Bisphenol S

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  • Identifiers

    CAS number
    80-09-1

    Molecular formula
    C12H10O4S

    SMILES
    C1=CC(=CC=C1O)S(=O)(=O)C2=CC=C(C=C2)O

    Safety labels

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Odorless 60.97%
    Phenolic 39.75%
    Burnt 36.7%
    Bitter 29.17%
    Meaty 25.88%
    Roasted 25.29%
    Savory 24.77%
    Nutty 24.56%
    Medicinal 24.09%
    Cooked 23.3%

     

    Flavor
    Bitter 87.56%
    Odorless 25.05%
    Nitrile 21.03%
    Very strong 19.16%
    Indole 19.0%
    Urine 18.77%
    Moth ball 18.73%
    Bread crust 18.72%
    Lovage 18.45%
    Taco 18.3%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    1.9

    pKa est.
    9.57 (weak base)

    Molecular weight
    250.27 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    502°C

    Melting point expt.

    • 240.5 °C

    Flash point

    • 243.5 ˚C est.

    Solubility expt.

    • Insoluble in water
    • Soluble in ethanol, ether; slightly soluble in benzene, DMSO

  • Synonyms

    • 4,4'-Sulfonyldiphenol
    • 80-09-1
    • Bisphenol S
    • Bis(4-hydroxyphenyl) sulfone
    • Phenol, 4,4'-sulfonylbis-
    • 4-(4-hydroxyphenyl)sulfonylphenol
    • 4,4'-Dihydroxydiphenyl sulfone
    • Bis(p-hydroxyphenyl) sulfone
    • Diphone C
    • Bis(4-hydroxyphenyl)sulfone
    • 1,1'-Sulfonylbis(4-hydroxybenzene)
    • BPS 1
    • 4,4'-Sulphonyldiphenol
    • 3OX4RR782R
    • DTXSID3022409
    • NSC-8712
    • NSC-683541
    • DTXCID602409
    • CHEBI:34372
    • 1,1'-Sulfonylbis[4-hydroxybenzene]
    • RefChem:569577
    • 201-250-5
    • 4,4'-Sulfonylbisphenol
    • 4-Hydroxyphenyl sulfone
    • 4,4-Sulfonyldiphenol
    • 4,4'-Bisphenol S
    • Sulphonylbisphenol
    • Bis(p-hydroxyphenyl)sulfone
    • MFCD00002350
    • P,P'-Dihydroxydiphenyl sulfone
    • C12H10O4S
    • NSC 8712
    • PHENOL, 4,4'-SULFONYLDI-
    • 4-[(4-hydroxyphenyl)sulfonyl]phenol
    • NSC 683541
    • 4,4'-dihydroxydiphenylsulfone
    • 4,4'-dihydroxy diphenyl sulfone
    • 4,4'-Dihydroxydiphenyl sulphone
    • NSC8712
    • NSC683541
    • 25641-61-6
    • CAS-80-09-1
    • CCRIS 2647
    • BISPHENOL-S
    • 4-(4-hydroxybenzenesulfonyl)phenol
    • EINECS 201-250-5
    • bisphenols
    • BRN 2052954
    • UNII-3OX4RR782R
    • AI3-08667
    • HSDB 8087
    • 4-(4-hydroxyphenylsulfonyl)phenol
    • DHDPhS
    • Phenol,4'-sulfonylbis-
    • 4,4\'-sulfonyldiphenol
    • WLN: QR DSWR DQ
    • Bisphenol S (4,4')
    • ChemDiv3_000253
    • EC 201-250-5
    • 4,4'-Sulfonylbis[phenol]
    • Cambridge id 5137133
    • di-(4-Hydroxyphenyl)sulfone
    • Oprea1_709121
    • SCHEMBL18838
    • 4-06-00-05809 (Beilstein Handbook Reference)
    • MLS001195068
    • BIDD:ER0209
    • bis(4-hydroxylphenyl) sulfone
    • SCHEMBL124022
    • 4,4'-Dihydroxydiphenylsulphone
    • 4,4'-dihydroxy diphenylsulfone
    • CHEMBL384441
    • orb3025845
    • SCHEMBL2038611
    • SCHEMBL8632609
    • 4,4'-Sulfonyldiphenol, 98%
    • BP_06 (BPS)
    • Bisphenol??S, analytical standard
    • HMS2866C04
    • EINECS 247-158-9
    • Tox21_201743
    • Tox21_302843
    • BBL004108
    • EBC-65154
    • MSK000912
    • NSC 57909
    • SBB056786
    • STK267009
    • AKOS000119535
    • BIS(4-HYDROXY(PHENYL))SULFONE
    • BIS(4-HYDROXY(PHENYL))SULPHONE
    • CS-W012643
    • DS-5781
    • FB62571
    • HY-W011927
    • MSK000912-100A
    • IDI1_019571
    • MSK000912-1000A
    • NCGC00164029-01
    • NCGC00164029-02
    • NCGC00256437-01
    • NCGC00259292-01
    • AC-11720
    • SMR000554491
    • SY048754
    • B0495
    • EU-0066997
    • NS00010610
    • ST50308058
    • 1, 1'-SULFONYLBIS(4-HYDROXYBENZENE)
    • EN300-18083
    • 4,4 inverted exclamation mark -Sulfonyldiphenol
    • E82999
    • AB00275288-05
    • Bisphenol S Solution in Acetonitrile, 100ug/mL
    • Bisphenol S Solution in Acetonitrile, 1000ug/mL
    • F239904
    • Q418379
    • Z57158549
    • F0266-0794
    • 6JD
    • InChI=1/C12H10O4S/c13-9-1-5-11(6-2-9)17(15,16)12-7-3-10(14)4-8-12/h1-8,13-14
    • 80-09-1

  • Applications

    Bisphenol S (CAS 80-09-1) is primarily used as a monomer for epoxy resins and related coating polymers, notably for metal can linings and protective coatings where corrosion resistance and adhesion are important. It is also used to produce BPA-free polycarbonate and other engineering plastics in certain applications, and serves as a component or compatibilizer in adhesives and industrial sealants. In electronics and electrical insulation, epoxy systems based on BPS are used for encapsulation, potting, and protective coatings for circuit boards. It is employed as a color-developer in some thermal papers and as an intermediate in polymer synthesis to tailor material properties such as thermal stability and chemical resistance, with formulation and regulatory considerations varying by region.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 2.76
    methanol 3.53
    isopropanol 1.45
    water 0.07
    ethyl acetate 42.58
    n-propanol 2.28
    acetone 83.36
    n-butanol 1.97
    acetonitrile 52.82
    DMF 773.2
    toluene 1.19
    isobutanol 1.28
    1,4-dioxane 62.96
    methyl acetate 106.04
    THF 177.85
    2-butanone 285.85
    n-pentanol 3.9
    sec-butanol 56.74
    n-hexane 0.03
    ethylene glycol 4.75
    NMP 347.96
    cyclohexane 0.09
    DMSO 192.39
    n-butyl acetate 29.89
    n-octanol 6.16
    chloroform 0.93
    n-propyl acetate 31.29
    acetic acid 25.62
    dichloromethane 1.18
    cyclohexanone 241.54
    propylene glycol 16.54
    isopropyl acetate 52.07
    DMAc 731.83
    2-ethoxyethanol 48.71
    isopentanol 3.57
    n-heptane 0.2
    ethyl formate 34.3
    1,2-dichloroethane 2.93
    n-hexanol 6.79
    2-methoxyethanol 90.4
    isobutyl acetate 8.48
    tetrachloromethane 0.15
    n-pentyl acetate 19.59
    transcutol 171.36
    n-heptanol 6.46
    ethylbenzene 1.46
    MIBK 30.08
    2-propoxyethanol 46.79
    tert-butanol 10.25
    MTBE 30.72
    2-butoxyethanol 27.54
    propionic acid 31.28
    o-xylene 2.33
    formic acid 24.62
    diethyl ether 9.96
    m-xylene 1.25
    p-xylene 2.08
    chlorobenzene 2.52
    dimethyl carbonate 37.04
    n-octane 0.11
    formamide 318.41
    cyclopentanone 322.0
    2-pentanone 67.63
    anisole 25.14
    cyclopentyl methyl ether 28.32
    gamma-butyrolactone 268.82
    1-methoxy-2-propanol 77.01
    pyridine 40.6
    3-pentanone 66.01
    furfural 154.02
    n-dodecane 0.2
    diethylene glycol 42.38
    diisopropyl ether 3.75
    tert-amyl alcohol 50.59
    acetylacetone 153.17
    n-hexadecane 0.24
    acetophenone 43.16
    methyl propionate 57.03
    isopentyl acetate 23.03
    trichloroethylene 11.74
    n-nonanol 7.02
    cyclohexanol 12.98
    benzyl alcohol 16.3
    2-ethylhexanol 6.85
    isooctanol 5.6
    dipropyl ether 10.42
    1,2-dichlorobenzene 3.93
    ethyl lactate 30.24
    propylene carbonate 79.18
    n-methylformamide 171.2
    2-pentanol 6.09
    n-pentane 0.02
    1-propoxy-2-propanol 42.72
    1-methoxy-2-propyl acetate 64.09
    2-(2-methoxypropoxy) propanol 51.24
    mesitylene 1.29
    ε-caprolactone 139.51
    p-cymene 3.11
    epichlorohydrin 111.99
    1,1,1-trichloroethane 2.05
    2-aminoethanol 10.81
    morpholine-4-carbaldehyde 308.79
    sulfolane 285.22
    2,2,4-trimethylpentane 0.2
    2-methyltetrahydrofuran 85.56
    n-hexyl acetate 24.99
    isooctane 0.09
    2-(2-butoxyethoxy)ethanol 55.78
    sec-butyl acetate 24.27
    tert-butyl acetate 55.79
    decalin 0.18
    glycerin 42.73
    diglyme 124.15
    acrylic acid 32.64
    isopropyl myristate 11.28
    n-butyric acid 21.75
    acetyl acetate 35.2
    di(2-ethylhexyl) phthalate 10.81
    ethyl propionate 30.88
    nitromethane 249.2
    1,2-diethoxyethane 42.34
    benzonitrile 20.02
    trioctyl phosphate 7.96
    1-bromopropane 0.72
    gamma-valerolactone 389.29
    n-decanol 5.59
    triethyl phosphate 16.43
    4-methyl-2-pentanol 4.03
    propionitrile 19.63
    vinylene carbonate 59.38
    1,1,2-trichlorotrifluoroethane 87.98
    DMS 37.2
    cumene 1.26
    2-octanol 5.21
    2-hexanone 40.3
    octyl acetate 14.57
    limonene 5.66
    1,2-dimethoxyethane 113.94
    ethyl orthosilicate 13.74
    tributyl phosphate 10.72
    diacetone alcohol 89.16
    N,N-dimethylaniline 16.82
    acrylonitrile 43.2
    aniline 9.22
    1,3-propanediol 11.97
    bromobenzene 1.35
    dibromomethane 0.41
    1,1,2,2-tetrachloroethane 9.86
    2-methyl-cyclohexyl acetate 22.48
    tetrabutyl urea 20.41
    diisobutyl methanol 5.71
    2-phenylethanol 17.89
    styrene 1.87
    dioctyl adipate 21.54
    dimethyl sulfate 95.63
    ethyl butyrate 28.89
    methyl lactate 60.67
    butyl lactate 24.76
    diethyl carbonate 17.89
    propanediol butyl ether 30.6
    triethyl orthoformate 22.61
    p-tert-butyltoluene 3.21
    methyl 4-tert-butylbenzoate 34.03
    morpholine 111.5
    tert-butylamine 3.18
    n-dodecanol 4.08
    dimethoxymethane 98.71
    ethylene carbonate 42.87
    cyrene 69.38
    2-ethoxyethyl acetate 45.03
    2-ethylhexyl acetate 17.34
    1,2,4-trichlorobenzene 8.01
    4-methylpyridine 37.78
    dibutyl ether 9.58
    2,6-dimethyl-4-heptanol 5.71
    DEF 151.1
    dimethyl isosorbide 87.66
    tetrachloroethylene 4.02
    eugenol 34.22
    triacetin 51.04
    span 80 30.53
    1,4-butanediol 5.68
    1,1-dichloroethane 1.45
    2-methyl-1-pentanol 6.36
    methyl formate 93.62
    2-methyl-1-butanol 6.11
    n-decane 0.29
    butyronitrile 12.14
    3,7-dimethyl-1-octanol 7.4
    1-chlorooctane 1.94
    1-chlorotetradecane 1.0
    n-nonane 0.2
    undecane 0.24
    tert-butylcyclohexane 0.16
    cyclooctane 0.05
    cyclopentanol 17.56
    tetrahydropyran 33.65
    tert-amyl methyl ether 39.53
    2,5,8-trioxanonane 92.22
    1-hexene 0.28
    2-isopropoxyethanol 32.21
    2,2,2-trifluoroethanol 22.1
    methyl butyrate 45.31

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction