Bis(2-Methoxyethyl)amine

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  • Identifiers

    CAS number
    111-95-5

    Molecular formula
    C6H15NO2

    SMILES
    COCCNCCOC

    Safety labels

    Flammable
    Flammable

    Corrosive
    Corrosive

  • Odor profile

    Fragrance
    Fishy 45.82%
    Alcoholic 34.94%
    Odorless 30.88%
    Sweet 24.91%
    Ethereal 23.9%
    Cheesy 23.16%
    Fresh 20.55%
    Ripe 20.48%
    Oily 19.86%
    Solvent 18.67%

     

    Flavor
    Sulfurous 41.7%
    Vegetable 31.94%
    Onion 31.09%
    Sweet 28.72%
    Roasted 28.58%
    Alcoholic 26.64%
    Sulfury 25.81%
    Fishy 25.79%
    Meaty 24.01%
    Fatty 23.96%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    -0.5

    pKa est.
    5.67 (weak acid)

    Molecular weight
    133.19 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Fast

    Boiling point est.
    177°C

    Flash point

    • 71.85 ˚C est.

  • Synonyms

    • Bis(2-Methoxyethyl)amine
    • 111-95-5
    • 2-Methoxy-N-(2-methoxyethyl)ethanamine
    • Dimethoxyethylamine
    • Ethanamine, 2-methoxy-N-(2-methoxyethyl)-
    • DTXSID4059411
    • RefChem:134193
    • DTXCID0033207
    • 203-923-9
    • 2,2'-Dimethoxydiethylamine
    • Bis(methoxyethyl)amine
    • MFCD00025906
    • Bis-(2-methoxyethyl)-amine
    • Di-(2-methoxyethyl)amine
    • N,N-bis(2-methoxyethyl)amine
    • Diethylamine, 2,2'-dimethoxy-
    • NSC-78431
    • 2-Methoxy-N-(2-methoxyethyl)ethanamine; 2,2'-Dimethoxydiethylamine; Bis(2-methoxyethyl)amine; Di(2-methoxyethyl)amine; N,N-Bis(2-methoxyethyl)amine; NSC 78431
    • Bis(2-methoxyethyl);amine
    • bismethoxyethylamine
    • bis-methoxyethylamine
    • EINECS 203-923-9
    • NSC 78431
    • bis (2-methoxyethyl)amine
    • bis(2- methoxyethyl)amine
    • bis(2-methoxy-ethyl)amine
    • bis(2-methoxyethyl) amine
    • bis(2-methoxyethyl)-amine
    • bis-(2-methoxyethyl)amine
    • Diethylamine,2'-dimethoxy-
    • bis-(2-methoxyethyl) amine
    • NCIOpen2_009189
    • UEJ75Q8JL5
    • SCHEMBL11119
    • bis-(2-methoxy-ethyl)-amine
    • bis[2-(methyloxy)ethyl]amine
    • BIDD:GT0278
    • SCHEMBL197370
    • N,N-bis(-2methoxyethyl)amine
    • N,N-bis(-2-methoxyethyl)amine
    • SCHEMBL12813254
    • Bis(2-methoxyethyl)amine, 98%
    • IBZKBSXREAQDTO-UHFFFAOYSA-
    • N,N-bis-(2-methoxy-ethyl)amine
    • BB_SC-07130
    • CS-D1692
    • NSC78431
    • BBL011287
    • SBB059845
    • STK941144
    • AKOS000119885
    • SB75653
    • AS-47076
    • 2-Methoxy-N-(2-methoxyethyl)ethanamine #
    • 2-Methoxy-N-(2-methoxyethyl)ethan-1-amine
    • DB-041022
    • NS00023594
    • ST51046109
    • EN300-19765
    • F11888
    • 2-(methyloxy)-N-[2-(methyloxy)ethyl]ethanamine
    • F788433
    • F2190-0307
    • Z104475212
    • InChI=1/C6H15NO2/c1-8-5-3-7-4-6-9-2/h7H,3-6H2,1-2H3
    • 111-95-5

  • Applications

    Bis(2-Methoxyethyl)amine (CAS 111-95-5) is a secondary amine bearing two 2-methoxyethyl substituents; in industry it is commonly used as an intermediate in organic synthesis and as a reactive curing agent for epoxy resins and polyurethanes. It can also function as a polar solvent or co-solvent in coatings, inks, and cleaning formulations, leveraging the ether groups to improve solubility of polar constituents. Additionally, it serves as a building block for preparing specialty ligands and catalysts in organometallic chemistry and as a starting material for certain surfactant or polymer chemistries. Formulations using this chemical should comply with local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 236.08
    methanol 637.19
    isopropanol 70.62
    water 128.44
    ethyl acetate 31.13
    n-propanol 145.54
    acetone 32.94
    n-butanol 91.49
    acetonitrile 50.07
    DMF 189.47
    toluene 6.31
    isobutanol 70.86
    1,4-dioxane 82.07
    methyl acetate 43.87
    THF 104.94
    2-butanone 29.63
    n-pentanol 31.13
    sec-butanol 61.98
    n-hexane 2.06
    ethylene glycol 315.71
    NMP 270.13
    cyclohexane 11.83
    DMSO 364.48
    n-butyl acetate 25.08
    n-octanol 15.68
    chloroform 192.33
    n-propyl acetate 16.33
    acetic acid 831.61
    dichloromethane 182.78
    cyclohexanone 84.44
    propylene glycol 196.99
    isopropyl acetate 10.44
    DMAc 112.08
    2-ethoxyethanol 102.35
    isopentanol 34.94
    n-heptane 5.85
    ethyl formate 67.27
    1,2-dichloroethane 80.21
    n-hexanol 40.13
    2-methoxyethanol 303.24
    isobutyl acetate 8.36
    tetrachloromethane 57.43
    n-pentyl acetate 13.65
    transcutol 153.75
    n-heptanol 20.38
    ethylbenzene 3.34
    MIBK 5.52
    2-propoxyethanol 93.94
    tert-butanol 53.36
    MTBE 10.54
    2-butoxyethanol 54.69
    propionic acid 295.06
    o-xylene 8.1
    formic acid 985.36
    diethyl ether 15.96
    m-xylene 4.64
    p-xylene 5.1
    chlorobenzene 26.3
    dimethyl carbonate 13.53
    n-octane 1.76
    formamide 686.94
    cyclopentanone 106.58
    2-pentanone 14.44
    anisole 11.25
    cyclopentyl methyl ether 33.52
    gamma-butyrolactone 202.47
    1-methoxy-2-propanol 99.3
    pyridine 92.6
    3-pentanone 16.71
    furfural 270.05
    n-dodecane 1.3
    diethylene glycol 157.39
    diisopropyl ether 2.59
    tert-amyl alcohol 51.65
    acetylacetone 19.34
    n-hexadecane 1.38
    acetophenone 19.4
    methyl propionate 34.6
    isopentyl acetate 16.51
    trichloroethylene 175.02
    n-nonanol 13.8
    cyclohexanol 91.03
    benzyl alcohol 32.81
    2-ethylhexanol 20.97
    isooctanol 14.19
    dipropyl ether 17.03
    1,2-dichlorobenzene 32.46
    ethyl lactate 29.27
    propylene carbonate 87.63
    n-methylformamide 263.22
    2-pentanol 26.19
    n-pentane 3.81
    1-propoxy-2-propanol 55.87
    1-methoxy-2-propyl acetate 25.03
    2-(2-methoxypropoxy) propanol 42.19
    mesitylene 3.33
    ε-caprolactone 89.23
    p-cymene 7.7
    epichlorohydrin 119.93
    1,1,1-trichloroethane 50.85
    2-aminoethanol 351.19
    morpholine-4-carbaldehyde 181.01
    sulfolane 325.09
    2,2,4-trimethylpentane 2.27
    2-methyltetrahydrofuran 63.04
    n-hexyl acetate 18.85
    isooctane 0.8
    2-(2-butoxyethoxy)ethanol 55.41
    sec-butyl acetate 7.32
    tert-butyl acetate 8.94
    decalin 2.91
    glycerin 356.94
    diglyme 98.31
    acrylic acid 368.75
    isopropyl myristate 6.55
    n-butyric acid 197.68
    acetyl acetate 28.6
    di(2-ethylhexyl) phthalate 16.84
    ethyl propionate 15.04
    nitromethane 368.89
    1,2-diethoxyethane 19.72
    benzonitrile 32.28
    trioctyl phosphate 11.03
    1-bromopropane 29.43
    gamma-valerolactone 167.43
    n-decanol 9.74
    triethyl phosphate 21.82
    4-methyl-2-pentanol 7.77
    propionitrile 44.36
    vinylene carbonate 98.14
    1,1,2-trichlorotrifluoroethane 334.17
    DMS 21.81
    cumene 3.71
    2-octanol 9.03
    2-hexanone 9.75
    octyl acetate 10.91
    limonene 13.34
    1,2-dimethoxyethane 62.0
    ethyl orthosilicate 19.07
    tributyl phosphate 14.21
    diacetone alcohol 23.62
    N,N-dimethylaniline 11.51
    acrylonitrile 82.1
    aniline 47.92
    1,3-propanediol 263.72
    bromobenzene 18.75
    dibromomethane 105.66
    1,1,2,2-tetrachloroethane 150.28
    2-methyl-cyclohexyl acetate 21.43
    tetrabutyl urea 19.07
    diisobutyl methanol 9.17
    2-phenylethanol 30.16
    styrene 5.12
    dioctyl adipate 16.99
    dimethyl sulfate 41.91
    ethyl butyrate 21.62
    methyl lactate 51.96
    butyl lactate 29.29
    diethyl carbonate 18.19
    propanediol butyl ether 53.81
    triethyl orthoformate 21.63
    p-tert-butyltoluene 7.76
    methyl 4-tert-butylbenzoate 29.6
    morpholine 150.14
    tert-butylamine 30.4
    n-dodecanol 7.41
    dimethoxymethane 37.26
    ethylene carbonate 68.39
    cyrene 62.4
    2-ethoxyethyl acetate 22.35
    2-ethylhexyl acetate 14.17
    1,2,4-trichlorobenzene 47.15
    4-methylpyridine 42.97
    dibutyl ether 10.22
    2,6-dimethyl-4-heptanol 9.17
    DEF 47.56
    dimethyl isosorbide 66.32
    tetrachloroethylene 177.98
    eugenol 39.75
    triacetin 34.32
    span 80 51.2
    1,4-butanediol 81.97
    1,1-dichloroethane 41.43
    2-methyl-1-pentanol 17.22
    methyl formate 144.32
    2-methyl-1-butanol 51.79
    n-decane 2.15
    butyronitrile 36.09
    3,7-dimethyl-1-octanol 12.76
    1-chlorooctane 7.77
    1-chlorotetradecane 3.23
    n-nonane 2.07
    undecane 1.61
    tert-butylcyclohexane 2.26
    cyclooctane 2.9
    cyclopentanol 131.91
    tetrahydropyran 59.73
    tert-amyl methyl ether 11.6
    2,5,8-trioxanonane 71.76
    1-hexene 5.36
    2-isopropoxyethanol 36.94
    2,2,2-trifluoroethanol 338.27
    methyl butyrate 24.27

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction