Bis(2,5-dimethyl-3-furyl) disulfide

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  • Identifiers

    CAS number
    28588-73-0

    Molecular formula
    C12H14O2S2

    SMILES
    CC1=CC(=C(O1)C)SSC2=C(OC(=C2)C)C

  • Odor profile

    Fragrance
    Meaty 84.38%
    Roasted 78.25%
    Sulfurous 55.44%
    Savory 44.46%
    Cooked 42.35%
    Beefy 41.74%
    Burnt 40.59%
    Coffee 39.99%
    Onion 29.21%
    Smoky 26.92%

     

    Flavor
    Roasted 69.19%
    Meaty 60.38%
    Coffee 52.47%
    Sulfury 50.39%
    Burnt 45.44%
    Roast 38.13%
    Nutty 37.39%
    Onion 37.19%
    Cooked 30.17%
    Cocoa 27.19%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    3.8

    pKa est.
    5.78 (weak acid)

    Molecular weight
    254.4 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Slow

    Boiling point

    • 110.00 to 111.00 °C. @ 1.00 mm Hg

    Flash point

    • 141.35 ˚C est.

    Solubility expt.

    • Insoluble in water; slighty soulble in fat
    • Miscible at room temperature (in ethanol)

  • Synonyms

    • 28588-73-0
    • 3,3'-Dithiobis(2,5-dimethylfuran)
    • 3,3'-dithiobis[2,5-dimethylfuran]
    • bis(2,5-Dimethyl-3-furyl) disulfide
    • furan, 3,3'-dithiobis[2,5-dimethyl-
    • 3-[(2,5-dimethylfuran-3-yl)disulfanyl]-2,5-dimethylfuran
    • FEMA No. 3476
    • 1,2-Bis(2,5-dimethylfuran-3-yl)disulfane
    • Furan, 3,3'-dithiobis(2,5-dimethyl-
    • Y4J0329QJ8
    • EINECS 249-093-1
    • Bis(2,5-dimethyl-3-furanyl) disulfide
    • DTXSID2067400
    • BIS(2,5-DIMETHYL-3-FURYL) DISULFIDE [FHFI]
    • 3,3'-Dithiobis(2,5-dimethyl-Furan
    • 3,3'-Dithiobis[2,5-dimethyl-furan
    • UNII-Y4J0329QJ8
    • SCHEMBL3508454
    • DTXCID2037841
    • FEMA 3476
    • CHEBI:174346
    • 3,3"Dithio-bis(2,5-dimethylfuran)
    • bis(2,5-dimethyl-3-furyl)disulphide
    • AKOS015899542
    • AS-62082
    • NS00021987
    • D92978
    • 3,3'-Dithiobis[2,5-dimethylfuran], 9CI, 8CI
    • Q27294259
    • 3-[(2,5-dimethyluran-3-yl)disulanyl]-2,5-dimethyluran
    • 249-093-1

  • Applications

    Bis(2,5-dimethyl-3-furyl) disulfide (CAS 28588-73-0) is primarily used as a fragrance-related chemical in perfumery and cosmetics, where the furyl framework contributes to distinctive aroma notes and it can function as a fixative or controlled-release odorant in formulations. It is commonly evaluated as an organic synthesis intermediate and can serve as a sulfur-containing building block for the preparation of other organosulfur compounds. In polymer and materials processing, it may act as a crosslinking aid or sulfur donor to influence curing behavior and network formation in plastics, rubbers, coatings, and inks. It may also find use in industrial manufacturing as a precursor or reagent in chemical synthesis workflows and in adhesive and coating systems where sulfur-containing moieties enable specific bonding or compatibility. Subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 52.43
    methanol 44.99
    isopropanol 43.64
    water 0.22
    ethyl acetate 349.32
    n-propanol 56.34
    acetone 401.6
    n-butanol 58.51
    acetonitrile 214.06
    DMF 934.23
    toluene 316.9
    isobutanol 53.92
    1,4-dioxane 821.87
    methyl acetate 385.74
    THF 1204.66
    2-butanone 326.6
    n-pentanol 49.56
    sec-butanol 57.34
    n-hexane 23.7
    ethylene glycol 23.84
    NMP 1352.34
    cyclohexane 70.82
    DMSO 577.0
    n-butyl acetate 208.66
    n-octanol 42.38
    chloroform 1216.95
    n-propyl acetate 185.17
    acetic acid 140.73
    dichloromethane 1149.59
    cyclohexanone 638.37
    propylene glycol 31.7
    isopropyl acetate 228.98
    DMAc 1089.06
    2-ethoxyethanol 173.14
    isopentanol 62.3
    n-heptane 19.16
    ethyl formate 176.78
    1,2-dichloroethane 630.17
    n-hexanol 59.25
    2-methoxyethanol 275.92
    isobutyl acetate 138.63
    tetrachloromethane 134.19
    n-pentyl acetate 135.91
    transcutol 542.08
    n-heptanol 33.83
    ethylbenzene 136.73
    MIBK 182.73
    2-propoxyethanol 227.04
    tert-butanol 78.13
    MTBE 208.01
    2-butoxyethanol 99.29
    propionic acid 104.44
    o-xylene 187.57
    formic acid 50.44
    diethyl ether 229.26
    m-xylene 192.12
    p-xylene 172.57
    chlorobenzene 502.09
    dimethyl carbonate 311.12
    n-octane 9.32
    formamide 145.54
    cyclopentanone 893.79
    2-pentanone 267.84
    anisole 449.43
    cyclopentyl methyl ether 551.41
    gamma-butyrolactone 1033.84
    1-methoxy-2-propanol 207.72
    pyridine 682.54
    3-pentanone 302.25
    furfural 997.28
    n-dodecane 9.15
    diethylene glycol 166.93
    diisopropyl ether 95.99
    tert-amyl alcohol 87.91
    acetylacetone 588.65
    n-hexadecane 11.4
    acetophenone 361.36
    methyl propionate 350.7
    isopentyl acetate 209.4
    trichloroethylene 1518.74
    n-nonanol 44.18
    cyclohexanol 129.31
    benzyl alcohol 179.08
    2-ethylhexanol 62.43
    isooctanol 34.7
    dipropyl ether 139.88
    1,2-dichlorobenzene 519.54
    ethyl lactate 96.66
    propylene carbonate 509.58
    n-methylformamide 248.08
    2-pentanol 49.81
    n-pentane 18.15
    1-propoxy-2-propanol 152.74
    1-methoxy-2-propyl acetate 372.7
    2-(2-methoxypropoxy) propanol 199.2
    mesitylene 120.97
    ε-caprolactone 534.76
    p-cymene 82.79
    epichlorohydrin 1220.2
    1,1,1-trichloroethane 660.38
    2-aminoethanol 42.14
    morpholine-4-carbaldehyde 1265.3
    sulfolane 1269.14
    2,2,4-trimethylpentane 19.03
    2-methyltetrahydrofuran 689.35
    n-hexyl acetate 188.47
    isooctane 11.63
    2-(2-butoxyethoxy)ethanol 201.36
    sec-butyl acetate 159.23
    tert-butyl acetate 306.58
    decalin 45.66
    glycerin 75.68
    diglyme 511.58
    acrylic acid 131.13
    isopropyl myristate 94.07
    n-butyric acid 137.92
    acetyl acetate 344.59
    di(2-ethylhexyl) phthalate 104.77
    ethyl propionate 229.06
    nitromethane 662.14
    1,2-diethoxyethane 288.2
    benzonitrile 283.72
    trioctyl phosphate 56.18
    1-bromopropane 251.14
    gamma-valerolactone 1281.26
    n-decanol 34.73
    triethyl phosphate 156.31
    4-methyl-2-pentanol 38.88
    propionitrile 145.62
    vinylene carbonate 519.26
    1,1,2-trichlorotrifluoroethane 734.32
    DMS 405.36
    cumene 83.02
    2-octanol 29.55
    2-hexanone 177.79
    octyl acetate 111.54
    limonene 131.61
    1,2-dimethoxyethane 494.92
    ethyl orthosilicate 142.45
    tributyl phosphate 88.66
    diacetone alcohol 216.73
    N,N-dimethylaniline 282.93
    acrylonitrile 223.1
    aniline 285.94
    1,3-propanediol 68.31
    bromobenzene 632.01
    dibromomethane 598.9
    1,1,2,2-tetrachloroethane 1125.49
    2-methyl-cyclohexyl acetate 219.79
    tetrabutyl urea 136.33
    diisobutyl methanol 44.0
    2-phenylethanol 168.05
    styrene 199.66
    dioctyl adipate 169.24
    dimethyl sulfate 651.84
    ethyl butyrate 197.36
    methyl lactate 161.43
    butyl lactate 94.93
    diethyl carbonate 167.9
    propanediol butyl ether 85.19
    triethyl orthoformate 183.1
    p-tert-butyltoluene 89.66
    methyl 4-tert-butylbenzoate 254.01
    morpholine 706.56
    tert-butylamine 55.92
    n-dodecanol 29.66
    dimethoxymethane 548.24
    ethylene carbonate 391.18
    cyrene 319.4
    2-ethoxyethyl acetate 275.5
    2-ethylhexyl acetate 206.06
    1,2,4-trichlorobenzene 633.06
    4-methylpyridine 639.11
    dibutyl ether 116.04
    2,6-dimethyl-4-heptanol 44.0
    DEF 437.48
    dimethyl isosorbide 546.65
    tetrachloroethylene 558.81
    eugenol 195.47
    triacetin 320.96
    span 80 149.17
    1,4-butanediol 34.48
    1,1-dichloroethane 474.77
    2-methyl-1-pentanol 61.18
    methyl formate 259.26
    2-methyl-1-butanol 65.62
    n-decane 13.97
    butyronitrile 135.88
    3,7-dimethyl-1-octanol 57.17
    1-chlorooctane 63.9
    1-chlorotetradecane 34.3
    n-nonane 12.78
    undecane 10.87
    tert-butylcyclohexane 34.23
    cyclooctane 30.52
    cyclopentanol 157.49
    tetrahydropyran 502.86
    tert-amyl methyl ether 212.33
    2,5,8-trioxanonane 411.05
    1-hexene 62.18
    2-isopropoxyethanol 128.57
    2,2,2-trifluoroethanol 118.13
    methyl butyrate 245.82

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction