Benzophenone-6

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  • Identifiers

    CAS number
    131-54-4

    Molecular formula
    C15H14O5

    SMILES
    COC1=CC(=C(C=C1)C(=O)C2=C(C=C(C=C2)OC)O)O

    Safety labels

    Irritant
    Irritant

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Sweet 82.54%
    Phenolic 56.75%
    Vanilla 49.63%
    Balsamic 43.04%
    Spicy 40.61%
    Powdery 36.59%
    Aromatic 33.69%
    Woody 33.49%
    Medicinal 32.02%
    Floral 31.69%

     

    Flavor
    Bitter 89.48%
    Odorless 28.14%
    Bland 24.54%
    Parsley 20.31%
    Lovage 20.26%
    Sweet-like 19.98%
    Cedarleaf 19.83%
    Ethyl benzoate 19.16%
    Nitrile 18.9%
    Ripe apricot 18.89%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    3.3

    pKa est.
    8.73 (weak base)

    Molecular weight
    274.27 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    413°C

    Melting point expt.

    • 139.1 °C
    • MP: 139-149 °C

    Flash point

    • 195.25 ˚C est.

  • Synonyms

    • 131-54-4
    • 2,2'-Dihydroxy-4,4'-dimethoxybenzophenone
    • Benzophenone-6
    • Bis(2-hydroxy-4-methoxyphenyl)methanone
    • Methanone, bis(2-hydroxy-4-methoxyphenyl)-
    • Cyasorb UV 12
    • Uvinul D 49
    • 2,2-Dihydroxy-4,4-Dimethoxybenzophenone
    • Caswell No. 353C
    • BENZOPHENONE 6
    • 4,4'-Dimethoxy-2,2'-dihydroxybenzophenone
    • EINECS 205-027-3
    • NSC 40149
    • BRN 1887087
    • DTXSID6038875
    • BENZOPHENONE, 2,2'-DIHYDROXY-4,4'-DIMETHOXY-
    • 7813J9CS1G
    • HELISORB 11
    • NSC-40149
    • BENZOPHENONE-6 [MI]
    • DTXCID4018875
    • BENZOPHENONE-6 [MART.]
    • HSDB 8473
    • BENZOPHENONE-6 [WHO-DD]
    • BENZOPHENONE-6 (MART.)
    • RefChem:566261
    • 2,2'-Dihydroxy-4,4'-dimethoxybenzophenone (8CI)
    • BENZOPHENONE-6 [INCI]
    • 205-027-3
    • MFCD00009606
    • di2-hydroxy-4-methoxyphenyl ketone
    • UNII-7813J9CS1G
    • 2-(2-hydroxy-4-methoxybenzoyl)-5-methoxyphenol
    • bis(2-hydroxy-4-methoxy-phenyl)methanone
    • 4,2'-dihydroxybenzophenone
    • UVINUL-D-49
    • Oprea1_596131
    • SCHEMBL38652
    • MLS000078302
    • BIDD:ER0037
    • CHEMBL1598017
    • SCHEMBL29365072
    • MSK3448
    • CHEBI:229993
    • HMS1607E21
    • HMS2337I05
    • BB_NC-00330
    • NSC40149
    • Tox21_200543
    • BBL027762
    • MSK3448-100A
    • SBB057212
    • STK835235
    • AKOS001483238
    • MSK3448-1000A
    • CCG-103162
    • NCGC00066968-02
    • NCGC00258097-01
    • AS-14402
    • Bis(2-hydroxy-4-methoxyphenyl) methanone
    • CAS-131-54-4
    • SMR000034072
    • Benzophenone,2'-dihydroxy-4,4'-dimethoxy-
    • DB-042042
    • 2,2'-dihydroxy-4,4'-dimethoxy-benzophenone
    • CS-0204684
    • D0575
    • NS00008303
    • ST50308262
    • 2,2/'-Dihydroxy-4,4/'-dimethoxybenzophenone
    • 2,2\'-Dihydroxy-4,4\'-dimethoxybenzophenone
    • D89680
    • 2,2'-Dihydroxy-4,4'-dimethoxybenzophenone, 98%
    • SR-01000389299
    • SR-01000389299-1
    • Q27266628
    • 2,2'-Dihydroxy-4,4'-dimethoxybenzophenone Solution in Acetonitrile, 1000ug/mL
    • 2,2'-Dihydroxy-4,4'-dimethoxybenzophenone Solution in Acetonitrile, 100ug/mL
    • 131-54-4

  • Applications

    Benzophenone-6 (CAS 131-54-4) is commonly used as a UV absorber and light stabilizer across multiple industries. In cosmetics and personal care, it often serves as a UV-filtering ingredient to help protect formulations and skin from UV exposure. In polymers and plastics, it acts as a UV stabilizer to suppress photo-oxidative degradation of light-colored or transparent resins. In coatings and inks, it is added to improve color stability and durability under sunlight. In adhesives and sealants, it can function as a UV stabilizer to extend service life of bonded assemblies. In electronics and optical materials, it may be employed to protect polymer components from UV-induced yellowing and degradation. These roles reflect common use of BP-6 as a UV absorber and light stabilizer, with implementation depending on local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 4.06
    methanol 5.79
    isopropanol 6.36
    water 0.0
    ethyl acetate 28.68
    n-propanol 6.79
    acetone 72.34
    n-butanol 4.35
    acetonitrile 25.9
    DMF 236.5
    toluene 2.21
    isobutanol 4.47
    1,4-dioxane 47.91
    methyl acetate 42.3
    THF 383.0
    2-butanone 50.62
    n-pentanol 5.17
    sec-butanol 6.91
    n-hexane 0.32
    ethylene glycol 6.99
    NMP 175.19
    cyclohexane 0.34
    DMSO 1073.63
    n-butyl acetate 16.99
    n-octanol 3.34
    chloroform 27.25
    n-propyl acetate 19.35
    acetic acid 26.96
    dichloromethane 30.93
    cyclohexanone 55.92
    propylene glycol 14.7
    isopropyl acetate 19.45
    DMAc 291.85
    2-ethoxyethanol 36.93
    isopentanol 5.23
    n-heptane 0.46
    ethyl formate 16.21
    1,2-dichloroethane 28.77
    n-hexanol 4.97
    2-methoxyethanol 71.71
    isobutyl acetate 10.23
    tetrachloromethane 2.14
    n-pentyl acetate 7.79
    transcutol 85.72
    n-heptanol 3.2
    ethylbenzene 2.47
    MIBK 18.23
    2-propoxyethanol 43.94
    tert-butanol 19.66
    MTBE 13.54
    2-butoxyethanol 14.88
    propionic acid 19.36
    o-xylene 2.97
    formic acid 12.52
    diethyl ether 10.45
    m-xylene 2.29
    p-xylene 3.84
    chlorobenzene 6.23
    dimethyl carbonate 40.77
    n-octane 0.22
    formamide 54.79
    cyclopentanone 166.54
    2-pentanone 29.05
    anisole 17.23
    cyclopentyl methyl ether 40.03
    gamma-butyrolactone 200.81
    1-methoxy-2-propanol 57.59
    pyridine 23.46
    3-pentanone 28.16
    furfural 85.44
    n-dodecane 0.28
    diethylene glycol 47.67
    diisopropyl ether 3.88
    tert-amyl alcohol 12.51
    acetylacetone 67.9
    n-hexadecane 0.34
    acetophenone 23.25
    methyl propionate 41.83
    isopentyl acetate 15.32
    trichloroethylene 56.04
    n-nonanol 3.75
    cyclohexanol 7.75
    benzyl alcohol 12.25
    2-ethylhexanol 4.89
    isooctanol 3.38
    dipropyl ether 11.53
    1,2-dichlorobenzene 8.74
    ethyl lactate 20.28
    propylene carbonate 49.67
    n-methylformamide 63.36
    2-pentanol 4.34
    n-pentane 0.17
    1-propoxy-2-propanol 32.39
    1-methoxy-2-propyl acetate 42.08
    2-(2-methoxypropoxy) propanol 28.65
    mesitylene 2.02
    ε-caprolactone 44.04
    p-cymene 3.42
    epichlorohydrin 166.55
    1,1,1-trichloroethane 17.98
    2-aminoethanol 10.81
    morpholine-4-carbaldehyde 126.28
    sulfolane 326.14
    2,2,4-trimethylpentane 0.33
    2-methyltetrahydrofuran 66.75
    n-hexyl acetate 11.04
    isooctane 0.24
    2-(2-butoxyethoxy)ethanol 28.26
    sec-butyl acetate 12.93
    tert-butyl acetate 27.63
    decalin 0.56
    glycerin 39.16
    diglyme 70.09
    acrylic acid 22.53
    isopropyl myristate 6.12
    n-butyric acid 15.47
    acetyl acetate 24.17
    di(2-ethylhexyl) phthalate 7.3
    ethyl propionate 22.85
    nitromethane 159.38
    1,2-diethoxyethane 23.75
    benzonitrile 11.84
    trioctyl phosphate 5.18
    1-bromopropane 7.3
    gamma-valerolactone 134.12
    n-decanol 3.02
    triethyl phosphate 16.94
    4-methyl-2-pentanol 3.89
    propionitrile 17.2
    vinylene carbonate 36.46
    1,1,2-trichlorotrifluoroethane 92.31
    DMS 27.08
    cumene 2.43
    2-octanol 2.39
    2-hexanone 20.98
    octyl acetate 7.17
    limonene 4.92
    1,2-dimethoxyethane 79.72
    ethyl orthosilicate 13.75
    tributyl phosphate 7.62
    diacetone alcohol 43.66
    N,N-dimethylaniline 12.83
    acrylonitrile 28.81
    aniline 8.82
    1,3-propanediol 15.23
    bromobenzene 5.46
    dibromomethane 15.02
    1,1,2,2-tetrachloroethane 48.28
    2-methyl-cyclohexyl acetate 16.67
    tetrabutyl urea 12.0
    diisobutyl methanol 4.65
    2-phenylethanol 11.97
    styrene 2.95
    dioctyl adipate 13.0
    dimethyl sulfate 124.11
    ethyl butyrate 19.38
    methyl lactate 42.54
    butyl lactate 11.8
    diethyl carbonate 17.79
    propanediol butyl ether 14.06
    triethyl orthoformate 18.31
    p-tert-butyltoluene 3.41
    methyl 4-tert-butylbenzoate 20.13
    morpholine 73.77
    tert-butylamine 5.94
    n-dodecanol 2.41
    dimethoxymethane 109.65
    ethylene carbonate 30.24
    cyrene 42.98
    2-ethoxyethyl acetate 18.85
    2-ethylhexyl acetate 11.79
    1,2,4-trichlorobenzene 13.41
    4-methylpyridine 20.63
    dibutyl ether 6.7
    2,6-dimethyl-4-heptanol 4.65
    DEF 47.29
    dimethyl isosorbide 71.12
    tetrachloroethylene 19.52
    eugenol 18.51
    triacetin 23.57
    span 80 16.22
    1,4-butanediol 5.38
    1,1-dichloroethane 16.33
    2-methyl-1-pentanol 5.55
    methyl formate 52.18
    2-methyl-1-butanol 4.65
    n-decane 0.45
    butyronitrile 10.49
    3,7-dimethyl-1-octanol 4.26
    1-chlorooctane 2.34
    1-chlorotetradecane 1.17
    n-nonane 0.36
    undecane 0.35
    tert-butylcyclohexane 0.54
    cyclooctane 0.18
    cyclopentanol 18.76
    tetrahydropyran 28.09
    tert-amyl methyl ether 12.18
    2,5,8-trioxanonane 54.03
    1-hexene 1.66
    2-isopropoxyethanol 23.55
    2,2,2-trifluoroethanol 20.29
    methyl butyrate 27.26

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction