Bilirubin

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  • Identifiers

    CAS number
    635-65-4

    Molecular formula
    C33H36N4O6

    SMILES
    CC1=C(NC(=C1CCC(=O)O)CC2=C(C(=C(N2)/C=C\3/C(=C(C(=O)N3)C)C=C)C)CCC(=O)O)/C=C\4/C(=C(C(=O)N4)C=C)C

    Safety labels

  • Odor profile

    Fragrance
    Odorless 56.8%
    Savory 27.14%
    Roasted 26.14%
    Burnt 23.21%
    Cooked 23.08%
    Meaty 21.47%
    Milky 17.69%
    Bitter 16.94%
    Nutty 16.52%
    Fruity 16.18%

     

    Flavor
    Bitter 81.55%
    Odorless 40.04%
    Bland 21.59%
    Nitrile 20.14%
    Very mild 20.1%
    Taco 19.53%
    Sweet-like 19.49%
    Bread crust 19.26%
    Cedarleaf 18.88%
    Roasted peanuts 18.54%

     

    Odor impact est.
    Odorless

  • Properties

    XLogP3-AA
    2.9

    pKa est.
    4.45 (weak acid)

    Molecular weight
    584.7 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    1060°C

    Flash point

    • 340.0 ˚C est.

    Solubility expt.

    • 0.009 mg/mL at 25 °C

  • Synonyms

    • bilirubin
    • 635-65-4
    • Hematoidin
    • Hemetoidin
    • Bilirubin IX-alpha
    • Cholerythrin
    • Bilirubin IXalpha
    • Bilirubin IX alpha
    • Bilirubin test
    • 3-[2-[[3-(2-carboxyethyl)-5-[(Z)-(3-ethenyl-4-methyl-5-oxopyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-2-yl]methyl]-5-[(Z)-(4-ethenyl-3-methyl-5-oxopyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-3-yl]propanoic acid
    • RFM9X3LJ49
    • 2,17-diethenyl-1,10,19,22,23,24-hexahydro-3,7,13,18-tetramethyl-1,19-dioxo-21H-biline-8,12-dipropanoic acid
    • DTXSID8060905
    • NSC-26685
    • 21H-Biline-8,12-dipropanoic acid, 2,17-diethenyl-1,10,19,22,23,24-hexahydro-3,7,13,18-tetramethyl-1,19-dioxo-
    • CHEBI:16990
    • 1,10,19,22,23,24-hexahydro-2,7,13,17-tetramethyl-1,19-dioxo-3,18-divinylbiline-8,12-dipropionic acid
    • delta Bilirubin
    • 3-(2-{[3-(2-carboxyethyl)-5-{[(2Z)-3-ethenyl-4-methyl-5-oxo-2,5-dihydro-1H-pyrrol-2-ylidene]methyl}-4-methyl-1H-pyrrol-2-yl]methyl}-5-{[(2Z)-4-ethenyl-3-methyl-5-oxo-2,5-dihydro-1H-pyrrol-2-ylidene]methyl}-4-methyl-1H-pyrrol-3-yl)propanoic acid
    • 3-(2-{[3-(2-carboxyethyl)-5-{[(2Z)-4-ethenyl-3-methyl-5-oxo-2,5-dihydro-1H-pyrrol-2-ylidene]methyl}-4-methyl-1H-pyrrol-2-yl]methyl}-5-{[(2Z)-3-ethenyl-4-methyl-5-oxo-2,5-dihydro-1H-pyrrol-2-ylidene]methyl}-4-methyl-1H-pyrrol-3-yl)propanoic acid
    • Bilirubinate, Calcium
    • Calcium Salt Bilirubin
    • Disodium Salt Bilirubin
    • Salt Bilirubin, Calcium
    • Monosodium Salt Bilirubin
    • NSC26685
    • 3-(2-((3-(2-carboxyethyl)-5-(((2Z)-3-ethenyl-4-methyl-5-oxo-2,5-dihydro-1H-pyrrol-2-ylidene)methyl)-4-methyl-1H-pyrrol-2-yl)methyl)-5-(((2Z)-4-ethenyl-3-methyl-5-oxo-2,5-dihydro-1H-pyrrol-2-ylidene)methyl)-4-methyl-1H-pyrrol-3-yl)propanoic acid
    • 3-(2-((3-(2-carboxyethyl)-5-(((2Z)-4-ethenyl-3-methyl-5-oxo-2,5-dihydro-1H-pyrrol-2-ylidene)methyl)-4-methyl-1H-pyrrol-2-yl)methyl)-5-(((2Z)-3-ethenyl-4-methyl-5-oxo-2,5-dihydro-1H-pyrrol-2-ylidene)methyl)-4-methyl-1H-pyrrol-3-yl)propanoic acid
    • 3-(2-((3-(2-carboxyethyl)-5-((Z)-(3-ethenyl-4-methyl-5-oxopyrrol-2-ylidene)methyl)-4-methyl-1H-pyrrol-2-yl)methyl)-5-((Z)-(4-ethenyl-3-methyl-5-oxopyrrol-2-ylidene)methyl)-4-methyl-1H-pyrrol-3-yl)propanoic acid
    • RefChem:568345
    • DTXCID40162318
    • 211-239-7
    • (4z,15z)-bilirubin ixalpha
    • MFCD00005499
    • Bilirubin IX.alpha.
    • 93891-87-3
    • Bilibubin
    • (4z,15z)-bilirubin ix.alpha.
    • Disodium bilirubinate IXalpha
    • PHEOPHYTIN
    • 3-(2-((3-(2-carboxyethyl)-4-methyl-5-((Z)-(3-methyl-5-oxo-4-vinyl-1H-pyrrol-2(5H)-ylidene)methyl)-1H-pyrrol-2-yl)methyl)-4-methyl-5-((Z)-(4-methyl-5-oxo-3-vinyl-1H-pyrrol-2(5H)-ylidene)methyl)-1H-pyrrol-3-yl)propanoic acid
    • Biline-8,12-dipropionic acid, 1,10,19,22,23,24-hexahydro-2,7,13,17-tetramethyl-1,19-dioxo-3,18-divinyl-
    • Bilirubin (>90%)
    • 21H-Biline-8,12-dipropanoic acid,2,17-diethenyl-1,10,19,22,23,24-hexahydro-3,7,13,18-tetramethyl-1,19-dioxo-
    • Calcium bilirubinate
    • Basinite
    • EINECS 211-239-7
    • 3-(2-((3-(2-carboxyethyl)-4-methyl-5-((Z)-(3-methyl-5-oxo-4-vinyl-1H-pyrrol-2(5H)-ylidene)methyl)-1H-pyrrol-2-yl)methyl)-4-methyl-5-((Z)-(4-methyl-5-oxo-3-vinyl-1H-pyrrol-2(5H)-ylidene)methyl)-1H-pyrr
    • 3-[5-[(Z)-(4-Ethenyl-3-Methyl-5-Oxidanylidene-Pyrrol-2-Ylidene)methyl]-2-[[5-[(Z)-(3-Ethenyl-4-Methyl-5-Oxidanylidene-Pyrrol-2-Ylidene)methyl]-3-(3-Hydroxy-3-Oxopropyl)-4-Methyl-1h-Pyrrol-2-Yl]methyl]-4-Methyl-1h-Pyrrol-3-Yl]propanoic Acid
    • NSC 26685
    • UNII-RFM9X3LJ49
    • BRN 0074376
    • AI3-23078
    • CCRIS 9347
    • bilirubin-IXalpha
    • bilirubin(Z,Z)
    • EINECS 299-468-9
    • Bilirubin, 98%
    • (Z,Z)-Bilirubin IXa
    • Bilirubin - unconjugated
    • BILIRUBIN [MI]
    • Spectrum5_000410
    • bmse000627
    • BILIRUBIN [WHO-DD]
    • SCHEMBL19065
    • (4Z,15Z)-Bilirubin IXa
    • BSPBio_002531
    • 5-26-15-00523 (Beilstein Handbook Reference)
    • SPECTRUM1500857
    • BILIRUBIN TEST [VANDF]
    • CHEMBL501680
    • GTPL4577
    • orb1304828
    • SCHEMBL27308256
    • MSK2819
    • S00334a
    • ALBB-030171
    • HY-N0323
    • BDBM50442897
    • CCG-38548
    • HSCI1_000394
    • s5116
    • STL564421
    • AKOS015895627
    • Bilirubin, purum, >=95.0% (UV)
    • EBC-616133
    • FB01719
    • FB01720
    • SDCCGMLS-0066651.P001
    • NCGC00095645-01
    • 18422-02-1
    • 3-{2-({3-(2-Carboxyethyl)-4-methyl-5-[(Z)-(3-methyl-5-oxo-4-vinyl-1,5-dihydro-2H-pyrrol-2-ylidene)methyl]-1H-pyrrol-2-yl}methyl)-4-methyl-5-[(Z)-(4-methyl-5-ox
    • AC-20194
    • AC-34137
    • Disodium 1,10,19,22,23,24-hexahydro-3,7,13,18-tetramethyl-1,19-dioxo-2,17-divinyl-21H-biline-8,12-dipropionate
    • SY076603
    • CS-0008888
    • NS00014797
    • C00486
    • 635B654
    • Bilirubin, >=98% (EmM/453 = 60), powder
    • F814174
    • Q104219
    • SR-05000002757
    • SR-05000002757-1
    • 1,3,6,7-TETRAMETHYL-4,5-DICARBOXYETHYL-2,8-DIVINYL-(B-13)-DIHYDROBILENONE
    • 1,10,19,22,23,24-hexahydro-2,7,13,17-tetramethyl-1,19-dioxo-3,18-divinyl-Biline-8,12-dipropionate
    • 1,10,19,22,23,24-hexahydro-2,7,13,17-tetramethyl-1,19-dioxo-3,18-divinyl-Biline-8,12-dipropionic acid
    • 2,17-diethenyl-1,10,19,22,23,24-hexahydro-3,7,13,18-tetramethyl-1,19-dioxo-21H-Biline-8,12-dipropanoate
    • 2,7,13,17-tetramethyl-1,19-dioxo-3,18-divinyl-1,10,19,22,23,24-hexahydro-21H-biline-8,12-dipropanoic acid
    • 21H-Biline-8,12-dipropanoic acid, 2,17-diethenyl-1,10,19,22,23,24-hexahydro-3,7,13,18-tetramethyl-1,19-dioxo-, calcium salt
    • 21H-Biline-8,12-dipropanoic acid, 2,17-diethenyl-1,10,19,22,23,24-hexahydro-3,7,13,18-tetramethyl-1,19-dioxo-, disodium salt
    • 3,18-diethenyl-2,7,13,17-tetramethyl-1,19-dioxo-1,10,19,22,23,24-hexahydro-21H-biline-8,12-dipropanoic acid
    • 3-(2-((3-(2-carboxyethyl)-4-methyl-5-((3-methyl-5-oxo-4-vinyl-1,5-dihydro-2H-pyrrol-2-ylidene)methyl)-1H-pyrrol-2-yl)methyl)-4-methyl-5-((4-methyl-5-oxo-3-vinyl-1,5-dihydro-2H-pyrrol-2-ylidene)methyl)-1H-pyrrol-3-yl)propanoate
    • 3-(2-((3-(2-carboxyethyl)-4-methyl-5-((3-methyl-5-oxo-4-vinyl-1,5-dihydro-2H-pyrrol-2-ylidene)methyl)-1H-pyrrol-2-yl)methyl)-4-methyl-5-((4-methyl-5-oxo-3-vinyl-1,5-dihydro-2H-pyrrol-2-ylidene)methyl)-1H-pyrrol-3-yl)propanoic acid
    • 3-(2-((3-(2-carboxyethyl)-4-methyl-5-((Z)-(3-methyl-5-oxo-4-vinyl-1H-pyrrol-2(5H)-ylidene)methyl)-1H-pyrrol-2-yl)methyl)-4-methyl-5-((Z)-(4-methyl-5-oxo-3-vinyl-1H-pyrrol-2(5H)-ylidene)methyl)-1H-pyrrol-3-yl)propanoicacid
    • 3-(2-((3-(2-Carboxyethyl)-4-methyl-5-[(Z)-(3-methyl-5-oxo-4-vinyl-1,5-dihydro-2H-pyrrol-2-ylidene)methyl]-1H-pyrrol-2-yl)methyl)-4-methyl-5-[(Z)-(4-methyl-5-oxo-3-vinyl-1,5-dihydro-2H-pyrrol-2-ylidene
    • 3-(2-((3-(2-Carboxyethyl)-4-methyl-5-[(Z)-(3-methyl-5-oxo-4-vinyl-1,5-dihydro-2H-pyrrol-2-ylidene)methyl]-1H-pyrrol-2-yl)methyl)-4-methyl-5-[(Z)-(4-methyl-5-oxo-3-vinyl-1,5-dihydro-2H-pyrrol-2-ylidene #
    • 3-[2-[[3-(2-carboxyethyl)-5-[(3-ethenyl-4-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-2-yl]methyl]-5-[(4-ethenyl-3-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-3-yl]propanoate
    • 3-[2-[[3-(2-carboxyethyl)-5-[(3-ethenyl-4-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-2-yl]methyl]-5-[(4-ethenyl-3-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-3-yl]propanoic acid
    • 3-[2-[[3-(2-carboxyethyl)-5-[(Z)-(3-ethenyl-4-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-2-yl]methyl]-5-[(Z)-(4-ethenyl-3-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-3-yl]propanoate
    • 3-[2-[[3-(2-carboxyethyl)-5-[(Z)-(3-ethenyl-4-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-2-yl]methyl]-5-[(Z)-(4-ethenyl-3-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-3-yl]propanoic acid
    • 3-[2-[[3-(2-carboxyethyl)-5-[(Z)-(3-ethenyl-4-methyl-5-oxopyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-2-yl]methyl]-5-[(Z)-(4-ethenyl-3-methyl-5-oxopyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-3-yl]propanoicacid
    • 3-[2-[3-(2-Carboxy-ethyl)-4-methyl-5-(3-methyl-5-oxo-4-vinyl-1,5-dihydro-pyrrol-2-ylidenemethyl)-1H-pyrrol-2-ylmethyl]-4-methyl-5-(4-methyl-5-oxo-3-vinyl-1,5-dihydro-pyrrol-2-ylidenemethyl)-1H-pyrrol-
    • 3-{2-({3-(2-Carboxyethyl)-5-[(Z)-(4-ethenyl-3-methyl-5-oxo-1,5-dihydro-2H-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-2-yl}methyl)-5-[(Z)-(3-ethenyl-4-methyl-5-oxo-1,5-dihydro-2H-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-3-yl}propanoic acid
    • 3Q9
    • 8,12-bis(2-carboxyethyl)-2,7,13,17-tetramethyl-3,18-divinylbiladiene-ac-1,19(21H,24H)-dione
    • 635-65-4

  • Applications

    Bilirubin (CAS 635-65-4) is a natural bile pigment primarily used in clinical chemistry and laboratory work as an analytical reference; bilirubin standards and solutions are used to calibrate colorimetric assays for total and direct bilirubin in blood, serum, plasma, and urine. In research, bilirubin serves as a reference colorant and a model compound for studying the oxidation and photodegradation of heme-derived pigments. It is also used as a model pigment for spectroscopy method development and pigment chemistry related to the bilirubin/heme catabolic pathway. Due to instability and limited industrial applicability, much of bilirubin’s use is confined to laboratory and research settings and is subject to formulation and regulatory constraints.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 0.5
    methanol 1.43
    isopropanol 0.26
    water 0.01
    ethyl acetate 0.33
    n-propanol 0.5
    acetone 0.69
    n-butanol 0.33
    acetonitrile 0.13
    DMF 15.35
    toluene 0.06
    isobutanol 0.22
    1,4-dioxane 1.64
    methyl acetate 0.67
    THF 3.78
    2-butanone 1.27
    n-pentanol 0.26
    sec-butanol 0.33
    n-hexane 0.01
    ethylene glycol 0.34
    NMP 17.86
    cyclohexane 0.0
    DMSO 3.76
    n-butyl acetate 0.16
    n-octanol 0.08
    chloroform 1.08
    n-propyl acetate 0.28
    acetic acid 1.69
    dichloromethane 0.78
    cyclohexanone 1.05
    propylene glycol 0.93
    isopropyl acetate 0.17
    DMAc 23.0
    2-ethoxyethanol 2.57
    isopentanol 0.17
    n-heptane 0.0
    ethyl formate 0.44
    1,2-dichloroethane 0.27
    n-hexanol 0.08
    2-methoxyethanol 5.72
    isobutyl acetate 0.13
    tetrachloromethane 0.07
    n-pentyl acetate 0.23
    transcutol 3.6
    n-heptanol 0.1
    ethylbenzene 0.03
    MIBK 0.17
    2-propoxyethanol 2.23
    tert-butanol 0.16
    MTBE 0.19
    2-butoxyethanol 1.32
    propionic acid 0.82
    o-xylene 0.04
    formic acid 1.88
    diethyl ether 0.22
    m-xylene 0.03
    p-xylene 0.05
    chlorobenzene 0.08
    dimethyl carbonate 0.87
    n-octane 0.0
    formamide 2.22
    cyclopentanone 2.66
    2-pentanone 0.5
    anisole 0.25
    cyclopentyl methyl ether 0.37
    gamma-butyrolactone 3.43
    1-methoxy-2-propanol 3.32
    pyridine 1.23
    3-pentanone 0.47
    furfural 3.76
    n-dodecane 0.0
    diethylene glycol 1.54
    diisopropyl ether 0.02
    tert-amyl alcohol 0.23
    acetylacetone 0.75
    n-hexadecane 0.0
    acetophenone 0.38
    methyl propionate 0.8
    isopentyl acetate 0.14
    trichloroethylene 1.4
    n-nonanol 0.09
    cyclohexanol 0.15
    benzyl alcohol 0.33
    2-ethylhexanol 0.04
    isooctanol 0.07
    dipropyl ether 0.14
    1,2-dichlorobenzene 0.09
    ethyl lactate 0.45
    propylene carbonate 0.79
    n-methylformamide 3.35
    2-pentanol 0.14
    n-pentane 0.01
    1-propoxy-2-propanol 1.05
    1-methoxy-2-propyl acetate 0.53
    2-(2-methoxypropoxy) propanol 1.13
    mesitylene 0.01
    ε-caprolactone 1.29
    p-cymene 0.01
    epichlorohydrin 3.37
    1,1,1-trichloroethane 0.15
    2-aminoethanol 0.78
    morpholine-4-carbaldehyde 12.68
    sulfolane 5.82
    2,2,4-trimethylpentane 0.0
    2-methyltetrahydrofuran 0.83
    n-hexyl acetate 0.23
    isooctane 0.0
    2-(2-butoxyethoxy)ethanol 1.59
    sec-butyl acetate 0.16
    tert-butyl acetate 0.17
    decalin 0.0
    glycerin 2.72
    diglyme 3.88
    acrylic acid 1.25
    isopropyl myristate 0.06
    n-butyric acid 0.65
    acetyl acetate 0.2
    di(2-ethylhexyl) phthalate 0.15
    ethyl propionate 0.31
    nitromethane 3.77
    1,2-diethoxyethane 0.44
    benzonitrile 0.13
    trioctyl phosphate 0.07
    1-bromopropane 0.11
    gamma-valerolactone 10.33
    n-decanol 0.05
    triethyl phosphate 0.15
    4-methyl-2-pentanol 0.06
    propionitrile 0.17
    vinylene carbonate 0.94
    1,1,2-trichlorotrifluoroethane 6.96
    DMS 0.38
    cumene 0.02
    2-octanol 0.06
    2-hexanone 0.39
    octyl acetate 0.11
    limonene 0.02
    1,2-dimethoxyethane 3.7
    ethyl orthosilicate 0.14
    tributyl phosphate 0.09
    diacetone alcohol 0.61
    N,N-dimethylaniline 0.17
    acrylonitrile 0.36
    aniline 0.18
    1,3-propanediol 1.15
    bromobenzene 0.06
    dibromomethane 0.25
    1,1,2,2-tetrachloroethane 1.15
    2-methyl-cyclohexyl acetate 0.12
    tetrabutyl urea 0.22
    diisobutyl methanol 0.02
    2-phenylethanol 0.16
    styrene 0.04
    dioctyl adipate 0.15
    dimethyl sulfate 2.38
    ethyl butyrate 0.19
    methyl lactate 1.31
    butyl lactate 0.46
    diethyl carbonate 0.11
    propanediol butyl ether 1.33
    triethyl orthoformate 0.26
    p-tert-butyltoluene 0.01
    methyl 4-tert-butylbenzoate 0.48
    morpholine 2.88
    tert-butylamine 0.04
    n-dodecanol 0.03
    dimethoxymethane 3.66
    ethylene carbonate 0.51
    cyrene 2.21
    2-ethoxyethyl acetate 0.73
    2-ethylhexyl acetate 0.11
    1,2,4-trichlorobenzene 0.19
    4-methylpyridine 0.71
    dibutyl ether 0.09
    2,6-dimethyl-4-heptanol 0.02
    DEF 1.47
    dimethyl isosorbide 1.4
    tetrachloroethylene 0.56
    eugenol 0.66
    triacetin 0.54
    span 80 0.79
    1,4-butanediol 0.42
    1,1-dichloroethane 0.21
    2-methyl-1-pentanol 0.17
    methyl formate 1.93
    2-methyl-1-butanol 0.24
    n-decane 0.0
    butyronitrile 0.14
    3,7-dimethyl-1-octanol 0.04
    1-chlorooctane 0.02
    1-chlorotetradecane 0.01
    n-nonane 0.0
    undecane 0.0
    tert-butylcyclohexane 0.0
    cyclooctane 0.0
    cyclopentanol 0.34
    tetrahydropyran 0.51
    tert-amyl methyl ether 0.21
    2,5,8-trioxanonane 2.03
    1-hexene 0.04
    2-isopropoxyethanol 1.02
    2,2,2-trifluoroethanol 0.75
    methyl butyrate 0.48

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction