Bis(2-(2-butoxyethoxy)ethoxy)methane

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  • Identifiers

    CAS number
    143-29-3

    Molecular formula
    C17H36O6

    SMILES
    CCCCOCCOCCOCOCCOCCOCCCC

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Alcoholic 51.5%
    Ethereal 48.62%
    Fruity 40.34%
    Odorless 27.85%
    Fermented 26.36%
    Oily 24.1%
    Sweet 23.92%
    Solvent 22.69%
    Fresh 20.89%
    Green 16.56%

     

    Flavor
    Sweet 41.97%
    Vegetable 33.34%
    Earthy 30.34%
    Alcoholic 29.05%
    Green 28.77%
    Fatty 28.17%
    Musty 27.13%
    Oily 26.02%
    Fruit 25.34%
    Mushroom 25.02%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    1.6

    pKa est.
    4.4 (weak acid)

    Molecular weight
    336.5 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    376°C

    Flash point

    • 151.9 ˚C est.

  • Synonyms

    • 5,8,11,13,16,19-Hexaoxatricosane
    • Cryoflex
    • Butylcarbitol formal
    • Bis[2-(2-butoxyethoxy)ethoxy]methane
    • Dibutoxyethoxyethyl formal
    • Bis(butoxyethoxyethoxy)methane
    • Dibutylcarbitol formal
    • Bis(butylcarbitol)formal
    • Bis(butoxyethoxyethyl)formal
    • Dibutylcarbitolformal
    • BIS(2-(2-BUTOXYETHOXY)ETHOXY)METHANE
    • TP 90B
    • HSDB 5647
    • Methane, bis(2-(2-butoxyethoxy)ethoxy)-
    • NSC 7185
    • EINECS 205-598-9
    • UNII-L0Y73G495R
    • BRN 2450899
    • L0Y73G495R
    • NSC-7185
    • DTXSID3027112
    • EC 205-598-9
    • Methane, bis[2-(2-butoxyethoxy)ethoxy]-
    • BIS(2-(2-BUTOXYETHOXY)ETHOXY)METHANE [HSDB]
    • RefChem:120045
    • DTXCID007112
    • Methane, bis(2(2butoxyethoxy)ethoxy)
    • 5,8,11,13,16,19Hexaoxatricosane
    • 205-598-9
    • 143-29-3
    • 1-[2-[2-[2-(2-butoxyethoxy)ethoxymethoxy]ethoxy]ethoxy]butane
    • Di(Butylcarbitol)formal
    • SCHEMBL323671
    • NSC7185
    • DKWHHTWSTXZKDW-UHFFFAOYSA-N
    • 5,11,13,16,19-Hexaoxatricosane
    • DB-254053
    • NS00002619
    • Q27282566
    • 143-29-3

  • Applications

    Bis(2-(2-butoxyethoxy)ethoxy)methane is typically used as a nonionic solvent and surfactant in industrial formulations, providing improved solubility and wetting for coatings, inks, and cleaners. It also serves as a co-solvent and rheology modifier, helping stabilize emulsions and disperse active ingredients in paints, coatings, and detergents. The compound can function as an intermediate in the synthesis of other polyether-based surfactants and specialty solvents. In polymer and plastics processing, it may act as a processing aid or compatibilizer, improving compatibility between resin systems and additives. In cosmetics and personal care, it may be used as a solvent or solubilizer for fragrance and active ingredients, subject to formulation constraints and regulatory requirements.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 32.13
    methanol 52.58
    isopropanol 26.66
    water 2.14
    ethyl acetate 192.39
    n-propanol 40.33
    acetone 155.98
    n-butanol 35.32
    acetonitrile 111.09
    DMF 187.66
    toluene 84.95
    isobutanol 36.68
    1,4-dioxane 224.44
    methyl acetate 163.16
    THF 358.95
    2-butanone 152.44
    n-pentanol 37.67
    sec-butanol 44.77
    n-hexane 15.11
    ethylene glycol 13.97
    NMP 483.91
    cyclohexane 106.81
    DMSO 675.14
    n-butyl acetate 140.61
    n-octanol 41.14
    chloroform 994.03
    n-propyl acetate 170.2
    acetic acid 265.24
    dichloromethane 1175.4
    cyclohexanone 448.74
    propylene glycol 16.78
    isopropyl acetate 119.85
    DMAc 371.74
    2-ethoxyethanol 113.21
    isopentanol 40.63
    n-heptane 24.81
    ethyl formate 118.82
    1,2-dichloroethane 628.52
    n-hexanol 32.25
    2-methoxyethanol 112.32
    isobutyl acetate 91.5
    tetrachloromethane 199.02
    n-pentyl acetate 160.28
    transcutol 382.97
    n-heptanol 35.94
    ethylbenzene 50.89
    MIBK 72.44
    2-propoxyethanol 89.03
    tert-butanol 49.56
    MTBE 63.74
    2-butoxyethanol 99.24
    propionic acid 146.28
    o-xylene 83.35
    formic acid 102.62
    diethyl ether 76.95
    m-xylene 56.98
    p-xylene 80.67
    chlorobenzene 169.55
    dimethyl carbonate 73.33
    n-octane 12.13
    formamide 164.83
    cyclopentanone 438.75
    2-pentanone 120.49
    anisole 95.38
    cyclopentyl methyl ether 206.41
    gamma-butyrolactone 560.48
    1-methoxy-2-propanol 82.75
    pyridine 286.52
    3-pentanone 145.06
    furfural 465.48
    n-dodecane 6.9
    diethylene glycol 63.28
    diisopropyl ether 31.6
    tert-amyl alcohol 69.29
    acetylacetone 206.51
    n-hexadecane 8.09
    acetophenone 160.42
    methyl propionate 151.7
    isopentyl acetate 112.73
    trichloroethylene 1042.75
    n-nonanol 41.78
    cyclohexanol 124.54
    benzyl alcohol 80.6
    2-ethylhexanol 44.83
    isooctanol 37.68
    dipropyl ether 93.66
    1,2-dichlorobenzene 219.09
    ethyl lactate 92.08
    propylene carbonate 305.91
    n-methylformamide 120.56
    2-pentanol 32.8
    n-pentane 13.11
    1-propoxy-2-propanol 90.41
    1-methoxy-2-propyl acetate 127.53
    2-(2-methoxypropoxy) propanol 111.07
    mesitylene 44.89
    ε-caprolactone 395.56
    p-cymene 48.58
    epichlorohydrin 532.91
    1,1,1-trichloroethane 481.66
    2-aminoethanol 28.66
    morpholine-4-carbaldehyde 322.59
    sulfolane 912.43
    2,2,4-trimethylpentane 12.59
    2-methyltetrahydrofuran 267.58
    n-hexyl acetate 141.25
    isooctane 4.71
    2-(2-butoxyethoxy)ethanol 128.06
    sec-butyl acetate 105.7
    tert-butyl acetate 120.61
    decalin 30.22
    glycerin 42.69
    diglyme 342.09
    acrylic acid 142.19
    isopropyl myristate 53.26
    n-butyric acid 190.29
    acetyl acetate 210.44
    di(2-ethylhexyl) phthalate 57.83
    ethyl propionate 149.54
    nitromethane 490.03
    1,2-diethoxyethane 158.35
    benzonitrile 133.27
    trioctyl phosphate 42.98
    1-bromopropane 218.58
    gamma-valerolactone 516.47
    n-decanol 28.54
    triethyl phosphate 131.62
    4-methyl-2-pentanol 22.61
    propionitrile 85.16
    vinylene carbonate 299.85
    1,1,2-trichlorotrifluoroethane 479.14
    DMS 142.51
    cumene 39.4
    2-octanol 30.47
    2-hexanone 115.17
    octyl acetate 69.09
    limonene 78.89
    1,2-dimethoxyethane 228.08
    ethyl orthosilicate 117.83
    tributyl phosphate 65.74
    diacetone alcohol 111.43
    N,N-dimethylaniline 78.77
    acrylonitrile 123.42
    aniline 95.3
    1,3-propanediol 42.02
    bromobenzene 216.53
    dibromomethane 683.07
    1,1,2,2-tetrachloroethane 941.5
    2-methyl-cyclohexyl acetate 134.09
    tetrabutyl urea 87.53
    diisobutyl methanol 31.58
    2-phenylethanol 62.75
    styrene 63.23
    dioctyl adipate 112.21
    dimethyl sulfate 195.83
    ethyl butyrate 172.18
    methyl lactate 78.4
    butyl lactate 122.0
    diethyl carbonate 131.77
    propanediol butyl ether 74.42
    triethyl orthoformate 150.43
    p-tert-butyltoluene 41.83
    methyl 4-tert-butylbenzoate 151.31
    morpholine 251.54
    tert-butylamine 36.18
    n-dodecanol 21.6
    dimethoxymethane 106.89
    ethylene carbonate 262.91
    cyrene 151.54
    2-ethoxyethyl acetate 184.7
    2-ethylhexyl acetate 106.81
    1,2,4-trichlorobenzene 282.41
    4-methylpyridine 198.2
    dibutyl ether 93.58
    2,6-dimethyl-4-heptanol 31.58
    DEF 200.37
    dimethyl isosorbide 236.37
    tetrachloroethylene 651.9
    eugenol 122.06
    triacetin 247.95
    span 80 95.79
    1,4-butanediol 25.93
    1,1-dichloroethane 361.97
    2-methyl-1-pentanol 42.15
    methyl formate 104.77
    2-methyl-1-butanol 45.45
    n-decane 14.55
    butyronitrile 73.78
    3,7-dimethyl-1-octanol 41.94
    1-chlorooctane 58.57
    1-chlorotetradecane 19.9
    n-nonane 15.03
    undecane 9.3
    tert-butylcyclohexane 17.01
    cyclooctane 29.92
    cyclopentanol 127.62
    tetrahydropyran 258.83
    tert-amyl methyl ether 76.53
    2,5,8-trioxanonane 217.15
    1-hexene 32.93
    2-isopropoxyethanol 83.31
    2,2,2-trifluoroethanol 178.71
    methyl butyrate 212.89

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction