Benzyl 4-Hydroxybenzoate

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  • Identifiers

    CAS number
    94-18-8

    Molecular formula
    C14H12O3

    SMILES
    C1=CC=C(C=C1)COC(=O)C2=CC=C(C=C2)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Balsamic 66.0%
    Sweet 61.67%
    Phenolic 52.95%
    Floral 49.2%
    Herbal 39.98%
    Aromatic 38.26%
    Fruity 37.22%
    Spicy 36.48%
    Medicinal 32.72%
    Powdery 31.6%

     

    Flavor
    Sweet 74.49%
    Balsam 72.07%
    Herbal 58.56%
    Balsamic 45.14%
    Wintergreen 44.79%
    Floral 44.53%
    Powdery 39.74%
    Cherry 38.34%
    Strawberry 38.16%
    Almond 38.11%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    3.6

    pKa est.
    8.2 (weak base)

    Molecular weight
    228.24 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    391°C

    Flash point

    • 178.04 ˚C est.

  • Synonyms

    • Benzyl 4-hydroxybenzoate
    • 94-18-8
    • Benzylparaben
    • Benzyl paraben
    • Benzyl p-hydroxybenzoate
    • Nipabenzyl
    • Benzyl Tegosept
    • Benzyl parahydroxybenzoate
    • p-Hydroxybenzoic acid benzyl ester
    • Benzoic acid, 4-hydroxy-, phenylmethyl ester
    • Phenylmethyl 4-hydroxybenzoate
    • DTXSID9022526
    • 8Y41DYV4VG
    • NSC-8080
    • DTXCID202526
    • 4-Hydroxybenzoic acid, benzyl ester
    • RefChem:118993
    • 202-311-9
    • Parosept
    • Benzyl Parasept
    • Solbrol Z
    • Benzyl-Parasept
    • 4-Hydroxybenzoic acid benzyl ester
    • MFCD00016471
    • NSC 8080
    • Benzyl hydroxybenzoate
    • Benzoic acid, p-hydroxy-, benzyl ester
    • 4-Hydroxybenzoic acid-benzyl ester
    • NCGC00164155-01
    • CAS-94-18-8
    • Benzyl 4-?Hydroxybenzoate(Benzyl Paraben)
    • benzyl-4-hydroxybenzoate
    • EINECS 202-311-9
    • UNII-8Y41DYV4VG
    • AI3-02955
    • Nisapulvol (TN)
    • (Benzyl Paraben)
    • benzyl 4-hydroxy-benzoate
    • Benzyl 4-?Hydroxybenzoate
    • 4-(Benzyloxycarbonyl)phenol
    • Oprea1_135204
    • SCHEMBL27578
    • MLS004734666
    • BIDD:ER0230
    • CHEMBL447861
    • SCHEMBL4391242
    • Benzyl 4-hydroxybenzoate, 99%
    • CHEBI:34571
    • NSC8080
    • HMS1581F21
    • 4-Hydroxy-benzoic acid benzyl ester
    • Tox21_112088
    • Tox21_302330
    • EBC-26250
    • MSK3325-100M
    • SBB068798
    • STL226811
    • AKOS001280007
    • BENZYL HYDROXYBENZOATE [MART.]
    • MSK3325-1000M
    • Tox21_112088_1
    • BENZYL HYDROXYBENZOATE [WHO-DD]
    • BENZYL HYDROXYBENZOATE [WHO-IP]
    • CS-W014198
    • DB14176
    • FB18305
    • HY-W013482
    • 4-Hydroxybenzoic acid phenylmethyl ester
    • Benzyl 4-Hydroxybenzoate(Benzyl Paraben)
    • NCGC00164155-02
    • NCGC00255352-01
    • SMR001600273
    • SY049476
    • DB-022610
    • B3768
    • Benzyl 4-hydroxybenzoate, analytical standard
    • H0209
    • NS00013407
    • ST50170807
    • BENZYLIS HYDROXYBENZOAS [WHO-IP LATIN]
    • D07518
    • F16506
    • SBI-0653849.0001
    • EN300-7101475
    • F018211
    • SR-01000390750
    • SR-01000390750-1
    • Q27116155
    • Z19674825
    • Benzyl p-hydroxybenzoate Solution in Methanol, 100ug/mL
    • Benzyl p-hydroxybenzoate Solution in Methanol, 1000ug/mL
    • 94-18-8

  • Applications

    Benzyl 4-Hydroxybenzoate (CAS 94-18-8) is commonly used as a preservative in cosmetics and personal-care products, providing antimicrobial protection in creams, lotions, and makeup formulations. It is also used in pharmaceutical topical formulations to extend shelf life as a preservative. In household products such as cleaners and detergents, it can serve as a preservative for aqueous systems. Additionally, it is often employed as an intermediate in the synthesis of parabens and hydroxybenzoate derivatives, which appear in fragrance-related formulations and other polymer or coating applications. Its use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 66.52
    methanol 124.42
    isopropanol 27.74
    water 0.08
    ethyl acetate 165.73
    n-propanol 45.85
    acetone 19.44
    n-butanol 40.41
    acetonitrile 77.13
    DMF 39.64
    toluene 20.43
    isobutanol 19.18
    1,4-dioxane 149.87
    methyl acetate 113.71
    THF 178.85
    2-butanone 85.41
    n-pentanol 34.53
    sec-butanol 45.53
    n-hexane 0.24
    ethylene glycol 15.6
    NMP 24.31
    cyclohexane 0.28
    DMSO 113.56
    n-butyl acetate 51.04
    n-octanol 10.6
    chloroform 46.56
    n-propyl acetate 56.86
    acetic acid 78.27
    dichloromethane 51.31
    cyclohexanone 49.95
    propylene glycol 30.45
    isopropyl acetate 80.48
    DMAc 129.81
    2-ethoxyethanol 123.15
    isopentanol 41.7
    n-heptane 0.62
    ethyl formate 36.35
    1,2-dichloroethane 60.72
    n-hexanol 26.48
    2-methoxyethanol 198.5
    isobutyl acetate 32.82
    tetrachloromethane 1.56
    n-pentyl acetate 24.62
    transcutol 911.0
    n-heptanol 14.0
    ethylbenzene 12.68
    MIBK 61.96
    2-propoxyethanol 95.27
    tert-butanol 54.29
    MTBE 67.68
    2-butoxyethanol 53.47
    propionic acid 51.9
    o-xylene 13.62
    formic acid 48.45
    diethyl ether 89.44
    m-xylene 13.0
    p-xylene 11.84
    chlorobenzene 18.39
    dimethyl carbonate 46.36
    n-octane 0.3
    formamide 164.02
    cyclopentanone 49.94
    2-pentanone 67.23
    anisole 70.23
    cyclopentyl methyl ether 44.99
    gamma-butyrolactone 96.62
    1-methoxy-2-propanol 140.99
    pyridine 96.34
    3-pentanone 52.66
    furfural 101.92
    n-dodecane 0.55
    diethylene glycol 85.71
    diisopropyl ether 16.89
    tert-amyl alcohol 68.15
    acetylacetone 121.01
    n-hexadecane 0.64
    acetophenone 58.5
    methyl propionate 92.67
    isopentyl acetate 54.96
    trichloroethylene 129.32
    n-nonanol 12.35
    cyclohexanol 20.38
    benzyl alcohol 45.62
    2-ethylhexanol 19.48
    isooctanol 14.29
    dipropyl ether 29.67
    1,2-dichlorobenzene 20.94
    ethyl lactate 35.45
    propylene carbonate 52.31
    n-methylformamide 47.83
    2-pentanol 37.31
    n-pentane 0.2
    1-propoxy-2-propanol 68.81
    1-methoxy-2-propyl acetate 95.86
    2-(2-methoxypropoxy) propanol 108.19
    mesitylene 8.35
    ε-caprolactone 69.0
    p-cymene 9.43
    epichlorohydrin 199.23
    1,1,1-trichloroethane 20.64
    2-aminoethanol 44.41
    morpholine-4-carbaldehyde 105.77
    sulfolane 84.17
    2,2,4-trimethylpentane 1.11
    2-methyltetrahydrofuran 68.19
    n-hexyl acetate 35.19
    isooctane 0.9
    2-(2-butoxyethoxy)ethanol 150.19
    sec-butyl acetate 53.45
    tert-butyl acetate 100.55
    decalin 1.01
    glycerin 61.8
    diglyme 297.75
    acrylic acid 49.65
    isopropyl myristate 18.59
    n-butyric acid 66.14
    acetyl acetate 74.43
    di(2-ethylhexyl) phthalate 18.23
    ethyl propionate 59.22
    nitromethane 209.92
    1,2-diethoxyethane 147.71
    benzonitrile 37.4
    trioctyl phosphate 11.44
    1-bromopropane 15.28
    gamma-valerolactone 111.85
    n-decanol 9.73
    triethyl phosphate 27.47
    4-methyl-2-pentanol 24.7
    propionitrile 51.79
    vinylene carbonate 52.21
    1,1,2-trichlorotrifluoroethane 110.77
    DMS 55.92
    cumene 9.03
    2-octanol 7.87
    2-hexanone 51.13
    octyl acetate 20.1
    limonene 12.63
    1,2-dimethoxyethane 182.11
    ethyl orthosilicate 27.28
    tributyl phosphate 17.74
    diacetone alcohol 118.99
    N,N-dimethylaniline 36.56
    acrylonitrile 75.45
    aniline 34.65
    1,3-propanediol 72.86
    bromobenzene 15.83
    dibromomethane 19.79
    1,1,2,2-tetrachloroethane 95.17
    2-methyl-cyclohexyl acetate 39.11
    tetrabutyl urea 23.28
    diisobutyl methanol 17.4
    2-phenylethanol 39.72
    styrene 16.02
    dioctyl adipate 36.46
    dimethyl sulfate 65.68
    ethyl butyrate 49.23
    methyl lactate 53.96
    butyl lactate 31.04
    diethyl carbonate 36.08
    propanediol butyl ether 53.78
    triethyl orthoformate 39.92
    p-tert-butyltoluene 9.66
    methyl 4-tert-butylbenzoate 53.98
    morpholine 159.69
    tert-butylamine 20.52
    n-dodecanol 7.53
    dimethoxymethane 140.01
    ethylene carbonate 38.82
    cyrene 65.12
    2-ethoxyethyl acetate 70.6
    2-ethylhexyl acetate 36.9
    1,2,4-trichlorobenzene 31.51
    4-methylpyridine 53.85
    dibutyl ether 25.15
    2,6-dimethyl-4-heptanol 17.4
    DEF 70.67
    dimethyl isosorbide 144.5
    tetrachloroethylene 42.68
    eugenol 57.73
    triacetin 76.08
    span 80 55.36
    1,4-butanediol 19.82
    1,1-dichloroethane 24.99
    2-methyl-1-pentanol 42.75
    methyl formate 36.14
    2-methyl-1-butanol 36.56
    n-decane 0.77
    butyronitrile 37.37
    3,7-dimethyl-1-octanol 18.81
    1-chlorooctane 5.4
    1-chlorotetradecane 2.82
    n-nonane 0.54
    undecane 0.64
    tert-butylcyclohexane 1.29
    cyclooctane 0.22
    cyclopentanol 13.68
    tetrahydropyran 64.17
    tert-amyl methyl ether 62.76
    2,5,8-trioxanonane 211.52
    1-hexene 3.39
    2-isopropoxyethanol 81.3
    2,2,2-trifluoroethanol 23.54
    methyl butyrate 59.01

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction