Bezafibrate

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  • Identifiers

    CAS number
    41859-67-0

    Molecular formula
    C19H20ClNO4

    SMILES
    CC(C)(C(=O)O)OC1=CC=C(C=C1)CCNC(=O)C2=CC=C(C=C2)Cl

    Safety labels

    Irritant
    Irritant

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Grape 40.15%
    Odorless 39.59%
    Savory 32.34%
    Citrus 28.88%
    Meaty 26.23%
    Milky 26.22%
    Fruity 25.8%
    Animal 25.71%
    Grapefruit 24.65%
    Cooked 23.91%

     

    Flavor
    Fruity 53.07%
    Bitter 41.67%
    Odorless 38.84%
    Mild 33.34%
    Grape 32.32%
    Powdery 23.96%
    Sweet 22.52%
    Orange flower 21.53%
    Orange blossom 20.85%
    Bland 20.11%

     

    Odor impact est.
    Odorless

  • Properties

    XLogP3-AA
    3.8

    pKa est.
    7.86 (neutral)

    Molecular weight
    361.8 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    601°C

    Melting point expt.

    • 186 °C

    Flash point

    • 226.26 ˚C est.

    Solubility expt.

    • 1.55e-03 g/L
    • >54.3 [ug/mL] (The mean of the results at pH 7.4)

  • Synonyms

    • bezafibrate
    • 41859-67-0
    • Bezalip
    • Bezafibrato
    • Bezatol SR
    • Bezafibratum
    • BM-15.075
    • BM-15075
    • BM 15.075
    • DTXSID3029869
    • NSC-758174
    • Y9449Q51XH
    • Propanoic acid, 2-(4-(2-((4-chlorobenzoyl)amino)ethyl)phenoxy)-2-methyl-
    • DTXCID909869
    • CHEBI:47612
    • Propanoic acid, 2-[4-[2-[(4-chlorobenzoyl)amino]ethyl]phenoxy]-2-methyl-
    • Beza Lande
    • Beza Puren
    • BM15.075
    • Bezalip-mono
    • Fibrazate xl
    • Zimbacol xl
    • Bezagen xl
    • Liparol xl
    • RefChem:58600
    • C10AB02
    • 255-567-9
    • Cedur
    • Befizal
    • Bezafibrat
    • Sklerofibrat
    • Azufibrat
    • Bezafibratum [INN-Latin]
    • Bezafibrato [INN-Spanish]
    • 2-(4-(2-(4-Chlorobenzamido)ethyl)phenoxy)-2-methylpropanoic acid
    • Bezatol SR (TN)
    • 2-[4-[2-[(4-chlorobenzoyl)amino]ethyl]phenoxy]-2-methylpropanoic acid
    • 2-(p-(2-(p-Chlorobenzamido)ethyl)phenoxy)-2-methylpropionic acid
    • MFCD00078970
    • Difaterol
    • Bezatol
    • 2-[4-[2-(4-Chlorobenzamido)ethyl]phenoxy]-2-methylpropanoic acid
    • 2-[4-[2-[(4-chlorobenzoyl)amino]ethyl]phenoxy]-2-methyl-propanoic acid
    • MLS000028533
    • CHEMBL264374
    • durabezur
    • Reducterol
    • Bezabeta
    • Bezacur
    • Bezamerck
    • Eulitop
    • Solibay
    • Lipox
    • Bezafibrat PB
    • Beza-Lande
    • Beza-Puren
    • Regadrin B
    • 2-(4-{2-[(4-chlorophenyl)formamido]ethyl}phenoxy)-2-methylpropanoic acid
    • BM15075
    • NCGC00016850-01
    • SMR000058298
    • Bezafibrate 100 microg/mL in Acetonitrile
    • Bezafibrato [Spanish]
    • Bezalip Retard
    • CAS-41859-67-0
    • BF-759
    • Bezafibrate-d6 (dimethyl-d6)
    • 2-{4-[2-(4-chlorobenzamido)ethyl]phenoxy}-2-methylpropanoic acid
    • BM 15075
    • LO 44
    • 2-(4-{2-[(4-chlorobenzoyl)amino]ethyl}phenoxy)-2-methylpropanoic acid
    • 2-[P-[2-P-CHLOROBENZAMIDO)ETHYL]PHENOXY]-2-METHYLPROPIONIC ACID
    • CCRIS 9085
    • SR-01000000106
    • EINECS 255-567-9
    • BRN 4267656
    • UNII-Y9449Q51XH
    • Bezafibrate CRS
    • Bezalip SR
    • 2-[4-[2-[(4-Chlorobenzoyl)amino]ethyl]phenoxyl]-2-methylpropanoic Acid
    • Bezafibrate [USAN:INN:BAN:JAN]
    • PEM
    • Prestwick_724
    • BENAFIBRATE
    • a-[4-(4-chlorobenzoylaminoethyl)phenoxy]isobutyric acid
    • Bezafibrate (Standard)
    • Spectrum_001443
    • Opera_ID_376
    • BEZAFIBRATE [MI]
    • Prestwick0_000378
    • Prestwick1_000378
    • Prestwick2_000378
    • Prestwick3_000378
    • Spectrum2_000922
    • Spectrum3_001500
    • Spectrum4_000325
    • Spectrum5_001079
    • Spectrum5_001967
    • BEZAFIBRATE [INN]
    • BEZAFIBRATE [JAN]
    • BEZAFIBRATE [USAN]
    • BEZAFIBRATE [MART.]
    • SCHEMBL16299
    • BEZAFIBRATE [WHO-DD]
    • BSPBio_000535
    • BSPBio_001314
    • BSPBio_003119
    • KBioGR_000034
    • KBioGR_000669
    • KBioSS_000034
    • KBioSS_001923
    • MLS001148205
    • Bezafibrate, >=98%, solid
    • DivK1c_000092
    • SPECTRUM1502046
    • SPBio_000824
    • SPBio_002456
    • BPBio1_000589
    • GTPL2668
    • orb1310243
    • orb3025853
    • Bezafibrate - Bio-X trade mark
    • BDBM28701
    • Bezafibrate (JP18/USAN/INN)
    • HMS500E14
    • HY-B0637R
    • KBio1_000092
    • 41859-67-0

  • Applications

    Bezafibrate is primarily used in the pharmaceutical industry as an active pharmaceutical ingredient (API) in fibrate-class formulations. It is also widely supplied as a reference standard for analytical laboratories enabling method development and quality control of fibrate-containing products. In manufacturing settings, it serves as a bulk chemical for formulation development and scale-up of fibrate APIs. It is common in research and development laboratories for pharmacokinetic and formulation studies. Handling and use are subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 25.27
    methanol 29.71
    isopropanol 14.9
    water 0.05
    ethyl acetate 4.12
    n-propanol 21.1
    acetone 16.94
    n-butanol 16.3
    acetonitrile 1.93
    DMF 104.06
    toluene 2.07
    isobutanol 9.91
    1,4-dioxane 31.43
    methyl acetate 7.2
    THF 140.66
    2-butanone 12.94
    n-pentanol 14.04
    sec-butanol 17.1
    n-hexane 0.18
    ethylene glycol 5.71
    NMP 41.81
    cyclohexane 0.17
    DMSO 75.82
    n-butyl acetate 2.58
    n-octanol 5.25
    chloroform 28.71
    n-propyl acetate 2.96
    acetic acid 20.98
    dichloromethane 23.87
    cyclohexanone 29.21
    propylene glycol 12.27
    isopropyl acetate 4.77
    DMAc 203.08
    2-ethoxyethanol 50.37
    isopentanol 10.32
    n-heptane 0.2
    ethyl formate 5.1
    1,2-dichloroethane 10.96
    n-hexanol 6.96
    2-methoxyethanol 74.04
    isobutyl acetate 2.82
    tetrachloromethane 1.25
    n-pentyl acetate 6.03
    transcutol 87.66
    n-heptanol 7.13
    ethylbenzene 1.99
    MIBK 8.82
    2-propoxyethanol 34.28
    tert-butanol 15.98
    MTBE 12.62
    2-butoxyethanol 22.78
    propionic acid 8.77
    o-xylene 2.42
    formic acid 17.37
    diethyl ether 6.61
    m-xylene 1.78
    p-xylene 2.37
    chlorobenzene 3.11
    dimethyl carbonate 11.11
    n-octane 0.21
    formamide 28.41
    cyclopentanone 34.89
    2-pentanone 9.42
    anisole 9.98
    cyclopentyl methyl ether 12.57
    gamma-butyrolactone 27.23
    1-methoxy-2-propanol 52.88
    pyridine 14.27
    3-pentanone 7.69
    furfural 27.45
    n-dodecane 0.22
    diethylene glycol 31.6
    diisopropyl ether 1.66
    tert-amyl alcohol 18.23
    acetylacetone 16.48
    n-hexadecane 0.25
    acetophenone 9.94
    methyl propionate 8.14
    isopentyl acetate 4.62
    trichloroethylene 32.08
    n-nonanol 5.98
    cyclohexanol 10.73
    benzyl alcohol 12.81
    2-ethylhexanol 3.62
    isooctanol 6.16
    dipropyl ether 4.49
    1,2-dichlorobenzene 4.65
    ethyl lactate 7.98
    propylene carbonate 10.2
    n-methylformamide 23.63
    2-pentanol 8.05
    n-pentane 0.13
    1-propoxy-2-propanol 19.71
    1-methoxy-2-propyl acetate 12.86
    2-(2-methoxypropoxy) propanol 25.89
    mesitylene 1.24
    ε-caprolactone 17.4
    p-cymene 1.53
    epichlorohydrin 46.4
    1,1,1-trichloroethane 5.41
    2-aminoethanol 15.16
    morpholine-4-carbaldehyde 64.91
    sulfolane 43.01
    2,2,4-trimethylpentane 0.31
    2-methyltetrahydrofuran 21.47
    n-hexyl acetate 8.31
    isooctane 0.17
    2-(2-butoxyethoxy)ethanol 32.65
    sec-butyl acetate 3.15
    tert-butyl acetate 9.63
    decalin 0.28
    glycerin 22.5
    diglyme 65.51
    acrylic acid 9.92
    isopropyl myristate 4.04
    n-butyric acid 10.45
    acetyl acetate 4.32
    di(2-ethylhexyl) phthalate 6.57
    ethyl propionate 4.14
    nitromethane 28.44
    1,2-diethoxyethane 16.76
    benzonitrile 5.13
    trioctyl phosphate 4.23
    1-bromopropane 4.1
    gamma-valerolactone 63.9
    n-decanol 4.33
    triethyl phosphate 5.0
    4-methyl-2-pentanol 5.18
    propionitrile 3.41
    vinylene carbonate 10.48
    1,1,2-trichlorotrifluoroethane 45.56
    DMS 9.32
    cumene 1.59
    2-octanol 4.61
    2-hexanone 7.13
    octyl acetate 5.3
    limonene 2.1
    1,2-dimethoxyethane 62.6
    ethyl orthosilicate 5.55
    tributyl phosphate 4.6
    diacetone alcohol 21.85
    N,N-dimethylaniline 8.88
    acrylonitrile 5.47
    aniline 6.93
    1,3-propanediol 24.79
    bromobenzene 2.7
    dibromomethane 9.54
    1,1,2,2-tetrachloroethane 31.12
    2-methyl-cyclohexyl acetate 6.39
    tetrabutyl urea 8.99
    diisobutyl methanol 3.28
    2-phenylethanol 9.28
    styrene 2.28
    dioctyl adipate 7.99
    dimethyl sulfate 24.85
    ethyl butyrate 3.64
    methyl lactate 16.81
    butyl lactate 10.14
    diethyl carbonate 3.12
    propanediol butyl ether 20.51
    triethyl orthoformate 5.99
    p-tert-butyltoluene 1.71
    methyl 4-tert-butylbenzoate 17.16
    morpholine 49.98
    tert-butylamine 5.55
    n-dodecanol 3.11
    dimethoxymethane 67.51
    ethylene carbonate 7.77
    cyrene 28.66
    2-ethoxyethyl acetate 13.64
    2-ethylhexyl acetate 3.15
    1,2,4-trichlorobenzene 6.75
    4-methylpyridine 11.09
    dibutyl ether 5.47
    2,6-dimethyl-4-heptanol 3.28
    DEF 22.6
    dimethyl isosorbide 35.51
    tetrachloroethylene 16.39
    eugenol 19.21
    triacetin 15.2
    span 80 18.01
    1,4-butanediol 12.19
    1,1-dichloroethane 6.64
    2-methyl-1-pentanol 11.13
    methyl formate 16.26
    2-methyl-1-butanol 11.92
    n-decane 0.41
    butyronitrile 4.03
    3,7-dimethyl-1-octanol 5.04
    1-chlorooctane 2.15
    1-chlorotetradecane 0.87
    n-nonane 0.31
    undecane 0.29
    tert-butylcyclohexane 0.29
    cyclooctane 0.09
    cyclopentanol 12.73
    tetrahydropyran 15.52
    tert-amyl methyl ether 12.72
    2,5,8-trioxanonane 48.19
    1-hexene 1.28
    2-isopropoxyethanol 26.13
    2,2,2-trifluoroethanol 8.17
    methyl butyrate 5.74

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction