Ascorbyl Tocopheryl Maleate

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  • Identifiers

    CAS number
    320616-16-8

    Molecular formula
    C39H58O10

    SMILES
    CC1=C(C(=C(C2=C1O[C@](CC2)(C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)C)OC(=O)/C=C\C(=O)OC3=C([C@H](OC3=O)[C@H](CO)O)O)C

    Safety labels

  • Odor profile

    Fragrance
    Odorless 49.89%
    Woody 25.36%
    Dry 24.83%
    Milky 24.24%
    Musk 23.47%
    Balsamic 22.44%
    Fatty 22.2%
    Powdery 20.7%
    Amber 20.57%
    Lactonic 20.4%

     

    Flavor
    Bitter 43.25%
    Bland 34.95%
    Odorless 30.99%
    Mild 23.31%
    Herbal 22.33%
    Parsley 20.29%
    Cedarleaf 20.12%
    Lovage 19.65%
    Heather 19.17%
    Woody 18.91%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    9.6

    pKa est.
    8.08 (weak base)

    Molecular weight
    686.9 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    1612°C

    Flash point

    • 227.96 ˚C est.

  • Synonyms

    • Ascorbyl tocopheryl maleate
    • UNII-D2G6259XR5
    • D2G6259XR5
    • 2-L-ascorbyl 6-dalphatocopheryl 2-butenedioate
    • 320616-16-8
    • L-Ascorbic acid, 2-((2R)-3,4-dihydro-2,5,7,8-tetramethyl-2-((4R,8R)-4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl (2Z)-2-butenedioate)
    • 2-L-ASCORBYL 6-D-ALPHA-TOCOPHERYL 2-BUTENEDIOATE
    • RefChem:114481
    • ASCORBYL TOCOPHERYL MALEATE [INCI]
    • CME
    • SCHEMBL29393088
    • Q27276014
    • 320616-16-8

  • Applications

    Ascorbyl Tocopheryl Maleate (CAS 320616-16-8) is commonly used as an antioxidant and stabilizer in cosmetics and personal care, helping protect lipid-based ingredients from oxidation and supporting the stability of oil-in-water or other emulsions. It can act as a skin-conditioning agent in creams, lotions, serums, and color cosmetics by contributing to feel and compatibility. In coatings and inks, it is used as an antioxidant with oil-soluble characteristics to extend the oxidative stability of resins and pigments. In polymer and plastics formulations it can serve as an oxidation stabilizer to improve product shelf life. In cleaning and household products it may function as an antioxidant stabilizer to protect formulations from oxidative degradation during storage. In pharmaceutical formulations it may be evaluated as a stabilizer or excipient, subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 7.66
    methanol 14.11
    isopropanol 5.49
    water 0.05
    ethyl acetate 12.42
    n-propanol 9.36
    acetone 34.43
    n-butanol 5.67
    acetonitrile 7.7
    DMF 52.57
    toluene 4.69
    isobutanol 5.23
    1,4-dioxane 25.4
    methyl acetate 18.47
    THF 73.79
    2-butanone 29.15
    n-pentanol 9.41
    sec-butanol 6.72
    n-hexane 0.22
    ethylene glycol 2.0
    NMP 81.11
    cyclohexane 0.21
    DMSO 64.25
    n-butyl acetate 7.45
    n-octanol 5.86
    chloroform 44.38
    n-propyl acetate 12.37
    acetic acid 52.56
    dichloromethane 37.58
    cyclohexanone 34.4
    propylene glycol 5.2
    isopropyl acetate 9.43
    DMAc 107.04
    2-ethoxyethanol 33.33
    isopentanol 4.71
    n-heptane 0.2
    ethyl formate 11.36
    1,2-dichloroethane 18.73
    n-hexanol 4.05
    2-methoxyethanol 27.79
    isobutyl acetate 9.0
    tetrachloromethane 4.64
    n-pentyl acetate 17.99
    transcutol 49.89
    n-heptanol 5.62
    ethylbenzene 3.3
    MIBK 9.45
    2-propoxyethanol 23.11
    tert-butanol 6.24
    MTBE 7.34
    2-butoxyethanol 23.08
    propionic acid 17.65
    o-xylene 3.4
    formic acid 13.77
    diethyl ether 4.84
    m-xylene 3.37
    p-xylene 4.77
    chlorobenzene 9.82
    dimethyl carbonate 13.35
    n-octane 0.19
    formamide 18.92
    cyclopentanone 60.2
    2-pentanone 17.21
    anisole 11.71
    cyclopentyl methyl ether 12.14
    gamma-butyrolactone 59.38
    1-methoxy-2-propanol 22.22
    pyridine 23.84
    3-pentanone 13.77
    furfural 40.89
    n-dodecane 0.17
    diethylene glycol 12.13
    diisopropyl ether 1.45
    tert-amyl alcohol 8.23
    acetylacetone 34.07
    n-hexadecane 0.2
    acetophenone 19.08
    methyl propionate 15.69
    isopentyl acetate 8.55
    trichloroethylene 55.87
    n-nonanol 6.07
    cyclohexanol 4.74
    benzyl alcohol 15.71
    2-ethylhexanol 2.73
    isooctanol 5.0
    dipropyl ether 3.43
    1,2-dichlorobenzene 10.41
    ethyl lactate 10.55
    propylene carbonate 22.34
    n-methylformamide 23.66
    2-pentanol 3.17
    n-pentane 0.14
    1-propoxy-2-propanol 14.06
    1-methoxy-2-propyl acetate 14.56
    2-(2-methoxypropoxy) propanol 18.57
    mesitylene 1.68
    ε-caprolactone 33.04
    p-cymene 1.86
    epichlorohydrin 65.36
    1,1,1-trichloroethane 19.84
    2-aminoethanol 6.63
    morpholine-4-carbaldehyde 63.18
    sulfolane 87.46
    2,2,4-trimethylpentane 0.18
    2-methyltetrahydrofuran 24.15
    n-hexyl acetate 17.63
    isooctane 0.09
    2-(2-butoxyethoxy)ethanol 25.41
    sec-butyl acetate 8.27
    tert-butyl acetate 12.17
    decalin 0.29
    glycerin 8.14
    diglyme 43.42
    acrylic acid 20.42
    isopropyl myristate 4.68
    n-butyric acid 19.45
    acetyl acetate 14.14
    di(2-ethylhexyl) phthalate 8.69
    ethyl propionate 8.91
    nitromethane 71.23
    1,2-diethoxyethane 13.48
    benzonitrile 9.95
    trioctyl phosphate 5.43
    1-bromopropane 5.81
    gamma-valerolactone 97.82
    n-decanol 3.63
    triethyl phosphate 4.84
    4-methyl-2-pentanol 2.19
    propionitrile 6.65
    vinylene carbonate 23.37
    1,1,2-trichlorotrifluoroethane 55.87
    DMS 11.97
    cumene 2.38
    2-octanol 4.47
    2-hexanone 18.48
    octyl acetate 7.96
    limonene 2.06
    1,2-dimethoxyethane 40.16
    ethyl orthosilicate 4.76
    tributyl phosphate 5.18
    diacetone alcohol 19.27
    N,N-dimethylaniline 8.8
    acrylonitrile 11.73
    aniline 7.91
    1,3-propanediol 10.02
    bromobenzene 9.77
    dibromomethane 16.98
    1,1,2,2-tetrachloroethane 44.72
    2-methyl-cyclohexyl acetate 9.59
    tetrabutyl urea 9.13
    diisobutyl methanol 1.37
    2-phenylethanol 10.71
    styrene 4.02
    dioctyl adipate 10.26
    dimethyl sulfate 24.61
    ethyl butyrate 6.0
    methyl lactate 13.9
    butyl lactate 15.72
    diethyl carbonate 3.99
    propanediol butyl ether 21.78
    triethyl orthoformate 6.22
    p-tert-butyltoluene 1.76
    methyl 4-tert-butylbenzoate 19.63
    morpholine 31.63
    tert-butylamine 1.79
    n-dodecanol 2.16
    dimethoxymethane 31.02
    ethylene carbonate 17.06
    cyrene 35.04
    2-ethoxyethyl acetate 28.16
    2-ethylhexyl acetate 6.71
    1,2,4-trichlorobenzene 16.95
    4-methylpyridine 19.06
    dibutyl ether 4.36
    2,6-dimethyl-4-heptanol 1.37
    DEF 19.69
    dimethyl isosorbide 29.83
    tetrachloroethylene 23.62
    eugenol 20.38
    triacetin 25.34
    span 80 18.31
    1,4-butanediol 8.41
    1,1-dichloroethane 16.41
    2-methyl-1-pentanol 8.17
    methyl formate 21.09
    2-methyl-1-butanol 5.56
    n-decane 0.36
    butyronitrile 5.25
    3,7-dimethyl-1-octanol 3.89
    1-chlorooctane 2.62
    1-chlorotetradecane 0.8
    n-nonane 0.29
    undecane 0.23
    tert-butylcyclohexane 0.27
    cyclooctane 0.11
    cyclopentanol 10.07
    tetrahydropyran 15.53
    tert-amyl methyl ether 6.46
    2,5,8-trioxanonane 27.87
    1-hexene 1.34
    2-isopropoxyethanol 24.0
    2,2,2-trifluoroethanol 16.25
    methyl butyrate 13.6

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction