Betamethasone

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  • Identifiers

    CAS number
    378-44-9

    Molecular formula
    C22H29FO5

    SMILES
    C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)CO)O)C)O)F)C

    Safety labels

    Acute Toxic
    Acute Toxic

    Health Hazard
    Health

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Woody 46.2%
    Odorless 44.02%
    Spicy 25.98%
    Cooling 20.99%
    Cedar 20.54%
    Mint 20.07%
    Sweet 19.67%
    Dry 19.35%
    Earthy 18.8%
    Camphoreous 18.08%

     

    Flavor
    Bitter 88.99%
    Odorless 22.88%
    Sweet-like 22.34%
    Cedarleaf 20.76%
    Bland 20.05%
    Fenugreek 19.06%
    Leaves 18.93%
    Ripe apricot 18.9%
    Lovage 18.88%
    Nitrile 18.84%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    1.9

    pKa est.
    6.42 (neutral)

    Molecular weight
    392.5 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Melting point expt.

    • 178°C
    • 231-234 °C, decomposes
    • 231 - 234 °C

    Boiling point

    • 568.2°C

    Flash point

    • 247.65 ˚C est.

    Solubility expt.

    • 66.5 mg/L (at 25 °C)
    • SOLUBILITIES: 1 G IN 1.6 ML WATER & 6.25 ML METHANOL; PRACTICALLY INSOL IN ACETONE, CHLOROFORM /SODIUM PHOSPHATE/
    • SPARINGLY SOL IN ACETONE AND ALC
    • SPARINGLY SOL IN DIOXANE, METHANOL; VERY SLIGHTLY SOL IN CHLOROFORM & ETHER
    • In water, 66.5 mg/l @ 25 °C
    • 5.05e-02 g/L

  • Synonyms

    • betamethasone
    • 378-44-9
    • Betadexamethasone
    • Flubenisolone
    • Celestene
    • Rinderon
    • Visubeta
    • Betamethazone
    • Becort
    • Desacort-Beta
    • Betamamallet
    • Betametasone
    • Betacorlan
    • Betacortril
    • Betapredol
    • Betasolon
    • Betnelan
    • Betsolan
    • Methazon
    • Bebate
    • Bedifos
    • Cidoten
    • beta-Methasone
    • Betametasona
    • beta-Methasone alcohol
    • Celestone
    • Rinderon A
    • Betamethasone cream
    • Betamethasonum
    • Betamethasone alcohol
    • SCH 4831
    • NSC-39470
    • 9alpha-Fluoro-16beta-methylprednisolone
    • 9-Fluoro-16beta-methylprednisolone
    • SCH-4831
    • Betametasona [INN-Spanish]
    • Betamethasonum [INN-Latin]
    • HSDB 3015
    • Betamethasone (Celestone)
    • 9-alpha-Fluoro-16-beta-methylprednisolone
    • EINECS 206-825-4
    • MFCD00062969
    • NSC 39470
    • Prednisolone, 9-fluoro-16beta-methyl-
    • BRN 3176546
    • FLOSTERON
    • CHEBI:3077
    • MLS000859943
    • Betamethasone, topical
    • DTXSID3022667
    • UNII-9842X06Q6M
    • 9842X06Q6M
    • 9a-Fluoro-11b,17a,21-trihydroxy-16b-methylpregna-1,4-diene-3,20-dione
    • 9-Fluoro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione
    • C22H29FO5
    • Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17,21-trihydroxy-16-methyl-, (11.beta.,16.beta.)-
    • DTXCID002667
    • Corticosterone, 1-dehydro-9-fluoro-17-hydroxy-16beta-methyl-
    • EC 206-825-4
    • Betametasone [DCIT]
    • 4-08-00-03501 (Beilstein Handbook Reference)
    • NSC39470
    • NCS-39470
    • (8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
    • NCGC00164401-01
    • Betamethasone [USAN:USP:INN:BAN:JAN]
    • SMR000058601
    • Betametasona (INN-Spanish)
    • Betamethasonum (INN-Latin)
    • 16beta-Methyl-1,4-pregnadiene-9alpha-fluoro-11beta,17alpha,21-triol-3,20-dione
    • BETAMETHASONE (MART.)
    • BETAMETHASONE [MART.]
    • BETAMETHASONE (USP-RS)
    • BETAMETHASONE [USP-RS]
    • .beta.-Methasone
    • BETAMETHASONE (EP IMPURITY)
    • BETAMETHASONE [EP IMPURITY]
    • BETAMETHASONE (EP MONOGRAPH)
    • BETAMETHASONE [EP MONOGRAPH]
    • BETAMETHASONE (USP MONOGRAPH)
    • BETAMETHASONE [USP MONOGRAPH]
    • 9-Fluoro-16.beta.-methylprednisolone
    • Rinderon (TN)
    • Betamethasone (USAN:USP:INN:BAN:JAN)
    • .beta.-Methasone alcohol
    • 9.alpha.-Fluoro-16.beta.-methylprednisolone
    • DEXAMETHASONE IMPURITY B (EP IMPURITY)
    • DEXAMETHASONE IMPURITY B [EP IMPURITY]
    • Desacort-.beta.
    • (11beta,16beta)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
    • .beta.-Corlan
    • 9alpha-Fluoro-11beta,17alpha,21-trihydroxy-16beta-methyl-1,4-pregnadiene-3,20-dione
    • NCGC00091019-08
    • CAS-378-44-9
    • Prestwick_703
    • Prednisolone, 9-fluoro-16.beta.-methyl-
    • 9-Fluoro-11-beta,17,21-trihydroxy-16-beta-methylpregna-1,4-diene-3,20-dione
    • Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17,21-trihydroxy-16-methyl-, (11beta,16beta)-
    • Celestone; Flubenisolone
    • Betamethasone (Standard)
    • Betamethasone, >=98%
    • Prestwick0_000362
    • Prestwick1_000362
    • Prestwick2_000362
    • Prestwick3_000362
    • BETAMETHASONE [MI]
    • CHEMBL632
    • BETAMETHASONE [INN]
    • BETAMETHASONE [JAN]
    • cid_9782
    • SCHEMBL4565
    • 16-beta-Methyl-1,4-pregnadiene-9-alpha-fluoro-11-beta,17-alpha,21-triol-3,20-dione
    • 9-alpha-Fluoro-16-beta-methyl-1,4-pregnadiene-11-beta,17-alpha,21-triol-3,20-dione
    • BETAMETHASONE [USAN]
    • Pregna-1,4-diene-3,20-dione, 9-fluoro-11beta,17,21-trihydroxy-16beta-methyl-
    • BIDD:PXR0047
    • BETAMETHASONE [VANDF]
    • BSPBio_000483
    • MLS001066413
    • MLS001332616
    • MLS002153244
    • SPBio_002404
    • BETAMETHASONE [WHO-DD]
    • BETAMETHASONE [WHO-IP]
    • Corticosterone, 1-dehydro-9-fluoro-17-hydroxy-16.beta.-methyl-
    • BPBio1_000533
    • GTPL7061
    • BDBM73823

  • Applications

    Betamethasone (CAS 378-44-9) is used in pharmaceuticals as a potent corticosteroid, appearing in topical formulations (creams and ointments for inflammatory dermatologic conditions), in injectable preparations for systemic anti-inflammatory therapy, and in ophthalmic anti-inflammatory formulations to address ocular inflammation; it is also employed in veterinary medicine for inflammatory conditions in animals, and serves as a reference corticosteroid in pharmacology studies, with potential use as an intermediate in the synthesis of related corticosteroids.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 50.42
    methanol 148.62
    isopropanol 19.27
    water 1.16
    ethyl acetate 11.79
    n-propanol 26.19
    acetone 41.68
    n-butanol 14.72
    acetonitrile 19.99
    DMF 168.22
    toluene 4.89
    isobutanol 9.91
    1,4-dioxane 48.59
    methyl acetate 12.68
    THF 109.28
    2-butanone 17.34
    n-pentanol 6.47
    sec-butanol 6.37
    n-hexane 0.33
    ethylene glycol 36.72
    NMP 52.66
    cyclohexane 0.63
    DMSO 177.98
    n-butyl acetate 5.86
    n-octanol 3.23
    chloroform 19.27
    n-propyl acetate 5.65
    acetic acid 54.11
    dichloromethane 17.88
    cyclohexanone 24.12
    propylene glycol 20.08
    isopropyl acetate 8.53
    DMAc 54.44
    2-ethoxyethanol 39.87
    isopentanol 7.75
    n-heptane 0.29
    ethyl formate 13.57
    1,2-dichloroethane 10.7
    n-hexanol 7.76
    2-methoxyethanol 130.88
    isobutyl acetate 3.12
    tetrachloromethane 3.39
    n-pentyl acetate 6.97
    transcutol 35.33
    n-heptanol 6.18
    ethylbenzene 2.2
    MIBK 9.23
    2-propoxyethanol 47.9
    tert-butanol 10.91
    MTBE 3.56
    2-butoxyethanol 22.96
    propionic acid 15.34
    o-xylene 3.23
    formic acid 84.51
    diethyl ether 11.21
    m-xylene 3.6
    p-xylene 2.26
    chlorobenzene 4.48
    dimethyl carbonate 21.74
    n-octane 0.18
    formamide 108.73
    cyclopentanone 46.73
    2-pentanone 16.61
    anisole 7.12
    cyclopentyl methyl ether 14.23
    gamma-butyrolactone 47.2
    1-methoxy-2-propanol 70.71
    pyridine 24.65
    3-pentanone 10.24
    furfural 43.23
    n-dodecane 0.09
    diethylene glycol 67.54
    diisopropyl ether 2.0
    tert-amyl alcohol 4.57
    acetylacetone 28.8
    n-hexadecane 0.11
    acetophenone 8.82
    methyl propionate 16.06
    isopentyl acetate 5.09
    trichloroethylene 21.88
    n-nonanol 3.6
    cyclohexanol 6.59
    benzyl alcohol 9.97
    2-ethylhexanol 2.72
    isooctanol 4.27
    dipropyl ether 4.24
    1,2-dichlorobenzene 4.23
    ethyl lactate 8.04
    propylene carbonate 14.86
    n-methylformamide 92.63
    2-pentanol 4.98
    n-pentane 0.53
    1-propoxy-2-propanol 19.75
    1-methoxy-2-propyl acetate 16.2
    2-(2-methoxypropoxy) propanol 14.12
    mesitylene 2.09
    ε-caprolactone 17.5
    p-cymene 1.48
    epichlorohydrin 51.07
    1,1,1-trichloroethane 5.62
    2-aminoethanol 45.75
    morpholine-4-carbaldehyde 80.88
    sulfolane 64.18
    2,2,4-trimethylpentane 0.15
    2-methyltetrahydrofuran 15.6
    n-hexyl acetate 6.96
    isooctane 0.18
    2-(2-butoxyethoxy)ethanol 20.19
    sec-butyl acetate 3.38
    tert-butyl acetate 8.77
    decalin 0.27
    glycerin 54.67
    diglyme 38.77
    acrylic acid 23.81
    isopropyl myristate 2.37
    n-butyric acid 16.95
    acetyl acetate 12.31
    di(2-ethylhexyl) phthalate 4.71
    ethyl propionate 6.45
    nitromethane 90.91
    1,2-diethoxyethane 9.01
    benzonitrile 7.52
    trioctyl phosphate 3.41
    1-bromopropane 3.91
    gamma-valerolactone 85.74
    n-decanol 2.17
    triethyl phosphate 3.66
    4-methyl-2-pentanol 3.45
    propionitrile 11.38
    vinylene carbonate 18.34
    1,1,2-trichlorotrifluoroethane 46.69
    DMS 9.32
    cumene 1.42
    2-octanol 2.78
    2-hexanone 6.43
    octyl acetate 3.48
    limonene 1.8
    1,2-dimethoxyethane 44.58
    ethyl orthosilicate 3.34
    tributyl phosphate 2.92
    diacetone alcohol 17.53
    N,N-dimethylaniline 5.32
    acrylonitrile 21.73
    aniline 9.39
    1,3-propanediol 53.24
    bromobenzene 3.53
    dibromomethane 8.87
    1,1,2,2-tetrachloroethane 14.27
    2-methyl-cyclohexyl acetate 4.92
    tetrabutyl urea 5.16
    diisobutyl methanol 1.99
    2-phenylethanol 11.03
    styrene 2.32
    dioctyl adipate 4.85
    dimethyl sulfate 33.92
    ethyl butyrate 4.9
    methyl lactate 26.26
    butyl lactate 9.11
    diethyl carbonate 3.63
    propanediol butyl ether 17.68
    triethyl orthoformate 4.61
    p-tert-butyltoluene 1.52
    methyl 4-tert-butylbenzoate 11.75
    morpholine 55.13
    tert-butylamine 3.8
    n-dodecanol 1.29
    dimethoxymethane 119.79
    ethylene carbonate 14.07
    cyrene 22.09
    2-ethoxyethyl acetate 13.88
    2-ethylhexyl acetate 3.47
    1,2,4-trichlorobenzene 5.72
    4-methylpyridine 13.81
    dibutyl ether 2.0
    2,6-dimethyl-4-heptanol 1.99
    DEF 19.81
    dimethyl isosorbide 23.43
    tetrachloroethylene 13.57
    eugenol 14.75
    triacetin 10.43
    span 80 11.78
    1,4-butanediol 14.71
    1,1-dichloroethane 6.41
    2-methyl-1-pentanol 3.82
    methyl formate 63.49
    2-methyl-1-butanol 6.05
    n-decane 0.21
    butyronitrile 8.44
    3,7-dimethyl-1-octanol 2.22
    1-chlorooctane 1.03
    1-chlorotetradecane 0.32
    n-nonane 0.18
    undecane 0.13
    tert-butylcyclohexane 0.21
    cyclooctane 0.28
    cyclopentanol 11.71
    tetrahydropyran 17.25
    tert-amyl methyl ether 2.99
    2,5,8-trioxanonane 25.44
    1-hexene 1.15
    2-isopropoxyethanol 15.35
    2,2,2-trifluoroethanol 27.21
    methyl butyrate 7.8

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction