Artemisinin

Overview IFRA Botanical Request a quote

  • Identifiers

    CAS number
    63968-64-9

    Molecular formula
    C15H22O5

    SMILES
    C[C@@H]1CC[C@H]2[C@H](C(=O)O[C@H]3[C@@]24[C@H]1CC[C@](O3)(OO4)C)C

    Safety labels

    Flammable
    Flammable

    Environmental Hazard
    Environmental

  • Odor profile

    Woody 38.37%
    Lactonic 35.02%
    Spicy 33.99%
    Sweet 30.3%
    Coconut 29.82%
    Coumarinic 28.02%
    Odorless 27.51%
    Mint 25.87%
    Herbal 24.5%
    Celery 24.39%

    Scent© AI

  • Properties

    XLogP3-AA
    2.8

    Molecular weight
    282.33 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    416°C

    Flash point est.
    142.03 ˚C

  • Synonyms

    • artemisinin
    • Qinghaosu
    • 63968-64-9
    • Huanghuahaosu
    • Artemisinine
    • Artemisine
    • (+)-Artemisinin
    • Artemisinina
    • Artemisininum
    • Qinghosu
    • Quing Hau Sau
    • Qing Hau SU
    • Artemisinin [INN]
    • Qing Hau Sau
    • Artemisininum [Latin]
    • CHEBI:223316
    • UNII-9RMU91N5K2
    • NSC 369397
    • BRN 4194670
    • 9RMU91N5K2
    • DTXSID2040652
    • MFCD00081057
    • GNF-Pf-5341
    • Octahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano(4,3-j)-1,2-benzodioxepin-10(3H)-one
    • DTXCID40819890
    • EC 700-290-5
    • (+)-Arteannuin
    • (1R,4S,5R,8S,9R,12S,13R)-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-one
    • (3R,5aS,6R,8aS,9R,12S,12aR)-Octahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano(4,3-j)-1,2-benzodioxepin-10(3H)-one
    • Artemisininum (Latin)
    • quinghaosu
    • ARTEMISININ (MART.)
    • ARTEMISININ [MART.]
    • ARTEMISININ (USP-RS)
    • ARTEMISININ [USP-RS]
    • (1R,4S,5R,8S,9R,12S,13R)-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.0^{4,13}.0^{8,13}]hexadecan-10-one
    • (3R,5aS,6R,8aS,9R,12S,12aR)-3,6,9-Trimethyloctahydro-3,12-epoxypyrano(4,3-j)(1,2)benzodioxepin-10(3H)-one
    • 3,12-Epoxy-12H-pyranol(4,3-j)-1,2-benzodioxepin-10(3H)-one, octahydro-3,6,9-trimethyl-, (3-alpha,5a-beta,6-beta,8a-beta,9-alpha,12-beta,12aR*)-(+)-
    • Qinghaosu [Chinese]
    • Artemisinine [French]
    • Artemisinina [Spanish]
    • Qing Hau Sau [Chinese]
    • qing hao su
    • NSC-369397
    • (3R,5aS,6R,8aS,9R,12S,12aR)-3,6,9-trimethyloctahydro-3,12-epoxypyrano[4,3-j][1,2]benzodioxepin-10(3H)-one
    • (3R,5aS,6R,8aS,9R,12S,12aR)-Octahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one
    • 1,5,9-trimethyl-(1R,4S,5R,9R,12S,13R)-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-one
    • SMR000578089
    • SR-01000802560
    • Artesin
    • NCGC00160207-01
    • 1,5,9-trimethyl-(1R,4S,5R,9R,12S,13R)-11,14,15,16-tetraoxatetracyclo(10.3.1.04,13.08,13)hexadecan-10-one
    • Artemisinin; (3R,5aS,6R,8aS,9R,12S,12aR)-Octahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one
    • CAS-63968-64-9
    • (+/-)-Artemisinin
    • Artemisinin (Standard)
    • Spectrum_001351
    • ARTEMISININ [MI]
    • Prestwick0_000498
    • Prestwick1_000498
    • Prestwick2_000498
    • Prestwick3_000498
    • Spectrum2_001512
    • Spectrum3_001549
    • Spectrum4_000721
    • Spectrum5_001098
    • SCHEMBL60304
    • ARTEMISININ [WHO-DD]
    • ARTEMISININ [WHO-IP]
    • BSPBio_000395
    • BSPBio_002998
    • KBioGR_000982
    • KBioSS_001831
    • MLS001097650
    • MLS001304036
    • MLS002153846
    • DivK1c_000656
    • SPBio_001583
    • SPBio_002316
    • BPBio1_000435
    • CHEMBL269671
    • GTPL9954
    • HY-B0094R
    • KBio1_000656
    • KBio2_001831
    • KBio2_004399
    • KBio2_006967
    • KBio3_002498
    • P01BE01
    • NINDS_000656
    • DTXSID501045125
    • HMS2090I17
    • HMS2096D17
    • HMS2267N09
    • HMS3269L13
    • HMS3413P13
    • HMS3677P13
    • HMS3713D17
    • Pharmakon1600-01503042
    • BCP02096
    • HY-B0094
    • Tox21_111750
    • ARTEMISININUM [WHO-IP LATIN]
    • BDBM50088447
    • HB1115
    • NSC758216
    • AKOS024457231
    • Tox21_111750_1
    • CCG-220498
    • CS-1794
    • DB13132
    • FA09640
    • LMPR0103190003
    • NSC-758216
    • IDI1_000656
    • NCGC00161634-06
    • NCGC00161634-18
    • (3R,5aS,6R,8aS,9R,12S,12aR)-3,6,9-trimethyloctahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10(3H)-one
    • (3R,5AS,6R,8AS,9R,12S,12aR)-3,6,9-trimethyloctahydro-3,12-epoxypyrano(4,3-j)-1,2-benzodioxepin-10(3H)-one
    • AS-12692
    • NS00010623
    • S1282
    • EN300-7390753
    • Q426921
    • SR-01000802560-2
    • SR-01000802560-3
    • SR-01000802560-4
    • BRD-K13112821-001-08-3

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 17.36
    methanol 9.23
    isopropanol 8.94
    water 0.42
    ethyl acetate 47.85
    n-propanol 15.12
    acetone 35.37
    n-butanol 9.23
    acetonitrile 4.6
    DMF 86.68
    toluene 128.25
    isobutanol 12.6
    1,4-dioxane 104.4
    methyl acetate 56.41
    THF 115.61
    2-butanone 108.07
    n-pentanol 14.83
    sec-butanol 10.8
    n-hexane 0.29
    ethylene glycol 7.46
    NMP 239.17
    cyclohexane 2.73
    DMSO 92.85
    n-butyl acetate 48.75
    n-octanol 15.44
    chloroform 437.19
    n-propyl acetate 40.9
    acetic acid 57.25
    dichloromethane 256.09
    cyclohexanone 197.83
    propylene glycol 6.48
    isopropyl acetate 32.59
    DMAc 136.48
    2-ethoxyethanol 36.23
    isopentanol 13.38
    n-heptane 0.34
    ethyl formate 40.27
    1,2-dichloroethane 107.13
    n-hexanol 20.39
    2-methoxyethanol 42.2
    isobutyl acetate 34.9
    tetrachloromethane 27.05
    n-pentyl acetate 48.62
    transcutol 92.89
    n-heptanol 17.91
    ethylbenzene 35.29
    MIBK 33.1
    2-propoxyethanol 58.24
    tert-butanol 10.36
    MTBE 7.11
    2-butoxyethanol 45.33
    propionic acid 50.39
    o-xylene 61.55
    formic acid 35.1
    diethyl ether 7.96
    m-xylene 55.07
    p-xylene 56.51
    chlorobenzene 156.1
    dimethyl carbonate 34.92
    n-octane 0.4
    formamide 38.17
    cyclopentanone 183.06
    2-pentanone 39.61
    anisole 54.65
    cyclopentyl methyl ether 37.09
    gamma-butyrolactone 218.63
    1-methoxy-2-propanol 30.8
    pyridine 256.43
    3-pentanone 49.84
    furfural 278.96
    n-dodecane 1.05
    diethylene glycol 53.94
    diisopropyl ether 4.69
    tert-amyl alcohol 10.76
    acetylacetone 65.62
    n-hexadecane 1.33
    acetophenone 94.32
    methyl propionate 50.44
    isopentyl acetate 51.15
    trichloroethylene 377.64
    n-nonanol 16.56
    cyclohexanol 29.61
    benzyl alcohol 83.06
    2-ethylhexanol 17.67
    isooctanol 17.87
    dipropyl ether 7.11
    1,2-dichlorobenzene 134.64
    ethyl lactate 30.5
    propylene carbonate 125.61
    n-methylformamide 38.86
    2-pentanol 5.87
    n-pentane 0.38
    1-propoxy-2-propanol 34.41
    1-methoxy-2-propyl acetate 58.72
    2-(2-methoxypropoxy) propanol 57.09
    mesitylene 25.83
    ε-caprolactone 179.65
    p-cymene 23.2
    epichlorohydrin 187.04
    1,1,1-trichloroethane 84.36
    2-aminoethanol 13.03
    morpholine-4-carbaldehyde 187.94
    sulfolane 228.6
    2,2,4-trimethylpentane 0.82
    2-methyltetrahydrofuran 73.31
    n-hexyl acetate 54.18
    isooctane 0.62
    2-(2-butoxyethoxy)ethanol 60.13
    sec-butyl acetate 32.56
    tert-butyl acetate 32.71
    decalin 2.8
    glycerin 20.61
    diglyme 96.7
    acrylic acid 60.45
    isopropyl myristate 25.12
    n-butyric acid 51.77
    acetyl acetate 52.02
    di(2-ethylhexyl) phthalate 47.6
    ethyl propionate 34.91
    nitromethane 71.97
    1,2-diethoxyethane 30.0
    benzonitrile 116.54
    trioctyl phosphate 29.4
    1-bromopropane 31.03
    gamma-valerolactone 282.54
    n-decanol 12.76
    triethyl phosphate 32.58
    4-methyl-2-pentanol 8.1
    propionitrile 14.02
    vinylene carbonate 163.25
    1,1,2-trichlorotrifluoroethane 141.77
    DMS 73.32
    cumene 22.87
    2-octanol 12.03
    2-hexanone 43.64
    octyl acetate 32.43
    limonene 23.37
    1,2-dimethoxyethane 53.51
    ethyl orthosilicate 27.65
    tributyl phosphate 32.54
    diacetone alcohol 38.93
    N,N-dimethylaniline 36.27
    acrylonitrile 28.5
    aniline 94.67
    1,3-propanediol 18.94
    bromobenzene 164.98
    dibromomethane 125.92
    1,1,2,2-tetrachloroethane 240.07
    2-methyl-cyclohexyl acetate 53.49
    tetrabutyl urea 42.22
    diisobutyl methanol 9.98
    2-phenylethanol 83.97
    styrene 44.26
    dioctyl adipate 45.31
    dimethyl sulfate 68.72
    ethyl butyrate 36.13
    methyl lactate 34.21
    butyl lactate 41.71
    diethyl carbonate 32.73
    propanediol butyl ether 36.1
    triethyl orthoformate 28.51
    p-tert-butyltoluene 18.65
    methyl 4-tert-butylbenzoate 72.04
    morpholine 89.01
    tert-butylamine 5.07
    n-dodecanol 10.34
    dimethoxymethane 44.41
    ethylene carbonate 115.59
    cyrene 96.43
    2-ethoxyethyl acetate 69.76
    2-ethylhexyl acetate 47.8
    1,2,4-trichlorobenzene 176.01
    4-methylpyridine 193.52
    dibutyl ether 11.2
    2,6-dimethyl-4-heptanol 9.98
    DEF 55.53
    dimethyl isosorbide 105.88
    tetrachloroethylene 164.79
    eugenol 74.35
    triacetin 70.38
    span 80 49.52
    1,4-butanediol 13.73
    1,1-dichloroethane 74.31
    2-methyl-1-pentanol 21.49
    methyl formate 41.41
    2-methyl-1-butanol 13.4
    n-decane 1.31
    butyronitrile 14.01
    3,7-dimethyl-1-octanol 19.09
    1-chlorooctane 9.15
    1-chlorotetradecane 5.72
    n-nonane 0.8
    undecane 1.14
    tert-butylcyclohexane 1.82
    cyclooctane 0.94
    cyclopentanol 36.6
    tetrahydropyran 62.74
    tert-amyl methyl ether 9.1
    2,5,8-trioxanonane 83.43
    1-hexene 2.55
    2-isopropoxyethanol 30.41
    2,2,2-trifluoroethanol 35.25
    methyl butyrate 46.75

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction

Botanical

Name CAS Botanical Proportion
Annual wormwood (China) 2b 84775-74-6 Artemisia annua L., fam. Asteraceae (Compositae) 1.7%
Annual wormwood (Vietnam) 2b 84775-74-6 Annua artemisia L., fam. Asteraceae (Compositae) 22.3%