Asiatic Acid

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  • Identifiers

    CAS number
    464-92-6

    Molecular formula
    C30H48O5

    SMILES
    C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(C[C@H]([C@@H]([C@@]5(C)CO)O)O)C)C)[C@@H]2[C@H]1C)C)C(=O)O

    Safety labels

  • Odor profile

    Fragrance
    Woody 75.81%
    Balsamic 46.58%
    Amber 45.67%
    Spicy 40.48%
    Cedar 40.13%
    Dry 39.64%
    Sandalwood 38.2%
    Herbal 31.79%
    Camphoreous 30.93%
    Pine 28.74%

     

    Flavor
    Woody 44.84%
    Bitter 41.6%
    Balsam 36.94%
    Pine 36.84%
    Herbal 36.3%
    Camphor 34.3%
    Sweet 33.52%
    Earthy 27.39%
    Spicy 27.04%
    Minty 26.73%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    5.7

    pKa est.
    5.64 (weak acid)

    Molecular weight
    488.7 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Boiling point est.
    130°C

    Flash point

    • 291.91 ˚C est.

  • Synonyms

    • Asiatic acid
    • 464-92-6
    • Dammarolic acid
    • 9PA5A687X5
    • DTXSID901019207
    • (1S,2R,4aS,6aR,6aS,6bR,8aR,9R,10R,11R,12aR,14bS)-10,11-dihydroxy-9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4a-carboxylic acid
    • NSC-166063
    • CHEBI:2873
    • 2alpha,3beta,23-trihydroxyurs-12-en-28-oic acid
    • Urs-12-en-28-oic acid, 2,3,23-trihydroxy-, (2alpha,3beta,4alpha)-
    • Urs-12en-28-oic acid, 2,3,23-trihydroxy-, (2alpha, 3beta, 4alpha)-
    • RefChem:28615
    • DTXCID601477197
    • 482-720-9
    • 610-307-7
    • MFCD00238541
    • Asiantic acid
    • CHEMBL404313
    • (1S,2R,4aS,6aS,6bR,8aR,9R,10R,11R,12aR,12bR,14bS)-10,11-dihydroxy-9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-4a-carboxylic acid
    • Asiaticacid
    • 2,3,23-trihydroxyurs-12-en-28-oic acid
    • Esculentic acid (Diplazium)
    • UNII-9PA5A687X5
    • Asiatic-acid
    • HSDB 7662
    • NSC 166063
    • Asiatic acid, 97%
    • Asiatic acid (Standard)
    • ASIATIC ACID [HSDB]
    • 2alpha,3beta,23-Trihydroxyurs-12-ene-28-oic acid
    • ASIATIC ACID [WHO-DD]
    • orb1304969
    • SCHEMBL3285999
    • HY-N0194R
    • Asiatic acid, analytical standard
    • BB_NC-01743
    • HY-N0194
    • BDBM50241487
    • EBC-24054
    • AKOS007930256
    • Urs-12-en-28-oic acid, 2,3,23-trihydroxy-, (2.alpha.,3.beta.,4.alpha.)-
    • CCG-208549
    • DB14054
    • FA63149
    • NCGC00346584-02
    • NCGC00346584-03
    • A2475
    • CS-0007893
    • NS00013372
    • NS00099270
    • C08617
    • 464A926
    • Asiatic acid, >=98% (HPLC), from Centella asiatica
    • BRD-K35079116-001-02-5
    • BRD-K35079116-001-03-3
    • Q15478109
    • ASIATIC ACID (CONSTITUENT OF BANABA LEAF) [DSC]
    • (2alpha,3beta)-2,3,23-trihydroxyurs-12-en-28-oic acid
    • ASIATIC ACID (CONSTITUENT OF HOLY BASIL LEAF) [DSC]
    • (4alpha)-2alpha,3beta,23-trihydroxy-urs-12-en-28-oic acid
    • ASIATIC ACID (CONSTITUENT OF CENTELLA ASIATICA) [DSC]
    • (2alpha,3beta,5beta,20beta)-2,3,23-trihydroxyurs-12-en-28-oic acid
    • (4I+/-)-a?I+/-,a?I(2),a?3-atrihydroxy-aurs-a?2-aen-a?8-aoic acid
    • (2.ALPHA.,3.BETA.,4.ALPHA.)-2,3,23-TRIHYDROXYURS-12-EN-28-OIC ACID
    • (1S,2R,4aS,6aR,6aS,6bR,8aR,9R,10R,11R,12aR,14bS)-10,11-dihydroxy-9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4a-carboxylicacid
    • (1S,2R,4aS,6aS,6bR,8aR,9R,10R,11R,12aR,12bR,14bS)-10,11-Dihydroxy-9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-1,3,4,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydropicene-4a(2H)-carboxylic acid
    • 0AS
    • 1S,2R,4aS,6aR,6aS,6bR,8aR,9S,10S,11R,12aS,14bR)-10,11-dihydroxy-9-(hydro-xymethyl)-1,2,6a,6b,9,12a-hexamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4a-carboxylic acid
    • Dammarolic acid; (1S,2R,4aS,6aS,6bR,8aR,9R,10R,11R,12aR,12bR,14bS)-10,11-dihydroxy-9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-1,3,4,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydropicene-4a(2H)-carboxylic acid
    • 464-92-6

  • Applications

    Asiatic Acid (CAS 464-92-6) is a pentacyclic triterpenoid derived from Centella asiatica, used primarily as a cosmetic active ingredient in skin-care formulations. In cosmetics/personal care, it is typically present as an active constituent from Centella asiatica extracts and is associated with skin soothing, support for scar or wound repair, and anti-inflammatory effects. In pharmaceuticals, asiatic acid is evaluated for wound healing and anti-inflammatory activities and may be incorporated into topical dermatological formulations based on plant extracts. In nutraceuticals/dietary supplements, Centella-based products sometimes include asiatic acid as a bioactive component. In industrial/chemical research and ingredient supply, asiatic acid is used as a marker compound for standardizing Centella-based extracts and as a reference in isolation and analytical workflows.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 9.86
    methanol 20.52
    isopropanol 4.73
    water 0.01
    ethyl acetate 1.79
    n-propanol 8.03
    acetone 4.39
    n-butanol 4.43
    acetonitrile 0.95
    DMF 40.15
    toluene 1.52
    isobutanol 3.41
    1,4-dioxane 18.04
    methyl acetate 1.99
    THF 36.13
    2-butanone 4.02
    n-pentanol 3.06
    sec-butanol 1.86
    n-hexane 0.09
    ethylene glycol 2.03
    NMP 18.25
    cyclohexane 0.09
    DMSO 18.11
    n-butyl acetate 1.87
    n-octanol 1.49
    chloroform 4.48
    n-propyl acetate 1.34
    acetic acid 4.69
    dichloromethane 2.76
    cyclohexanone 6.1
    propylene glycol 3.53
    isopropyl acetate 1.58
    DMAc 18.0
    2-ethoxyethanol 12.42
    isopentanol 2.36
    n-heptane 0.08
    ethyl formate 1.69
    1,2-dichloroethane 1.93
    n-hexanol 3.32
    2-methoxyethanol 27.94
    isobutyl acetate 1.07
    tetrachloromethane 0.67
    n-pentyl acetate 3.38
    transcutol 14.92
    n-heptanol 3.14
    ethylbenzene 0.78
    MIBK 2.09
    2-propoxyethanol 23.93
    tert-butanol 2.51
    MTBE 1.56
    2-butoxyethanol 13.93
    propionic acid 2.58
    o-xylene 0.92
    formic acid 4.36
    diethyl ether 2.45
    m-xylene 1.14
    p-xylene 0.78
    chlorobenzene 1.23
    dimethyl carbonate 2.84
    n-octane 0.04
    formamide 5.14
    cyclopentanone 11.64
    2-pentanone 3.05
    anisole 2.5
    cyclopentyl methyl ether 4.8
    gamma-butyrolactone 9.56
    1-methoxy-2-propanol 20.72
    pyridine 8.5
    3-pentanone 2.13
    furfural 8.52
    n-dodecane 0.02
    diethylene glycol 15.62
    diisopropyl ether 0.47
    tert-amyl alcohol 1.44
    acetylacetone 4.07
    n-hexadecane 0.02
    acetophenone 2.66
    methyl propionate 2.99
    isopentyl acetate 1.96
    trichloroethylene 4.6
    n-nonanol 1.65
    cyclohexanol 1.74
    benzyl alcohol 4.09
    2-ethylhexanol 1.09
    isooctanol 2.14
    dipropyl ether 1.53
    1,2-dichlorobenzene 1.14
    ethyl lactate 1.82
    propylene carbonate 2.87
    n-methylformamide 11.54
    2-pentanol 1.34
    n-pentane 0.09
    1-propoxy-2-propanol 11.47
    1-methoxy-2-propyl acetate 5.89
    2-(2-methoxypropoxy) propanol 6.39
    mesitylene 0.62
    ε-caprolactone 4.96
    p-cymene 0.55
    epichlorohydrin 12.51
    1,1,1-trichloroethane 1.07
    2-aminoethanol 7.37
    morpholine-4-carbaldehyde 29.45
    sulfolane 13.77
    2,2,4-trimethylpentane 0.05
    2-methyltetrahydrofuran 5.41
    n-hexyl acetate 3.13
    isooctane 0.05
    2-(2-butoxyethoxy)ethanol 10.69
    sec-butyl acetate 0.87
    tert-butyl acetate 2.03
    decalin 0.08
    glycerin 7.27
    diglyme 18.0
    acrylic acid 3.02
    isopropyl myristate 0.65
    n-butyric acid 3.38
    acetyl acetate 1.36
    di(2-ethylhexyl) phthalate 1.91
    ethyl propionate 1.2
    nitromethane 6.37
    1,2-diethoxyethane 3.31
    benzonitrile 1.82
    trioctyl phosphate 1.21
    1-bromopropane 0.87
    gamma-valerolactone 24.88
    n-decanol 0.75
    triethyl phosphate 0.93
    4-methyl-2-pentanol 0.99
    propionitrile 1.35
    vinylene carbonate 3.56
    1,1,2-trichlorotrifluoroethane 11.09
    DMS 2.7
    cumene 0.55
    2-octanol 1.16
    2-hexanone 2.09
    octyl acetate 1.16
    limonene 0.62
    1,2-dimethoxyethane 13.3
    ethyl orthosilicate 1.06
    tributyl phosphate 0.86
    diacetone alcohol 4.34
    N,N-dimethylaniline 2.15
    acrylonitrile 2.2
    aniline 2.7
    1,3-propanediol 10.41
    bromobenzene 0.98
    dibromomethane 1.63
    1,1,2,2-tetrachloroethane 3.86
    2-methyl-cyclohexyl acetate 1.68
    tetrabutyl urea 1.55
    diisobutyl methanol 0.65
    2-phenylethanol 4.71
    styrene 0.77
    dioctyl adipate 1.46
    dimethyl sulfate 4.76
    ethyl butyrate 1.21
    methyl lactate 4.36
    butyl lactate 4.47
    diethyl carbonate 0.75
    propanediol butyl ether 10.8
    triethyl orthoformate 1.58
    p-tert-butyltoluene 0.58
    methyl 4-tert-butylbenzoate 5.21
    morpholine 25.91
    tert-butylamine 0.83
    n-dodecanol 0.35
    dimethoxymethane 26.03
    ethylene carbonate 2.7
    cyrene 7.96
    2-ethoxyethyl acetate 6.82
    2-ethylhexyl acetate 1.38
    1,2,4-trichlorobenzene 1.86
    4-methylpyridine 4.61
    dibutyl ether 0.63
    2,6-dimethyl-4-heptanol 0.65
    DEF 4.24
    dimethyl isosorbide 9.99
    tetrachloroethylene 3.38
    eugenol 6.52
    triacetin 3.4
    span 80 5.93
    1,4-butanediol 3.42
    1,1-dichloroethane 1.23
    2-methyl-1-pentanol 1.68
    methyl formate 6.18
    2-methyl-1-butanol 2.11
    n-decane 0.05
    butyronitrile 1.26
    3,7-dimethyl-1-octanol 0.99
    1-chlorooctane 0.32
    1-chlorotetradecane 0.07
    n-nonane 0.05
    undecane 0.03
    tert-butylcyclohexane 0.07
    cyclooctane 0.05
    cyclopentanol 3.35
    tetrahydropyran 6.1
    tert-amyl methyl ether 1.12
    2,5,8-trioxanonane 9.72
    1-hexene 0.36
    2-isopropoxyethanol 5.95
    2,2,2-trifluoroethanol 1.73
    methyl butyrate 1.61

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction