Bis(2-hydroxyphenyl)methane

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  • Identifiers

    CAS number
    2467-02-9

    Molecular formula
    C13H12O2

    SMILES
    C1=CC=C(C(=C1)CC2=CC=CC=C2O)O

    Safety labels

    Corrosive
    Corrosive

    Irritant
    Irritant

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Phenolic 84.58%
    Medicinal 58.3%
    Smoky 52.95%
    Spicy 47.96%
    Sweet 40.64%
    Burnt 40.22%
    Animal 31.06%
    Leathery 30.41%
    Balsamic 29.66%
    Vanilla 27.3%

     

    Flavor
    Phenolic 68.43%
    Medicinal 47.29%
    Sweet 36.99%
    Bitter 35.31%
    Phenol 34.78%
    Mild 29.65%
    Smoke 28.97%
    Fruity 25.96%
    Meaty 25.21%
    Smoky 24.85%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    3.1

    pKa est.
    9.99 (weak base)

    Molecular weight
    200.23 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    337°C

    Flash point

    • 180.56 ˚C est.

  • Synonyms

    • 2,2'-Methylenediphenol
    • 2467-02-9
    • 2,2'-Bisphenol F
    • Bis(2-hydroxyphenyl)methane
    • 2,2'-Dihydroxydiphenylmethane
    • Phenol, 2,2'-methylenebis-
    • o-(o-Hydroxybenzyl)phenol
    • Phenol, 2,2'-methylenedi-
    • NSC-402103
    • 04D0A23747
    • ortho, ortho-bisphenol F
    • RefChem:917246
    • (2,2'-dihydroxydiphenyl)methane
    • 219-578-2
    • 2-[(2-hydroxyphenyl)methyl]phenol
    • 2,2'-Bis(hydroxyphenyl)methane
    • 2,2'-Methylenebis(phenol)
    • MFCD00002243
    • 1333-16-0
    • CHEMBL148831
    • DTXSID4022446
    • CHEBI:34207
    • NSC 402103
    • Methylenebisphenol
    • 2-(2-hydroxybenzyl)phenol
    • 2,2-methylenediphenol
    • O,O'-Methylenediphenol
    • Phenol,2'-methylenedi-
    • Phenol,2'-methylenebis-
    • bis(hydroxyphenyl) methane
    • bis-(hydroxyphenyl)methane
    • Bis(o-hydroxyphenyl)methane
    • SCHEMBL49745
    • bis-(2-hydroxyphenyl)methane
    • BIDD:ER0432
    • 2,2-Bis(hydroxyphenyl)methane
    • DTXCID602446
    • SCHEMBL1416793
    • SCHEMBL2186450
    • phenol, 2-(2-hydroxybenzyl)-
    • 2,2a(2)-Methylenebis[phenol]
    • bis-(2-hydroxy-phenyl)-methane
    • SCHEMBL17443017
    • SCHEMBL29357407
    • MQCPOLNSJCWPGT-UHFFFAOYSA-
    • KUC106449N
    • KUC112930N
    • UNII-04D0A23747
    • Bis(2-hydroxyphenyl)methane, 98%
    • ALBB-031663
    • EINECS 219-578-2
    • Tox21_303599
    • BDBM50522653
    • MSK8709-100M
    • NSC402103
    • AKOS015912954
    • O,O'-BIS(HYDROXYPHENYL)METHANE
    • KSC-19-053
    • NCGC00257306-01
    • 2,2'-Dihydroxydiphenylmethane, >/=99%
    • AS-58785
    • SY051507
    • CAS-2467-02-9
    • KSC-336-004-1
    • D1939
    • NS00010221
    • ST50319684
    • D89951
    • 2,2 inverted exclamation mark -Methylenediphenol
    • Q27115904
    • 2,2 inverted exclamation mark -Dihydroxydiphenylmethane
    • 2,2'-Dihydroxydiphenylmethane Solution in Methanol, 100ug/mL
    • InChI=1/C13H12O2/c14-12-7-3-1-5-10(12)9-11-6-2-4-8-13(11)15/h1-8,14-15H,9H2
    • 1333-16-0

  • Applications

    Bis(2-hydroxyphenyl)methane (CAS 2467-02-9) is primarily used as a dihydroxy phenyl building block in polymer and resin chemistry. It serves as an intermediate for phenolic resins and crosslinkable coating systems based on phenolic chemistry (novolac and resol), and can function as a reactive diol in epoxy and polyurethane formulations to tailor crosslink density. The two ortho-hydroxy groups enable metal complex formation, making it suitable as a chelating ligand in catalyst systems or pigment stabilization. It is also evaluated as a precursor for specialty dyes and pigments, and can serve as a starting point for high-performance polymers used in electronics or specialty coatings.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 44.41
    methanol 66.73
    isopropanol 21.59
    water 0.3
    ethyl acetate 124.96
    n-propanol 34.17
    acetone 46.28
    n-butanol 24.71
    acetonitrile 81.36
    DMF 91.57
    toluene 13.92
    isobutanol 12.12
    1,4-dioxane 146.91
    methyl acetate 110.84
    THF 247.85
    2-butanone 87.01
    n-pentanol 17.98
    sec-butanol 21.42
    n-hexane 0.66
    ethylene glycol 10.47
    NMP 37.85
    cyclohexane 0.92
    DMSO 129.95
    n-butyl acetate 42.64
    n-octanol 10.97
    chloroform 32.96
    n-propyl acetate 46.59
    acetic acid 56.61
    dichloromethane 32.87
    cyclohexanone 57.36
    propylene glycol 15.74
    isopropyl acetate 62.11
    DMAc 156.09
    2-ethoxyethanol 57.49
    isopentanol 21.96
    n-heptane 2.02
    ethyl formate 45.63
    1,2-dichloroethane 44.09
    n-hexanol 21.06
    2-methoxyethanol 102.81
    isobutyl acetate 25.73
    tetrachloromethane 3.95
    n-pentyl acetate 25.88
    transcutol 301.56
    n-heptanol 14.32
    ethylbenzene 12.27
    MIBK 39.57
    2-propoxyethanol 56.04
    tert-butanol 40.12
    MTBE 52.18
    2-butoxyethanol 40.16
    propionic acid 48.96
    o-xylene 12.49
    formic acid 28.81
    diethyl ether 81.25
    m-xylene 10.93
    p-xylene 12.01
    chlorobenzene 13.67
    dimethyl carbonate 50.37
    n-octane 1.05
    formamide 159.64
    cyclopentanone 110.75
    2-pentanone 58.04
    anisole 52.13
    cyclopentyl methyl ether 42.92
    gamma-butyrolactone 158.3
    1-methoxy-2-propanol 68.39
    pyridine 93.71
    3-pentanone 55.49
    furfural 107.26
    n-dodecane 1.06
    diethylene glycol 41.03
    diisopropyl ether 16.48
    tert-amyl alcohol 37.67
    acetylacetone 91.13
    n-hexadecane 1.21
    acetophenone 44.52
    methyl propionate 83.98
    isopentyl acetate 39.88
    trichloroethylene 90.32
    n-nonanol 12.31
    cyclohexanol 13.01
    benzyl alcohol 26.15
    2-ethylhexanol 17.09
    isooctanol 13.58
    dipropyl ether 37.06
    1,2-dichlorobenzene 18.71
    ethyl lactate 23.49
    propylene carbonate 68.81
    n-methylformamide 78.86
    2-pentanol 17.02
    n-pentane 0.58
    1-propoxy-2-propanol 42.42
    1-methoxy-2-propyl acetate 63.31
    2-(2-methoxypropoxy) propanol 53.03
    mesitylene 8.54
    ε-caprolactone 65.49
    p-cymene 10.87
    epichlorohydrin 177.91
    1,1,1-trichloroethane 24.69
    2-aminoethanol 26.02
    morpholine-4-carbaldehyde 92.59
    sulfolane 116.72
    2,2,4-trimethylpentane 1.56
    2-methyltetrahydrofuran 79.78
    n-hexyl acetate 30.48
    isooctane 1.28
    2-(2-butoxyethoxy)ethanol 73.15
    sec-butyl acetate 36.52
    tert-butyl acetate 68.95
    decalin 1.81
    glycerin 31.95
    diglyme 168.0
    acrylic acid 43.76
    isopropyl myristate 18.14
    n-butyric acid 57.88
    acetyl acetate 60.34
    di(2-ethylhexyl) phthalate 16.17
    ethyl propionate 49.68
    nitromethane 212.12
    1,2-diethoxyethane 83.87
    benzonitrile 27.52
    trioctyl phosphate 11.48
    1-bromopropane 12.31
    gamma-valerolactone 137.57
    n-decanol 10.03
    triethyl phosphate 23.7
    4-methyl-2-pentanol 15.02
    propionitrile 60.04
    vinylene carbonate 58.65
    1,1,2-trichlorotrifluoroethane 80.13
    DMS 41.82
    cumene 10.2
    2-octanol 8.89
    2-hexanone 40.2
    octyl acetate 19.08
    limonene 12.84
    1,2-dimethoxyethane 128.82
    ethyl orthosilicate 24.23
    tributyl phosphate 15.15
    diacetone alcohol 68.64
    N,N-dimethylaniline 30.35
    acrylonitrile 80.49
    aniline 24.92
    1,3-propanediol 40.19
    bromobenzene 11.55
    dibromomethane 13.43
    1,1,2,2-tetrachloroethane 67.77
    2-methyl-cyclohexyl acetate 31.9
    tetrabutyl urea 19.33
    diisobutyl methanol 15.66
    2-phenylethanol 28.03
    styrene 13.03
    dioctyl adipate 27.44
    dimethyl sulfate 68.93
    ethyl butyrate 44.5
    methyl lactate 36.46
    butyl lactate 23.99
    diethyl carbonate 33.43
    propanediol butyl ether 30.83
    triethyl orthoformate 33.34
    p-tert-butyltoluene 11.68
    methyl 4-tert-butylbenzoate 44.82
    morpholine 135.26
    tert-butylamine 20.0
    n-dodecanol 8.29
    dimethoxymethane 122.68
    ethylene carbonate 48.22
    cyrene 45.53
    2-ethoxyethyl acetate 54.42
    2-ethylhexyl acetate 29.11
    1,2,4-trichlorobenzene 24.25
    4-methylpyridine 40.37
    dibutyl ether 26.58
    2,6-dimethyl-4-heptanol 15.66
    DEF 58.92
    dimethyl isosorbide 96.5
    tetrachloroethylene 40.46
    eugenol 41.17
    triacetin 48.82
    span 80 35.26
    1,4-butanediol 10.81
    1,1-dichloroethane 19.93
    2-methyl-1-pentanol 21.38
    methyl formate 55.4
    2-methyl-1-butanol 18.0
    n-decane 1.62
    butyronitrile 37.77
    3,7-dimethyl-1-octanol 14.52
    1-chlorooctane 7.19
    1-chlorotetradecane 3.67
    n-nonane 1.24
    undecane 1.29
    tert-butylcyclohexane 2.15
    cyclooctane 0.62
    cyclopentanol 16.09
    tetrahydropyran 74.59
    tert-amyl methyl ether 39.61
    2,5,8-trioxanonane 107.77
    1-hexene 5.17
    2-isopropoxyethanol 38.93
    2,2,2-trifluoroethanol 26.52
    methyl butyrate 51.97

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction