Bromhexine Hydrochloride

Overview IFRA Request a quote

  • Identifiers

    CAS number
    611-75-6

    Molecular formula
    C14H21Br2ClN2

    SMILES
    CN(CC1=C(C(=CC(=C1)Br)Br)N)C2CCCCC2.Cl

    Safety labels

  • Odor profile

    Fragrance
    Odorless 36.08%
    Fishy 35.99%
    Animal 35.58%
    Cheesy 31.49%
    Ripe 30.15%
    Meaty 26.68%
    Cooling 24.69%
    Savory 23.48%
    Burnt 22.74%
    Roasted 20.52%

     

    Flavor
    Bitter 47.21%
    Odorless 26.72%
    Mild 21.65%
    Bland 20.33%
    Nitrile 20.19%
    Cedarleaf 20.08%
    Alkaline 19.97%
    Very strong 19.85%
    Indole 19.78%
    Scallion 19.3%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    6.23 (neutral)

    Molecular weight
    412.59 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    443°C

    Flash point

    • 185.51 ˚C est.

  • Synonyms

    • Bromhexine hydrochloride
    • 611-75-6
    • Bromhexine HCl
    • Bisolvon
    • Auxit
    • Broncokin
    • Viscolyt
    • Bromhexine chloride
    • Quentan
    • Bromohexine monohydrochloride
    • NA 274
    • Bromehexine hydrochloride
    • YC2ZOM3Z8V
    • NSC-758383
    • DTXSID0045886
    • NA-274
    • N-Cyclohexyl-N-methyl-(2-amino-3,5-dibromobenzyl)ammonium chloride
    • DTXCID8025886
    • CHEBI:31303
    • 2-Amino-N-cyclohexyl-3,5-dibromo-N-methylbenzylamine hydrochloride
    • N-(2-Amino-3,5-dibromobenzyl)-N-methyl-cyclohexylammonium chloride
    • Benzenemethanamine, 2-amino-3,5-dibromo-N-cyclohexyl-N-methyl-, monohydrochloride
    • RefChem:6621
    • Hydrochloride, Bromhexine
    • Bromhexine Monohydrochloride
    • Monohydrochloride, Bromhexine
    • 2-Amino-3,5-dibromo-N-cyclohexyl-N-methylbenzylamine monohydrochloride
    • 210-280-8
    • 2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride
    • Bromhexine (hydrochloride)
    • MFCD00056626
    • 2,4-dibromo-6-{[cyclohexyl(methyl)amino]methyl}aniline hydrochloride
    • 611-75-6 (HCl)
    • NCGC00095005-01
    • N-(2-Amino-3,5-dibromobenzyl)-N-methylcyclohexylamine hydrochloride
    • Bromessina
    • Lisomucin
    • 2,4-dibromo-6-[[cyclohexyl(methyl)amino]methyl]aniline;hydrochloride
    • C14H21Br2ClN2
    • CAS-611-75-6
    • Bromessina [Italian]
    • Bromihexine hydrochloride
    • UNII-YC2ZOM3Z8V
    • Ophtolsol
    • [(2-amino-3,5-dibromophenyl)methyl]cyclohexylmethylamine, chloride
    • SR-05000001825
    • Bisolvon (TN)
    • EINECS 210-280-8
    • Bromhexine hydrochloride [USAN:JAN]
    • BROMBENZONIUM
    • 2-Amino-3,5-dibromo-N-cyclohexyl-N-methylbenzylamine hydrochloride
    • Bromhexine hydrochloride CRS
    • SCHEMBL99613
    • SPECTRUM1503107
    • HY-B0372AR
    • orb1310255
    • CHEMBL1319139
    • SCHEMBL10704011
    • Bromhexine for system suitability
    • HY-B0372A
    • GLXC-06089
    • HMS1922E19
    • HMS5080A04
    • Pharmakon1600-01503107
    • MSK10772
    • Tox21_111385
    • BROMHEXINE HYDROCHLORIDE [MI]
    • CCG-39304
    • EBC-07637
    • NSC758383
    • s2060
    • SBB001448
    • Bromhexine for system suitability CRS
    • BROMHEXINE HYDROCHLORIDE [JAN]
    • AKOS015906433
    • Benzylamine, 2-amino-N-cyclohexyl-3,5-dibromo-N-methyl-, hydrochloride
    • Bromhexine (hydrochloride) (Standard)
    • Tox21_111385_1
    • AC-6857
    • Bromhexine hydrochloride (JP18/USAN)
    • BROMHEXINE HYDROCHLORIDE [USAN]
    • FB64964
    • KS-5253
    • NSC 758383
    • BROMHEXINE HYDROCHLORIDE [MART.]
    • BROMHEXINE HYDROCHLORIDE [WHO-DD]
    • NCGC00095005-02
    • NCGC00178520-03
    • 3,5-Dibromo-N(sup alpha)-cyclohexyl-N(sup alpha)-methyltoluene-alpha,2-diamine monohydrochloride
    • ST007548
    • SY046825
    • Bromhexine hydrochloride, >=98.0% (AT)
    • B4054
    • Bromhexine hydrochloride, analytical standard
    • NS00021246
    • SW199599-2
    • BROMHEXINE HYDROCHLORIDE [EP MONOGRAPH]
    • D01778
    • D70838
    • EN300-651495
    • 611B756
    • SR-05000001825-2
    • Q27114269
    • 2,4-Dibromo-6-[(cyclohexyl-methyl-amino)-methyl]-phenylamine
    • Bromhexine Hydrochloride 1.0 mg/ml in Methanol (as free base)
    • 2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)anilinehydrochloride
    • N-(2-Amino-3,5-dibromobenzyl)-N-methylcyclohexanamine hydrochloride
    • N-(2-amino-3,5-dibromobenzyl)-N-methylcyclohexanaminium chloride
    • Bromhexine hydrochloride, European Pharmacopoeia (EP) Reference Standard
    • 2,4-Dibromo-6-{[cyclohexyl(methyl)amino]methyl}aniline--hydrogen chloride (1/1)
    • 3,5-dibromo-N(alpha)-cyclohexyl-N(alpha)-methyltoluene-alpha,2-diamine monohydrochloride
    • Bromhexine for system suitability, European Pharmacopoeia (EP) Reference Standard
    • Bromhexine hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material
    • 2-Amino-3,5-dibromo-N-cyclohexyl-N-methylbenzylamine hydrochloride, N-(2-Amino-3,5-dibromobenzyl)-N-methylcyclohexylamine hydrochloride
    • 3,5-DIBROMO-N(SUP .ALPHA.)-CYCLOHEXYL-N(SUP .ALPHA.)-METHYLTOLUENE-.ALPHA.,2-DIAMINE MONOHYDROCHLORIDE
    • Toluene-alpha,2-diamine, 3,5-dibromo-N(sup alpha)-cyclohexyl-N-(sup alpha)-methyl-, monohydrochloride
    • 611-75-6

  • Applications

    Chemical name: Bromhexine Hydrochloride; CAS number: 611-75-6. Bromhexine Hydrochloride is primarily used as an active pharmaceutical ingredient (API) with mucolytic/expectorant action for cough and respiratory conditions. In pharmaceutical formulations, it is included in oral dosage forms such as syrups, solutions, and tablets. It may be used as an intermediate in the synthesis of related pharmaceutical compounds. It is also employed in research and development as a compound to evaluate mucolytic activity and mechanism of action. The material is supplied as a bulk chemical for pharmaceutical manufacturing and quality-control testing, subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 61.18
    methanol 42.41
    isopropanol 40.21
    water 0.43
    ethyl acetate 195.7
    n-propanol 67.84
    acetone 276.76
    n-butanol 75.26
    acetonitrile 53.67
    DMF 334.12
    toluene 70.66
    isobutanol 51.67
    1,4-dioxane 273.67
    methyl acetate 161.6
    THF 682.13
    2-butanone 201.51
    n-pentanol 66.17
    sec-butanol 43.03
    n-hexane 1.82
    ethylene glycol 18.41
    NMP 415.96
    cyclohexane 4.83
    DMSO 320.55
    n-butyl acetate 171.0
    n-octanol 24.65
    chloroform 600.53
    n-propyl acetate 148.8
    acetic acid 194.07
    dichloromethane 488.17
    cyclohexanone 352.36
    propylene glycol 29.57
    isopropyl acetate 122.42
    DMAc 371.52
    2-ethoxyethanol 176.9
    isopentanol 65.88
    n-heptane 3.68
    ethyl formate 172.25
    1,2-dichloroethane 271.58
    n-hexanol 67.98
    2-methoxyethanol 217.63
    isobutyl acetate 111.81
    tetrachloromethane 76.07
    n-pentyl acetate 107.7
    transcutol 369.05
    n-heptanol 42.32
    ethylbenzene 23.12
    MIBK 100.47
    2-propoxyethanol 193.73
    tert-butanol 55.38
    MTBE 70.09
    2-butoxyethanol 124.44
    propionic acid 94.83
    o-xylene 40.62
    formic acid 64.16
    diethyl ether 68.57
    m-xylene 53.18
    p-xylene 37.77
    chlorobenzene 165.36
    dimethyl carbonate 124.28
    n-octane 1.55
    formamide 95.73
    cyclopentanone 581.2
    2-pentanone 187.14
    anisole 96.72
    cyclopentyl methyl ether 224.27
    gamma-butyrolactone 594.39
    1-methoxy-2-propanol 148.77
    pyridine 270.83
    3-pentanone 142.36
    furfural 550.78
    n-dodecane 1.26
    diethylene glycol 144.87
    diisopropyl ether 21.75
    tert-amyl alcohol 51.69
    acetylacetone 297.11
    n-hexadecane 1.48
    acetophenone 136.82
    methyl propionate 179.57
    isopentyl acetate 141.58
    trichloroethylene 762.26
    n-nonanol 25.82
    cyclohexanol 83.11
    benzyl alcohol 120.35
    2-ethylhexanol 48.16
    isooctanol 38.78
    dipropyl ether 55.27
    1,2-dichlorobenzene 150.39
    ethyl lactate 84.7
    propylene carbonate 335.19
    n-methylformamide 138.33
    2-pentanol 43.93
    n-pentane 2.53
    1-propoxy-2-propanol 140.09
    1-methoxy-2-propyl acetate 209.2
    2-(2-methoxypropoxy) propanol 96.64
    mesitylene 27.46
    ε-caprolactone 328.67
    p-cymene 27.32
    epichlorohydrin 659.31
    1,1,1-trichloroethane 267.61
    2-aminoethanol 38.32
    morpholine-4-carbaldehyde 415.65
    sulfolane 588.64
    2,2,4-trimethylpentane 3.23
    2-methyltetrahydrofuran 304.66
    n-hexyl acetate 85.67
    isooctane 2.39
    2-(2-butoxyethoxy)ethanol 132.5
    sec-butyl acetate 94.12
    tert-butyl acetate 123.04
    decalin 3.59
    glycerin 57.12
    diglyme 298.01
    acrylic acid 106.12
    isopropyl myristate 31.72
    n-butyric acid 179.77
    acetyl acetate 174.51
    di(2-ethylhexyl) phthalate 53.28
    ethyl propionate 104.06
    nitromethane 366.21
    1,2-diethoxyethane 131.25
    benzonitrile 130.03
    trioctyl phosphate 39.34
    1-bromopropane 88.42
    gamma-valerolactone 705.2
    n-decanol 19.47
    triethyl phosphate 68.68
    4-methyl-2-pentanol 33.34
    propionitrile 54.67
    vinylene carbonate 304.67
    1,1,2-trichlorotrifluoroethane 423.53
    DMS 112.59
    cumene 19.75
    2-octanol 24.92
    2-hexanone 123.65
    octyl acetate 46.71
    limonene 37.67
    1,2-dimethoxyethane 260.62
    ethyl orthosilicate 65.48
    tributyl phosphate 46.41
    diacetone alcohol 136.37
    N,N-dimethylaniline 63.34
    acrylonitrile 78.72
    aniline 132.48
    1,3-propanediol 82.42
    bromobenzene 153.21
    dibromomethane 249.48
    1,1,2,2-tetrachloroethane 497.42
    2-methyl-cyclohexyl acetate 97.24
    tetrabutyl urea 53.96
    diisobutyl methanol 27.88
    2-phenylethanol 115.5
    styrene 33.34
    dioctyl adipate 60.95
    dimethyl sulfate 216.69
    ethyl butyrate 117.06
    methyl lactate 104.89
    butyl lactate 100.38
    diethyl carbonate 84.48
    propanediol butyl ether 89.92
    triethyl orthoformate 94.39
    p-tert-butyltoluene 28.4
    methyl 4-tert-butylbenzoate 104.37
    morpholine 342.84
    tert-butylamine 27.64
    n-dodecanol 14.56
    dimethoxymethane 286.37
    ethylene carbonate 253.6
    cyrene 169.85
    2-ethoxyethyl acetate 190.01
    2-ethylhexyl acetate 118.04
    1,2,4-trichlorobenzene 208.38
    4-methylpyridine 239.08
    dibutyl ether 29.38
    2,6-dimethyl-4-heptanol 27.88
    DEF 212.64
    dimethyl isosorbide 225.63
    tetrachloroethylene 309.93
    eugenol 107.29
    triacetin 123.11
    span 80 88.12
    1,4-butanediol 45.2
    1,1-dichloroethane 222.75
    2-methyl-1-pentanol 62.64
    methyl formate 167.97
    2-methyl-1-butanol 63.19
    n-decane 2.02
    butyronitrile 74.04
    3,7-dimethyl-1-octanol 30.21
    1-chlorooctane 14.48
    1-chlorotetradecane 5.84
    n-nonane 1.65
    undecane 1.55
    tert-butylcyclohexane 3.65
    cyclooctane 1.94
    cyclopentanol 116.71
    tetrahydropyran 206.07
    tert-amyl methyl ether 60.15
    2,5,8-trioxanonane 176.55
    1-hexene 11.27
    2-isopropoxyethanol 126.0
    2,2,2-trifluoroethanol 122.03
    methyl butyrate 147.75

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction