Astragaloside A

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  • Identifiers

    CAS number
    83207-58-3

    Molecular formula
    C41H68O14

    SMILES
    C[C@]12CC[C@@]34C[C@@]35CC[C@@H](C([C@@H]5[C@H](C[C@H]4[C@@]1(C[C@@H]([C@@H]2[C@@]6(CC[C@@H](O6)C(C)(C)O)C)O)C)O[C@H]7[C@@H]([C@H]([C@@H]([C@H](O7)CO)O)O)O)(C)C)O[C@H]8[C@@H]([C@H]([C@@H](CO8)O)O)O

    Safety labels

  • Odor profile

    Fragrance
    Woody 51.1%
    Odorless 45.28%
    Sweet 38.37%
    Amber 30.27%
    Balsamic 30.17%
    Spicy 29.98%
    Mint 29.83%
    Cooling 29.36%
    Dry 26.42%
    Sandalwood 25.01%

     

    Flavor
    Bitter 46.93%
    Fatty 34.42%
    Sweet 33.67%
    Odorless 26.85%
    Sweet-like 25.68%
    Earthy 22.87%
    Metallic 22.8%
    Herbal 22.24%
    Cedarleaf 22.16%
    Mentholic 21.59%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    1.3

    pKa est.
    4.66 (weak acid)

    Molecular weight
    785.0 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Boiling point est.
    983°C

    Flash point

    • 197.7 ˚C est.

  • Synonyms

    • Astragaloside A
    • 83207-58-3
    • Cyclosiversioside F
    • Astragaloside-A
    • Astramembrannin I
    • 3A592W8XKE
    • DTXSID301347884
    • (2R,3R,4S,5S,6R)-2-[[(1S,3R,6S,8R,9S,11S,12S,14S,15R,16R)-14-hydroxy-15-[(2S,5R)-5-(2-hydroxypropan-2-yl)-2-methyloxolan-2-yl]-7,7,12,16-tetramethyl-6-[(2S,3R,4S,5R)-3,4,5-trihydroxyoxan-2-yl]oxy-9-pentacyclo[9.7.0.01,3.03,8.012,16]octadecanyl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triol
    • (2R,3R,4S,5S,6R)-2-(((1S,3R,6S,8R,9S,11S,12S,14S,15R,16R)-14-hydroxy-15-((2S,5R)-5-(2-hydroxypropan-2-yl)-2-methyloxolan-2-yl)-7,7,12,16-tetramethyl-6-((2S,3R,4S,5R)-3,4,5-trihydroxyoxan-2-yl)oxy-9-pentacyclo(9.7.0.01,3.03,8.012,16)octadecanyl)oxy)-6-(hydroxymethyl)oxane-3,4,5-triol
    • RefChem:115337
    • DTXCID001776624
    • Astragalin A
    • C41H68O14
    • (2R,3R,4S,5S,6R)-2-(((2aR,3R,4S,5aS,5bS,7S,7aR,9S,11aR,12aS)-4-Hydroxy-3-((2S,5R)-5-(2-hydroxypropan-2-yl)-2-methyltetrahydrofuran-2-yl)-2a,5a,8,8-tetramethyl-9-(((2S,3R,4S,5R)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)hexadecahydrocyclopenta[a]cyclopropa[e]phenanthren-7-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
    • UNII-3A592W8XKE
    • Astragaloside A?
    • astragaloside iv(p)
    • (+)-ASTRAGALOSIDE A
    • orb1300805
    • SCHEMBL29437837
    • HMS3884H17
    • Astragaloside A (Astragaloside IV)
    • HY-N0099
    • s2415
    • AKOS022168196
    • CCG-270471
    • CS-3710
    • EBC-616319
    • SY289865
    • G79087
    • BRD-K08188887-001-02-4
    • Q27256953
    • (2R,3R,4S,5S,6R)-2-[[(1S,3R,6S,8R,9S,11S,12S,14S,15R,16R)-14-hydroxy-15-[(2S,5R)-5-(1-hydroxy-1-methyl-ethyl)-2-methyl-tetrahydrofuran-2-yl]-7,7,12,16-tetramethyl-6-[(2S,3R,4S,5R)-3,4,5-trihydroxytetrahydropyran-2-yl]oxy-9-pentacyclo[9.7.0.01,3.03,8.012,16]octadecanyl]oxy]-6-(hydroxymethyl)tetrahydropyran-3,4,5-triol
    • (2R,3R,4S,5S,6R)-2-{[(1S,3R,6S,8R,9S,11S,12S,14S,15R,16R)-14-hydroxy-15-[(2S,5R)-5-(2-hydroxypropan-2-yl)-2-methyloxolan-2-yl]-7,7,12,16-tetramethyl-6-{[(2S,3R,4S,5R)-3,4,5-trihydroxyoxan-2-yl]oxy}pentacyclo[9.7.0.0^{1,3}.0^{3,8}.0^{12,16}]octadecan-9-yl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triol
    • .BETA.-D-GLUCOPYRANOSIDE, (3.BETA.,6.ALPHA.,16.BETA.,24R)-20,24-EPOXY-16,25-DIHYDROXY-3-(.BETA.-D-XYLOPYRANOSYLOXY)-9,19-CYCLOLANOSTAN-6-YL-
    • beta-D-Glucopyranoside, (3beta,6alpha,16beta,24R)-20,24-epoxy-16,25-dihydroxy-3-(beta-D-xylopyranosyloxy)-9,19-cyclolanostan-6-yl
    • 83207-58-3

  • Applications

    Astragaloside A is a triterpene glycoside isolated from Astragalus membranaceus (CAS 83207-58-3) and is mainly encountered in research, quality-control, and botanical extract workflows rather than bulk industrial use. Real-world applications include serving as a marker compound and reference standard for characterizing Astragalus-based extracts in pharmaceutical and nutraceutical development; being investigated as a bioactive constituent in pharmacological research to support structure–activity studies; appearing as a component of botanical extracts in cosmetic formulations within personal care products; and providing a target molecule for analytical method development (e.g., LC–MS) and chemotaxonomic studies of saponin chemistry.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 14.14
    methanol 45.3
    isopropanol 3.94
    water 0.18
    ethyl acetate 5.52
    n-propanol 7.4
    acetone 10.66
    n-butanol 4.03
    acetonitrile 4.39
    DMF 47.91
    toluene 0.72
    isobutanol 2.53
    1,4-dioxane 15.08
    methyl acetate 6.31
    THF 34.24
    2-butanone 7.47
    n-pentanol 2.35
    sec-butanol 2.23
    n-hexane 0.05
    ethylene glycol 11.46
    NMP 43.39
    cyclohexane 0.07
    DMSO 73.33
    n-butyl acetate 2.78
    n-octanol 1.88
    chloroform 8.93
    n-propyl acetate 2.33
    acetic acid 62.36
    dichloromethane 7.73
    cyclohexanone 9.11
    propylene glycol 10.56
    isopropyl acetate 3.21
    DMAc 38.58
    2-ethoxyethanol 22.9
    isopentanol 1.9
    n-heptane 0.07
    ethyl formate 7.61
    1,2-dichloroethane 4.06
    n-hexanol 2.32
    2-methoxyethanol 59.0
    isobutyl acetate 1.27
    tetrachloromethane 1.05
    n-pentyl acetate 4.32
    transcutol 30.4
    n-heptanol 2.62
    ethylbenzene 0.32
    MIBK 2.81
    2-propoxyethanol 25.79
    tert-butanol 2.19
    MTBE 1.48
    2-butoxyethanol 17.71
    propionic acid 10.14
    o-xylene 0.43
    formic acid 59.66
    diethyl ether 2.79
    m-xylene 0.43
    p-xylene 0.3
    chlorobenzene 1.12
    dimethyl carbonate 8.37
    n-octane 0.04
    formamide 49.04
    cyclopentanone 20.14
    2-pentanone 5.42
    anisole 1.79
    cyclopentyl methyl ether 4.6
    gamma-butyrolactone 27.82
    1-methoxy-2-propanol 27.41
    pyridine 9.08
    3-pentanone 3.57
    furfural 27.17
    n-dodecane 0.03
    diethylene glycol 27.3
    diisopropyl ether 0.45
    tert-amyl alcohol 1.7
    acetylacetone 10.83
    n-hexadecane 0.03
    acetophenone 2.84
    methyl propionate 7.53
    isopentyl acetate 2.3
    trichloroethylene 11.39
    n-nonanol 1.97
    cyclohexanol 1.75
    benzyl alcohol 3.22
    2-ethylhexanol 0.89
    isooctanol 1.63
    dipropyl ether 1.55
    1,2-dichlorobenzene 1.12
    ethyl lactate 4.17
    propylene carbonate 10.1
    n-methylformamide 35.94
    2-pentanol 1.33
    n-pentane 0.07
    1-propoxy-2-propanol 10.83
    1-methoxy-2-propyl acetate 9.23
    2-(2-methoxypropoxy) propanol 8.99
    mesitylene 0.21
    ε-caprolactone 11.08
    p-cymene 0.33
    epichlorohydrin 28.97
    1,1,1-trichloroethane 1.95
    2-aminoethanol 19.32
    morpholine-4-carbaldehyde 54.25
    sulfolane 45.26
    2,2,4-trimethylpentane 0.04
    2-methyltetrahydrofuran 6.87
    n-hexyl acetate 4.31
    isooctane 0.02
    2-(2-butoxyethoxy)ethanol 15.23
    sec-butyl acetate 1.34
    tert-butyl acetate 3.07
    decalin 0.04
    glycerin 29.54
    diglyme 28.94
    acrylic acid 17.83
    isopropyl myristate 0.87
    n-butyric acid 11.44
    acetyl acetate 5.73
    di(2-ethylhexyl) phthalate 2.02
    ethyl propionate 2.33
    nitromethane 65.08
    1,2-diethoxyethane 4.57
    benzonitrile 2.12
    trioctyl phosphate 1.54
    1-bromopropane 1.21
    gamma-valerolactone 61.46
    n-decanol 1.0
    triethyl phosphate 1.46
    4-methyl-2-pentanol 0.79
    propionitrile 2.76
    vinylene carbonate 12.02
    1,1,2-trichlorotrifluoroethane 44.5
    DMS 4.26
    cumene 0.22
    2-octanol 1.09
    2-hexanone 2.36
    octyl acetate 1.87
    limonene 0.5
    1,2-dimethoxyethane 17.18
    ethyl orthosilicate 1.32
    tributyl phosphate 1.32
    diacetone alcohol 8.1
    N,N-dimethylaniline 1.23
    acrylonitrile 6.11
    aniline 2.14
    1,3-propanediol 21.09
    bromobenzene 0.83
    dibromomethane 3.37
    1,1,2,2-tetrachloroethane 7.12
    2-methyl-cyclohexyl acetate 1.93
    tetrabutyl urea 1.89
    diisobutyl methanol 0.45
    2-phenylethanol 3.66
    styrene 0.34
    dioctyl adipate 2.01
    dimethyl sulfate 17.76
    ethyl butyrate 2.11
    methyl lactate 14.12
    butyl lactate 5.96
    diethyl carbonate 1.47
    propanediol butyl ether 14.25
    triethyl orthoformate 2.08
    p-tert-butyltoluene 0.32
    methyl 4-tert-butylbenzoate 6.08
    morpholine 23.23
    tert-butylamine 0.55
    n-dodecanol 0.53
    dimethoxymethane 28.93
    ethylene carbonate 8.23
    cyrene 14.07
    2-ethoxyethyl acetate 11.38
    2-ethylhexyl acetate 1.54
    1,2,4-trichlorobenzene 1.78
    4-methylpyridine 4.34
    dibutyl ether 0.81
    2,6-dimethyl-4-heptanol 0.45
    DEF 8.63
    dimethyl isosorbide 14.65
    tetrachloroethylene 5.35
    eugenol 7.21
    triacetin 8.01
    span 80 8.48
    1,4-butanediol 6.02
    1,1-dichloroethane 2.3
    2-methyl-1-pentanol 1.27
    methyl formate 24.34
    2-methyl-1-butanol 2.0
    n-decane 0.07
    butyronitrile 2.38
    3,7-dimethyl-1-octanol 1.05
    1-chlorooctane 0.44
    1-chlorotetradecane 0.11
    n-nonane 0.05
    undecane 0.04
    tert-butylcyclohexane 0.03
    cyclooctane 0.04
    cyclopentanol 3.59
    tetrahydropyran 5.26
    tert-amyl methyl ether 1.34
    2,5,8-trioxanonane 15.69
    1-hexene 0.19
    2-isopropoxyethanol 8.41
    2,2,2-trifluoroethanol 23.01
    methyl butyrate 3.18

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction