Bismuth Subsalicylate

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  • Identifiers

    CAS number
    14882-18-9

    Molecular formula
    C7H6BiO4

    SMILES
    C1=CC=C2C(=C1)C(=O)O[Bi]O2.O

    Safety labels

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Sweet 62.01%
    Coumarinic 54.07%
    Spicy 44.6%
    Coconut 43.13%
    Phenolic 39.97%
    Nutty 37.82%
    Herbal 35.36%
    Green 34.79%
    Hay 32.52%
    Balsamic 31.54%

     

    Flavor
    Sweet 68.0%
    Bitter 59.41%
    Tonka 50.88%
    Coconut 47.35%
    Herbal 45.11%
    Tobacco 38.61%
    Coumarin 35.51%
    Almond 32.41%
    Creamy 31.66%
    Balsam 28.41%

     

  • Properties

    pKa est.
    6.18 (neutral)

    Molecular weight
    363.1 g/mol

    Melting point expt.

    • >350

    Flash point

    • 115.33 ˚C est.

    Solubility expt.

    • Insoluble (<1 mg/ml at 71.1 °F) (NTP, 1992)
    • ALMOST INSOL IN WATER OR ALCOHOL
    • SOL IN ACIDS & ALKALIES; INSOL IN ETHER
    • SOL IN OIL

  • Synonyms

    • BISMUTH SUBSALICYLATE
    • 14882-18-9
    • Bismuth oxysalicylate
    • Bismuth oxide salicylate
    • Wismutsubsalicylat
    • Pepto-bismol
    • 4H-1,3,2-Benzodioxabismin-4-one, 2-hydroxy-
    • Stabisol
    • Basic bismuth salicylate
    • Trigastronol
    • Kaopectate
    • Bismuthi subsalicylas
    • Bismutum subsalicylicum
    • Bismuth(III) subsalicylate
    • pink bismuth
    • Bismuth salicylate, basic
    • Bismuth, oxo(salicylato)-
    • Bismogenol tosse inj
    • CCRIS 4751
    • HSDB 332
    • Salicylic acid basic bismuth salt
    • Bismuth, (2-hydroxybenzoato-O1,O2)oxo-
    • Salicylic acid, bismuth basic salt
    • EINECS 238-953-1
    • Pepto-bismol (TN)
    • DTXSID6024622
    • Bismuth subsalicylate [USAN:USP:JAN]
    • (2-Hydroxybenzoato-O(sup 1))-oxobismuth
    • 2-Hydroxy-benzo[1,3,2]dioxabismin-4-one
    • 62TEY51RR1
    • DTXCID004622
    • 2-hydroxy-2H,4H-benzo[d]1,3-dioxa-2-bismacyclohexan-4-one
    • 2-Hydroxy-4H-1,3,2-benzodioxabismin-4-one
    • Vismut
    • Spiromak forte
    • CHEBI:261649
    • EC 238-953-1
    • NSC 759117
    • NSC-759117
    • NCGC00166299-01
    • Bismuth oxysalicylate;Bismuth(III) salicylate basic
    • Bismuth subsalicylate [USAN)
    • Bismatrol
    • Bismogenol "tosse" inj
    • BISMUTH SUBSALICYLATE [USAN]
    • Wismutsalicylat, basisches
    • Bismuth subsalicylate (USAN:USP:JAN)
    • 87-27-4
    • subsalicylate bismuth
    • 2-Hydroxy-benzo(1,3,2)dioxabismin-4-one
    • UNII-62TEY51RR1
    • Corrective
    • Bismukote
    • Chewable
    • Gastrobiz
    • Stomach
    • 2-hydroxy-2H,4H-benzo(d)1,3-dioxa-2-bismacyclohexan-4-one
    • PeptoBismol
    • Threda
    • Medique Diotame
    • Pepto Diarrhea
    • Percy Medicine
    • Pink-bismuth
    • Rexall Bismuth
    • Peptic Relief
    • Pepto Bismol
    • Pepto Relief
    • Ultra Bismuth
    • Bismuth Chewable
    • Digestive Relief
    • Estomaquil Polvo
    • Gastro-Cote
    • Treda Ultra
    • McKesson Bismuth
    • Kao-bis
    • QC Pink Bismuth
    • Bismuth, (2-hydroxybenzoato-O(1),O(2))oxo-
    • Stomach Circle K
    • Wismutoxidsalicylat
    • Pep Tum
    • GNP Pink Bismuth
    • Ka Pec
    • 2-Hydroxybenzoic acid bismuth (3+) salt, basic
    • Bismusal Suspension
    • GS Stomach Relief
    • QC Anti Diarrheal
    • QC Stomach Relief
    • Pepto Bismol Chews
    • Pepto Bismol Ultra
    • bismuth-subsalicylate
    • CVS Stomach Relief
    • GNP Stomach Relief
    • HEB Stomach Relief
    • Pepto-Bismol Cherry
    • BISMUTH Suspension
    • Bismuth Subsalycilate
    • Corrective Suspension
    • MFCD00085368
    • BISMUSAL
    • BISMUSOL
    • HEB Diarrhea Relief
    • Pepto-Bismol ULTRA
    • Stomach Relief Ultra
    • Topco Stomach Relief
    • Ultra Stomach Relief
    • Upset Stomach Relief
    • Equate Stomach Relief
    • Guardian Pink Bismuth
    • Kroger Stomach Relief
    • Leader Stomach Relief
    • Meijer Stomach Relief
    • Pepto-Bismol Diarrhea
    • Soothe Ultra Strength
    • Stomach Relief Cherry
    • BISMU-KOTE
    • Careone Stomach Relief
    • PEPT-ACHE
    • Pepto Bismol Liquicaps
    • Rapidol Stomach Relief
    • Sunmark Stomach Relief
    • Topcare Stomach Relief
    • Medi-first Pep-T-med
    • Chewable Stomach Relief
    • Equaline Stomach Relief
    • Kroger Digestive Relief
    • Kroger Regular Strength
    • Walgreen Stomach Relief
    • PUBLIX Stomach Relief

  • Applications

    Primarily used in pharmaceutical formulations as the bismuth salicylate salt in over-the-counter oral dosage forms. In addition, it appears in research contexts as a representative bismuth salt used in coordination chemistry and materials science studies, and may serve as a reference material for analytical methods involving bismuth-containing compounds.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 38.02
    methanol 36.82
    isopropanol 37.32
    water 1.0
    ethyl acetate 71.56
    n-propanol 36.06
    acetone 101.18
    n-butanol 40.45
    acetonitrile 59.47
    DMF 355.92
    toluene 60.0
    isobutanol 34.99
    1,4-dioxane 137.22
    methyl acetate 74.22
    THF 211.03
    2-butanone 85.0
    n-pentanol 45.95
    sec-butanol 44.69
    n-hexane 9.01
    ethylene glycol 28.65
    NMP 320.22
    cyclohexane 14.15
    DMSO 268.27
    n-butyl acetate 73.71
    n-octanol 64.46
    chloroform 132.66
    n-propyl acetate 67.9
    acetic acid 42.78
    dichloromethane 121.03
    cyclohexanone 129.23
    propylene glycol 23.39
    isopropyl acetate 68.61
    DMAc 297.49
    2-ethoxyethanol 99.13
    isopentanol 47.07
    n-heptane 18.41
    ethyl formate 57.1
    1,2-dichloroethane 109.49
    n-hexanol 61.37
    2-methoxyethanol 137.73
    isobutyl acetate 50.62
    tetrachloromethane 26.58
    n-pentyl acetate 78.45
    transcutol 242.37
    n-heptanol 53.03
    ethylbenzene 46.37
    MIBK 82.43
    2-propoxyethanol 122.72
    tert-butanol 55.66
    MTBE 59.46
    2-butoxyethanol 88.81
    propionic acid 36.68
    o-xylene 61.31
    formic acid 28.58
    diethyl ether 69.8
    m-xylene 59.98
    p-xylene 50.3
    chlorobenzene 67.71
    dimethyl carbonate 82.76
    n-octane 12.88
    formamide 68.2
    cyclopentanone 170.86
    2-pentanone 92.73
    anisole 91.77
    cyclopentyl methyl ether 120.85
    gamma-butyrolactone 160.02
    1-methoxy-2-propanol 127.79
    pyridine 126.29
    3-pentanone 82.98
    furfural 183.18
    n-dodecane 14.19
    diethylene glycol 111.94
    diisopropyl ether 39.93
    tert-amyl alcohol 60.44
    acetylacetone 131.37
    n-hexadecane 15.83
    acetophenone 102.3
    methyl propionate 87.49
    isopentyl acetate 68.02
    trichloroethylene 172.74
    n-nonanol 62.54
    cyclohexanol 60.6
    benzyl alcohol 78.38
    2-ethylhexanol 56.78
    isooctanol 48.14
    dipropyl ether 68.65
    1,2-dichlorobenzene 76.36
    ethyl lactate 61.22
    propylene carbonate 93.2
    n-methylformamide 106.43
    2-pentanol 45.61
    n-pentane 12.23
    1-propoxy-2-propanol 102.78
    1-methoxy-2-propyl acetate 98.0
    2-(2-methoxypropoxy) propanol 106.63
    mesitylene 45.74
    ε-caprolactone 108.62
    p-cymene 45.4
    epichlorohydrin 179.79
    1,1,1-trichloroethane 72.39
    2-aminoethanol 37.01
    morpholine-4-carbaldehyde 278.54
    sulfolane 227.21
    2,2,4-trimethylpentane 9.64
    2-methyltetrahydrofuran 119.48
    n-hexyl acetate 89.52
    isooctane 7.41
    2-(2-butoxyethoxy)ethanol 128.48
    sec-butyl acetate 59.25
    tert-butyl acetate 80.1
    decalin 12.63
    glycerin 51.08
    diglyme 200.09
    acrylic acid 43.05
    isopropyl myristate 56.8
    n-butyric acid 49.22
    acetyl acetate 56.26
    di(2-ethylhexyl) phthalate 54.03
    ethyl propionate 69.14
    nitromethane 109.5
    1,2-diethoxyethane 112.26
    benzonitrile 92.38
    trioctyl phosphate 47.88
    1-bromopropane 60.72
    gamma-valerolactone 199.42
    n-decanol 54.8
    triethyl phosphate 49.68
    4-methyl-2-pentanol 43.01
    propionitrile 57.58
    vinylene carbonate 85.18
    1,1,2-trichlorotrifluoroethane 145.52
    DMS 79.79
    cumene 37.68
    2-octanol 53.72
    2-hexanone 83.31
    octyl acetate 64.7
    limonene 56.39
    1,2-dimethoxyethane 177.92
    ethyl orthosilicate 48.78
    tributyl phosphate 49.82
    diacetone alcohol 110.66
    N,N-dimethylaniline 95.88
    acrylonitrile 81.65
    aniline 71.82
    1,3-propanediol 50.04
    bromobenzene 72.49
    dibromomethane 87.96
    1,1,2,2-tetrachloroethane 155.98
    2-methyl-cyclohexyl acetate 65.86
    tetrabutyl urea 86.67
    diisobutyl methanol 45.91
    2-phenylethanol 83.08
    styrene 50.71
    dioctyl adipate 65.65
    dimethyl sulfate 135.65
    ethyl butyrate 68.08
    methyl lactate 80.51
    butyl lactate 73.42
    diethyl carbonate 47.96
    propanediol butyl ether 101.06
    triethyl orthoformate 58.79
    p-tert-butyltoluene 44.94
    methyl 4-tert-butylbenzoate 100.52
    morpholine 144.89
    tert-butylamine 41.78
    n-dodecanol 48.01
    dimethoxymethane 199.45
    ethylene carbonate 70.05
    cyrene 124.03
    2-ethoxyethyl acetate 93.12
    2-ethylhexyl acetate 62.32
    1,2,4-trichlorobenzene 85.5
    4-methylpyridine 125.88
    dibutyl ether 69.45
    2,6-dimethyl-4-heptanol 45.91
    DEF 162.57
    dimethyl isosorbide 175.09
    tetrachloroethylene 109.24
    eugenol 121.58
    triacetin 87.79
    span 80 95.6
    1,4-butanediol 32.67
    1,1-dichloroethane 70.91
    2-methyl-1-pentanol 50.74
    methyl formate 95.63
    2-methyl-1-butanol 44.83
    n-decane 18.9
    butyronitrile 61.87
    3,7-dimethyl-1-octanol 60.98
    1-chlorooctane 50.31
    1-chlorotetradecane 29.58
    n-nonane 17.26
    undecane 16.22
    tert-butylcyclohexane 11.23
    cyclooctane 11.09
    cyclopentanol 70.62
    tetrahydropyran 94.65
    tert-amyl methyl ether 70.66
    2,5,8-trioxanonane 167.66
    1-hexene 27.86
    2-isopropoxyethanol 86.0
    2,2,2-trifluoroethanol 37.16
    methyl butyrate 82.94

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction