Benzene, 1-methoxy-4-(2-methoxyethyl)-

Overview IFRA Request a quote

  • Identifiers

    CAS number
    80314-58-5

    Molecular formula
    C10H14O2

    SMILES
    COCCC1=CC=C(C=C1)OC

    Safety labels

  • Odor profile

    Fragrance
    Floral 83.98%
    Green 70.66%
    Anisic 53.86%
    Rose 52.85%
    Sweet 51.82%
    Earthy 48.76%
    Hyacinth 44.87%
    Fruity 40.38%
    Spicy 39.7%
    Fresh 37.82%

     

    Flavor
    Floral 68.1%
    Rose 57.44%
    Fruity 51.14%
    Sweet 49.58%
    Green 48.37%
    Hyacinth 41.96%
    Bitter 37.98%
    Earthy 37.64%
    Honey 35.61%
    Spicy 33.44%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    2.0

    pKa est.
    6.88 (neutral)

    Molecular weight
    166.22 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Slow

    Boiling point est.
    244°C

    Flash point

    • 90.14 ˚C est.

  • Synonyms

    • Benzene, 1-methoxy-4-(2-methoxyethyl)-
    • RefChem:562511
    • 1-methoxy-4-(2-methoxyethyl)benzene
    • 80314-58-5
    • p-(2-Methoxyethyl)anisole
    • Benzene,1-methoxy-4-(2-methoxyethyl)-
    • p-Methoxyphenethyl Methyl Ether
    • p-Methoxyphenethyl methyl ether-d3
    • EINECS 279-449-1
    • p-(?-Methoxyethyl)-anisole; 1-(2-Methoxyethyl)-4-methoxybenzene; 2-(4-Methoxyphenyl)ethyl Methyl Ether
    • SCHEMBL792026
    • para-(2-methoxyethyl) anisole
    • Q856AD87HS
    • SCHEMBL4073089
    • SCHEMBL11490631
    • DTXSID60868567
    • FDA31458
    • MFCD17015353
    • DA-02667
    • NS00060229
    • G31270
    • EN300-6479803
    • 80314-58-5

  • Applications

    Benzene, 1-methoxy-4-(2-methoxyethyl)- (CAS 80314-58-5) is used as a chemical intermediate and specialty solvent in industrial manufacturing. In perfumery and cosmetics, it can function as a fragrance ingredient or fragrance precursor, contributing anisole-like notes and serving as a fixative or carrier. It is also employed as a processing solvent or aid in coatings, inks, and adhesives, supporting solubility of aromatic components and formulation of aromatic formulations. As a building block for more complex anisole derivatives, it is commonly evaluated for organic synthesis in polymer and pharmaceutical applications and may appear in consumer products as a fragrance additive or solvent under local regulatory controls.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1418.04
    methanol 1205.5
    isopropanol 953.34
    water 4.67
    ethyl acetate 1244.12
    n-propanol 1064.34
    acetone 424.51
    n-butanol 825.63
    acetonitrile 990.74
    DMF 472.62
    toluene 328.28
    isobutanol 562.05
    1,4-dioxane 2902.73
    methyl acetate 925.37
    THF 875.67
    2-butanone 487.73
    n-pentanol 484.05
    sec-butanol 726.48
    n-hexane 29.13
    ethylene glycol 585.32
    NMP 181.98
    cyclohexane 131.26
    DMSO 950.06
    n-butyl acetate 258.74
    n-octanol 87.3
    chloroform 2916.32
    n-propyl acetate 311.89
    acetic acid 1217.69
    dichloromethane 2420.86
    cyclohexanone 479.6
    propylene glycol 844.52
    isopropyl acetate 306.8
    DMAc 449.12
    2-ethoxyethanol 1285.74
    isopentanol 438.69
    n-heptane 34.43
    ethyl formate 539.98
    1,2-dichloroethane 1359.23
    n-hexanol 400.18
    2-methoxyethanol 2006.43
    isobutyl acetate 154.45
    tetrachloromethane 363.47
    n-pentyl acetate 102.59
    transcutol 1520.18
    n-heptanol 107.24
    ethylbenzene 127.29
    MIBK 141.62
    2-propoxyethanol 782.17
    tert-butanol 1137.04
    MTBE 508.99
    2-butoxyethanol 269.76
    propionic acid 793.46
    o-xylene 187.51
    formic acid 503.73
    diethyl ether 909.75
    m-xylene 157.7
    p-xylene 135.63
    chlorobenzene 400.71
    dimethyl carbonate 186.69
    n-octane 12.95
    formamide 664.94
    cyclopentanone 317.77
    2-pentanone 310.16
    anisole 369.56
    cyclopentyl methyl ether 374.01
    gamma-butyrolactone 531.04
    1-methoxy-2-propanol 1052.47
    pyridine 1137.26
    3-pentanone 273.65
    furfural 721.29
    n-dodecane 11.73
    diethylene glycol 864.74
    diisopropyl ether 112.19
    tert-amyl alcohol 638.04
    acetylacetone 367.11
    n-hexadecane 13.2
    acetophenone 238.63
    methyl propionate 601.22
    isopentyl acetate 187.53
    trichloroethylene 2137.31
    n-nonanol 82.79
    cyclohexanol 603.23
    benzyl alcohol 381.28
    2-ethylhexanol 155.2
    isooctanol 77.76
    dipropyl ether 219.37
    1,2-dichlorobenzene 304.03
    ethyl lactate 184.94
    propylene carbonate 325.16
    n-methylformamide 494.57
    2-pentanol 407.26
    n-pentane 45.45
    1-propoxy-2-propanol 392.79
    1-methoxy-2-propyl acetate 307.33
    2-(2-methoxypropoxy) propanol 211.48
    mesitylene 85.16
    ε-caprolactone 536.73
    p-cymene 66.46
    epichlorohydrin 1186.23
    1,1,1-trichloroethane 1120.08
    2-aminoethanol 951.44
    morpholine-4-carbaldehyde 733.82
    sulfolane 406.05
    2,2,4-trimethylpentane 24.75
    2-methyltetrahydrofuran 738.33
    n-hexyl acetate 138.34
    isooctane 16.7
    2-(2-butoxyethoxy)ethanol 349.38
    sec-butyl acetate 176.18
    tert-butyl acetate 255.02
    decalin 39.35
    glycerin 921.43
    diglyme 722.14
    acrylic acid 623.79
    isopropyl myristate 58.78
    n-butyric acid 918.95
    acetyl acetate 513.03
    di(2-ethylhexyl) phthalate 64.62
    ethyl propionate 290.85
    nitromethane 1295.09
    1,2-diethoxyethane 470.16
    benzonitrile 336.01
    trioctyl phosphate 40.34
    1-bromopropane 648.61
    gamma-valerolactone 761.28
    n-decanol 64.79
    triethyl phosphate 107.21
    4-methyl-2-pentanol 133.34
    propionitrile 685.05
    vinylene carbonate 410.71
    1,1,2-trichlorotrifluoroethane 1020.42
    DMS 185.81
    cumene 73.52
    2-octanol 56.38
    2-hexanone 194.03
    octyl acetate 76.98
    limonene 106.57
    1,2-dimethoxyethane 1128.87
    ethyl orthosilicate 112.68
    tributyl phosphate 57.01
    diacetone alcohol 302.08
    N,N-dimethylaniline 172.64
    acrylonitrile 766.36
    aniline 625.38
    1,3-propanediol 1283.35
    bromobenzene 405.1
    dibromomethane 1430.13
    1,1,2,2-tetrachloroethane 1685.25
    2-methyl-cyclohexyl acetate 136.91
    tetrabutyl urea 67.37
    diisobutyl methanol 83.35
    2-phenylethanol 277.25
    styrene 193.06
    dioctyl adipate 97.5
    dimethyl sulfate 221.76
    ethyl butyrate 210.47
    methyl lactate 307.77
    butyl lactate 100.21
    diethyl carbonate 177.49
    propanediol butyl ether 203.71
    triethyl orthoformate 153.74
    p-tert-butyltoluene 67.58
    methyl 4-tert-butylbenzoate 139.61
    morpholine 2935.06
    tert-butylamine 565.03
    n-dodecanol 53.89
    dimethoxymethane 606.62
    ethylene carbonate 378.62
    cyrene 190.09
    2-ethoxyethyl acetate 222.89
    2-ethylhexyl acetate 142.58
    1,2,4-trichlorobenzene 381.62
    4-methylpyridine 688.52
    dibutyl ether 129.86
    2,6-dimethyl-4-heptanol 83.35
    DEF 469.45
    dimethyl isosorbide 275.49
    tetrachloroethylene 1089.2
    eugenol 159.05
    triacetin 197.04
    span 80 176.32
    1,4-butanediol 461.65
    1,1-dichloroethane 1299.5
    2-methyl-1-pentanol 292.42
    methyl formate 354.53
    2-methyl-1-butanol 441.76
    n-decane 18.2
    butyronitrile 566.02
    3,7-dimethyl-1-octanol 91.38
    1-chlorooctane 66.01
    1-chlorotetradecane 30.53
    n-nonane 17.01
    undecane 14.07
    tert-butylcyclohexane 30.95
    cyclooctane 33.83
    cyclopentanol 440.04
    tetrahydropyran 1514.59
    tert-amyl methyl ether 300.6
    2,5,8-trioxanonane 467.68
    1-hexene 137.05
    2-isopropoxyethanol 612.98
    2,2,2-trifluoroethanol 372.46
    methyl butyrate 346.64

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction