Bisacodyl

Overview IFRA Request a quote

  • Identifiers

    CAS number
    603-50-9

    Molecular formula
    C22H19NO4

    SMILES
    CC(=O)OC1=CC=C(C=C1)C(C2=CC=C(C=C2)OC(=O)C)C3=CC=CC=N3

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Floral 70.93%
    Phenolic 48.56%
    Animal 45.29%
    Balsamic 40.95%
    Honey 40.12%
    Woody 34.74%
    Fruity 34.72%
    Powdery 33.55%
    Aromatic 31.98%
    Neroli 31.17%

     

    Flavor
    Sweet 53.42%
    Floral 47.16%
    Bitter 45.69%
    Fruity 37.17%
    Mild 29.72%
    Powdery 28.82%
    Honey 27.78%
    Balsam 27.14%
    Herbal 23.53%
    Orange blossom 21.71%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    3.8

    pKa est.
    6.36 (neutral)

    Molecular weight
    361.4 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    457°C

    Melting point expt.

    • 138
    • 138 °C

    Flash point

    • 232.68 ˚C est.

    Solubility expt.

    • Practically insoluble in water and alkaline solvents. Soluble in acids, alcohol, acetone, propylene glycol and other organic solvents.
    • 1 G SOL IN 210 ML ALCOHOL, 2.5 ML CHLOROFORM, 275 ML ETHER
    • >54.2 [ug/mL] (The mean of the results at pH 7.4)

  • Synonyms

    • bisacodyl
    • 603-50-9
    • Dulcolax
    • Theralax
    • Sk-bisacodyl
    • Brocalax
    • Dulcolan
    • Fenilaxan
    • Laxans
    • Pyrilax
    • Telemin
    • Endokolat
    • Eulaxan
    • Godalax
    • Hillcolax
    • Laxadin
    • Laxorex
    • Nigalax
    • Stadalax
    • Ivilax
    • Laxine
    • Neolax
    • Zetrax
    • Bisacodilo
    • Deficol
    • Modane
    • LACO
    • Phenol, 4,4'-(2-pyridinylmethylene)bis-, diacetate (ester)
    • Evac-Q-Tabs
    • LA96a
    • Bisacodylum
    • Feen-a-Mint Tablets
    • Bis(p-acetoxyphenyl)-2-pyridylmethane
    • Di-(p-acetoxyphenyl)-2-pyridylmethane
    • Di-(4-acetoxyphenyl)-2-pyridylmethane
    • 2-(4,4'-Diacetoxydiphenylmethyl)pyridine
    • Correctol Tablets, Caplets
    • (4,4'-Diacetoxydiphenyl)(2-pyridyl)methane
    • 4,4'-(2-Pyridylmethylene)diphenol diacetate
    • NSC-755914
    • DTXSID1022681
    • Phenol, 4,4'-(2-pyridylmethylene)di-, diacetate (ester)
    • 10X0709Y6I
    • DTXCID202681
    • 4-{[4-(acetyloxy)phenyl](pyridin-2-yl)methyl}phenyl acetate
    • 5-21-05-00415 (Beilstein Handbook Reference)
    • bisacodil
    • Bisacody
    • Dulcodos
    • Entrolax
    • 4-((4-(acetyloxy)phenyl)(pyridin-2-yl)methyl)phenyl acetate
    • Biolax
    • Conlax
    • BIisacodyl
    • Dulcolax perles
    • ratio Bisacodyl
    • Laxative Gentle
    • Laxative Women
    • Womans Laxative
    • Womens Laxative
    • Apo Bisacodyl
    • Bisco Zitron
    • Proctozone-B
    • Publix Women
    • Bisac Evac
    • Bisacodyl 5mg
    • Laxans ratiopharm
    • Bisco Lax
    • C-lax Laxative
    • Dulco Lax
    • Dulco lax perles
    • Dulco-Lax
    • Dulcolax Laxative
    • Bisacodyl, Fleet
    • The Magic Bullet
    • Bisacodyl Laxative
    • Stimulant Laxative
    • Tannex, Bisacodyl
    • Bisacodyl, Bekunis
    • Laxative for Women
    • Uniserts, Bisacodyl
    • Cvs Gentle Laxative
    • Unit Dose Bisacodyl
    • Bisacodyl Suppository
    • Stratuscare Bisacodyl
    • BISCODYL
    • HEB Gentle Laxative
    • P Lax Dr
    • Y Lax Dr
    • Extra Gentle Laxative
    • Publix Women Laxative
    • Leader Womens Laxative
    • Meijer Gentle Laxative
    • Womens Gentle Laxative
    • Avedana Gentle Laxative
    • Bisacody Enteric Coated
    • Laxative Enteric Coated
    • RefChem:5607
    • TopCare Gentle Laxative
    • Bisacodyl Enteric Coated
    • GaviLyte-H and Bisacodyl
    • Gentle Laxative Bisacodyl
    • Gentle Overnight Laxative
    • Publix Stimulant Laxative
    • Rite-Aid Gentle Laxative
    • Simpex Bisacodyl Laxative
    • Walgreens Gentle Laxative
    • up and up gentle laxative
    • Dulcolax Simulant Laxative
    • Dulcolax Stimulant Laxative
    • Bisacodyl Stimulant Laxative
    • Rite Aid fast relief laxative
    • Dollar General Gentle Laxative
    • Dulcolax Pink Stimulant Laxative
    • Premier Value Bisacodyl Laxative
    • A06AB02
    • A06AG02
    • Discount Drugmart Gentle Laxative
    • Enteric Coated Stimulant Laxative
    • Stimulant Laxative Enteric Coated
    • Foster and Thrive Gentle Laxative
    • GOOD REMEDIES GENTLE Laxative
    • Gentle Laxative Stimulant Laxative
    • The Medicine Shoppe Gentle Laxative
    • WOMENS LAXATIVE ENTERIC COATED
    • Good Neighbor Pharmacy Gentle Laxative
    • BISAC-10 Bisacodyl Stimulant Laxative
    • 603-50-9

  • Applications

    Bisacodyl (CAS 603-50-9) is primarily used as an active pharmaceutical ingredient in stimulant laxative products, formulated as tablets and rectal suppositories, to stimulate intestinal motility and relieve constipation in the short term; it is also used for bowel preparation prior to diagnostic procedures such as colonoscopy; it appears in consumer healthcare laxative products sold OTC; in pharmaceutical manufacturing it is considered during formulation development and quality control, with use subject to local regulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 2.76
    methanol 5.81
    isopropanol 1.25
    water 0.0
    ethyl acetate 6.66
    n-propanol 1.54
    acetone 35.93
    n-butanol 1.31
    acetonitrile 33.23
    DMF 58.03
    toluene 2.67
    isobutanol 1.47
    1,4-dioxane 11.72
    methyl acetate 16.59
    THF 121.83
    2-butanone 21.37
    n-pentanol 2.08
    sec-butanol 1.53
    n-hexane 0.1
    ethylene glycol 1.23
    NMP 41.7
    cyclohexane 0.07
    DMSO 183.47
    n-butyl acetate 7.25
    n-octanol 1.34
    chloroform 49.32
    n-propyl acetate 7.52
    acetic acid 12.81
    dichloromethane 68.15
    cyclohexanone 22.84
    propylene glycol 1.75
    isopropyl acetate 4.26
    DMAc 186.83
    2-ethoxyethanol 13.85
    isopentanol 1.77
    n-heptane 0.08
    ethyl formate 9.51
    1,2-dichloroethane 31.48
    n-hexanol 1.44
    2-methoxyethanol 18.03
    isobutyl acetate 4.87
    tetrachloromethane 1.28
    n-pentyl acetate 3.6
    transcutol 27.92
    n-heptanol 1.25
    ethylbenzene 2.11
    MIBK 5.62
    2-propoxyethanol 13.86
    tert-butanol 2.16
    MTBE 2.77
    2-butoxyethanol 6.99
    propionic acid 6.1
    o-xylene 1.63
    formic acid 7.88
    diethyl ether 2.85
    m-xylene 1.26
    p-xylene 3.21
    chlorobenzene 8.03
    dimethyl carbonate 9.78
    n-octane 0.06
    formamide 18.63
    cyclopentanone 52.98
    2-pentanone 8.63
    anisole 10.75
    cyclopentyl methyl ether 7.13
    gamma-butyrolactone 51.15
    1-methoxy-2-propanol 10.42
    pyridine 25.54
    3-pentanone 9.08
    furfural 45.03
    n-dodecane 0.12
    diethylene glycol 12.18
    diisopropyl ether 0.62
    tert-amyl alcohol 2.34
    acetylacetone 19.55
    n-hexadecane 0.14
    acetophenone 13.35
    methyl propionate 9.9
    isopentyl acetate 7.2
    trichloroethylene 67.14
    n-nonanol 1.6
    cyclohexanol 1.73
    benzyl alcohol 8.92
    2-ethylhexanol 1.8
    isooctanol 1.39
    dipropyl ether 3.37
    1,2-dichlorobenzene 8.74
    ethyl lactate 7.31
    propylene carbonate 17.27
    n-methylformamide 18.85
    2-pentanol 0.77
    n-pentane 0.04
    1-propoxy-2-propanol 9.2
    1-methoxy-2-propyl acetate 12.51
    2-(2-methoxypropoxy) propanol 15.07
    mesitylene 0.67
    ε-caprolactone 15.52
    p-cymene 1.52
    epichlorohydrin 78.59
    1,1,1-trichloroethane 11.55
    2-aminoethanol 2.31
    morpholine-4-carbaldehyde 37.71
    sulfolane 69.17
    2,2,4-trimethylpentane 0.08
    2-methyltetrahydrofuran 18.05
    n-hexyl acetate 4.76
    isooctane 0.04
    2-(2-butoxyethoxy)ethanol 13.13
    sec-butyl acetate 4.54
    tert-butyl acetate 5.4
    decalin 0.19
    glycerin 5.53
    diglyme 30.13
    acrylic acid 8.73
    isopropyl myristate 2.91
    n-butyric acid 6.11
    acetyl acetate 6.4
    di(2-ethylhexyl) phthalate 5.53
    ethyl propionate 7.52
    nitromethane 52.03
    1,2-diethoxyethane 9.06
    benzonitrile 12.44
    trioctyl phosphate 2.62
    1-bromopropane 7.45
    gamma-valerolactone 47.48
    n-decanol 1.33
    triethyl phosphate 7.11
    4-methyl-2-pentanol 0.86
    propionitrile 11.07
    vinylene carbonate 16.9
    1,1,2-trichlorotrifluoroethane 41.66
    DMS 9.88
    cumene 1.55
    2-octanol 0.84
    2-hexanone 9.86
    octyl acetate 3.59
    limonene 1.7
    1,2-dimethoxyethane 34.84
    ethyl orthosilicate 5.86
    tributyl phosphate 4.29
    diacetone alcohol 9.02
    N,N-dimethylaniline 7.25
    acrylonitrile 20.94
    aniline 6.02
    1,3-propanediol 3.41
    bromobenzene 7.66
    dibromomethane 28.74
    1,1,2,2-tetrachloroethane 41.33
    2-methyl-cyclohexyl acetate 8.22
    tetrabutyl urea 6.97
    diisobutyl methanol 1.41
    2-phenylethanol 6.67
    styrene 3.07
    dioctyl adipate 7.04
    dimethyl sulfate 25.09
    ethyl butyrate 7.65
    methyl lactate 10.12
    butyl lactate 5.25
    diethyl carbonate 7.06
    propanediol butyl ether 5.6
    triethyl orthoformate 7.17
    p-tert-butyltoluene 1.12
    methyl 4-tert-butylbenzoate 10.99
    morpholine 16.6
    tert-butylamine 0.91
    n-dodecanol 1.11
    dimethoxymethane 25.75
    ethylene carbonate 11.86
    cyrene 19.09
    2-ethoxyethyl acetate 8.34
    2-ethylhexyl acetate 5.71
    1,2,4-trichlorobenzene 11.57
    4-methylpyridine 17.22
    dibutyl ether 3.11
    2,6-dimethyl-4-heptanol 1.41
    DEF 13.87
    dimethyl isosorbide 28.42
    tetrachloroethylene 17.94
    eugenol 12.49
    triacetin 10.43
    span 80 7.92
    1,4-butanediol 2.28
    1,1-dichloroethane 16.05
    2-methyl-1-pentanol 2.69
    methyl formate 18.46
    2-methyl-1-butanol 1.73
    n-decane 0.17
    butyronitrile 7.83
    3,7-dimethyl-1-octanol 1.92
    1-chlorooctane 1.19
    1-chlorotetradecane 0.63
    n-nonane 0.12
    undecane 0.14
    tert-butylcyclohexane 0.15
    cyclooctane 0.03
    cyclopentanol 3.16
    tetrahydropyran 7.94
    tert-amyl methyl ether 2.99
    2,5,8-trioxanonane 24.79
    1-hexene 0.93
    2-isopropoxyethanol 8.55
    2,2,2-trifluoroethanol 7.2
    methyl butyrate 10.65

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction