Bisphenol A bis(2-hydroxypropyl) ether

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  • Identifiers

    CAS number
    116-37-0

    Molecular formula
    C21H28O4

    SMILES
    CC(COC1=CC=C(C=C1)C(C)(C)C2=CC=C(C=C2)OCC(C)O)O

    Safety labels

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Floral 61.36%
    Fruity 37.01%
    Powdery 34.22%
    Sweet 33.51%
    Balsamic 30.39%
    Animal 28.68%
    Rose 27.96%
    Vanilla 27.67%
    Musk 27.59%
    Fresh 26.04%

     

    Flavor
    Sweet 50.42%
    Floral 47.89%
    Fruity 39.28%
    Green 37.56%
    Bitter 33.82%
    Herbal 32.56%
    Woody 32.22%
    Mild 29.39%
    Spicy 26.59%
    Musty 26.58%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    4.2

    pKa est.
    8.43 (weak base)

    Molecular weight
    344.4 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    510°C

    Flash point

    • 211.26 ˚C est.

  • Synonyms

    • 116-37-0
    • Bisphenol A bis(2-hydroxypropyl) ether
    • Dianol 33
    • Isopropylidenediphenoxypropanol
    • Dow Resin 565
    • Bisphenol A bis(beta-hydroxypropyl) ether
    • 2,2-Bis(p-(2-hydroxy-2-methylethoxy)phenyl)propane
    • 2,2-Bis(p-(2-hydroxypropoxy)phenyl)propane
    • S5K2510L3D
    • 2,2-Bis(4-(2-hydroxypropoxy)phenyl)propane
    • 2,2-Bis(p-(beta-hydroxypropoxy)phenyl)propane
    • NSC-408494
    • 2-Propanol, 1,1'-((1-methylethylidene)bis(4,1-phenyleneoxy))bis-
    • 1,1'-(Isopropylidenebis(p-phenyleneoxy))di-2-propanol
    • DTXSID8051592
    • 2-Propanol, 1,1'-[(1-methylethylidene)bis(4,1-phenyleneoxy)]bis-
    • 2-Propanol, 1,1'-(isopropylidenebis(p-phenyleneoxy))di-
    • 2,2-Bis[4-(2-hydroxy-2-methylethoxy)phenyl]propane
    • 1,1'-[Isopropylidenebis(p-phenyleneoxy)]di-2-propanol
    • 2,2-BIS(4-(2-HYDROXY-2-METHYLETHOXY)PHENYL)PROPANE
    • 2,2-Bis[4-(2-hydroxypropoxy)phenyl]propane
    • 2,2-Bis[p-(2-hydroxypropoxy)phenyl]propane
    • RefChem:120497
    • GlyTouCan:G73632YE
    • DTXCID2030144
    • G73632YE
    • 204-137-9
    • Bisphenol A propoxylate
    • 37353-75-6
    • 1,1'-Isopropylidenebis(p-phenyleneoxy)dipropan-2-ol
    • Oxypropyldiphenylolpropane
    • 1,1'-((Propane-2,2-diylbis(4,1-phenylene))bis(oxy))bis(propan-2-ol)
    • 1-[4-[2-[4-(2-hydroxypropoxy)phenyl]propan-2-yl]phenoxy]propan-2-ol
    • 1-[4-[1-[4-(2-hydroxypropoxy)phenyl]-1-methyl-ethyl]phenoxy]propan-2-ol
    • Propane, 2,2-bis[4-(2-hydroxypropyloxy)-phenyl]-
    • HSDB 5583
    • 2,2-Bis[p-(.beta.-hydroxypropoxy)phenyl]propane
    • EINECS 204-137-9
    • 2,2-BIS(P-(.BETA.-HYDROXYPROPOXY)PHENYL)PROPANE
    • NSC 408494
    • UNII-S5K2510L3D
    • AI3-15588
    • 2,2-Bis(4-(beta-hydroxypropoxy)phenyl)propane
    • 2-Propanol, 1,1'-isopropylidenebis(p-phenyleneoxy)di-
    • Bisphenol apropoxylate
    • Bisphenol A di(2-hydroxypropyl) ether
    • 1,1'-((1-Methylethylidene)bis(4,1-phenyleneoxy))bis-2-propanol
    • EC 204-137-9
    • SCHEMBL376300
    • SCHEMBL2768639
    • CHEBI:79721
    • Bisphenol A poly(oxypropylene) ether
    • MFCD00191826
    • NSC408494
    • AKOS027276331
    • MSK170571-100M
    • BS-47759
    • FB152823
    • FB173300
    • Bisphenol A bis(.beta.-hydroxypropyl) ether
    • ISOPROPYLIDENEDIPHENOXYPROPANOL [HSDB]
    • NS00010620
    • F73047
    • BISPHENOL A BIS-(2-HYDROXYPROPYL) ETHER
    • 2,2-Bis[4-(.beta.-hydroxypropoxy)phenyl]propane
    • 353B756
    • 1,1'-Isopropylidenebis(p-phenyleneoxy)di-2-propanol
    • 1,1/'-isopropylidenebis(p-phenyleneoxy)dipropan-2-ol
    • 2-Propanol,1'-[isopropylidenebis(p-phenyleneoxy)]di-
    • Q27148853
    • 1,1\'-[Isopropylidenebis(p-phenyleneoxy)]di-2-propanol
    • 1,1'-ISOPROPYLIDENEBIS(4-(2-HYDROXYPROPOXY)BENZENE)
    • 1,1'-[Propane-2,2-diylbis(4,1-phenyleneoxy)]di(propan-2-ol)
    • 2-Propanol,1'-[(1-methylethylidene)bis(4,1-phenyleneoxy)]bis-
    • Bisphenol A bis(2-hydroxypropyl) ether Solution in Methanol, 100ug/mL
    • 116-37-0

  • Applications

    Bisphenol A bis(2-hydroxypropyl) ether (CAS 116-37-0) is a difunctional diol used as a building block in polymer formulations. In industry, it is commonly employed as a polyol component for polyurethane systems, including coatings, adhesives, and sealants, where it contributes to mechanical strength and elevated thermal performance. It is also used as a diol-based building block for BPA-containing polyesters and other high‑performance polymers, enabling tailored rigidity and glass transition behavior. Additionally, it can act as a resin modifier in coatings and inks to adjust hardness and chemical resistance, and is sometimes evaluated as a precursor for specialty polymers in electronics encapsulation and related engineering plastics, depending on regulatory constraints.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 60.28
    methanol 75.08
    isopropanol 32.79
    water 0.3
    ethyl acetate 97.63
    n-propanol 46.23
    acetone 125.82
    n-butanol 30.86
    acetonitrile 38.91
    DMF 161.82
    toluene 14.05
    isobutanol 25.86
    1,4-dioxane 154.27
    methyl acetate 98.39
    THF 474.38
    2-butanone 85.07
    n-pentanol 29.01
    sec-butanol 28.46
    n-hexane 1.86
    ethylene glycol 10.97
    NMP 96.38
    cyclohexane 3.06
    DMSO 327.34
    n-butyl acetate 44.47
    n-octanol 16.27
    chloroform 254.2
    n-propyl acetate 53.74
    acetic acid 88.32
    dichloromethane 255.49
    cyclohexanone 119.81
    propylene glycol 24.02
    isopropyl acetate 62.71
    DMAc 283.35
    2-ethoxyethanol 133.05
    isopentanol 27.2
    n-heptane 2.44
    ethyl formate 46.5
    1,2-dichloroethane 145.05
    n-hexanol 26.12
    2-methoxyethanol 163.19
    isobutyl acetate 38.92
    tetrachloromethane 14.36
    n-pentyl acetate 31.82
    transcutol 280.76
    n-heptanol 17.52
    ethylbenzene 11.17
    MIBK 49.24
    2-propoxyethanol 101.89
    tert-butanol 58.47
    MTBE 74.48
    2-butoxyethanol 56.35
    propionic acid 45.81
    o-xylene 12.42
    formic acid 31.09
    diethyl ether 65.69
    m-xylene 10.87
    p-xylene 15.3
    chlorobenzene 33.07
    dimethyl carbonate 55.04
    n-octane 1.64
    formamide 67.91
    cyclopentanone 185.54
    2-pentanone 70.99
    anisole 44.26
    cyclopentyl methyl ether 88.55
    gamma-butyrolactone 210.76
    1-methoxy-2-propanol 109.57
    pyridine 63.11
    3-pentanone 64.53
    furfural 117.33
    n-dodecane 1.43
    diethylene glycol 80.5
    diisopropyl ether 16.34
    tert-amyl alcohol 45.15
    acetylacetone 123.96
    n-hexadecane 1.61
    acetophenone 50.11
    methyl propionate 89.15
    isopentyl acetate 48.0
    trichloroethylene 240.58
    n-nonanol 18.08
    cyclohexanol 29.1
    benzyl alcohol 34.54
    2-ethylhexanol 18.57
    isooctanol 16.62
    dipropyl ether 39.06
    1,2-dichlorobenzene 37.88
    ethyl lactate 36.91
    propylene carbonate 85.25
    n-methylformamide 59.75
    2-pentanol 19.24
    n-pentane 1.08
    1-propoxy-2-propanol 62.99
    1-methoxy-2-propyl acetate 83.16
    2-(2-methoxypropoxy) propanol 63.3
    mesitylene 7.73
    ε-caprolactone 102.93
    p-cymene 10.4
    epichlorohydrin 273.04
    1,1,1-trichloroethane 81.11
    2-aminoethanol 27.7
    morpholine-4-carbaldehyde 172.9
    sulfolane 215.33
    2,2,4-trimethylpentane 2.02
    2-methyltetrahydrofuran 135.21
    n-hexyl acetate 40.13
    isooctane 1.24
    2-(2-butoxyethoxy)ethanol 84.15
    sec-butyl acetate 38.66
    tert-butyl acetate 73.12
    decalin 2.81
    glycerin 41.43
    diglyme 190.6
    acrylic acid 38.88
    isopropyl myristate 18.26
    n-butyric acid 57.69
    acetyl acetate 68.2
    di(2-ethylhexyl) phthalate 19.81
    ethyl propionate 50.73
    nitromethane 198.17
    1,2-diethoxyethane 87.09
    benzonitrile 28.23
    trioctyl phosphate 13.96
    1-bromopropane 47.3
    gamma-valerolactone 220.62
    n-decanol 13.64
    triethyl phosphate 31.2
    4-methyl-2-pentanol 15.78
    propionitrile 30.21
    vinylene carbonate 75.79
    1,1,2-trichlorotrifluoroethane 156.02
    DMS 58.75
    cumene 9.73
    2-octanol 11.02
    2-hexanone 48.47
    octyl acetate 22.3
    limonene 15.13
    1,2-dimethoxyethane 200.27
    ethyl orthosilicate 31.78
    tributyl phosphate 18.67
    diacetone alcohol 76.13
    N,N-dimethylaniline 32.39
    acrylonitrile 37.33
    aniline 26.21
    1,3-propanediol 45.4
    bromobenzene 32.61
    dibromomethane 135.12
    1,1,2,2-tetrachloroethane 211.69
    2-methyl-cyclohexyl acetate 42.73
    tetrabutyl urea 25.58
    diisobutyl methanol 14.31
    2-phenylethanol 32.53
    styrene 13.15
    dioctyl adipate 32.47
    dimethyl sulfate 106.57
    ethyl butyrate 42.86
    methyl lactate 47.84
    butyl lactate 33.39
    diethyl carbonate 35.0
    propanediol butyl ether 42.43
    triethyl orthoformate 42.36
    p-tert-butyltoluene 10.58
    methyl 4-tert-butylbenzoate 52.83
    morpholine 187.13
    tert-butylamine 24.32
    n-dodecanol 10.27
    dimethoxymethane 184.64
    ethylene carbonate 69.69
    cyrene 71.14
    2-ethoxyethyl acetate 68.16
    2-ethylhexyl acetate 36.84
    1,2,4-trichlorobenzene 50.64
    4-methylpyridine 50.86
    dibutyl ether 28.25
    2,6-dimethyl-4-heptanol 14.31
    DEF 82.61
    dimethyl isosorbide 122.12
    tetrachloroethylene 103.78
    eugenol 44.95
    triacetin 69.06
    span 80 45.1
    1,4-butanediol 22.45
    1,1-dichloroethane 98.07
    2-methyl-1-pentanol 27.17
    methyl formate 62.63
    2-methyl-1-butanol 25.06
    n-decane 2.69
    butyronitrile 27.88
    3,7-dimethyl-1-octanol 17.9
    1-chlorooctane 12.41
    1-chlorotetradecane 4.67
    n-nonane 2.34
    undecane 1.87
    tert-butylcyclohexane 2.72
    cyclooctane 1.32
    cyclopentanol 38.76
    tetrahydropyran 116.66
    tert-amyl methyl ether 54.17
    2,5,8-trioxanonane 125.0
    1-hexene 8.58
    2-isopropoxyethanol 81.81
    2,2,2-trifluoroethanol 39.48
    methyl butyrate 61.43

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction