Bismuth Subsalicylate

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  • Identifiers

    CAS number
    14882-18-9

    Molecular formula
    C7H6BiO4

    SMILES
    C1=CC=C2C(=C1)C(=O)O[Bi]O2.O

    Safety labels

    Environmental Hazard
    Environmental

  • Odor profile

    Odorless 54.97%
    Phenolic 37.46%
    Sweet 35.65%
    Bitter 31.58%
    Coumarinic 29.64%
    Spicy 25.45%
    Almond 25.15%
    Coconut 24.45%
    Tobacco 24.31%
    Burnt 23.84%

    Scent© AI

  • Properties

    Molecular weight
    363.1 g/mol

    Melting point expt.

    • >350

    Flash point est.
    127.17 ˚C

    Solubility expt.

    • Insoluble (<1 mg/ml at 71.1 °F) (NTP, 1992)
    • ALMOST INSOL IN WATER OR ALCOHOL
    • SOL IN ACIDS & ALKALIES; INSOL IN ETHER
    • SOL IN OIL

  • Synonyms

    • BISMUTH SUBSALICYLATE
    • 14882-18-9
    • Bismuth oxysalicylate
    • Bismuth oxide salicylate
    • Wismutsubsalicylat
    • Pepto-bismol
    • 4H-1,3,2-Benzodioxabismin-4-one, 2-hydroxy-
    • Stabisol
    • Basic bismuth salicylate
    • Trigastronol
    • Kaopectate
    • Bismuthi subsalicylas
    • Bismutum subsalicylicum
    • Bismuth(III) subsalicylate
    • pink bismuth
    • Bismuth salicylate, basic
    • Bismuth, oxo(salicylato)-
    • Bismogenol tosse inj
    • CCRIS 4751
    • HSDB 332
    • Salicylic acid basic bismuth salt
    • Bismuth, (2-hydroxybenzoato-O1,O2)oxo-
    • Salicylic acid, bismuth basic salt
    • EINECS 238-953-1
    • Pepto-bismol (TN)
    • DTXSID6024622
    • Bismuth subsalicylate [USAN:USP:JAN]
    • (2-Hydroxybenzoato-O(sup 1))-oxobismuth
    • 2-Hydroxy-benzo[1,3,2]dioxabismin-4-one
    • 62TEY51RR1
    • DTXCID004622
    • 2-hydroxy-2H,4H-benzo[d]1,3-dioxa-2-bismacyclohexan-4-one
    • 2-Hydroxy-4H-1,3,2-benzodioxabismin-4-one
    • Vismut
    • Spiromak forte
    • CHEBI:261649
    • EC 238-953-1
    • NSC 759117
    • NSC-759117
    • NCGC00166299-01
    • Bismuth oxysalicylate;Bismuth(III) salicylate basic
    • Bismuth subsalicylate [USAN)
    • Bismatrol
    • Bismogenol "tosse" inj
    • BISMUTH SUBSALICYLATE [USAN]
    • Wismutsalicylat, basisches
    • Bismuth subsalicylate (USAN:USP:JAN)
    • 87-27-4
    • subsalicylate bismuth
    • 2-Hydroxy-benzo(1,3,2)dioxabismin-4-one
    • UNII-62TEY51RR1
    • Corrective
    • Bismukote
    • Chewable
    • Gastrobiz
    • Stomach
    • 2-hydroxy-2H,4H-benzo(d)1,3-dioxa-2-bismacyclohexan-4-one
    • PeptoBismol
    • Threda
    • Medique Diotame
    • Pepto Diarrhea
    • Percy Medicine
    • Pink-bismuth
    • Rexall Bismuth
    • Peptic Relief
    • Pepto Bismol
    • Pepto Relief
    • Ultra Bismuth
    • Bismuth Chewable
    • Digestive Relief
    • Estomaquil Polvo
    • Gastro-Cote
    • Treda Ultra
    • McKesson Bismuth
    • Kao-bis
    • QC Pink Bismuth
    • Bismuth, (2-hydroxybenzoato-O(1),O(2))oxo-
    • Stomach Circle K
    • Wismutoxidsalicylat
    • Pep Tum
    • GNP Pink Bismuth
    • Ka Pec
    • 2-Hydroxybenzoic acid bismuth (3+) salt, basic
    • Bismusal Suspension
    • GS Stomach Relief
    • QC Anti Diarrheal
    • QC Stomach Relief
    • Pepto Bismol Chews
    • Pepto Bismol Ultra
    • bismuth-subsalicylate
    • CVS Stomach Relief
    • GNP Stomach Relief
    • HEB Stomach Relief
    • Pepto-Bismol Cherry
    • BISMUTH Suspension
    • Bismuth Subsalycilate
    • Corrective Suspension
    • MFCD00085368
    • BISMUSAL
    • BISMUSOL
    • HEB Diarrhea Relief
    • Pepto-Bismol ULTRA
    • Stomach Relief Ultra
    • Topco Stomach Relief
    • Ultra Stomach Relief
    • Upset Stomach Relief
    • Equate Stomach Relief
    • Guardian Pink Bismuth
    • Kroger Stomach Relief
    • Leader Stomach Relief
    • Meijer Stomach Relief
    • Pepto-Bismol Diarrhea
    • Soothe Ultra Strength
    • Stomach Relief Cherry
    • BISMU-KOTE
    • Careone Stomach Relief
    • PEPT-ACHE
    • Pepto Bismol Liquicaps
    • Rapidol Stomach Relief
    • Sunmark Stomach Relief
    • Topcare Stomach Relief
    • Medi-first Pep-T-med
    • Chewable Stomach Relief
    • Equaline Stomach Relief
    • Kroger Digestive Relief
    • Kroger Regular Strength
    • Walgreen Stomach Relief
    • PUBLIX Stomach Relief

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 38.51
    methanol 56.34
    isopropanol 32.87
    water 6.14
    ethyl acetate 22.69
    n-propanol 31.02
    acetone 43.08
    n-butanol 33.39
    acetonitrile 26.03
    DMF 253.21
    toluene 8.27
    isobutanol 24.11
    1,4-dioxane 35.01
    methyl acetate 24.44
    THF 92.53
    2-butanone 36.59
    n-pentanol 29.85
    sec-butanol 31.5
    n-hexane 1.38
    ethylene glycol 39.74
    NMP 187.9
    cyclohexane 2.41
    DMSO 257.4
    n-butyl acetate 24.37
    n-octanol 27.95
    chloroform 18.74
    n-propyl acetate 21.91
    acetic acid 24.59
    dichloromethane 22.25
    cyclohexanone 49.39
    propylene glycol 25.51
    isopropyl acetate 18.53
    DMAc 224.0
    2-ethoxyethanol 68.76
    isopentanol 29.08
    n-heptane 3.91
    ethyl formate 29.31
    1,2-dichloroethane 22.93
    n-hexanol 31.82
    2-methoxyethanol 129.35
    isobutyl acetate 11.7
    tetrachloromethane 4.12
    n-pentyl acetate 25.93
    transcutol 80.85
    n-heptanol 28.33
    ethylbenzene 6.65
    MIBK 25.27
    2-propoxyethanol 78.86
    tert-butanol 35.23
    MTBE 14.68
    2-butoxyethanol 50.87
    propionic acid 19.5
    o-xylene 10.3
    formic acid 43.35
    diethyl ether 21.12
    m-xylene 9.16
    p-xylene 7.1
    chlorobenzene 8.3
    dimethyl carbonate 32.51
    n-octane 2.63
    formamide 80.72
    cyclopentanone 67.03
    2-pentanone 39.26
    anisole 18.03
    cyclopentyl methyl ether 35.92
    gamma-butyrolactone 65.01
    1-methoxy-2-propanol 102.54
    pyridine 34.94
    3-pentanone 29.69
    furfural 70.83
    n-dodecane 2.53
    diethylene glycol 93.01
    diisopropyl ether 7.13
    tert-amyl alcohol 32.26
    acetylacetone 36.86
    n-hexadecane 2.74
    acetophenone 28.78
    methyl propionate 35.57
    isopentyl acetate 19.73
    trichloroethylene 29.28
    n-nonanol 26.75
    cyclohexanol 32.39
    benzyl alcohol 29.38
    2-ethylhexanol 20.82
    isooctanol 21.23
    dipropyl ether 19.59
    1,2-dichlorobenzene 11.4
    ethyl lactate 31.26
    propylene carbonate 34.15
    n-methylformamide 83.51
    2-pentanol 28.92
    n-pentane 2.75
    1-propoxy-2-propanol 57.43
    1-methoxy-2-propyl acetate 36.14
    2-(2-methoxypropoxy) propanol 47.3
    mesitylene 6.44
    ε-caprolactone 42.32
    p-cymene 9.83
    epichlorohydrin 62.94
    1,1,1-trichloroethane 8.45
    2-aminoethanol 44.85
    morpholine-4-carbaldehyde 130.78
    sulfolane 109.97
    2,2,4-trimethylpentane 1.24
    2-methyltetrahydrofuran 39.23
    n-hexyl acetate 28.55
    isooctane 0.84
    2-(2-butoxyethoxy)ethanol 56.51
    sec-butyl acetate 14.23
    tert-butyl acetate 18.67
    decalin 1.5
    glycerin 63.29
    diglyme 81.01
    acrylic acid 22.89
    isopropyl myristate 14.91
    n-butyric acid 28.26
    acetyl acetate 11.93
    di(2-ethylhexyl) phthalate 19.86
    ethyl propionate 21.9
    nitromethane 50.72
    1,2-diethoxyethane 29.69
    benzonitrile 26.4
    trioctyl phosphate 18.88
    1-bromopropane 12.83
    gamma-valerolactone 81.3
    n-decanol 21.73
    triethyl phosphate 16.02
    4-methyl-2-pentanol 16.3
    propionitrile 28.34
    vinylene carbonate 31.21
    1,1,2-trichlorotrifluoroethane 70.62
    DMS 21.4
    cumene 5.72
    2-octanol 23.2
    2-hexanone 28.02
    octyl acetate 20.71
    limonene 11.96
    1,2-dimethoxyethane 90.56
    ethyl orthosilicate 15.27
    tributyl phosphate 16.97
    diacetone alcohol 46.63
    N,N-dimethylaniline 24.61
    acrylonitrile 39.7
    aniline 23.08
    1,3-propanediol 54.29
    bromobenzene 6.13
    dibromomethane 15.14
    1,1,2,2-tetrachloroethane 33.49
    2-methyl-cyclohexyl acetate 20.2
    tetrabutyl urea 32.16
    diisobutyl methanol 13.58
    2-phenylethanol 33.06
    styrene 6.71
    dioctyl adipate 20.27
    dimethyl sulfate 55.22
    ethyl butyrate 20.72
    methyl lactate 51.62
    butyl lactate 32.56
    diethyl carbonate 14.31
    propanediol butyl ether 50.8
    triethyl orthoformate 19.3
    p-tert-butyltoluene 8.82
    methyl 4-tert-butylbenzoate 35.9
    morpholine 61.82
    tert-butylamine 18.72
    n-dodecanol 17.57
    dimethoxymethane 123.97
    ethylene carbonate 26.45
    cyrene 56.85
    2-ethoxyethyl acetate 30.74
    2-ethylhexyl acetate 16.24
    1,2,4-trichlorobenzene 13.65
    4-methylpyridine 35.86
    dibutyl ether 16.89
    2,6-dimethyl-4-heptanol 13.58
    DEF 80.96
    dimethyl isosorbide 62.49
    tetrachloroethylene 23.43
    eugenol 45.14
    triacetin 26.76
    span 80 39.12
    1,4-butanediol 31.81
    1,1-dichloroethane 11.75
    2-methyl-1-pentanol 23.51
    methyl formate 58.74
    2-methyl-1-butanol 27.03
    n-decane 3.76
    butyronitrile 31.37
    3,7-dimethyl-1-octanol 21.08
    1-chlorooctane 10.75
    1-chlorotetradecane 5.73
    n-nonane 3.4
    undecane 3.03
    tert-butylcyclohexane 1.11
    cyclooctane 1.65
    cyclopentanol 39.6
    tetrahydropyran 26.08
    tert-amyl methyl ether 18.39
    2,5,8-trioxanonane 68.23
    1-hexene 4.95
    2-isopropoxyethanol 45.96
    2,2,2-trifluoroethanol 23.49
    methyl butyrate 29.8

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction