Benzaldehyde, 4-(2-hydroxyethoxy)-

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  • Identifiers

    CAS number
    22042-73-5

    Molecular formula
    C9H10O3

    SMILES
    C1=CC(=CC=C1C=O)OCCO

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Sweet 63.84%
    Floral 54.16%
    Vanilla 52.27%
    Balsamic 43.0%
    Spicy 37.85%
    Powdery 36.76%
    Creamy 33.19%
    Aromatic 31.88%
    Cinnamon 31.83%
    Hay 30.58%

     

    Flavor
    Sweet 87.04%
    Floral 59.5%
    Vanilla 58.3%
    Balsam 48.3%
    Bitter 48.12%
    Powdery 47.8%
    Almond 44.64%
    Creamy 42.96%
    Hawthorn 40.94%
    Cherry 40.11%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    1.1

    pKa est.
    6.98 (neutral)

    Molecular weight
    166.17 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    351°C

    Flash point

    • 156.04 ˚C est.

  • Synonyms

    • 4-(2-hydroxyethoxy)benzaldehyde
    • 22042-73-5
    • Benzaldehyde, 4-(2-hydroxyethoxy)-
    • DTXSID4066755
    • RefChem:561354
    • DTXCID3036600
    • 695-647-4
    • 4-(2-Hydroxy-ethoxy)-benzaldehyde
    • MFCD00191450
    • CHEMBL574227
    • Benzaldehyde, p-(2-hydroxyethoxy)-
    • 4-hydroxyethoxybenzaldehyde
    • Hydroxyethoxybenzaldehyde
    • 4-hydroxyethoxy benzaldehyde
    • 4-(hydroxyethoxy)benzaldehyde
    • SCHEMBL145373
    • 4(2-hydroxyethoxy)benzaldehyde
    • p-(2-hydroxyethoxy)benzaldehyde
    • SCHEMBL23478155
    • 4-(2-hydroxyethoxy)-benzaldehyde
    • 4-(2-hydroxyethyloxy)benzaldehyde
    • ALBB-030135
    • CS-M2027
    • XAA04273
    • BDBM50378351
    • SBB010472
    • AKOS000192639
    • EBC-612789
    • GS-3267
    • AC-18202
    • SY050502
    • DB-045771
    • H0859
    • ST50321542
    • EN300-227122
    • F19560
    • F042075
    • Z295452566
    • 22042-73-5

  • Applications

    Benzaldehyde, 4-(2-hydroxyethoxy)- serves primarily as a fragrance intermediate and odorant in perfumery, enabling tailored aroma notes for consumer products. It is commonly used as a chemical intermediate in cosmetics and personal-care formulations through derivatization of the aldehyde/ether scaffold to create specialty fragrance ingredients. The compound may be employed in household products as a fragrance additive to impart specific scent profiles. In industrial manufacturing, it functions as a building block for polymers, resins, coatings, and adhesive systems, providing a functionalized aromatic core for further synthesis. It also appears as a synthetic intermediate in pharmaceutical research and development, supporting the preparation of more complex active compounds. Usage is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 116.73
    methanol 248.72
    isopropanol 58.85
    water 5.08
    ethyl acetate 106.86
    n-propanol 64.59
    acetone 180.53
    n-butanol 49.75
    acetonitrile 136.95
    DMF 336.17
    toluene 11.95
    isobutanol 35.22
    1,4-dioxane 197.09
    methyl acetate 135.93
    THF 188.36
    2-butanone 100.52
    n-pentanol 45.38
    sec-butanol 39.59
    n-hexane 0.99
    ethylene glycol 138.41
    NMP 180.4
    cyclohexane 2.21
    DMSO 1041.56
    n-butyl acetate 60.31
    n-octanol 16.58
    chloroform 65.37
    n-propyl acetate 74.79
    acetic acid 303.49
    dichloromethane 114.34
    cyclohexanone 95.98
    propylene glycol 82.48
    isopropyl acetate 44.82
    DMAc 340.11
    2-ethoxyethanol 198.65
    isopentanol 45.71
    n-heptane 1.94
    ethyl formate 76.06
    1,2-dichloroethane 108.25
    n-hexanol 36.19
    2-methoxyethanol 274.84
    isobutyl acetate 38.21
    tetrachloromethane 7.16
    n-pentyl acetate 21.15
    transcutol 611.04
    n-heptanol 14.33
    ethylbenzene 10.13
    MIBK 42.49
    2-propoxyethanol 102.06
    tert-butanol 119.63
    MTBE 57.19
    2-butoxyethanol 51.35
    propionic acid 113.3
    o-xylene 15.41
    formic acid 286.6
    diethyl ether 49.98
    m-xylene 12.41
    p-xylene 13.39
    chlorobenzene 27.25
    dimethyl carbonate 52.59
    n-octane 0.96
    formamide 465.89
    cyclopentanone 140.84
    2-pentanone 62.82
    anisole 53.93
    cyclopentyl methyl ether 55.1
    gamma-butyrolactone 197.48
    1-methoxy-2-propanol 133.35
    pyridine 96.55
    3-pentanone 47.84
    furfural 207.9
    n-dodecane 1.16
    diethylene glycol 155.56
    diisopropyl ether 12.39
    tert-amyl alcohol 71.17
    acetylacetone 108.74
    n-hexadecane 1.3
    acetophenone 58.91
    methyl propionate 84.36
    isopentyl acetate 49.28
    trichloroethylene 178.1
    n-nonanol 15.75
    cyclohexanol 37.23
    benzyl alcohol 52.72
    2-ethylhexanol 23.61
    isooctanol 13.52
    dipropyl ether 29.94
    1,2-dichlorobenzene 32.27
    ethyl lactate 52.41
    propylene carbonate 93.35
    n-methylformamide 221.46
    2-pentanol 28.3
    n-pentane 0.96
    1-propoxy-2-propanol 69.98
    1-methoxy-2-propyl acetate 73.67
    2-(2-methoxypropoxy) propanol 90.82
    mesitylene 10.35
    ε-caprolactone 88.68
    p-cymene 11.73
    epichlorohydrin 235.43
    1,1,1-trichloroethane 40.91
    2-aminoethanol 139.06
    morpholine-4-carbaldehyde 232.64
    sulfolane 290.03
    2,2,4-trimethylpentane 1.87
    2-methyltetrahydrofuran 91.96
    n-hexyl acetate 34.28
    isooctane 1.36
    2-(2-butoxyethoxy)ethanol 112.42
    sec-butyl acetate 40.98
    tert-butyl acetate 54.8
    decalin 2.39
    glycerin 179.48
    diglyme 235.31
    acrylic acid 133.4
    isopropyl myristate 16.83
    n-butyric acid 98.74
    acetyl acetate 70.49
    di(2-ethylhexyl) phthalate 21.52
    ethyl propionate 56.72
    nitromethane 535.46
    1,2-diethoxyethane 93.95
    benzonitrile 52.27
    trioctyl phosphate 14.48
    1-bromopropane 26.72
    gamma-valerolactone 195.12
    n-decanol 12.7
    triethyl phosphate 32.85
    4-methyl-2-pentanol 20.66
    propionitrile 74.89
    vinylene carbonate 89.68
    1,1,2-trichlorotrifluoroethane 201.12
    DMS 55.61
    cumene 9.35
    2-octanol 9.44
    2-hexanone 56.46
    octyl acetate 20.56
    limonene 16.9
    1,2-dimethoxyethane 247.35
    ethyl orthosilicate 28.85
    tributyl phosphate 22.08
    diacetone alcohol 89.77
    N,N-dimethylaniline 37.68
    acrylonitrile 123.97
    aniline 43.41
    1,3-propanediol 133.83
    bromobenzene 21.33
    dibromomethane 51.91
    1,1,2,2-tetrachloroethane 117.9
    2-methyl-cyclohexyl acetate 39.14
    tetrabutyl urea 31.88
    diisobutyl methanol 16.94
    2-phenylethanol 40.03
    styrene 13.72
    dioctyl adipate 34.27
    dimethyl sulfate 122.61
    ethyl butyrate 52.78
    methyl lactate 73.21
    butyl lactate 32.87
    diethyl carbonate 45.16
    propanediol butyl ether 62.62
    triethyl orthoformate 42.22
    p-tert-butyltoluene 11.12
    methyl 4-tert-butylbenzoate 47.24
    morpholine 215.77
    tert-butylamine 43.45
    n-dodecanol 10.61
    dimethoxymethane 156.73
    ethylene carbonate 68.35
    cyrene 83.96
    2-ethoxyethyl acetate 51.51
    2-ethylhexyl acetate 35.55
    1,2,4-trichlorobenzene 44.63
    4-methylpyridine 63.27
    dibutyl ether 24.78
    2,6-dimethyl-4-heptanol 16.94
    DEF 105.9
    dimethyl isosorbide 117.83
    tetrachloroethylene 70.67
    eugenol 54.39
    triacetin 65.66
    span 80 51.72
    1,4-butanediol 71.04
    1,1-dichloroethane 48.27
    2-methyl-1-pentanol 42.24
    methyl formate 164.28
    2-methyl-1-butanol 37.2
    n-decane 1.66
    butyronitrile 56.42
    3,7-dimethyl-1-octanol 21.37
    1-chlorooctane 8.41
    1-chlorotetradecane 4.19
    n-nonane 1.43
    undecane 1.34
    tert-butylcyclohexane 2.45
    cyclooctane 1.08
    cyclopentanol 41.54
    tetrahydropyran 81.17
    tert-amyl methyl ether 42.17
    2,5,8-trioxanonane 169.87
    1-hexene 6.4
    2-isopropoxyethanol 105.52
    2,2,2-trifluoroethanol 119.48
    methyl butyrate 78.74

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction