Azelaic Acid

Overview IFRA Botanical Request a quote

  • Identifiers

    CAS number
    123-99-9

    Molecular formula
    C9H16O4

    SMILES
    C(CCCC(=O)O)CCCC(=O)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Sour 49.23%
    Fatty 45.55%
    Odorless 41.7%
    Cheesy 41.67%
    Dairy 29.4%
    Milky 28.31%
    Waxy 27.14%
    Creamy 26.11%
    Savory 25.87%
    Buttery 25.45%

    Scent© AI

  • Properties

    XLogP3-AA
    1.6

    pKa est.
    6.14 (neutral)

    Molecular weight
    188.22 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Melting point expt.

    • 106.5 °C
    • 160.5 °C

    Boiling point

    • 286.5 °C at 1.00E+02 mm Hg
    • 357.1 °C; 287 °C at 100 mm Hg
    • BP: 365 °C (decomposes)
    • Distills above 360 °C with partial anhydride formation. BP: 286.5 °C at 100 mm Hg; 265 °C at 50 mm Hg; 237 °C at 15 mm Hg; 225 dg C at 10 mm Hg

    Flash point est.
    183.25 ˚C

    Flash point expt.

    • 210 °C (closed cup)

    Solubility expt.

    • 2400 mg/L (at 20 °C)
    • Slightly soluble in ethy ether, benzene, DMSO; soluble in ethanol
    • Soluble in hot water, alcohol and organic solvents
    • One liter of water dissolves 1.0 g at 1.0 °C; 2.4 g at 20 °C; 8.2 g at 50 °C; 22 g at 50 °C ... 1000 g ether dissolves 18.8 g at 11 °C and 26.8 g at 15 °C
    • In water, 2.40X10+3 mg/L at 20 °C
    • 2.4 mg/mL

  • Synonyms

    • azelaic acid
    • NONANEDIOIC ACID
    • 123-99-9
    • Finacea
    • Anchoic acid
    • Azelex
    • Lepargylic acid
    • 1,7-Heptanedicarboxylic acid
    • Skinoren
    • 1,9-Nonanedioic acid
    • Heptanedicarboxylic acid
    • n-Nonanedioic acid
    • Emerox 1110
    • Emerox 1144
    • acide azelaique
    • azelate
    • Acido azelaico
    • acidum azelaicum
    • Finevin
    • Azelainic acid
    • 1,7-Dicarboxyheptane
    • Azelaic acid, technical grade
    • Skinorem
    • ZK 62498
    • ZK-62498
    • Emery's L-110
    • Acidum azelaicum [Latin]
    • NSC 19493
    • Azelainsaeure
    • Nonandisaeure
    • CHEBI:48131
    • UNII-F2VW3D43YT
    • EINECS 204-669-1
    • F2VW3D43YT
    • NSC-19493
    • BRN 1101094
    • DTXSID8021640
    • AI3-06299
    • HSDB 7659
    • NSC19493
    • MFCD00004432
    • MLS000069659
    • DTXCID501640
    • EC 204-669-1
    • 4-02-00-02055 (Beilstein Handbook Reference)
    • NCGC00014993-07
    • SMR000059164
    • Acidum azelaicum (Latin)
    • Azalaic Acid
    • Acide azelaique [French]
    • Acido azelaico [Spanish]
    • AZELAIC ACID (MART.)
    • AZELAIC ACID [MART.]
    • heptane-1,7-dicarboxylic acid
    • Azelaic acid [USAN:INN]
    • Azelaic
    • CAS-123-99-9
    • Finacea (TN)
    • Azelaic acid 99%
    • Azelex (TN)
    • SR-01000075671
    • Azelaic acid (USAN/INN)
    • Azelaicacidtech
    • Azelainsaure
    • Lepargylate
    • Nonandisaure
    • Anchoate
    • azelaic-acid
    • n-Nonanedioate
    • Acidum acelaicum
    • Finacea Foam
    • 1tuf
    • Azelaic Acid Gel
    • 1,9-Nonanedioate
    • SH-441
    • AGN-191861
    • Azelaic acid, 98%
    • Spectrum_000057
    • Water-solubleazelaicacid
    • Opera_ID_740
    • Azelaic acid (Standard)
    • 1,7-Heptanedicarboxylate
    • Spectrum2_000995
    • Spectrum3_000278
    • Spectrum4_000401
    • Spectrum5_001304
    • Water-soluble azelaic acid
    • AZELAIC ACID [MI]
    • Epitope ID:187039
    • AZELAIC ACID [INN]
    • Lopac-246379
    • SCHEMBL3887
    • AZELAIC ACID [HSDB]
    • AZELAIC ACID [USAN]
    • CHEMBL1238
    • Lopac0_000051
    • AZELAIC ACID [VANDF]
    • BSPBio_001756
    • KBioGR_000662
    • KBioSS_000437
    • Nonanedioic acid Azelaic acid
    • MLS001148615
    • BIDD:GT0315
    • DivK1c_000532
    • SPECTRUM1500648
    • SPBio_001089
    • AZELAIC ACID [WHO-DD]
    • GTPL7484
    • HMS501K14
    • HY-B0704R
    • KBio1_000532
    • KBio2_000437
    • KBio2_003005
    • KBio2_005573
    • KBio3_001256
    • Azelaic acid, analytical standard
    • D10AX03
    • NINDS_000532
    • HMS1921O11
    • HMS2092E22
    • HMS2234D10
    • HMS3260K03
    • HMS3372J07
    • Pharmakon1600-01500648
    • AZELAIC ACID [ORANGE BOOK]
    • BCP18690
    • HY-B0704
    • Tox21_110063

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 198.28
    methanol 247.83
    isopropanol 104.32
    water 1.19
    ethyl acetate 26.27
    n-propanol 85.1
    acetone 80.81
    n-butanol 64.34
    acetonitrile 10.42
    DMF 487.15
    toluene 4.88
    isobutanol 49.04
    1,4-dioxane 43.27
    methyl acetate 20.13
    THF 250.1
    2-butanone 36.7
    n-pentanol 44.22
    sec-butanol 50.89
    n-hexane 3.9
    ethylene glycol 80.02
    NMP 410.91
    cyclohexane 1.65
    DMSO 920.25
    n-butyl acetate 32.94
    n-octanol 20.8
    chloroform 11.53
    n-propyl acetate 23.63
    acetic acid 136.04
    dichloromethane 11.12
    cyclohexanone 86.65
    propylene glycol 107.37
    isopropyl acetate 26.44
    DMAc 315.59
    2-ethoxyethanol 114.84
    isopentanol 53.22
    n-heptane 1.7
    ethyl formate 25.62
    1,2-dichloroethane 18.24
    n-hexanol 37.06
    2-methoxyethanol 233.5
    isobutyl acetate 15.55
    tetrachloromethane 2.99
    n-pentyl acetate 23.94
    transcutol 274.33
    n-heptanol 21.03
    ethylbenzene 7.87
    MIBK 38.38
    2-propoxyethanol 101.16
    tert-butanol 133.3
    MTBE 30.51
    2-butoxyethanol 57.51
    propionic acid 77.59
    o-xylene 10.39
    formic acid 107.42
    diethyl ether 15.63
    m-xylene 9.47
    p-xylene 10.13
    chlorobenzene 7.93
    dimethyl carbonate 19.04
    n-octane 0.93
    formamide 144.23
    cyclopentanone 170.49
    2-pentanone 45.67
    anisole 23.03
    cyclopentyl methyl ether 65.87
    gamma-butyrolactone 192.73
    1-methoxy-2-propanol 174.59
    pyridine 29.78
    3-pentanone 22.9
    furfural 131.9
    n-dodecane 0.78
    diethylene glycol 103.94
    diisopropyl ether 8.51
    tert-amyl alcohol 80.07
    acetylacetone 69.2
    n-hexadecane 0.88
    acetophenone 36.01
    methyl propionate 31.13
    isopentyl acetate 38.7
    trichloroethylene 30.85
    n-nonanol 18.89
    cyclohexanol 45.24
    benzyl alcohol 31.84
    2-ethylhexanol 21.44
    isooctanol 17.44
    dipropyl ether 15.51
    1,2-dichlorobenzene 12.18
    ethyl lactate 30.47
    propylene carbonate 79.57
    n-methylformamide 138.79
    2-pentanol 35.99
    n-pentane 1.69
    1-propoxy-2-propanol 72.86
    1-methoxy-2-propyl acetate 49.83
    2-(2-methoxypropoxy) propanol 75.73
    mesitylene 8.81
    ε-caprolactone 87.98
    p-cymene 7.57
    epichlorohydrin 101.71
    1,1,1-trichloroethane 10.43
    2-aminoethanol 135.76
    morpholine-4-carbaldehyde 211.01
    sulfolane 429.22
    2,2,4-trimethylpentane 2.0
    2-methyltetrahydrofuran 91.25
    n-hexyl acetate 37.23
    isooctane 1.59
    2-(2-butoxyethoxy)ethanol 102.08
    sec-butyl acetate 17.92
    tert-butyl acetate 45.24
    decalin 2.74
    glycerin 162.4
    diglyme 148.76
    acrylic acid 74.76
    isopropyl myristate 14.28
    n-butyric acid 81.63
    acetyl acetate 18.8
    di(2-ethylhexyl) phthalate 23.55
    ethyl propionate 22.34
    nitromethane 129.18
    1,2-diethoxyethane 34.34
    benzonitrile 19.58
    trioctyl phosphate 17.18
    1-bromopropane 8.02
    gamma-valerolactone 206.9
    n-decanol 13.8
    triethyl phosphate 19.8
    4-methyl-2-pentanol 25.57
    propionitrile 12.28
    vinylene carbonate 53.95
    1,1,2-trichlorotrifluoroethane 117.7
    DMS 28.8
    cumene 8.34
    2-octanol 13.95
    2-hexanone 32.26
    octyl acetate 19.85
    limonene 10.8
    1,2-dimethoxyethane 126.46
    ethyl orthosilicate 18.5
    tributyl phosphate 21.84
    diacetone alcohol 106.54
    N,N-dimethylaniline 27.43
    acrylonitrile 20.64
    aniline 17.15
    1,3-propanediol 141.7
    bromobenzene 6.25
    dibromomethane 8.68
    1,1,2,2-tetrachloroethane 34.92
    2-methyl-cyclohexyl acetate 30.82
    tetrabutyl urea 34.97
    diisobutyl methanol 15.2
    2-phenylethanol 28.75
    styrene 7.67
    dioctyl adipate 29.95
    dimethyl sulfate 71.88
    ethyl butyrate 24.28
    methyl lactate 57.11
    butyl lactate 39.83
    diethyl carbonate 16.12
    propanediol butyl ether 84.37
    triethyl orthoformate 21.86
    p-tert-butyltoluene 8.02
    methyl 4-tert-butylbenzoate 51.19
    morpholine 102.03
    tert-butylamine 54.78
    n-dodecanol 9.87
    dimethoxymethane 104.18
    ethylene carbonate 40.33
    cyrene 81.58
    2-ethoxyethyl acetate 36.09
    2-ethylhexyl acetate 25.46
    1,2,4-trichlorobenzene 16.22
    4-methylpyridine 32.29
    dibutyl ether 14.61
    2,6-dimethyl-4-heptanol 15.2
    DEF 78.97
    dimethyl isosorbide 118.95
    tetrachloroethylene 24.03
    eugenol 51.91
    triacetin 46.28
    span 80 67.23
    1,4-butanediol 52.44
    1,1-dichloroethane 8.47
    2-methyl-1-pentanol 38.31
    methyl formate 63.14
    2-methyl-1-butanol 44.28
    n-decane 1.31
    butyronitrile 17.96
    3,7-dimethyl-1-octanol 21.37
    1-chlorooctane 6.33
    1-chlorotetradecane 2.78
    n-nonane 1.22
    undecane 0.98
    tert-butylcyclohexane 2.97
    cyclooctane 0.93
    cyclopentanol 83.42
    tetrahydropyran 38.92
    tert-amyl methyl ether 30.67
    2,5,8-trioxanonane 117.9
    1-hexene 11.57
    2-isopropoxyethanol 66.77
    2,2,2-trifluoroethanol 41.85
    methyl butyrate 36.04

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction

Botanical

Name CAS Botanical Proportion
Genet absolute 2 8023-80-1 Spartium junceum L., fam. Leguminosae (Papilionaceae) 0.03%