl acetate 85.7
    DMAc 473.1
    2-ethoxyethanol 267.25
    isopentanol 89.84
    n-heptane 5.53
    ethyl formate 161.3
    1,2-dichloroethane 356.05
    n-hexanol 90.49
    2-methoxyethanol 321.68
    isobutyl acetate 104.62
    tetrachloromethane 70.55
    n-pentyl acetate 77.91
    transcutol 505.03
    n-heptanol 51.6
    ethylbenzene 35.31
    MIBK 78.77
    2-propoxyethanol 212.79
    tert-butanol 66.5
    MTBE 68.03
    2-butoxyethanol 136.76
    propionic acid 133.0
    o-xylene 65.15
    formic acid 111.23
    diethyl ether 75.53
    m-xylene 68.02
    p-xylene 55.96
    chlorobenzene 174.92
    dimethyl carbonate 107.16
    n-octane 2.32
    formamide 139.55
    cyclopentanone 322.29
    2-pentanone 139.76
    anisole 112.08
    cyclopentyl methyl ether 164.73
    gamma-butyrolactone 346.02
    1-methoxy-2-propanol 168.01
    pyridine 307.13
    3-pentanone 146.46
    furfural 377.07
    n-dodecane 2.21
    diethylene glycol 211.37
    diisopropyl ether 20.68
    tert-amyl alcohol 70.94
    acetylacetone 177.56
    n-hexadecane 2.55
    acetophenone 136.92
    methyl propionate 165.03
    isopentyl acetate 115.36
    trichloroethylene 741.38
    n-nonanol 33.47
    cyclohexanol 113.86
    benzyl alcohol 150.04
    2-ethylhexanol 60.79
    isooctanol 45.98
    dipropyl ether 58.2
    1,2-dichlorobenzene 151.86
    ethyl lactate 90.3
    propylene carbonate 214.47
    n-methylformamide 150.64
    2-pentanol 54.2
    n-pentane 3.15
    1-propoxy-2-propanol 136.26
    1-methoxy-2-propyl acetate 163.9
    2-(2-methoxypropoxy) propanol 109.92
    mesitylene 33.99
    ε-caprolactone 248.49
    p-cymene 35.22
    epichlorohydrin 482.02
    1,1,1-trichloroethane 242.94
    2-aminoethanol 111.22
    morpholine-4-carbaldehyde 401.21
    sulfolane 368.44
    2,2,4-trimethylpentane 5.12
    2-methyltetrahydrofuran 232.97
    n-hexyl acetate 71.96
    isooctane 2.71
    2-(2-butoxyethoxy)ethanol 155.0
    sec-butyl acetate 84.3
    tert-butyl acetate 85.39
    decalin 6.15
    glycerin 148.41
    diglyme 323.7
    acrylic acid 150.28
    isopropyl myristate 31.84
    n-butyric acid 172.36
    acetyl acetate 121.48
    di(2-ethylhexyl) phthalate 56.94
    ethyl propionate 95.07
    nitromethane 307.63
    1,2-diethoxyethane 148.14
    benzonitrile 131.99
    trioctyl phosphate 36.47
    1-bromopropane 118.03
    gamma-valerolactone 475.23
    n-decanol 26.91
    triethyl phosphate 67.61
    4-methyl-2-pentanol 38.15
    propionitrile 80.88
    vinylene carbonate 240.07
    1,1,2-trichlorotrifluoroethane 435.35
    DMS 101.59
    cumene 28.75
    2-octanol 27.89
    2-hexanone 109.4
    octyl acetate 45.27
    limonene 49.71
    1,2-dimethoxyethane 270.84
    ethyl orthosilicate 66.24
    tributyl phosphate 43.89
    diacetone alcohol 111.33
    N,N-dimethylaniline 79.11
    acrylonitrile 106.27
    aniline 180.09
    1,3-propanediol 145.37
    bromobenzene 166.17
    dibromomethane 320.91
    1,1,2,2-tetrachloroethane 516.16
    2-methyl-cyclohexyl acetate 94.89
    tetrabutyl urea 54.33
    diisobutyl methanol 31.17
    2-phenylethanol 125.98
    styrene 53.36
    dioctyl adipate 64.49
    dimethyl sulfate 170.66
    ethyl butyrate 102.86
    methyl lactate 109.95
    butyl lactate 81.07
    diethyl carbonate 80.59
    propanediol butyl ether 101.12
    triethyl orthoformate 88.2
    p-tert-butyltoluene 33.57
    methyl 4-tert-butylbenzoate 98.79
    morpholine 354.55
    tert-butylamine 33.06
    n-dodecanol 21.23
    dimethoxymethane 224.13
    ethylene carbonate 195.19
    cyrene 163.32
    2-ethoxyethyl acetate 147.25
    2-ethylhexyl acetate 98.69
    1,2,4-trichlorobenzene 212.19
    4-methylpyridine 253.98
    dibutyl ether 35.1
    2,6-dimethyl-4-heptanol 31.17
    DEF 182.17
    dimethyl isosorbide 189.76
    tetrachloroethylene 355.13
    eugenol 106.8
    triacetin 114.52
    span 80 91.86
    1,4-butanediol 96.3
    1,1-dichloroethane 257.19
    2-methyl-1-pentanol 94.96
    methyl formate 157.07
    2-methyl-1-butanol 98.34
    n-decane 3.22
    butyronitrile 85.02
    3,7-dimethyl-1-octanol 38.01
    1-chlorooctane 18.87
    1-chlorotetradecane 9.04
    n-nonane 2.68
    undecane 2.58
    tert-butylcyclohexane 5.54
    cyclooctane 3.28
    cyclopentanol 115.98
    tetrahydropyran 233.27
    tert-amyl methyl ether 65.78
    2,5,8-trioxanonane 204.01
    1-hexene 14.45
    2-isopropoxyethanol 163.47
    2,2,2-trifluoroethanol 126.33
    methyl butyrate 128.06

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction