Asiaticoside

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  • Identifiers

    CAS number
    16830-15-2

    Molecular formula
    C48H78O19

    SMILES
    C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(C[C@H]([C@@H]([C@@]5(C)CO)O)O)C)C)[C@@H]2[C@H]1C)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO[C@H]7[C@@H]([C@H]([C@@H]([C@H](O7)CO)O[C@H]8[C@@H]([C@@H]([C@H]([C@@H](O8)C)O)O)O)O)O)O)O)O

    Safety labels

  • Odor profile

    Fragrance
    Odorless 61.17%
    Woody 37.44%
    Sweet 28.8%
    Spicy 28.49%
    Cooling 25.02%
    Balsamic 22.6%
    Amber 21.8%
    Mint 21.05%
    Dry 20.76%
    Warm 20.24%

     

    Flavor
    Bitter 56.01%
    Sweet 36.6%
    Odorless 34.19%
    Fatty 31.37%
    Sweet-like 28.45%
    Bland 24.11%
    Cedarleaf 21.85%
    Patchouli 21.13%
    Mentholic 21.08%
    Soil 20.76%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    0.1

    pKa est.
    3.46 (weak acid)

    Molecular weight
    959.1 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Boiling point est.
    2869°C

    Flash point

    • 253.35 ˚C est.

  • Synonyms

    • Asiaticoside
    • 16830-15-2
    • Madecassol
    • Asiaticosid
    • Centelase
    • Emdecassol
    • PKO39VY215
    • DTXSID30937476
    • BA-2742
    • NSC-36002
    • NSC-166062
    • RefChem:28503
    • DTXCID201777735
    • (2alpha,3beta)-2,3,23-Trihydroxyurs-12-en-28-oic acid, O-6-deoxy-alpha-L-mannopyranosyl-(1-4)-O-beta-D-glucopyranosyl-(1-6)-O-beta-D-glucopyranosyl Ester
    • 240-851-7
    • ((2S,3R,4S,5S,6R)-6-(((2R,3R,4R,5S,6R)-3,4-dihydroxy-6-(hydroxymethyl)-5-((2S,3R,4R,5R,6R)-3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-2-yl)oxymethyl)-3,4,5-trihydroxyoxan-2-yl) (1S,2R,4aS,6aR,6aS,6bR,8aR,9R,10R,11R,12aR,14bS)-10,11-dihydroxy-9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4a-carboxylate
    • ((2S,3R,4S,5S,6R)-6-(((2R,3R,4R,5S,6R)-3,4-dihydroxy-6-(hydroxymethyl)-5-((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-2-yl)oxymethyl)-3,4,5-trihydroxyoxan-2-yl) (1S,2R,4aS,6aR,6aS,6bR,8aR,9R,10R,11R,12aR,14bS)-10,11-dihydroxy-9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4a-carboxylate
    • (6-((3,4-dihydroxy-6-(hydroxymethyl)-5-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-2-yl)oxymethyl)-3,4,5-trihydroxyoxan-2-yl) 10,11-dihydroxy-9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4a-carboxylate
    • Dermatologico
    • Blastoestimulina
    • Asiaticoside (>90%)
    • Ba 2742
    • UNII-PKO39VY215
    • CCRIS 8995
    • MFCD06642601
    • Asiaticoside CRS
    • Madecassol (TN)
    • WYQVAPGDARQUBT-FGWHUCSPSA-N
    • Asiaticoside, 21
    • EINECS 240-851-7
    • NSC 36002
    • NSC 166062
    • BRN 0078195
    • Asiaticoside (Standard)
    • ASIATICOSIDE [MI]
    • 4-17-00-03627 (Beilstein Handbook Reference)
    • CENTELASE DERMATOLOGICO
    • ASIATICOSIDE [USP-RS]
    • ASIATICOSIDE [WHO-DD]
    • orb1304613
    • CHEMBL1684590
    • SCHEMBL27500173
    • BDBM23211
    • CHEBI:79928
    • HY-N0439R
    • HMS6019B05
    • HY-N0439
    • MSK158086
    • AKOS037514554
    • DB14081
    • EBC-615440
    • (O-alpha-L-Rhamnopyranoxyl-(1-4)-O-beta-D-glucopyranosyl-(1-6)-O-beta-D-glucopyranosyl)-2alpha,3beta,23-trihydroxy-12-ursen-28-oat
    • 2alpha,3beta,23-Trihydroxy-urs-12-en-28-saeure(O-alpha-L-rhamnopyranosyl-(1-4)-O-beta-D-glucopyranosyl-(1-6)-O-beta-D-glucopyranosyl)ester
    • O-6-Desoxy-alpha-L-mannopyranosyl-(1-4)-O-beta-D-glucopyranosyl-(1-6)-O-beta-D-glucopyranosyl 2alpha,3beta,23-trihydroxy-12-ursen-28-at
    • CS-0008960
    • NS00018029
    • D07576
    • Q27149094
    • ASIATICOSIDE (CONSTITUENT OF CENTELLA ASIATICA) [DSC]
    • 2-alpha,3-beta,23-trihydroxy-urs-12-en-28-oicacio-6-deoxy-alpha-l-mannopy
    • (2.ALPHA.,3.BETA.,4.ALPHA.)-2,3,23-TRIHYDROXYURS-12-EN-28-OIC ACID O-6-DEOXY-.ALPHA.-L-MANNOPYRANOSYL-(1->4)-O-.BETA.-D-GLUCOPYRANOSYL-(1->6)-O-.BETA.-D-GLUCOPYRANOSYL ESTER
    • 2alpha,3beta,23-trihydroxyurs-12-en-28-oic acid O-alpha-L-rhamnopyranosyl-(1->4)-O-beta-D-glucopyranosyl-(1->6)-beta-D-glucopyranosyl ester
    • 6-Deoxy-alpha-L-mannopyranosyl-(1->4)-beta-D-glucopyranosyl-(1->6)-1-O-(2alpha,3beta,23-trihydroxy-28-oxours-12-en-28-yl)-beta-D-glucopyranose
    • O-6-Deoxy-alpha-L-mannopyranosyl-(1.4)-O-beta-D-glucopyranosyl-(1.6)-beta-D-glucopyranosyl (2alpha,3beta,4alpha)-2,3,23-trihydroxyurs-12-en-28-oate
    • URS-12-EN-28-OIC ACID, 2,3,23-TRIHYDROXY-, O-6-DEOXY-.ALPHA.-L-MANNOPYRANOSYL-(1->4)-O-.BETA.-D-GLUCOPYRANOSYL-(1->6)-.BETA.-D-GLUCOPYRANOSYL ESTER, (2.ALPHA.,3.BETA.,4.ALPHA.)-
    • Urs-12-en-28-oic acid, 2,3,23-trihydroxy-, O-6-deoxy-alpha-L-mannopyranosyl-(1-4)-O-beta-D-glucopyranosyl-(1-6)-beta-D-glucopyranosyl ester, (2alpha,3beta,4alpha)-
    • Urs-12-en-28-oic acid, 2-alpha,3-beta,23-trihydroxy-, O-6-deoxy-alpha-L-mannopyranosyl-(1-4)-o-beta-D-glucopyranosyl-(1-6)-o-beta-D-glucopyranosyl ester
    • 16830-15-2

  • Applications

    Asiaticoside, CAS 16830-15-2, is a triterpenoid saponin glycoside derived from Centella asiatica. In industry it is typically encountered as a constituent of Centella extract used in cosmetics and personal care, where it appears as part of botanical formulations for skin care; it is also present in natural-product pharmaceutical or nutraceutical preparations that rely on Centella-based extracts. For quality-control and analytical work, asiaticoside serves as a marker compound to standardize Centella extracts. In research and development, it is often evaluated for formulation behavior and used as a representative example of this class of glycosides in natural-product studies. It remains subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1.62
    methanol 21.27
    isopropanol 0.41
    water 0.09
    ethyl acetate 0.61
    n-propanol 0.7
    acetone 1.97
    n-butanol 0.27
    acetonitrile 0.6
    DMF 20.97
    toluene 0.17
    isobutanol 0.24
    1,4-dioxane 4.61
    methyl acetate 0.99
    THF 5.8
    2-butanone 0.98
    n-pentanol 0.23
    sec-butanol 0.22
    n-hexane 0.01
    ethylene glycol 4.35
    NMP 16.47
    cyclohexane 0.02
    DMSO 23.85
    n-butyl acetate 0.32
    n-octanol 0.35
    chloroform 1.05
    n-propyl acetate 0.34
    acetic acid 11.55
    dichloromethane 1.14
    cyclohexanone 1.31
    propylene glycol 2.47
    isopropyl acetate 0.38
    DMAc 13.61
    2-ethoxyethanol 4.13
    isopentanol 0.16
    n-heptane 0.02
    ethyl formate 1.0
    1,2-dichloroethane 0.56
    n-hexanol 0.21
    2-methoxyethanol 10.99
    isobutyl acetate 0.18
    tetrachloromethane 0.16
    n-pentyl acetate 0.78
    transcutol 7.93
    n-heptanol 0.45
    ethylbenzene 0.08
    MIBK 0.34
    2-propoxyethanol 4.14
    tert-butanol 0.26
    MTBE 0.2
    2-butoxyethanol 3.38
    propionic acid 1.42
    o-xylene 0.13
    formic acid 24.43
    diethyl ether 0.37
    m-xylene 0.13
    p-xylene 0.09
    chlorobenzene 0.18
    dimethyl carbonate 2.36
    n-octane 0.01
    formamide 15.38
    cyclopentanone 3.06
    2-pentanone 0.61
    anisole 0.43
    cyclopentyl methyl ether 0.76
    gamma-butyrolactone 4.62
    1-methoxy-2-propanol 4.39
    pyridine 1.95
    3-pentanone 0.54
    furfural 6.73
    n-dodecane 0.01
    diethylene glycol 7.67
    diisopropyl ether 0.07
    tert-amyl alcohol 0.19
    acetylacetone 2.17
    n-hexadecane 0.01
    acetophenone 0.7
    methyl propionate 1.15
    isopentyl acetate 0.28
    trichloroethylene 1.7
    n-nonanol 0.37
    cyclohexanol 0.21
    benzyl alcohol 0.68
    2-ethylhexanol 0.1
    isooctanol 0.27
    dipropyl ether 0.27
    1,2-dichlorobenzene 0.22
    ethyl lactate 0.84
    propylene carbonate 1.52
    n-methylformamide 9.51
    2-pentanol 0.12
    n-pentane 0.01
    1-propoxy-2-propanol 1.81
    1-methoxy-2-propyl acetate 1.6
    2-(2-methoxypropoxy) propanol 2.34
    mesitylene 0.07
    ε-caprolactone 1.44
    p-cymene 0.07
    epichlorohydrin 4.27
    1,1,1-trichloroethane 0.23
    2-aminoethanol 3.53
    morpholine-4-carbaldehyde 19.2
    sulfolane 12.31
    2,2,4-trimethylpentane 0.01
    2-methyltetrahydrofuran 0.8
    n-hexyl acetate 0.75
    isooctane 0.0
    2-(2-butoxyethoxy)ethanol 3.5
    sec-butyl acetate 0.17
    tert-butyl acetate 0.44
    decalin 0.01
    glycerin 9.09
    diglyme 7.81
    acrylic acid 3.47
    isopropyl myristate 0.16
    n-butyric acid 0.94
    acetyl acetate 0.89
    di(2-ethylhexyl) phthalate 0.45
    ethyl propionate 0.33
    nitromethane 14.28
    1,2-diethoxyethane 1.07
    benzonitrile 0.39
    trioctyl phosphate 0.29
    1-bromopropane 0.12
    gamma-valerolactone 12.51
    n-decanol 0.19
    triethyl phosphate 0.27
    4-methyl-2-pentanol 0.09
    propionitrile 0.34
    vinylene carbonate 2.12
    1,1,2-trichlorotrifluoroethane 10.85
    DMS 1.14
    cumene 0.05
    2-octanol 0.21
    2-hexanone 0.35
    octyl acetate 0.35
    limonene 0.09
    1,2-dimethoxyethane 4.46
    ethyl orthosilicate 0.24
    tributyl phosphate 0.22
    diacetone alcohol 1.39
    N,N-dimethylaniline 0.39
    acrylonitrile 0.9
    aniline 0.41
    1,3-propanediol 2.47
    bromobenzene 0.14
    dibromomethane 0.41
    1,1,2,2-tetrachloroethane 1.2
    2-methyl-cyclohexyl acetate 0.3
    tetrabutyl urea 0.44
    diisobutyl methanol 0.07
    2-phenylethanol 0.65
    styrene 0.09
    dioctyl adipate 0.43
    dimethyl sulfate 5.93
    ethyl butyrate 0.29
    methyl lactate 3.43
    butyl lactate 1.21
    diethyl carbonate 0.21
    propanediol butyl ether 3.72
    triethyl orthoformate 0.39
    p-tert-butyltoluene 0.07
    methyl 4-tert-butylbenzoate 1.62
    morpholine 4.11
    tert-butylamine 0.07
    n-dodecanol 0.1
    dimethoxymethane 9.57
    ethylene carbonate 1.19
    cyrene 4.64
    2-ethoxyethyl acetate 2.42
    2-ethylhexyl acetate 0.2
    1,2,4-trichlorobenzene 0.4
    4-methylpyridine 0.83
    dibutyl ether 0.16
    2,6-dimethyl-4-heptanol 0.07
    DEF 1.57
    dimethyl isosorbide 3.95
    tetrachloroethylene 1.13
    eugenol 1.88
    triacetin 2.04
    span 80 2.17
    1,4-butanediol 1.04
    1,1-dichloroethane 0.25
    2-methyl-1-pentanol 0.14
    methyl formate 8.63
    2-methyl-1-butanol 0.17
    n-decane 0.02
    butyronitrile 0.2
    3,7-dimethyl-1-octanol 0.16
    1-chlorooctane 0.08
    1-chlorotetradecane 0.02
    n-nonane 0.01
    undecane 0.01
    tert-butylcyclohexane 0.01
    cyclooctane 0.01
    cyclopentanol 0.42
    tetrahydropyran 0.73
    tert-amyl methyl ether 0.19
    2,5,8-trioxanonane 4.79
    1-hexene 0.03
    2-isopropoxyethanol 1.59
    2,2,2-trifluoroethanol 4.64
    methyl butyrate 0.44

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction