Bicine

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  • Identifiers

    CAS number
    150-25-4

    Molecular formula
    C6H13NO4

    SMILES
    C(CO)N(CCO)CC(=O)O

    Safety labels

  • Odor profile

    Fragrance
    Sweet 54.94%
    Odorless 53.4%
    Fishy 31.01%
    Alcoholic 24.75%
    Savory 21.94%
    Oily 18.72%
    Cooling 14.72%
    Clean 14.61%
    Buttery 14.47%
    Bitter 14.22%

     

    Flavor
    Odorless 70.75%
    Mild 34.78%
    Bland 27.16%
    Sweet-like 26.43%
    Yeast 22.55%
    Very mild 22.22%
    Sulfury 21.6%
    Bitter 21.57%
    Very slight 21.14%
    Faint 20.98%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -3.8

    pKa est.
    6.06 (neutral)

    Molecular weight
    163.17 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    391°C

    Flash point

    • 206.78 ˚C est.

  • Synonyms

    • Bicine
    • 150-25-4
    • N,N-Bis(2-hydroxyethyl)glycine
    • Diethylolglycine
    • Diethanol glycine
    • Dihydroxyethylglycine
    • Bicene
    • 2-(bis(2-hydroxyethyl)amino)acetic acid
    • Glycine, N,N-bis(2-hydroxyethyl)-
    • N,N-Dihydroxyethyl glycine
    • N,N-Dihydroxyethylglycine
    • DHEG
    • 2-[bis(2-hydroxyethyl)amino]acetic acid
    • di(hydroxyethyl)glycine
    • 1J484QFI1O
    • NSC-7342
    • NSC-7512
    • CHEBI:40957
    • RefChem:568038
    • CHEBI:39065
    • 205-755-1
    • N,N-Di(2-hydroxyethyl)glycine
    • Fe-3-Specific
    • Bis(2-Hydroxyethyl)glycine
    • N,N-(2-Hydroxyethyl)glycine
    • MFCD00004295
    • Diethanolglycine
    • N,N-Bis(2-hydroxyethyl)aminoacetic acid
    • N,N-(2-Dihydroxyethyl)glycine
    • N,N-Bis(beta-hydroxyethyl)glycine
    • NSC 7342
    • GLYCINE, N,N-DIHYDROXYETHYL-
    • N,N-Bis(hydroxyethyl)glycine
    • bicine buffer
    • N,N-Bis(.beta.-hydroxyethyl)glycine
    • Glycine,N-dihydroxyethyl-
    • WLN: QV1N2Q2Q
    • Glycine,N-bis(2-hydroxyethyl)-
    • Chelest GA; DHEG;NSC 7342; NSC 7512;Diethanol glycine
    • 2-HxG
    • EINECS 205-755-1
    • BRN 1769362
    • UNII-1J484QFI1O
    • BICINE [MI]
    • N,N-di(hydroxyethyl)glycine
    • SCHEMBL34161
    • 4-04-00-02390 (Beilstein Handbook Reference)
    • Bicine (cell culture suitable)
    • di(hydroxyethyl)aminoacetic acid
    • orb1306037
    • CHEMBL1231251
    • DTXSID3041669
    • BICINE, >=99% (titration)
    • N,N-bis(2-hydroxyethyl)glycine]
    • NSC7342
    • NSC7512
    • N,N-bis(2-hydroxyethyl)-Glycine
    • HMS3604E14
    • n,n-bis-(2-hydroxyethyl)-glycine
    • BB_SC-02565
    • HY-D0868
    • AC8058
    • BBL011024
    • EBC-47240
    • s6276
    • SBB057746
    • STK802165
    • AKOS005622671
    • n,n-bis(2-hydroxyethyl)glycine bicine
    • DB03709
    • FB11031
    • [Bis(2-hydroxyethyl)amino]acetic acid #
    • BICINE, BioUltra, >=99.5% (T)
    • BICINE, BioXtra, >=99% (titration)
    • NCGC00342441-01
    • AS-12494
    • DA-55872
    • N,N-Bis(2-hydroxyethyl)glycine (Bicine)
    • N,N-Bis-(2-hydroxyethyl)aminoacetic acid
    • SY010805
    • N,N-bis-(2-hydroxyethyl) aminoacetic acid
    • N,N-DI(HYDROXYETHYL)AMINOACETIC ACID
    • B0484
    • CS-0015178
    • N,N-BIS(HYDROXYETHYL)AMINOACETIC ACID
    • NS00003493
    • ST50308630
    • AB00443773-03
    • EN300-7244555
    • F045147
    • Q4903636
    • 3-Azapentanoic acid, 5-hydroxy-3-(2-hydroxyethyl)-
    • Z336127920
    • 150-25-4

  • Applications

    Bicine (CAS 150-25-4) is a zwitterionic buffering agent widely used in biochemical and analytical laboratories; typical applications include serving as a pH buffer in enzyme assays, in protein purification and crystallization buffers, and in nucleic acid electrophoresis buffers, as well as use in pharmaceutical formulation research and in cosmetics/personal care as a pH adjuster.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 5.11
    methanol 30.49
    isopropanol 1.62
    water 483.52
    ethyl acetate 1.2
    n-propanol 3.95
    acetone 0.56
    n-butanol 2.15
    acetonitrile 1.0
    DMF 103.65
    toluene 0.21
    isobutanol 1.79
    1,4-dioxane 3.85
    methyl acetate 1.04
    THF 3.21
    2-butanone 0.68
    n-pentanol 1.06
    sec-butanol 1.61
    n-hexane 0.11
    ethylene glycol 116.93
    NMP 189.63
    cyclohexane 0.29
    DMSO 132.78
    n-butyl acetate 1.1
    n-octanol 1.08
    chloroform 0.53
    n-propyl acetate 0.65
    acetic acid 32.04
    dichloromethane 1.13
    cyclohexanone 4.63
    propylene glycol 46.9
    isopropyl acetate 0.64
    DMAc 68.04
    2-ethoxyethanol 12.15
    isopentanol 1.12
    n-heptane 0.35
    ethyl formate 2.6
    1,2-dichloroethane 1.08
    n-hexanol 1.92
    2-methoxyethanol 44.9
    isobutyl acetate 0.38
    tetrachloromethane 0.26
    n-pentyl acetate 0.81
    transcutol 15.56
    n-heptanol 1.5
    ethylbenzene 0.22
    MIBK 0.42
    2-propoxyethanol 12.83
    tert-butanol 1.38
    MTBE 0.31
    2-butoxyethanol 6.27
    propionic acid 16.13
    o-xylene 0.68
    formic acid 304.29
    diethyl ether 0.41
    m-xylene 0.43
    p-xylene 0.3
    chlorobenzene 0.32
    dimethyl carbonate 2.94
    n-octane 0.12
    formamide 150.59
    cyclopentanone 5.21
    2-pentanone 0.61
    anisole 0.53
    cyclopentyl methyl ether 1.84
    gamma-butyrolactone 19.09
    1-methoxy-2-propanol 16.81
    pyridine 1.87
    3-pentanone 0.9
    furfural 22.91
    n-dodecane 0.08
    diethylene glycol 39.59
    diisopropyl ether 0.19
    tert-amyl alcohol 1.53
    acetylacetone 1.46
    n-hexadecane 0.08
    acetophenone 1.49
    methyl propionate 2.88
    isopentyl acetate 0.8
    trichloroethylene 1.39
    n-nonanol 1.04
    cyclohexanol 3.51
    benzyl alcohol 2.03
    2-ethylhexanol 1.17
    isooctanol 1.05
    dipropyl ether 0.96
    1,2-dichlorobenzene 0.81
    ethyl lactate 4.4
    propylene carbonate 8.1
    n-methylformamide 49.49
    2-pentanol 0.84
    n-pentane 0.13
    1-propoxy-2-propanol 6.59
    1-methoxy-2-propyl acetate 3.32
    2-(2-methoxypropoxy) propanol 6.83
    mesitylene 0.44
    ε-caprolactone 9.04
    p-cymene 0.64
    epichlorohydrin 4.71
    1,1,1-trichloroethane 0.27
    2-aminoethanol 74.03
    morpholine-4-carbaldehyde 89.99
    sulfolane 80.29
    2,2,4-trimethylpentane 0.1
    2-methyltetrahydrofuran 1.71
    n-hexyl acetate 1.07
    isooctane 0.05
    2-(2-butoxyethoxy)ethanol 8.85
    sec-butyl acetate 0.38
    tert-butyl acetate 0.68
    decalin 0.16
    glycerin 159.43
    diglyme 11.75
    acrylic acid 31.82
    isopropyl myristate 0.44
    n-butyric acid 7.38
    acetyl acetate 1.01
    di(2-ethylhexyl) phthalate 1.77
    ethyl propionate 1.08
    nitromethane 17.23
    1,2-diethoxyethane 1.1
    benzonitrile 1.23
    trioctyl phosphate 1.35
    1-bromopropane 0.34
    gamma-valerolactone 25.73
    n-decanol 0.79
    triethyl phosphate 1.88
    4-methyl-2-pentanol 0.51
    propionitrile 1.08
    vinylene carbonate 9.46
    1,1,2-trichlorotrifluoroethane 31.47
    DMS 2.47
    cumene 0.3
    2-octanol 0.71
    2-hexanone 0.39
    octyl acetate 0.75
    limonene 0.9
    1,2-dimethoxyethane 5.48
    ethyl orthosilicate 1.5
    tributyl phosphate 1.38
    diacetone alcohol 2.95
    N,N-dimethylaniline 1.35
    acrylonitrile 2.99
    aniline 1.18
    1,3-propanediol 28.86
    bromobenzene 0.24
    dibromomethane 0.55
    1,1,2,2-tetrachloroethane 1.76
    2-methyl-cyclohexyl acetate 1.46
    tetrabutyl urea 2.72
    diisobutyl methanol 0.75
    2-phenylethanol 2.19
    styrene 0.19
    dioctyl adipate 1.24
    dimethyl sulfate 14.49
    ethyl butyrate 1.23
    methyl lactate 16.03
    butyl lactate 3.46
    diethyl carbonate 1.02
    propanediol butyl ether 9.33
    triethyl orthoformate 1.46
    p-tert-butyltoluene 0.61
    methyl 4-tert-butylbenzoate 3.75
    morpholine 8.66
    tert-butylamine 0.62
    n-dodecanol 0.61
    dimethoxymethane 7.5
    ethylene carbonate 6.17
    cyrene 20.75
    2-ethoxyethyl acetate 1.54
    2-ethylhexyl acetate 0.76
    1,2,4-trichlorobenzene 1.12
    4-methylpyridine 1.4
    dibutyl ether 0.42
    2,6-dimethyl-4-heptanol 0.75
    DEF 8.55
    dimethyl isosorbide 11.87
    tetrachloroethylene 1.67
    eugenol 5.57
    triacetin 3.01
    span 80 8.56
    1,4-butanediol 11.83
    1,1-dichloroethane 0.25
    2-methyl-1-pentanol 0.78
    methyl formate 16.36
    2-methyl-1-butanol 1.59
    n-decane 0.11
    butyronitrile 0.8
    3,7-dimethyl-1-octanol 0.83
    1-chlorooctane 0.28
    1-chlorotetradecane 0.16
    n-nonane 0.11
    undecane 0.09
    tert-butylcyclohexane 0.1
    cyclooctane 0.2
    cyclopentanol 4.69
    tetrahydropyran 1.25
    tert-amyl methyl ether 0.59
    2,5,8-trioxanonane 10.98
    1-hexene 0.17
    2-isopropoxyethanol 3.74
    2,2,2-trifluoroethanol 28.13
    methyl butyrate 1.54

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction