Benzyl hemiformal

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  • Identifiers

    CAS number
    14548-60-8

    Molecular formula
    C8H10O2

    SMILES
    C1=CC=C(C=C1)COCO

    Safety labels

    Corrosive
    Corrosive

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Sweet 72.39%
    Fruity 69.52%
    Floral 61.37%
    Green 59.11%
    Rose 55.98%
    Almond 54.5%
    Bitter 44.03%
    Hyacinth 43.69%
    Balsamic 38.12%
    Cherry 34.23%

     

    Flavor
    Floral 70.24%
    Sweet 66.91%
    Fruity 64.95%
    Rose 58.0%
    Hyacinth 41.06%
    Almond 39.83%
    Honey 39.74%
    Balsam 39.48%
    Spicy 37.99%
    Chocolate 37.04%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    1.3

    pKa est.
    6.5 (neutral)

    Molecular weight
    138.16 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Slow

    Boiling point est.
    235°C

    Flash point

    • 118.48 ˚C est.

  • Synonyms

    • (Benzyloxy)methanol
    • Benzylhemiformal
    • 14548-60-8
    • phenylmethoxymethanol
    • Benzyl hemiformal
    • AKYPO SEPT B
    • XDK482748R
    • DTXSID3042136
    • RefChem:118943
    • DTXCID1022136
    • 238-588-8
    • Methanol, (phenylmethoxy)-
    • Methanol, 1-(phenylmethoxy)-
    • benzyloxymethanol
    • (Phenylmethoxy)methanol
    • UNII-XDK482748R
    • benzyl-hemiformal
    • EINECS 238-588-8
    • SCHEMBL98297
    • SCHEMBL98298
    • SCHEMBL790911
    • SCHEMBL2988358
    • METHANOL, (BENZYLOXY)-
    • SCHEMBL25293204
    • MFCD20232978
    • FB167344
    • SY413080
    • NS00007713
    • Q27293795
    • 14548-60-8

  • Applications

    Benzyl hemiformal (CAS 14548-60-8) is primarily used as an organic synthesis intermediate and a precursor to benzyl-protected aldehyde derivatives. It may serve as a building block to access related benzyl-containing intermediates and functionalized materials. In industrial manufacturing it can function as a solvent or processing aid in coatings, inks and adhesives, acting as a reactive diluent under controlled conditions. In perfumery and cosmetics it can function as a fragrance intermediate or component in formulation work, contributing to odor profiles within regulatory limits. In polymer and plastics chemistry it is evaluated as a building block for resins and as a functionalizing reagent in polymerization. In pharmaceutical and fine-chemical synthesis it is considered a specialized starting material for more complex molecules, with use governed by safety and regulatory compliance.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 2122.86
    methanol 1871.52
    isopropanol 1313.06
    water 12.61
    ethyl acetate 533.81
    n-propanol 1489.41
    acetone 637.22
    n-butanol 969.06
    acetonitrile 680.26
    DMF 1199.32
    toluene 79.24
    isobutanol 744.87
    1,4-dioxane 946.98
    methyl acetate 570.83
    THF 710.32
    2-butanone 453.12
    n-pentanol 396.76
    sec-butanol 720.79
    n-hexane 9.2
    ethylene glycol 783.2
    NMP 463.83
    cyclohexane 24.04
    DMSO 1813.37
    n-butyl acetate 210.71
    n-octanol 93.82
    chloroform 630.03
    n-propyl acetate 254.38
    acetic acid 1277.25
    dichloromethane 747.0
    cyclohexanone 455.08
    propylene glycol 795.06
    isopropyl acetate 170.16
    DMAc 555.78
    2-ethoxyethanol 728.91
    isopentanol 487.44
    n-heptane 18.97
    ethyl formate 461.61
    1,2-dichloroethane 525.21
    n-hexanol 342.74
    2-methoxyethanol 1612.85
    isobutyl acetate 118.35
    tetrachloromethane 69.41
    n-pentyl acetate 82.02
    transcutol 1047.03
    n-heptanol 118.21
    ethylbenzene 42.81
    MIBK 161.71
    2-propoxyethanol 518.92
    tert-butanol 970.14
    MTBE 273.14
    2-butoxyethanol 247.6
    propionic acid 969.26
    o-xylene 62.39
    formic acid 649.73
    diethyl ether 345.16
    m-xylene 62.13
    p-xylene 49.57
    chlorobenzene 136.85
    dimethyl carbonate 165.28
    n-octane 5.85
    formamide 1083.32
    cyclopentanone 573.55
    2-pentanone 366.91
    anisole 170.97
    cyclopentyl methyl ether 299.95
    gamma-butyrolactone 751.88
    1-methoxy-2-propanol 816.4
    pyridine 506.02
    3-pentanone 204.33
    furfural 566.15
    n-dodecane 5.09
    diethylene glycol 530.55
    diisopropyl ether 53.23
    tert-amyl alcohol 514.29
    acetylacetone 279.1
    n-hexadecane 5.46
    acetophenone 153.03
    methyl propionate 422.94
    isopentyl acetate 145.35
    trichloroethylene 877.99
    n-nonanol 78.11
    cyclohexanol 405.73
    benzyl alcohol 194.7
    2-ethylhexanol 141.66
    isooctanol 89.03
    dipropyl ether 172.18
    1,2-dichlorobenzene 123.79
    ethyl lactate 153.76
    propylene carbonate 354.14
    n-methylformamide 1138.2
    2-pentanol 442.15
    n-pentane 15.65
    1-propoxy-2-propanol 333.32
    1-methoxy-2-propyl acetate 184.87
    2-(2-methoxypropoxy) propanol 174.57
    mesitylene 39.06
    ε-caprolactone 374.02
    p-cymene 39.47
    epichlorohydrin 833.92
    1,1,1-trichloroethane 243.29
    2-aminoethanol 1248.26
    morpholine-4-carbaldehyde 631.77
    sulfolane 707.29
    2,2,4-trimethylpentane 10.88
    2-methyltetrahydrofuran 507.99
    n-hexyl acetate 114.93
    isooctane 9.26
    2-(2-butoxyethoxy)ethanol 276.26
    sec-butyl acetate 113.62
    tert-butyl acetate 151.92
    decalin 11.22
    glycerin 803.49
    diglyme 586.54
    acrylic acid 672.17
    isopropyl myristate 44.13
    n-butyric acid 969.87
    acetyl acetate 186.33
    di(2-ethylhexyl) phthalate 52.46
    ethyl propionate 191.04
    nitromethane 1565.44
    1,2-diethoxyethane 209.41
    benzonitrile 174.94
    trioctyl phosphate 42.98
    1-bromopropane 188.17
    gamma-valerolactone 671.02
    n-decanol 58.62
    triethyl phosphate 68.83
    4-methyl-2-pentanol 145.62
    propionitrile 504.06
    vinylene carbonate 321.81
    1,1,2-trichlorotrifluoroethane 649.13
    DMS 106.71
    cumene 34.69
    2-octanol 56.45
    2-hexanone 185.19
    octyl acetate 58.92
    limonene 63.02
    1,2-dimethoxyethane 739.74
    ethyl orthosilicate 69.87
    tributyl phosphate 49.26
    diacetone alcohol 293.6
    N,N-dimethylaniline 103.4
    acrylonitrile 655.14
    aniline 255.97
    1,3-propanediol 1206.32
    bromobenzene 113.05
    dibromomethane 363.44
    1,1,2,2-tetrachloroethane 633.97
    2-methyl-cyclohexyl acetate 101.57
    tetrabutyl urea 71.03
    diisobutyl methanol 79.36
    2-phenylethanol 145.66
    styrene 60.21
    dioctyl adipate 76.51
    dimethyl sulfate 247.36
    ethyl butyrate 179.7
    methyl lactate 248.65
    butyl lactate 98.98
    diethyl carbonate 112.69
    propanediol butyl ether 227.52
    triethyl orthoformate 108.55
    p-tert-butyltoluene 38.18
    methyl 4-tert-butylbenzoate 126.95
    morpholine 1302.66
    tert-butylamine 458.19
    n-dodecanol 44.55
    dimethoxymethane 596.36
    ethylene carbonate 284.68
    cyrene 165.08
    2-ethoxyethyl acetate 132.57
    2-ethylhexyl acetate 97.19
    1,2,4-trichlorobenzene 151.82
    4-methylpyridine 323.24
    dibutyl ether 78.59
    2,6-dimethyl-4-heptanol 79.36
    DEF 478.35
    dimethyl isosorbide 230.31
    tetrachloroethylene 410.79
    eugenol 139.83
    triacetin 137.63
    span 80 155.46
    1,4-butanediol 389.77
    1,1-dichloroethane 380.82
    2-methyl-1-pentanol 226.93
    methyl formate 674.83
    2-methyl-1-butanol 495.06
    n-decane 7.9
    butyronitrile 450.65
    3,7-dimethyl-1-octanol 86.55
    1-chlorooctane 39.56
    1-chlorotetradecane 15.44
    n-nonane 7.75
    undecane 6.07
    tert-butylcyclohexane 11.29
    cyclooctane 8.5
    cyclopentanol 504.62
    tetrahydropyran 682.63
    tert-amyl methyl ether 166.85
    2,5,8-trioxanonane 343.45
    1-hexene 53.12
    2-isopropoxyethanol 379.49
    2,2,2-trifluoroethanol 356.91
    methyl butyrate 300.95

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction