beta-cyclodextrin, hydrogen sulfate, sodium salt

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  • Identifiers

    CAS number
    37191-69-8

    Molecular formula
    C42H70O56S7

    SMILES
    C([C@@H]1[C@@H]2[C@@H]([C@H]([C@H](O1)O[C@@H]3[C@H](O[C@@H]([C@@H]([C@H]3O)O)O[C@@H]4[C@H](O[C@@H]([C@@H]([C@H]4O)O)O[C@@H]5[C@H](O[C@@H]([C@@H]([C@H]5O)O)O[C@@H]6[C@H](O[C@@H]([C@@H]([C@H]6O)O)O[C@@H]7[C@H](O[C@@H]([C@@H]([C@H]7O)O)O[C@@H]8[C@H](O[C@H](O2)[C@@H]([C@H]8O)O)COS(=O)(=O)O)COS(=O)(=O)O)COS(=O)(=O)O)COS(=O)(=O)O)COS(=O)(=O)O)COS(=O)(=O)O)O)O)OS(=O)(=O)O

    Safety labels

  • Odor profile

    Fragrance
    Odorless 89.96%
    Savory 20.45%
    Cooked 15.11%
    Meaty 14.53%
    Sulfurous 13.78%
    Clean 12.52%
    Roasted 11.26%
    Cooling 10.11%
    Burnt 9.77%
    Alcoholic 9.2%

     

    Flavor
    Bitter 90.59%
    Bland 28.23%
    Odorless 27.64%
    Sweet-like 22.08%
    Cedarleaf 19.57%
    Nitrile 18.99%
    Alkaline 18.46%
    Formyl 18.38%
    Rotten 18.32%
    Shrimp 18.16%

     

    Odor impact est.
    Odorless

  • Properties

    XLogP3-AA
    -17.7

    pKa est.
    38.88 (strong base)

    Molecular weight
    1695.4 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderate

    Boiling point est.
    4322°C

    Flash point

    • 611.84 ˚C est.

  • Synonyms

    • 37191-69-8
    • beta-Cyclodextrin, sulfated sodium salt
    • beta-Cyclodextrin, hydrogen sulfate, sodium salt
    • .beta.-Cyclodextrin, hydrogen sulfate, sodium salt
    • RefChem:567287
    • DTXSID901014914
    • betaCyclodextrin, hydrogen sulfate, sodium salt
    • beta-Cyclodextrin sulfate
    • beta-Cycloheptadextrin heptasulfate
    • b.-C7(D)-7(SO2OH)
    • beta-Cyclodextrin, heptakis(hydrogen sulfate)
    • 120825-98-1
    • 2,4,7,9,12,14,17,19,22,24,27,29,32,34-Tetradecaoxaoctacyclo(31.2.2.23,6.28,11.213,16.218,21.223,26.228,31)nonatetracontane, b-cyclodextrin deriv.
    • CHEMBL1963431
    • SCHEMBL29395554
    • JFDDAIKYFLAHSD-FOUAGVGXSA-N
    • C42H70O56S7
    • Beta-cyclodextrin,sulfated sodium salt
    • |A-Cyclodextrin, sulfated sodium salt
    • OC34946
    • PD130996
    • b-Cyclodextrin hydrogen sulfate, sodium salt
    • 37191-69-8

  • Applications

    beta-cyclodextrin, hydrogen sulfate, sodium salt (CAS 37191-69-8) is widely used as an inclusion complexing and solubilizing excipient. In fragrance and flavor applications, it encapsulates volatile components to enable controlled release and improved stability. In cosmetics and personal care, it acts as a solubilizer and carrier for active ingredients and fragrances. In food processing, it supports flavor encapsulation and aroma stabilization. In pharmaceuticals, it helps solubilize poorly soluble drugs and stabilize formulations. In detergents and household products, it enhances solubility, supports controlled release of fragrances, and can bind metals to mitigate their effects. In agriculture, it serves as a carrier for crop protection products, enabling formulation uniformity and controlled release.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 4.32
    methanol 16.56
    isopropanol 1.45
    water 5.28
    ethyl acetate 1.23
    n-propanol 1.79
    acetone 5.12
    n-butanol 0.81
    acetonitrile 2.05
    DMF 99.1
    toluene 0.14
    isobutanol 0.54
    1,4-dioxane 5.25
    methyl acetate 2.68
    THF 7.68
    2-butanone 2.57
    n-pentanol 0.39
    sec-butanol 0.8
    n-hexane 0.01
    ethylene glycol 11.36
    NMP 53.83
    cyclohexane 0.04
    DMSO 86.23
    n-butyl acetate 0.93
    n-octanol 0.69
    chloroform 0.6
    n-propyl acetate 0.75
    acetic acid 18.35
    dichloromethane 0.97
    cyclohexanone 2.38
    propylene glycol 9.11
    isopropyl acetate 0.62
    DMAc 57.98
    2-ethoxyethanol 8.73
    isopentanol 0.3
    n-heptane 0.04
    ethyl formate 3.65
    1,2-dichloroethane 0.63
    n-hexanol 0.33
    2-methoxyethanol 30.31
    isobutyl acetate 0.2
    tetrachloromethane 0.12
    n-pentyl acetate 1.05
    transcutol 13.45
    n-heptanol 0.63
    ethylbenzene 0.04
    MIBK 0.39
    2-propoxyethanol 7.05
    tert-butanol 0.69
    MTBE 0.3
    2-butoxyethanol 5.74
    propionic acid 4.23
    o-xylene 0.12
    formic acid 51.43
    diethyl ether 0.63
    m-xylene 0.08
    p-xylene 0.07
    chlorobenzene 0.11
    dimethyl carbonate 5.4
    n-octane 0.03
    formamide 67.06
    cyclopentanone 6.87
    2-pentanone 1.31
    anisole 0.27
    cyclopentyl methyl ether 0.98
    gamma-butyrolactone 12.59
    1-methoxy-2-propanol 13.79
    pyridine 2.71
    3-pentanone 1.09
    furfural 14.07
    n-dodecane 0.02
    diethylene glycol 13.32
    diisopropyl ether 0.08
    tert-amyl alcohol 0.51
    acetylacetone 3.44
    n-hexadecane 0.02
    acetophenone 0.68
    methyl propionate 2.61
    isopentyl acetate 0.45
    trichloroethylene 1.1
    n-nonanol 0.68
    cyclohexanol 0.47
    benzyl alcohol 0.52
    2-ethylhexanol 0.16
    isooctanol 0.3
    dipropyl ether 0.57
    1,2-dichlorobenzene 0.11
    ethyl lactate 2.19
    propylene carbonate 3.88
    n-methylformamide 35.87
    2-pentanol 0.33
    n-pentane 0.02
    1-propoxy-2-propanol 4.35
    1-methoxy-2-propyl acetate 2.6
    2-(2-methoxypropoxy) propanol 4.17
    mesitylene 0.05
    ε-caprolactone 2.8
    p-cymene 0.08
    epichlorohydrin 4.88
    1,1,1-trichloroethane 0.18
    2-aminoethanol 9.93
    morpholine-4-carbaldehyde 43.09
    sulfolane 24.77
    2,2,4-trimethylpentane 0.01
    2-methyltetrahydrofuran 1.5
    n-hexyl acetate 0.93
    isooctane 0.0
    2-(2-butoxyethoxy)ethanol 6.17
    sec-butyl acetate 0.26
    tert-butyl acetate 0.52
    decalin 0.01
    glycerin 29.63
    diglyme 13.59
    acrylic acid 8.18
    isopropyl myristate 0.28
    n-butyric acid 2.5
    acetyl acetate 1.14
    di(2-ethylhexyl) phthalate 0.51
    ethyl propionate 0.66
    nitromethane 36.57
    1,2-diethoxyethane 1.83
    benzonitrile 0.48
    trioctyl phosphate 0.47
    1-bromopropane 0.16
    gamma-valerolactone 21.83
    n-decanol 0.43
    triethyl phosphate 0.57
    4-methyl-2-pentanol 0.11
    propionitrile 0.82
    vinylene carbonate 4.3
    1,1,2-trichlorotrifluoroethane 13.25
    DMS 1.51
    cumene 0.03
    2-octanol 0.35
    2-hexanone 0.57
    octyl acetate 0.64
    limonene 0.12
    1,2-dimethoxyethane 9.79
    ethyl orthosilicate 0.46
    tributyl phosphate 0.43
    diacetone alcohol 2.19
    N,N-dimethylaniline 0.34
    acrylonitrile 2.28
    aniline 0.54
    1,3-propanediol 7.99
    bromobenzene 0.07
    dibromomethane 0.34
    1,1,2,2-tetrachloroethane 1.03
    2-methyl-cyclohexyl acetate 0.38
    tetrabutyl urea 1.27
    diisobutyl methanol 0.09
    2-phenylethanol 0.47
    styrene 0.05
    dioctyl adipate 0.73
    dimethyl sulfate 13.72
    ethyl butyrate 0.78
    methyl lactate 9.53
    butyl lactate 2.5
    diethyl carbonate 0.63
    propanediol butyl ether 6.6
    triethyl orthoformate 0.91
    p-tert-butyltoluene 0.08
    methyl 4-tert-butylbenzoate 1.77
    morpholine 7.91
    tert-butylamine 0.2
    n-dodecanol 0.27
    dimethoxymethane 18.33
    ethylene carbonate 2.65
    cyrene 4.92
    2-ethoxyethyl acetate 2.8
    2-ethylhexyl acetate 0.34
    1,2,4-trichlorobenzene 0.2
    4-methylpyridine 1.31
    dibutyl ether 0.39
    2,6-dimethyl-4-heptanol 0.09
    DEF 5.56
    dimethyl isosorbide 5.78
    tetrachloroethylene 0.68
    eugenol 2.26
    triacetin 2.59
    span 80 3.13
    1,4-butanediol 2.71
    1,1-dichloroethane 0.27
    2-methyl-1-pentanol 0.14
    methyl formate 25.37
    2-methyl-1-butanol 0.34
    n-decane 0.04
    butyronitrile 0.6
    3,7-dimethyl-1-octanol 0.23
    1-chlorooctane 0.14
    1-chlorotetradecane 0.05
    n-nonane 0.04
    undecane 0.03
    tert-butylcyclohexane 0.0
    cyclooctane 0.02
    cyclopentanol 1.26
    tetrahydropyran 1.26
    tert-amyl methyl ether 0.32
    2,5,8-trioxanonane 8.92
    1-hexene 0.04
    2-isopropoxyethanol 2.48
    2,2,2-trifluoroethanol 13.37
    methyl butyrate 1.12

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction