Benzene, ((1-ethoxyethoxy)methyl)-

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  • Identifiers

    CAS number
    66222-24-0

    Molecular formula
    C11H16O2

    SMILES
    CCOC(C)OCC1=CC=CC=C1

  • Odor profile

    Fragrance
    Green 89.77%
    Fruity 79.34%
    Sweet 77.08%
    Almond 55.52%
    Bitter 44.16%
    Floral 41.39%
    Fresh 40.7%
    Spicy 39.44%
    Hyacinth 38.59%
    Earthy 37.48%

     

    Flavor
    Green 67.69%
    Fruity 65.89%
    Floral 60.72%
    Earthy 47.89%
    Rose 38.65%
    Sweet 36.37%
    Spicy 32.51%
    Pineapple 31.59%
    Wine 30.94%
    Bitter 30.6%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    2.3

    pKa est.
    6.7 (neutral)

    Molecular weight
    180.24 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderately slow

    Boiling point est.
    228°C

    Flash point

    • 89.85 ˚C est.

  • Synonyms

    • 66222-24-0
    • Acetaldehyde benzyl ethyl acetal
    • 1-ethoxyethoxymethylbenzene
    • Benzene, ((1-ethoxyethoxy)methyl)-
    • [(1-ETHOXYETHOXY)METHYL]BENZENE
    • DTXSID20867213
    • QZLCHWYDADOBGM-UHFFFAOYSA-N
    • AKOS006327939

  • Applications

    Benzene, ((1-ethoxyethoxy)methyl)- (CAS 66222-24-0) is primarily used as an organic synthesis intermediate and as a protecting group for alcohol functionality in multi-step routes. It can serve as a precursor for benzene-based specialty chemicals in pharmaceutical and agrochemical manufacturing. In materials science, it is evaluated as a building block for specialty polymers and coatings/resins, where the acetal moiety provides stability during processing and can be removed by deprotection under suitable conditions. It also functions as an industrial intermediate for the preparation of additional benzene-derived fine chemicals used in various chemical manufacturing processes.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1191.75
    methanol 1088.17
    isopropanol 751.59
    water 2.53
    ethyl acetate 1125.35
    n-propanol 850.41
    acetone 725.27
    n-butanol 853.59
    acetonitrile 1052.3
    DMF 470.81
    toluene 448.58
    isobutanol 582.61
    1,4-dioxane 2007.5
    methyl acetate 773.01
    THF 1227.07
    2-butanone 653.09
    n-pentanol 661.47
    sec-butanol 692.44
    n-hexane 299.44
    ethylene glycol 212.44
    NMP 406.91
    cyclohexane 446.18
    DMSO 975.18
    n-butyl acetate 729.94
    n-octanol 230.27
    chloroform 3990.82
    n-propyl acetate 586.73
    acetic acid 1156.24
    dichloromethane 3537.86
    cyclohexanone 869.2
    propylene glycol 257.99
    isopropyl acetate 521.71
    DMAc 620.05
    2-ethoxyethanol 839.48
    isopentanol 637.98
    n-heptane 153.88
    ethyl formate 450.94
    1,2-dichloroethane 1830.52
    n-hexanol 662.99
    2-methoxyethanol 947.17
    isobutyl acetate 375.44
    tetrachloromethane 521.42
    n-pentyl acetate 319.77
    transcutol 2031.92
    n-heptanol 203.04
    ethylbenzene 250.47
    MIBK 317.02
    2-propoxyethanol 793.37
    tert-butanol 941.21
    MTBE 873.46
    2-butoxyethanol 353.77
    propionic acid 625.1
    o-xylene 259.94
    formic acid 308.98
    diethyl ether 1481.84
    m-xylene 244.58
    p-xylene 330.63
    chlorobenzene 650.04
    dimethyl carbonate 216.83
    n-octane 49.81
    formamide 359.04
    cyclopentanone 587.2
    2-pentanone 510.79
    anisole 483.24
    cyclopentyl methyl ether 657.01
    gamma-butyrolactone 739.68
    1-methoxy-2-propanol 606.17
    pyridine 1170.09
    3-pentanone 486.52
    furfural 714.72
    n-dodecane 39.44
    diethylene glycol 529.81
    diisopropyl ether 297.88
    tert-amyl alcohol 702.7
    acetylacetone 565.7
    n-hexadecane 44.81
    acetophenone 387.66
    methyl propionate 539.54
    isopentyl acetate 544.88
    trichloroethylene 2619.48
    n-nonanol 206.95
    cyclohexanol 704.58
    benzyl alcohol 380.96
    2-ethylhexanol 373.78
    isooctanol 164.1
    dipropyl ether 614.67
    1,2-dichlorobenzene 582.14
    ethyl lactate 235.06
    propylene carbonate 518.52
    n-methylformamide 295.0
    2-pentanol 527.08
    n-pentane 217.12
    1-propoxy-2-propanol 537.62
    1-methoxy-2-propyl acetate 498.27
    2-(2-methoxypropoxy) propanol 375.86
    mesitylene 167.49
    ε-caprolactone 808.47
    p-cymene 153.24
    epichlorohydrin 1179.8
    1,1,1-trichloroethane 1449.5
    2-aminoethanol 418.88
    morpholine-4-carbaldehyde 719.35
    sulfolane 758.81
    2,2,4-trimethylpentane 85.48
    2-methyltetrahydrofuran 1078.68
    n-hexyl acetate 444.19
    isooctane 54.35
    2-(2-butoxyethoxy)ethanol 518.95
    sec-butyl acetate 381.22
    tert-butyl acetate 482.74
    decalin 143.23
    glycerin 317.66
    diglyme 974.36
    acrylic acid 488.55
    isopropyl myristate 182.5
    n-butyric acid 930.79
    acetyl acetate 698.73
    di(2-ethylhexyl) phthalate 161.32
    ethyl propionate 467.09
    nitromethane 1064.79
    1,2-diethoxyethane 949.29
    benzonitrile 489.6
    trioctyl phosphate 112.42
    1-bromopropane 1199.23
    gamma-valerolactone 795.44
    n-decanol 155.29
    triethyl phosphate 232.32
    4-methyl-2-pentanol 245.4
    propionitrile 709.19
    vinylene carbonate 533.84
    1,1,2-trichlorotrifluoroethane 866.48
    DMS 368.47
    cumene 169.25
    2-octanol 143.74
    2-hexanone 500.18
    octyl acetate 214.43
    limonene 244.4
    1,2-dimethoxyethane 1198.86
    ethyl orthosilicate 238.52
    tributyl phosphate 170.26
    diacetone alcohol 387.07
    N,N-dimethylaniline 302.32
    acrylonitrile 631.64
    aniline 541.74
    1,3-propanediol 567.37
    bromobenzene 762.52
    dibromomethane 2384.24
    1,1,2,2-tetrachloroethane 2362.06
    2-methyl-cyclohexyl acetate 337.49
    tetrabutyl urea 197.63
    diisobutyl methanol 189.58
    2-phenylethanol 340.12
    styrene 358.31
    dioctyl adipate 269.89
    dimethyl sulfate 293.13
    ethyl butyrate 529.47
    methyl lactate 215.85
    butyl lactate 230.63
    diethyl carbonate 372.8
    propanediol butyl ether 300.32
    triethyl orthoformate 367.53
    p-tert-butyltoluene 146.68
    methyl 4-tert-butylbenzoate 289.27
    morpholine 1805.1
    tert-butylamine 674.21
    n-dodecanol 125.35
    dimethoxymethane 522.64
    ethylene carbonate 512.2
    cyrene 301.89
    2-ethoxyethyl acetate 417.44
    2-ethylhexyl acetate 447.39
    1,2,4-trichlorobenzene 654.35
    4-methylpyridine 877.18
    dibutyl ether 475.06
    2,6-dimethyl-4-heptanol 189.58
    DEF 640.15
    dimethyl isosorbide 519.36
    tetrachloroethylene 1554.17
    eugenol 286.95
    triacetin 431.86
    span 80 334.8
    1,4-butanediol 283.62
    1,1-dichloroethane 1665.78
    2-methyl-1-pentanol 515.37
    methyl formate 240.92
    2-methyl-1-butanol 617.21
    n-decane 67.14
    butyronitrile 749.46
    3,7-dimethyl-1-octanol 239.53
    1-chlorooctane 213.7
    1-chlorotetradecane 91.48
    n-nonane 69.37
    undecane 48.37
    tert-butylcyclohexane 121.54
    cyclooctane 118.39
    cyclopentanol 479.36
    tetrahydropyran 1735.43
    tert-amyl methyl ether 584.15
    2,5,8-trioxanonane 677.41
    1-hexene 702.94
    2-isopropoxyethanol 538.74
    2,2,2-trifluoroethanol 322.63
    methyl butyrate 615.45

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction