AR-15512

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  • Identifiers

    CAS number
    68489-09-8

    Molecular formula
    C18H27NO2

    SMILES
    C[C@@H]1CC[C@H]([C@@H](C1)C(=O)NC2=CC=C(C=C2)OC)C(C)C

  • Odor profile

    Fragrance
    Cooling 54.51%
    Mint 51.68%
    Odorless 35.03%
    Herbal 28.91%
    Animal 27.72%
    Savory 25.37%
    Grapefruit 23.17%
    Spicy 22.61%
    Fresh 20.57%
    Citrus 20.28%

     

    Flavor
    Herbal 43.62%
    Bitter 31.87%
    Fruity 25.91%
    Herb 24.34%
    Woody 24.13%
    Mild 23.16%
    Spice 22.52%
    Odorless 21.51%
    Spicy 21.28%
    Cedarleaf 21.16%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    4.6

    pKa est.
    7.78 (neutral)

    Molecular weight
    289.4 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    424°C

    Flash point

    • 173.28 ˚C est.

    Solubility expt.

    • Insoluble in water; sparingly soluble in avocado oil
    • Sparingly soluble (in ethanol)

  • Synonyms

    • 68489-09-8
    • WS-12
    • WS 12
    • (1R,2S,5R)-N-(4-methoxyphenyl)-5-methyl-2-(propan-2-yl)cyclohexane-1-carboxamide
    • Fema No. 4681
    • Acoltremon
    • N-(4-methoxyphenyl)-p-menthanecarboxamide
    • Cyclohexanecarboxamide,N-(4-methoxyphenyl)-5-methyl-2-(1-methylethyl)-, (1R,2S,5R)-
    • 1L7BVT4Z4Z
    • AR-15512
    • (1R,2S,5R)-N-(4-methoxyphenyl)-5-methyl-2-propan-2-ylcyclohexane-1-carboxamide
    • CHEMBL2441929
    • AVX-012
    • (1R,2S,5R)-2-ISOPROPYL-N-(4-METHOXYPHENYL)-5-METHYLCYCLOHEXANE-1-CARBOXAMIDE
    • Cyclohexanecarboxamide, N-(4-methoxyphenyl)-5-methyl-2-(1-methylethyl)-, (1R,2S,5R)-
    • (1R,2S,5R)-N-(4-METHOXYPHENYL)-5-METHYL-2-(1-METHYLETHYL)CYCLOHEXANECARBOXAMIDE
    • [1R,2S,5R]-N-(4-Methoxyphenyl)-p-menthanecarboxamide
    • HNSGVPAAXJJOPQ-XOKHGSTOSA-N
    • acoltremon [INN]
    • UNII-1L7BVT4Z4Z
    • GTPL4343
    • SCHEMBL2575067
    • DTXSID10460636
    • TCA48909
    • BDBM50442649
    • AKOS024457397
    • WS 12 is known as a TRPM8 agonist.
    • DA-59157
    • KXS
    • HY-108449
    • N-(4-Methoxyphenyl)-p-menthane-carboxamide
    • CS-0028711
    • E77039
    • Q27089230
    • (1R,2S,5R)-Methoxyphenyl)-5-methyl-2-propan-N-(4-2-ylcyclohexane-1-carboxamide
    • N-(4-Methoxyphenyl)-5-methyl-2- (1-methylethyl)cyclohexanecarboxamide, (1R,2S,5R)-
    • N-(4-METHOXYPHENYL)-5-METHYL-2-(1-METHYLETHYL)CYCLOHEXANECARBOXAMIDE, (1R,2S,5R)-
    • 847565-93-9
    • Cyclohexanecarboxamide, N-(4-methoxyphenyl)-5-methyl-2-(1-methylethyl)-, [1R-(1alpha,2beta,5alpha)]-

  • Applications

    AR-15512 (CAS 68489-09-8) is typically employed as an intermediate in organic synthesis and is often evaluated as a solvent or processing aid in industrial manufacturing. It can participate in polymer formulations, serving as a plasticizer or stabilizer, and is used in coatings and inks to improve solubility and film formation. Depending on regulatory constraints and formulation goals, it may also be considered for fragrance or odorant applications, and it can appear as an intermediate in pharmaceutical or agrochemical syntheses under appropriate controls.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 170.86
    methanol 155.29
    isopropanol 110.32
    water 0.14
    ethyl acetate 183.59
    n-propanol 130.15
    acetone 165.81
    n-butanol 127.01
    acetonitrile 68.13
    DMF 143.81
    toluene 87.38
    isobutanol 74.51
    1,4-dioxane 361.03
    methyl acetate 124.42
    THF 338.64
    2-butanone 150.37
    n-pentanol 75.71
    sec-butanol 68.7
    n-hexane 2.26
    ethylene glycol 14.67
    NMP 77.24
    cyclohexane 8.63
    DMSO 169.78
    n-butyl acetate 110.29
    n-octanol 29.46
    chloroform 491.93
    n-propyl acetate 87.02
    acetic acid 132.46
    dichloromethane 358.18
    cyclohexanone 206.94
    propylene glycol 31.94
    isopropyl acetate 115.0
    DMAc 218.31
    2-ethoxyethanol 140.78
    isopentanol 98.0
    n-heptane 1.67
    ethyl formate 89.24
    1,2-dichloroethane 253.35
    n-hexanol 89.45
    2-methoxyethanol 207.26
    isobutyl acetate 68.97
    tetrachloromethane 34.69
    n-pentyl acetate 58.49
    transcutol 406.42
    n-heptanol 37.7
    ethylbenzene 35.91
    MIBK 82.13
    2-propoxyethanol 192.35
    tert-butanol 103.38
    MTBE 96.43
    2-butoxyethanol 95.97
    propionic acid 73.25
    o-xylene 44.4
    formic acid 35.46
    diethyl ether 120.77
    m-xylene 50.26
    p-xylene 47.26
    chlorobenzene 122.95
    dimethyl carbonate 42.8
    n-octane 1.53
    formamide 49.39
    cyclopentanone 187.85
    2-pentanone 123.53
    anisole 77.26
    cyclopentyl methyl ether 88.89
    gamma-butyrolactone 168.81
    1-methoxy-2-propanol 140.35
    pyridine 191.56
    3-pentanone 94.39
    furfural 174.38
    n-dodecane 1.71
    diethylene glycol 118.05
    diisopropyl ether 24.41
    tert-amyl alcohol 64.56
    acetylacetone 155.64
    n-hexadecane 2.05
    acetophenone 76.46
    methyl propionate 95.4
    isopentyl acetate 109.73
    trichloroethylene 398.74
    n-nonanol 31.47
    cyclohexanol 87.92
    benzyl alcohol 78.02
    2-ethylhexanol 40.55
    isooctanol 32.36
    dipropyl ether 35.12
    1,2-dichlorobenzene 100.38
    ethyl lactate 43.07
    propylene carbonate 103.47
    n-methylformamide 63.97
    2-pentanol 55.34
    n-pentane 2.22
    1-propoxy-2-propanol 108.31
    1-methoxy-2-propyl acetate 128.62
    2-(2-methoxypropoxy) propanol 81.04
    mesitylene 27.65
    ε-caprolactone 164.5
    p-cymene 23.15
    epichlorohydrin 274.49
    1,1,1-trichloroethane 168.95
    2-aminoethanol 49.58
    morpholine-4-carbaldehyde 173.53
    sulfolane 159.16
    2,2,4-trimethylpentane 3.34
    2-methyltetrahydrofuran 165.42
    n-hexyl acetate 68.94
    isooctane 2.72
    2-(2-butoxyethoxy)ethanol 120.73
    sec-butyl acetate 68.2
    tert-butyl acetate 98.85
    decalin 5.47
    glycerin 46.2
    diglyme 218.49
    acrylic acid 56.57
    isopropyl myristate 27.62
    n-butyric acid 150.21
    acetyl acetate 113.21
    di(2-ethylhexyl) phthalate 36.66
    ethyl propionate 68.96
    nitromethane 152.18
    1,2-diethoxyethane 139.71
    benzonitrile 82.14
    trioctyl phosphate 23.83
    1-bromopropane 104.98
    gamma-valerolactone 296.69
    n-decanol 23.8
    triethyl phosphate 35.81
    4-methyl-2-pentanol 40.6
    propionitrile 72.08
    vinylene carbonate 107.57
    1,1,2-trichlorotrifluoroethane 168.74
    DMS 70.14
    cumene 24.59
    2-octanol 23.06
    2-hexanone 77.67
    octyl acetate 36.04
    limonene 27.41
    1,2-dimethoxyethane 193.76
    ethyl orthosilicate 36.64
    tributyl phosphate 29.45
    diacetone alcohol 98.86
    N,N-dimethylaniline 45.07
    acrylonitrile 80.61
    aniline 101.64
    1,3-propanediol 121.66
    bromobenzene 116.72
    dibromomethane 209.31
    1,1,2,2-tetrachloroethane 340.7
    2-methyl-cyclohexyl acetate 57.73
    tetrabutyl urea 35.73
    diisobutyl methanol 25.29
    2-phenylethanol 84.91
    styrene 43.72
    dioctyl adipate 43.36
    dimethyl sulfate 54.23
    ethyl butyrate 66.97
    methyl lactate 47.34
    butyl lactate 54.54
    diethyl carbonate 48.56
    propanediol butyl ether 69.64
    triethyl orthoformate 51.63
    p-tert-butyltoluene 21.75
    methyl 4-tert-butylbenzoate 66.63
    morpholine 335.49
    tert-butylamine 48.32
    n-dodecanol 17.53
    dimethoxymethane 147.24
    ethylene carbonate 102.31
    cyrene 73.54
    2-ethoxyethyl acetate 114.14
    2-ethylhexyl acetate 79.0
    1,2,4-trichlorobenzene 109.79
    4-methylpyridine 162.31
    dibutyl ether 33.74
    2,6-dimethyl-4-heptanol 25.29
    DEF 98.07
    dimethyl isosorbide 129.08
    tetrachloroethylene 188.83
    eugenol 74.59
    triacetin 69.62
    span 80 65.55
    1,4-butanediol 43.27
    1,1-dichloroethane 204.1
    2-methyl-1-pentanol 66.58
    methyl formate 52.1
    2-methyl-1-butanol 78.6
    n-decane 2.86
    butyronitrile 89.69
    3,7-dimethyl-1-octanol 35.91
    1-chlorooctane 18.35
    1-chlorotetradecane 7.46
    n-nonane 2.25
    undecane 2.14
    tert-butylcyclohexane 4.42
    cyclooctane 2.37
    cyclopentanol 67.96
    tetrahydropyran 270.15
    tert-amyl methyl ether 56.85
    2,5,8-trioxanonane 136.93
    1-hexene 16.84
    2-isopropoxyethanol 102.03
    2,2,2-trifluoroethanol 40.75
    methyl butyrate 92.61

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction