Artemisinic alcohol

Overview IFRA Request a quote

  • Identifiers

    CAS number
    125184-95-4

    Molecular formula
    C15H24O

    SMILES
    C[C@@H]1CC[C@H]([C@@H]2[C@H]1CCC(=C2)C)C(=C)CO

  • Odor profile

    Fragrance
    Woody 64.74%
    Floral 57.5%
    Fruity 55.0%
    Herbal 47.23%
    Sweet 45.57%
    Fresh 38.96%
    Balsamic 36.21%
    Green 35.1%
    Spicy 33.26%
    Rose 28.99%

     

    Flavor
    Herbal 43.5%
    Sweet 40.47%
    Woody 37.82%
    Fruity 37.27%
    Spicy 35.28%
    Spice 33.08%
    Herb 32.16%
    Mint 28.75%
    Minty 26.34%
    Wood 25.79%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    3.8

    pKa est.
    9.14 (weak base)

    Molecular weight
    220.35 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    334°C

    Flash point

    • 127.47 ˚C est.

  • Synonyms

    • Artemisinic alcohol
    • (+)-artemisinic alcohol
    • 125184-95-4
    • Artemisinic Alcohol Impurity
    • amorpha-4,11-diene-12-ol
    • 2-[(1R,4R,4aS,8aR)-4,7-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalen-1-yl]prop-2-en-1-ol
    • CHEBI:64783
    • Arteannuic alcohol
    • amorpha-4,11-dien-12-ol
    • SCHEMBL14189186
    • DTXSID201315937
    • C20307
    • Q27133422

  • Applications

    Artemisinic alcohol (CAS 125184-95-4) is primarily used as a chemical intermediate in the semi-synthetic production of artemisinin and related sesquiterpene lactones in pharmaceutical manufacturing. It also serves as a versatile building block in chemical synthesis and process development for terpenoid derivatives, and is widely studied in research settings as a substrate for biocatalysis and synthetic routes toward artemisinin-related compounds. In laboratory and industrial contexts, it may be evaluated for fragrance research or as a component in exploratory synthesis workflows, with handling and use subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 2121.4
    methanol 1370.53
    isopropanol 2437.72
    water 0.26
    ethyl acetate 1774.13
    n-propanol 2406.36
    acetone 2089.77
    n-butanol 2023.05
    acetonitrile 1429.34
    DMF 1529.37
    toluene 1335.1
    isobutanol 1401.51
    1,4-dioxane 3339.63
    methyl acetate 1296.44
    THF 4991.81
    2-butanone 1857.57
    n-pentanol 689.33
    sec-butanol 1259.48
    n-hexane 40.51
    ethylene glycol 95.6
    NMP 500.65
    cyclohexane 179.48
    DMSO 1225.6
    n-butyl acetate 1254.7
    n-octanol 241.89
    chloroform 2841.63
    n-propyl acetate 781.03
    acetic acid 573.94
    dichloromethane 2386.43
    cyclohexanone 1750.45
    propylene glycol 242.36
    isopropyl acetate 960.44
    DMAc 632.98
    2-ethoxyethanol 844.13
    isopentanol 1400.47
    n-heptane 47.3
    ethyl formate 985.43
    1,2-dichloroethane 1579.44
    n-hexanol 1061.98
    2-methoxyethanol 2124.49
    isobutyl acetate 414.44
    tetrachloromethane 442.52
    n-pentyl acetate 501.38
    transcutol 3471.79
    n-heptanol 320.43
    ethylbenzene 288.51
    MIBK 734.23
    2-propoxyethanol 1487.84
    tert-butanol 1970.36
    MTBE 1884.2
    2-butoxyethanol 633.0
    propionic acid 628.23
    o-xylene 405.02
    formic acid 122.35
    diethyl ether 2263.55
    m-xylene 649.75
    p-xylene 322.54
    chlorobenzene 874.36
    dimethyl carbonate 323.16
    n-octane 15.16
    formamide 342.88
    cyclopentanone 2106.58
    2-pentanone 1641.52
    anisole 600.49
    cyclopentyl methyl ether 1466.34
    gamma-butyrolactone 1718.6
    1-methoxy-2-propanol 1632.67
    pyridine 2445.85
    3-pentanone 859.26
    furfural 1154.39
    n-dodecane 9.11
    diethylene glycol 643.7
    diisopropyl ether 397.16
    tert-amyl alcohol 965.1
    acetylacetone 1054.0
    n-hexadecane 11.56
    acetophenone 393.57
    methyl propionate 1010.78
    isopentyl acetate 951.28
    trichloroethylene 2552.79
    n-nonanol 198.29
    cyclohexanol 964.66
    benzyl alcohol 472.68
    2-ethylhexanol 436.63
    isooctanol 251.31
    dipropyl ether 743.37
    1,2-dichlorobenzene 551.28
    ethyl lactate 206.44
    propylene carbonate 720.42
    n-methylformamide 1051.51
    2-pentanol 1078.45
    n-pentane 92.28
    1-propoxy-2-propanol 1156.55
    1-methoxy-2-propyl acetate 923.36
    2-(2-methoxypropoxy) propanol 388.2
    mesitylene 316.99
    ε-caprolactone 1244.88
    p-cymene 184.71
    epichlorohydrin 2446.95
    1,1,1-trichloroethane 1286.54
    2-aminoethanol 412.78
    morpholine-4-carbaldehyde 1034.04
    sulfolane 945.55
    2,2,4-trimethylpentane 37.79
    2-methyltetrahydrofuran 2754.95
    n-hexyl acetate 571.31
    isooctane 49.67
    2-(2-butoxyethoxy)ethanol 751.16
    sec-butyl acetate 452.26
    tert-butyl acetate 789.84
    decalin 44.7
    glycerin 251.45
    diglyme 1513.91
    acrylic acid 359.81
    isopropyl myristate 155.7
    n-butyric acid 1526.14
    acetyl acetate 571.88
    di(2-ethylhexyl) phthalate 153.25
    ethyl propionate 526.6
    nitromethane 1152.91
    1,2-diethoxyethane 1440.6
    benzonitrile 759.28
    trioctyl phosphate 112.46
    1-bromopropane 1071.4
    gamma-valerolactone 2077.44
    n-decanol 132.78
    triethyl phosphate 160.91
    4-methyl-2-pentanol 478.82
    propionitrile 1431.57
    vinylene carbonate 692.89
    1,1,2-trichlorotrifluoroethane 825.94
    DMS 335.1
    cumene 161.19
    2-octanol 186.18
    2-hexanone 685.69
    octyl acetate 198.64
    limonene 265.65
    1,2-dimethoxyethane 1687.16
    ethyl orthosilicate 181.93
    tributyl phosphate 145.67
    diacetone alcohol 746.08
    N,N-dimethylaniline 263.59
    acrylonitrile 1227.25
    aniline 1136.43
    1,3-propanediol 1005.68
    bromobenzene 899.27
    dibromomethane 1660.55
    1,1,2,2-tetrachloroethane 1704.78
    2-methyl-cyclohexyl acetate 304.56
    tetrabutyl urea 163.99
    diisobutyl methanol 271.57
    2-phenylethanol 555.52
    styrene 373.78
    dioctyl adipate 201.93
    dimethyl sulfate 284.94
    ethyl butyrate 629.67
    methyl lactate 309.2
    butyl lactate 338.06
    diethyl carbonate 324.88
    propanediol butyl ether 484.95
    triethyl orthoformate 382.52
    p-tert-butyltoluene 194.01
    methyl 4-tert-butylbenzoate 305.18
    morpholine 4084.73
    tert-butylamine 1176.36
    n-dodecanol 91.05
    dimethoxymethane 1743.63
    ethylene carbonate 675.43
    cyrene 279.88
    2-ethoxyethyl acetate 707.23
    2-ethylhexyl acetate 623.99
    1,2,4-trichlorobenzene 628.13
    4-methylpyridine 1904.06
    dibutyl ether 395.0
    2,6-dimethyl-4-heptanol 271.57
    DEF 976.82
    dimethyl isosorbide 630.23
    tetrachloroethylene 1027.48
    eugenol 304.71
    triacetin 365.62
    span 80 332.15
    1,4-butanediol 202.09
    1,1-dichloroethane 1854.66
    2-methyl-1-pentanol 478.1
    methyl formate 675.32
    2-methyl-1-butanol 1040.88
    n-decane 20.46
    butyronitrile 1768.99
    3,7-dimethyl-1-octanol 283.27
    1-chlorooctane 137.43
    1-chlorotetradecane 36.25
    n-nonane 19.48
    undecane 12.89
    tert-butylcyclohexane 41.43
    cyclooctane 50.05
    cyclopentanol 979.9
    tetrahydropyran 4269.04
    tert-amyl methyl ether 699.39
    2,5,8-trioxanonane 698.5
    1-hexene 260.78
    2-isopropoxyethanol 522.27
    2,2,2-trifluoroethanol 145.42
    methyl butyrate 748.41

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction