Artemisinic Acid

Overview IFRA Botanical Request a quote

  • Identifiers

    CAS number
    80286-58-4

    Molecular formula
    C15H22O2

    SMILES
    C[C@@H]1CC[C@H]([C@@H]2[C@H]1CCC(=C2)C)C(=C)C(=O)O

  • Odor profile

    Green 61.56%
    Woody 52.92%
    Fruity 44.19%
    Herbal 41.49%
    Balsamic 35.51%
    Fresh 34.42%
    Spicy 32.07%
    Mint 29.93%
    Sweet 28.15%
    Dry 25.5%

    Scent© AI

  • Properties

    XLogP3-AA
    3.8

    Molecular weight
    234.33 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    360°C

    Flash point est.
    154.05 ˚C

  • Synonyms

    • Artemisinic acid
    • Artemisic acid
    • 80286-58-4
    • Arteannuic acid
    • (+)-artemisinic acid
    • 2-[(1R,4R,4aS,8aR)-4,7-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalen-1-yl]prop-2-enoic acid
    • CHEBI:63749
    • QING HAO ACID
    • QING HAU ACID
    • UNII-53N99527G7
    • ARTEMISININIC ACID
    • SINGLEEX ARTEMISINIC ACID
    • EC 617-040-5
    • MFCD00238540
    • 53N99527G7
    • 2-((1r,4r,4as,8ar)-4,7-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalen-1-yl)acrylic acid
    • 2-((1R,4R,4aS,8aR)-4,7-Dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalen-1-yl)prop-2-enoic acid
    • 1-NAPHTHALENEACETIC ACID, 1,2,3,4,4A,5,6,8A-OCTAHYDRO-4,7-DIMETHYL-.ALPHA.-METHYLENE-, (1R,4R,4AS,8AR)-
    • Artemisinicacid
    • Artemisinic-acid
    • 2-((4R)-4,7-Dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalen-1-yl)prop-2-enoate
    • 2-[(4R)-4,7-Dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalen-1-yl]prop-2-enoate
    • Qing Hao acid; Artemisinic acid; Arteannuic acid
    • SCHEMBL159983
    • CHEMBL457385
    • ARTEMISINIC ACID [INCI]
    • PLQMEXSCSAIXGB-SAXRGWBVSA-N
    • HY-N1984
    • MSK14288
    • s9135
    • AKOS017343176
    • CCG-266821
    • FA69967
    • LMPR0103190015
    • AC-34595
    • AS-78501
    • DA-61227
    • CS-0018305
    • C20309
    • Q27132774
    • 222F86B0-6F56-4D85-98B2-F1B0E146A747
    • Artemisinic acid;4,11(13)-Amorphadien-12-oic acid;Artemisic acid
    • 2-(4,7-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphtalen-1-yl)prop-2-enoic acid
    • 1-NAPHTHALENEACETIC ACID, 1,2,3,4,4A,5,6,8A-OCTAHYDRO-4,7-DIMETHYL-.ALPHA.-METHYLENE-, (1R-(1.ALPHA.,4.BETA.,4A.BETA.,8A.BETA.))-
    • 1-NAPHTHALENEACETIC ACID, 1,2,3,4,4A,5,6,8A-OCTAHYDRO-4,7-DIMETHYL-ALPHA-METHYLENE-, (1R,4R,4AS,8AR)-
    • 1-Naphthaleneacetic acid, 1,2,3,4,4a,5,6,8a-octahydro-4,7-dimethyl-alpha-methylene-, (1R-(1alpha,4beta,4abeta,8abeta))-
    • 2-[(1R,4R,4aS,8aR)-4,7-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalen-1-yl]prop-2-enoicacid
    • 617-040-5
    • Artemisinic acid(+)-artemisinic acid; Arteannuic acid; 2-[(1R,4R,4aS,8aR)-4,7-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalen-1-yl]prop-2-enoic acid

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 392.77
    methanol 432.73
    isopropanol 353.62
    water 0.12
    ethyl acetate 388.72
    n-propanol 475.56
    acetone 341.01
    n-butanol 394.7
    acetonitrile 142.06
    DMF 534.24
    toluene 341.4
    isobutanol 313.82
    1,4-dioxane 582.72
    methyl acetate 272.71
    THF 1051.23
    2-butanone 480.73
    n-pentanol 200.14
    sec-butanol 317.57
    n-hexane 9.7
    ethylene glycol 34.15
    NMP 451.34
    cyclohexane 19.31
    DMSO 489.17
    n-butyl acetate 313.26
    n-octanol 63.32
    chloroform 499.7
    n-propyl acetate 180.85
    acetic acid 112.87
    dichloromethane 463.82
    cyclohexanone 544.49
    propylene glycol 81.7
    isopropyl acetate 256.98
    DMAc 424.39
    2-ethoxyethanol 265.35
    isopentanol 346.59
    n-heptane 4.7
    ethyl formate 147.95
    1,2-dichloroethane 381.99
    n-hexanol 280.09
    2-methoxyethanol 515.78
    isobutyl acetate 114.12
    tetrachloromethane 77.38
    n-pentyl acetate 150.83
    transcutol 1270.1
    n-heptanol 104.19
    ethylbenzene 111.92
    MIBK 253.02
    2-propoxyethanol 463.01
    tert-butanol 388.24
    MTBE 370.98
    2-butoxyethanol 229.19
    propionic acid 167.04
    o-xylene 166.64
    formic acid 54.69
    diethyl ether 364.29
    m-xylene 228.24
    p-xylene 114.83
    chlorobenzene 249.09
    dimethyl carbonate 108.86
    n-octane 2.06
    formamide 135.45
    cyclopentanone 678.76
    2-pentanone 434.43
    anisole 220.45
    cyclopentyl methyl ether 460.21
    gamma-butyrolactone 581.56
    1-methoxy-2-propanol 485.11
    pyridine 515.08
    3-pentanone 266.4
    furfural 420.17
    n-dodecane 1.39
    diethylene glycol 240.74
    diisopropyl ether 90.76
    tert-amyl alcohol 304.92
    acetylacetone 320.44
    n-hexadecane 1.76
    acetophenone 187.36
    methyl propionate 318.42
    isopentyl acetate 288.84
    trichloroethylene 732.91
    n-nonanol 57.7
    cyclohexanol 267.92
    benzyl alcohol 207.16
    2-ethylhexanol 117.48
    isooctanol 86.89
    dipropyl ether 98.9
    1,2-dichlorobenzene 197.7
    ethyl lactate 81.48
    propylene carbonate 234.91
    n-methylformamide 329.13
    2-pentanol 249.59
    n-pentane 12.68
    1-propoxy-2-propanol 321.41
    1-methoxy-2-propyl acetate 330.24
    2-(2-methoxypropoxy) propanol 181.83
    mesitylene 113.51
    ε-caprolactone 433.61
    p-cymene 57.24
    epichlorohydrin 806.73
    1,1,1-trichloroethane 266.96
    2-aminoethanol 132.93
    morpholine-4-carbaldehyde 481.66
    sulfolane 550.25
    2,2,4-trimethylpentane 9.47
    2-methyltetrahydrofuran 700.63
    n-hexyl acetate 173.69
    isooctane 10.33
    2-(2-butoxyethoxy)ethanol 318.33
    sec-butyl acetate 143.39
    tert-butyl acetate 259.33
    decalin 12.68
    glycerin 104.25
    diglyme 511.51
    acrylic acid 113.61
    isopropyl myristate 48.48
    n-butyric acid 291.26
    acetyl acetate 123.61
    di(2-ethylhexyl) phthalate 66.87
    ethyl propionate 156.21
    nitromethane 242.73
    1,2-diethoxyethane 315.36
    benzonitrile 200.94
    trioctyl phosphate 44.8
    1-bromopropane 188.43
    gamma-valerolactone 802.8
    n-decanol 38.18
    triethyl phosphate 55.72
    4-methyl-2-pentanol 144.68
    propionitrile 190.18
    vinylene carbonate 197.57
    1,1,2-trichlorotrifluoroethane 337.1
    DMS 147.12
    cumene 69.49
    2-octanol 60.39
    2-hexanone 206.63
    octyl acetate 66.48
    limonene 72.18
    1,2-dimethoxyethane 371.63
    ethyl orthosilicate 57.39
    tributyl phosphate 53.66
    diacetone alcohol 329.66
    N,N-dimethylaniline 135.77
    acrylonitrile 208.93
    aniline 372.9
    1,3-propanediol 255.04
    bromobenzene 228.4
    dibromomethane 286.54
    1,1,2,2-tetrachloroethane 543.49
    2-methyl-cyclohexyl acetate 112.06
    tetrabutyl urea 64.86
    diisobutyl methanol 66.79
    2-phenylethanol 223.65
    styrene 119.21
    dioctyl adipate 74.58
    dimethyl sulfate 158.46
    ethyl butyrate 142.86
    methyl lactate 121.23
    butyl lactate 134.46
    diethyl carbonate 77.39
    propanediol butyl ether 221.03
    triethyl orthoformate 91.4
    p-tert-butyltoluene 59.61
    methyl 4-tert-butylbenzoate 144.09
    morpholine 836.9
    tert-butylamine 190.1
    n-dodecanol 24.5
    dimethoxymethane 464.56
    ethylene carbonate 171.59
    cyrene 169.45
    2-ethoxyethyl acetate 251.39
    2-ethylhexyl acetate 201.23
    1,2,4-trichlorobenzene 248.47
    4-methylpyridine 581.04
    dibutyl ether 64.59
    2,6-dimethyl-4-heptanol 66.79
    DEF 358.39
    dimethyl isosorbide 312.12
    tetrachloroethylene 321.11
    eugenol 152.29
    triacetin 140.11
    span 80 147.92
    1,4-butanediol 73.02
    1,1-dichloroethane 335.16
    2-methyl-1-pentanol 201.32
    methyl formate 183.94
    2-methyl-1-butanol 306.75
    n-decane 2.85
    butyronitrile 213.59
    3,7-dimethyl-1-octanol 85.51
    1-chlorooctane 27.53
    1-chlorotetradecane 7.27
    n-nonane 2.44
    undecane 1.93
    tert-butylcyclohexane 12.55
    cyclooctane 7.27
    cyclopentanol 293.82
    tetrahydropyran 675.08
    tert-amyl methyl ether 217.41
    2,5,8-trioxanonane 280.82
    1-hexene 60.4
    2-isopropoxyethanol 206.51
    2,2,2-trifluoroethanol 46.12
    methyl butyrate 194.92

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction

Botanical

Name CAS Botanical Proportion
Annual wormwood (China) 2a 84775-74-6 Artemisia annua L., fam. Asteraceae (Compositae) 0.05%
Annual wormwood (China) 2b 84775-74-6 Artemisia annua L., fam. Asteraceae (Compositae) 3.5%
Annual wormwood (Vietnam) 2a 84775-74-6 Artemisia annua L., fam. Asteraceae (Compositae) 0.05%
Annual wormwood (Vietnam) 2b 84775-74-6 Annua artemisia L., fam. Asteraceae (Compositae) 1.8%