Bromocresol Green

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  • Identifiers

    CAS number
    76-60-8

    Molecular formula
    C21H14Br4O5S

    SMILES
    CC1=C(C(=C(C=C1C2(C3=CC=CC=C3S(=O)(=O)O2)C4=CC(=C(C(=C4C)Br)O)Br)Br)O)Br

    Safety labels

  • Odor profile

    Fragrance
    Odorless 62.92%
    Phenolic 27.3%
    Burnt 26.39%
    Savory 20.84%
    Smoky 19.43%
    Bitter 18.67%
    Dry 17.12%
    Meaty 16.54%
    Cooked 15.63%
    Animal 15.15%

     

    Flavor
    Bitter 92.14%
    Odorless 29.81%
    Bland 21.03%
    Sweet-like 19.91%
    Nitrile 19.63%
    Very strong 19.52%
    Cedarleaf 19.37%
    Indole 19.1%
    Bread crust 18.31%
    Scallion 18.23%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    6.5

    pKa est.
    7.89 (neutral)

    Molecular weight
    698.0 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    861°C

    Flash point

    • 247.45 ˚C est.

  • Synonyms

    • Bromocresol green
    • 76-60-8
    • BROMCRESOL GREEN
    • Tetrabromo-m-cresolphthalein sulfone
    • 3',3'',5',5''-Tetrabromo-m-cresolsulfonephthalein
    • DTXSID9044459
    • 8YGN0Y942M
    • NSC-7817
    • DTXCID7024459
    • m-Cresol, 4,4'-(3H-2,1-benzoxathiol-3-ylidene)bis(2,6-dibromo-, S,S-dioxide
    • Phenol, 4,4'-(1,1-dioxido-3H-2,1-benzoxathiol-3-ylidene)bis(2,6-dibromo-3-methyl-
    • Phenol, 4,4'-(3H-2,1-benzoxathiol-3-ylidene)bis(2,6-dibromo-3-methyl-, S,S-dioxide
    • Green, Bromcresol
    • Phenol, 4,4'-(3H-2,1-benzoxathiol-3-ylidene)bis[2,6-dibromo-3-methyl-, S,S-dioxide
    • Green, Bromocresol
    • Tetrabromocresolsulfonphthalein
    • 3,3-bis(3,5-dibromo-4-hydroxy-2-methylphenyl)-3H-2,1$l^(6)-benzoxathiole-1,1-dione
    • 3,3-bis(3,5-dibromo-4-hydroxy-2-methylphenyl)-3H-2,1$l^{6}-benzoxathiole-1,1-dione
    • m-Cresol, 4,4'-(3H-2,1-benzoxathiol-3-ylidene)bis[2,6-dibromo-, S,S-dioxide
    • RefChem:191
    • Phenol, 4,4'-(3H-2,1-benzoxathiol-3-ylidene)bis(2,6-dibromo-3-methyl)-, S,S-dioxide
    • 200-972-8
    • Bromocresolgreen
    • bromo cresol green
    • 3,3-Bis(3,5-dibromo-4-hydroxy-2-methylphenyl)-3H-benzo[c][1,2]oxathiole 1,1-dioxide
    • MFCD00005874
    • Bromocresol blue
    • NSC 7817
    • Bromocresol Green solution
    • CHEMBL145704
    • NSC7817
    • 2,6-dibromo-4-[3-(3,5-dibromo-4-hydroxy-2-methylphenyl)-1,1-dioxo-2,1lambda6-benzoxathiol-3-yl]-3-methylphenol
    • 4,4'-(1,1-dioxido-3H-2,1-benzoxathiole-3,3-diyl)bis(2,6-dibromo-3-methylphenol)
    • 3,3-Bis(3,5-dibromo-4-hydroxy-2-methylphenyl)benzo[c]1,2-oxathiolene-1,1-dione
    • o-Toluenesulfonic acid, .alpha.,.alpha.-bis(3,5-dibromo-4-hydroxy-o-tolyl)-.alpha.-hydroxy-, .gamma.-sultone
    • C21H14Br4O5S
    • BCG [dye]
    • EINECS 200-972-8
    • BRN 0372527
    • UNII-8YGN0Y942M
    • BROMOCRESOL GREEN, ACS
    • Bromocresol Verde
    • Tetrabromo-m-cresolphthalein sulfone; 3',3'',5',5''-Tetrabromo-m-cresolsulfonephthalein; BCG
    • Vert de bromocresol
    • Verde de bromocresol
    • o-Toluenesulfonic acid, alpha-hydroxy-, gamma-sultone
    • Bromocresol green (BCG)
    • Bromocresol Green Indicator
    • GSP Chem Bromocresol Green
    • SCHEMBL38763
    • 5-19-03-00460 (Beilstein Handbook Reference)
    • Bromocresol Green, ACS grade
    • BROMCRESOL GREEN [MI]
    • Bromocresol green as indicator
    • Bromocresol Green Sultone Form
    • Bromocresol Green, ACS reagent
    • GTPL4530
    • orb2278615
    • SCHEMBL29350747
    • SCHEMBL29353290
    • Tetrabromo-m-cresolsulfonphthalein
    • CHEBI:183839
    • Tox21_302105
    • BDBM50420251
    • STL280536
    • Bromocresol Green, JIS special grade
    • AKOS015902660
    • BACIILUS CALMETTE GUERIN VACCINE
    • Bromocresol Green Sultone Form, powder
    • CS-W020884
    • FB01459
    • HY-W040144
    • 4,4'-(3H-2,1-Benzoxathiol-3-ylidene)bis(2,6-dibromo-3-methyl)phen- ol S,S-dioxide
    • CAS-76-60-8
    • NCGC00255852-01
    • 2,6-dibromo-4-[3-(3,5-dibromo-4-hydroxy-2-methyl-phenyl)-1,1-dioxo-2,1$l^{6}-benzoxathiol-3-yl]-3-methyl-phenol
    • B0114
    • B0578
    • B0579
    • B2401
    • NS00007498
    • ST51006967
    • 3',5',5''-Tetrabrom-m-cresolsulfonephthalein
    • 3',5',5''-Tetrabromo-m-cresolsulfonephthalein
    • D78150
    • A838763
    • F837422
    • Q418613
    • 3',3'',5',5''-Tetrabrom-m-cresolsulfonephthalein
    • Bromocresol Green, ACS reagent, Dye content 95 %
    • 3',3'',5',5''-Tetrabromo-m-cresol-sulfonephthalein
    • Bromocresol green sultone form (indicator (pH 3.8-5.4))
    • 3,3-Bis(3,5-dibromo-4-hydroxy-2-methylphenyl)-2,1lambda~6~-benzoxathiole-1,1(3H)-dione
    • 4,4'-(3H-2,1-Benzoxathiol-3-ylidene)bis(2,6-dibromo-3-methylphenol), S,S-dioxide-
    • m-Cresol,4'-(3H-2,1-benzoxathiol-3-ylidene)bis[2,6-dibromo-, S,S-dioxide
    • Phenol,4'-(3H-2,1-benzoxathiol-3-ylidene)bis[2,6-dibromo-3-methyl-, S,S-dioxide
    • 2,6-dibromo-4-[3-(3,5-dibromo-4-hydroxy-2-methylphenyl)-1,1-dioxo-2,1$l^{6}-benzoxathiol-3-yl]-3-methylphenol
    • 4-[3-[3,5-bis(bromanyl)-2-methyl-4-oxidanyl-phenyl]-1,1-bis(oxidanylidene)-2,1$l^{6}-benzoxathiol-3-yl]-2,6-bis(bromanyl)-3-methyl-phenol
    • Bromocresol Green Sultone Form, for microscopy (Bot., Hist., Vit.), indicator (pH 3.8-5.4)
    • 76-60-8

  • Applications

    Bromocresol Green (CAS 76-60-8) is used as a pH indicator in analytical chemistry for acid–base titrations and general pH measurements. It serves as the dye component in the bromocresol green assay for protein quantification, particularly to determine serum albumin levels in clinical chemistry. The dye is also employed as a colorant in coatings, inks, and textile or paper applications, providing a vivid color change in response to pH or formulation conditions. In laboratory and educational settings, it functions as a readily available colorimetric reagent and indicator for teaching and routine analytics.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 0.33
    methanol 0.4
    isopropanol 0.18
    water 0.01
    ethyl acetate 0.59
    n-propanol 0.37
    acetone 0.87
    n-butanol 0.29
    acetonitrile 0.38
    DMF 13.26
    toluene 0.85
    isobutanol 0.27
    1,4-dioxane 2.82
    methyl acetate 0.72
    THF 8.8
    2-butanone 1.19
    n-pentanol 0.47
    sec-butanol 0.26
    n-hexane 0.04
    ethylene glycol 0.29
    NMP 17.12
    cyclohexane 0.06
    DMSO 2.3
    n-butyl acetate 2.11
    n-octanol 1.45
    chloroform 2.84
    n-propyl acetate 1.33
    acetic acid 0.68
    dichloromethane 1.79
    cyclohexanone 3.7
    propylene glycol 0.28
    isopropyl acetate 0.85
    DMAc 11.86
    2-ethoxyethanol 1.79
    isopentanol 0.34
    n-heptane 0.12
    ethyl formate 0.74
    1,2-dichloroethane 0.99
    n-hexanol 0.88
    2-methoxyethanol 2.3
    isobutyl acetate 1.39
    tetrachloromethane 0.28
    n-pentyl acetate 3.81
    transcutol 5.19
    n-heptanol 1.49
    ethylbenzene 0.68
    MIBK 1.16
    2-propoxyethanol 5.21
    tert-butanol 0.24
    MTBE 0.5
    2-butoxyethanol 4.72
    propionic acid 0.59
    o-xylene 0.69
    formic acid 0.67
    diethyl ether 0.41
    m-xylene 0.69
    p-xylene 0.95
    chlorobenzene 1.05
    dimethyl carbonate 2.18
    n-octane 0.11
    formamide 1.3
    cyclopentanone 6.82
    2-pentanone 1.13
    anisole 2.0
    cyclopentyl methyl ether 2.61
    gamma-butyrolactone 6.02
    1-methoxy-2-propanol 2.33
    pyridine 3.95
    3-pentanone 1.06
    furfural 6.47
    n-dodecane 0.12
    diethylene glycol 2.71
    diisopropyl ether 0.24
    tert-amyl alcohol 0.38
    acetylacetone 2.15
    n-hexadecane 0.15
    acetophenone 3.22
    methyl propionate 1.32
    isopentyl acetate 2.37
    trichloroethylene 3.82
    n-nonanol 1.76
    cyclohexanol 0.58
    benzyl alcohol 1.76
    2-ethylhexanol 1.08
    isooctanol 1.45
    dipropyl ether 1.51
    1,2-dichlorobenzene 1.39
    ethyl lactate 1.63
    propylene carbonate 2.77
    n-methylformamide 2.54
    2-pentanol 0.23
    n-pentane 0.03
    1-propoxy-2-propanol 4.57
    1-methoxy-2-propyl acetate 4.38
    2-(2-methoxypropoxy) propanol 5.41
    mesitylene 0.52
    ε-caprolactone 3.71
    p-cymene 1.08
    epichlorohydrin 5.24
    1,1,1-trichloroethane 0.72
    2-aminoethanol 0.53
    morpholine-4-carbaldehyde 15.37
    sulfolane 8.67
    2,2,4-trimethylpentane 0.04
    2-methyltetrahydrofuran 2.31
    n-hexyl acetate 3.79
    isooctane 0.03
    2-(2-butoxyethoxy)ethanol 5.68
    sec-butyl acetate 1.07
    tert-butyl acetate 1.55
    decalin 0.1
    glycerin 0.93
    diglyme 8.43
    acrylic acid 0.92
    isopropyl myristate 2.08
    n-butyric acid 0.75
    acetyl acetate 0.66
    di(2-ethylhexyl) phthalate 3.07
    ethyl propionate 1.28
    nitromethane 1.78
    1,2-diethoxyethane 2.68
    benzonitrile 2.18
    trioctyl phosphate 2.21
    1-bromopropane 0.48
    gamma-valerolactone 12.17
    n-decanol 1.27
    triethyl phosphate 1.59
    4-methyl-2-pentanol 0.31
    propionitrile 0.68
    vinylene carbonate 2.95
    1,1,2-trichlorotrifluoroethane 6.88
    DMS 3.26
    cumene 0.57
    2-octanol 1.24
    2-hexanone 1.88
    octyl acetate 2.41
    limonene 1.26
    1,2-dimethoxyethane 4.64
    ethyl orthosilicate 1.72
    tributyl phosphate 2.08
    diacetone alcohol 2.12
    N,N-dimethylaniline 2.83
    acrylonitrile 1.38
    aniline 1.26
    1,3-propanediol 0.58
    bromobenzene 1.06
    dibromomethane 1.04
    1,1,2,2-tetrachloroethane 3.01
    2-methyl-cyclohexyl acetate 3.18
    tetrabutyl urea 4.81
    diisobutyl methanol 0.83
    2-phenylethanol 3.02
    styrene 0.74
    dioctyl adipate 3.05
    dimethyl sulfate 4.2
    ethyl butyrate 1.75
    methyl lactate 1.97
    butyl lactate 4.41
    diethyl carbonate 1.13
    propanediol butyl ether 4.06
    triethyl orthoformate 2.42
    p-tert-butyltoluene 1.16
    methyl 4-tert-butylbenzoate 6.43
    morpholine 3.98
    tert-butylamine 0.16
    n-dodecanol 0.94
    dimethoxymethane 5.62
    ethylene carbonate 1.97
    cyrene 8.18
    2-ethoxyethyl acetate 4.49
    2-ethylhexyl acetate 2.34
    1,2,4-trichlorobenzene 2.25
    4-methylpyridine 3.12
    dibutyl ether 1.56
    2,6-dimethyl-4-heptanol 0.83
    DEF 3.7
    dimethyl isosorbide 13.92
    tetrachloroethylene 1.92
    eugenol 7.26
    triacetin 4.31
    span 80 5.2
    1,4-butanediol 0.41
    1,1-dichloroethane 0.63
    2-methyl-1-pentanol 0.55
    methyl formate 1.87
    2-methyl-1-butanol 0.34
    n-decane 0.2
    butyronitrile 0.63
    3,7-dimethyl-1-octanol 1.32
    1-chlorooctane 0.81
    1-chlorotetradecane 0.44
    n-nonane 0.15
    undecane 0.15
    tert-butylcyclohexane 0.09
    cyclooctane 0.05
    cyclopentanol 1.02
    tetrahydropyran 1.59
    tert-amyl methyl ether 0.79
    2,5,8-trioxanonane 7.12
    1-hexene 0.2
    2-isopropoxyethanol 1.53
    2,2,2-trifluoroethanol 0.63
    methyl butyrate 1.71

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction