Bistris

Overview IFRA Request a quote

  • Identifiers

    CAS number
    6976-37-0

    Molecular formula
    C8H19NO5

    SMILES
    C(CO)N(CCO)C(CO)(CO)CO

    Safety labels

    Corrosive
    Corrosive

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Sweet 55.85%
    Odorless 47.43%
    Fishy 38.05%
    Alcoholic 31.13%
    Cooling 20.76%
    Oily 20.25%
    Savory 17.1%
    Mint 16.82%
    Bitter 15.74%
    Fresh 15.52%

     

    Flavor
    Odorless 62.5%
    Sweet 40.34%
    Bitter 35.03%
    Sweet-like 30.4%
    Mild 25.13%
    Bland 24.23%
    Very slight 21.69%
    Cauliflower 20.09%
    Soup 19.97%
    Bouillon 19.55%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -3.3

    pKa est.
    5.96 (weak acid)

    Molecular weight
    209.24 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderately slow

    Boiling point est.
    572°C

    Flash point

    • 237.52 ˚C est.

  • Synonyms

    • bis-tris
    • 6976-37-0
    • Bistris
    • 2,2-Bis(hydroxymethyl)-2,2',2''-nitrilotriethanol
    • 2-[bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)propane-1,3-diol
    • 2-(Bis(2-hydroxyethyl)amino)-2-(hydroxymethyl)propane-1,3-diol
    • Q1XC3631CP
    • CHEBI:41250
    • 1,3-Propanediol, 2-[bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)-
    • NSC-24868
    • NSC-119932
    • 1,3-Propanediol, 2-(bis(2-hydroxyethyl)amino)-2-(hydroxymethyl)-
    • 2,2-Bis[hydroxymethyl]-2,2',2''-nitrilotriethanol
    • RefChem:569580
    • GlyTouCan:G90356ZC
    • G90356ZC
    • bis(2-hydroxyethyl)imino-tris(hydroxymethyl)methane
    • 2-(bis(2-hydroxyethyl)amino)-2(hydroxymethyl)-1,3-propanediol
    • 2,2-BIS(HYDROXYETHYL)-(IMINOTRIS)-(HYDROXYMETHYL)METHANE
    • 230-237-7
    • 686-880-2
    • Bis(2-hydroxyethyl)aminotris(hydroxymethyl)methane
    • MFCD00002853
    • 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
    • Bis(2-hydroxyethyl)amino-tris(hydroxymethyl)methane
    • Bis(2-hydroxyethyl)iminotris(hydroxymethyl)methane
    • 2,2-Bis(hydroxymethyl)-2,2,2-nitrilotriethanol
    • 2-(Bis(2-hydroxyethyl)amino))-2-hydroxymethyl-1,3-propanediol
    • Bis-(2-hydroxyethyl)aminotris(hydroxymethyl)methane
    • BIS-2-HYDROXY-IMINO-TRIS-HYDROXYMETHYL-METHANE
    • Bistris; NSC 119932; NSC 24868; NuPage Bis-Tris
    • Bis(2-hydroxyethyl)iminotris(hydroxymethyl)methane BIS-TRIS
    • 2-(bis(2-hydroxyethyl)amino)-2-(hydroxymethyl)-1,3-propanediol
    • 1, 2-[bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)-
    • UNII-Q1XC3631CP
    • 2-[Bis(2-hydroxyethyl)amino)]-2-hydroxymethyl-1,3-propanediol
    • 2-[bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)-1,3-propanediol
    • 2,2-Bis(hydroxymethyl)-2,2',2"-nitrilotriethanol
    • EINECS 230-237-7
    • NSC 24868
    • NSC 119932
    • Epitope ID:161731
    • Bis-hydroxyethyl tromethamine
    • SCHEMBL35757
    • orb1305871
    • DTXSID6064537
    • SCHEMBL14110358
    • HY-D0856
    • NSC24868
    • NSC119932
    • AKOS015964206
    • BIS-TRIS, >=98.0% (titration)
    • FB15824
    • SB78428
    • AS-89673
    • BP-20533
    • PD069504
    • SY012935
    • BIS-TRIS, BioUltra, >=99.0% (NT)
    • BIS-TRIS, BioXtra, >=99.0% (NT)
    • CS-0015166
    • NS00021335
    • BIS-TRIS, BioXtra, >=98.0% (titration)
    • 2,2-Bishydroxymethyl-2,2',2''-nitriloethanol
    • D70475
    • F045157
    • Q865956
    • SR-01000883740
    • Bis(2-hydroxyethyl)-(iminotris)hydroxymethyl)methane
    • SR-01000883740-1
    • BIS-TRIS, anhydrous, free-flowing, Redi-Dri(TM), >=98.0%
    • 2,2 - BIS(HYDROXYETHYL)-(IMINOTRIS)-(HYDROXYMETHYL)METHANE
    • 2-[Bis(2-hydroxyethyl)imino]-2-(hydroxymethyl)-1,3-propanediol
    • BIS-TRIS, Vetec(TM) reagent grade, >=98%, RNase and DNase free
    • BIS-TRIS, BioPerformance Certified, cell culture tested, suitable for insect cell culture, >=98.0%
    • 6976-37-0

  • Applications

    Bistris, CAS 6976-37-0, is an organic synthesis intermediate and chelating agent with potential applications across several industries. In polymers/plastics, it may be used as a stabilizer and processing additive to improve processability and performance at elevated temperatures. In coatings and inks, it serves as an additive to enhance metal stability and to modulate dispersion and viscosity. In adhesives and sealants, it can function as a linking component or compatibilizer to improve adhesion and formulation compatibility. In cleaning formulations, it acts as a chelating agent to sequester metal ions and improve cleaning efficacy. In industrial manufacturing generally, it may function as a solvent or processing aid depending on the formulation. Use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 4.8
    methanol 29.12
    isopropanol 1.73
    water 342.96
    ethyl acetate 1.18
    n-propanol 3.9
    acetone 0.51
    n-butanol 2.39
    acetonitrile 0.8
    DMF 52.58
    toluene 0.21
    isobutanol 1.88
    1,4-dioxane 4.84
    methyl acetate 1.02
    THF 3.64
    2-butanone 0.83
    n-pentanol 1.28
    sec-butanol 2.01
    n-hexane 0.13
    ethylene glycol 69.38
    NMP 118.92
    cyclohexane 0.51
    DMSO 121.29
    n-butyl acetate 0.93
    n-octanol 1.1
    chloroform 1.07
    n-propyl acetate 0.58
    acetic acid 12.92
    dichloromethane 1.87
    cyclohexanone 4.36
    propylene glycol 27.99
    isopropyl acetate 0.68
    DMAc 40.9
    2-ethoxyethanol 10.09
    isopentanol 1.27
    n-heptane 0.46
    ethyl formate 1.94
    1,2-dichloroethane 1.59
    n-hexanol 1.71
    2-methoxyethanol 29.39
    isobutyl acetate 0.34
    tetrachloromethane 0.57
    n-pentyl acetate 0.81
    transcutol 8.41
    n-heptanol 1.69
    ethylbenzene 0.23
    MIBK 0.49
    2-propoxyethanol 9.0
    tert-butanol 1.45
    MTBE 0.45
    2-butoxyethanol 5.41
    propionic acid 8.84
    o-xylene 0.56
    formic acid 144.47
    diethyl ether 0.65
    m-xylene 0.35
    p-xylene 0.29
    chlorobenzene 0.37
    dimethyl carbonate 2.4
    n-octane 0.17
    formamide 82.61
    cyclopentanone 4.83
    2-pentanone 0.74
    anisole 0.51
    cyclopentyl methyl ether 2.08
    gamma-butyrolactone 14.74
    1-methoxy-2-propanol 13.08
    pyridine 1.8
    3-pentanone 1.1
    furfural 15.73
    n-dodecane 0.09
    diethylene glycol 26.8
    diisopropyl ether 0.28
    tert-amyl alcohol 1.83
    acetylacetone 1.28
    n-hexadecane 0.1
    acetophenone 1.24
    methyl propionate 2.46
    isopentyl acetate 0.72
    trichloroethylene 1.88
    n-nonanol 1.04
    cyclohexanol 3.9
    benzyl alcohol 1.79
    2-ethylhexanol 1.15
    isooctanol 1.2
    dipropyl ether 1.05
    1,2-dichlorobenzene 0.82
    ethyl lactate 3.48
    propylene carbonate 6.18
    n-methylformamide 26.55
    2-pentanol 1.13
    n-pentane 0.21
    1-propoxy-2-propanol 5.15
    1-methoxy-2-propyl acetate 2.63
    2-(2-methoxypropoxy) propanol 4.32
    mesitylene 0.39
    ε-caprolactone 7.35
    p-cymene 0.64
    epichlorohydrin 4.89
    1,1,1-trichloroethane 0.44
    2-aminoethanol 43.41
    morpholine-4-carbaldehyde 55.51
    sulfolane 69.89
    2,2,4-trimethylpentane 0.15
    2-methyltetrahydrofuran 2.15
    n-hexyl acetate 0.9
    isooctane 0.06
    2-(2-butoxyethoxy)ethanol 5.66
    sec-butyl acetate 0.43
    tert-butyl acetate 0.71
    decalin 0.21
    glycerin 97.27
    diglyme 9.27
    acrylic acid 15.95
    isopropyl myristate 0.36
    n-butyric acid 5.05
    acetyl acetate 0.89
    di(2-ethylhexyl) phthalate 1.21
    ethyl propionate 0.96
    nitromethane 9.69
    1,2-diethoxyethane 1.09
    benzonitrile 1.04
    trioctyl phosphate 1.06
    1-bromopropane 0.57
    gamma-valerolactone 17.57
    n-decanol 0.72
    triethyl phosphate 1.85
    4-methyl-2-pentanol 0.62
    propionitrile 0.98
    vinylene carbonate 6.03
    1,1,2-trichlorotrifluoroethane 26.62
    DMS 1.69
    cumene 0.29
    2-octanol 0.81
    2-hexanone 0.44
    octyl acetate 0.57
    limonene 0.99
    1,2-dimethoxyethane 5.05
    ethyl orthosilicate 1.53
    tributyl phosphate 0.92
    diacetone alcohol 2.59
    N,N-dimethylaniline 1.15
    acrylonitrile 2.06
    aniline 1.1
    1,3-propanediol 21.02
    bromobenzene 0.28
    dibromomethane 1.05
    1,1,2,2-tetrachloroethane 2.54
    2-methyl-cyclohexyl acetate 1.21
    tetrabutyl urea 1.75
    diisobutyl methanol 0.73
    2-phenylethanol 1.78
    styrene 0.19
    dioctyl adipate 0.88
    dimethyl sulfate 11.78
    ethyl butyrate 1.12
    methyl lactate 11.18
    butyl lactate 2.7
    diethyl carbonate 0.91
    propanediol butyl ether 6.68
    triethyl orthoformate 1.44
    p-tert-butyltoluene 0.6
    methyl 4-tert-butylbenzoate 3.09
    morpholine 9.07
    tert-butylamine 0.74
    n-dodecanol 0.53
    dimethoxymethane 5.84
    ethylene carbonate 4.53
    cyrene 16.69
    2-ethoxyethyl acetate 1.39
    2-ethylhexyl acetate 0.72
    1,2,4-trichlorobenzene 1.18
    4-methylpyridine 1.2
    dibutyl ether 0.44
    2,6-dimethyl-4-heptanol 0.73
    DEF 6.8
    dimethyl isosorbide 8.71
    tetrachloroethylene 2.6
    eugenol 3.85
    triacetin 2.1
    span 80 5.29
    1,4-butanediol 9.51
    1,1-dichloroethane 0.44
    2-methyl-1-pentanol 0.95
    methyl formate 9.49
    2-methyl-1-butanol 1.81
    n-decane 0.15
    butyronitrile 0.83
    3,7-dimethyl-1-octanol 0.76
    1-chlorooctane 0.35
    1-chlorotetradecane 0.16
    n-nonane 0.15
    undecane 0.11
    tert-butylcyclohexane 0.13
    cyclooctane 0.32
    cyclopentanol 5.0
    tetrahydropyran 1.83
    tert-amyl methyl ether 0.83
    2,5,8-trioxanonane 7.52
    1-hexene 0.2
    2-isopropoxyethanol 3.42
    2,2,2-trifluoroethanol 17.87
    methyl butyrate 1.31

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction