Antioxidant 245

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  • Identifiers

    CAS number
    36443-68-2

    Molecular formula
    C34H50O8

    SMILES
    CC1=CC(=CC(=C1O)C(C)(C)C)CCC(=O)OCCOCCOCCOC(=O)CCC2=CC(=C(C(=C2)C)O)C(C)(C)C

    Safety labels

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Fruity 51.29%
    Floral 50.03%
    Musk 40.65%
    Woody 39.52%
    Powdery 33.86%
    Dry 33.43%
    Sweet 32.17%
    Balsamic 28.84%
    Amber 25.6%
    Animal 25.2%

     

    Flavor
    Bitter 53.02%
    Mild 28.93%
    Woody 27.32%
    Bland 26.01%
    Odorless 24.54%
    Herbal 22.25%
    Floral 22.02%
    Parsley 21.9%
    Heather 20.97%
    Eugenol 20.66%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    6.9

    pKa est.
    8.34 (weak base)

    Molecular weight
    586.8 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    987°C

    Flash point

    • 246.35 ˚C est.

  • Synonyms

    • Antioxidant 245
    • 36443-68-2
    • TK 12627
    • R24A2HOY7J
    • TK-12627
    • Benzenepropanoic acid, 3,5-bis(1,1-dimethylethyl)-4-hydroxy-, 1,2-ethanediylbis(oxy-2,1-ethanediyl) ester
    • RefChem:899522
    • Triethylene glycol bis(3-tert-butyl-4-hydroxy-5-methylphenyl)propionate
    • Irganox 245
    • MFCD00134694
    • (ethane-1,2-diylbis(oxy))bis(ethane-2,1-diyl) bis(3-(3-(tert-butyl)-4-hydroxy-5-methylphenyl)propanoate)
    • Benzenepropanoic acid, 3-(1,1-dimethylethyl)-4-hydroxy-5-methyl-, 1,2-ethanediylbis(oxy-2,1-ethanediyl) ester
    • Benzenepropanoic acid, 3-(1,1-dimethylethyl)-4-hydroxy-5-methyl-,1,2-ethanediylbis(oxy-2,1-ethanediyl) ester
    • DTXSID0044236
    • Ethylenebis(oxyethylene) bis(3-(5-tert-butyl-4-hydroxy-m-tolyl)propionate)
    • Ethylenebis(oxyethylene) bis[3-(5-tert-butyl-4-hydroxy-m-tolyl)propionate]
    • Antioxidant245
    • triethylene glycol bis-(3-(3'-tert-butyl-4'-hydroxy-5'-methylphenyl)propionate)
    • Benzenepropanoic acid, 3-(1,1-dimethylethyl)-4-hydroxy-5-methyl-, 1,1'-(1,2-ethanediylbis(oxy-2,1-ethanediyl)) ester
    • EINECS 253-039-2
    • UNII-R24A2HOY7J
    • BRN 3579178
    • Triethylene Glycol Bis(3-?tert-?butyl-?4-?hydroxy-?5-?methylphenyl)?propionate
    • Irganox-245
    • 1,2-ethanediylbis(oxy-2,1-ethanediyl) bis{3-[4-hydroxy-3-methyl-5-(2-methyl-2-propanyl)phenyl]propanoate}
    • Antioxidant XH-245
    • TOMINOKUSU 917
    • EC 253-039-2
    • SCHEMBL97797
    • orb2664686
    • CHEMBL3187604
    • DTXCID8024236
    • SCHEMBL29351339
    • SCHEMBL29363126
    • MSK3120
    • Tox21_302408
    • AKOS015914940
    • FT40366
    • Antioxidant 245;Triethylene glycol bis-3-(3-tert-butyl-4-hydroxy-5-methylplenyl)propionate
    • NCGC00255928-01
    • AS-13805
    • CAS-36443-68-2
    • CS-0133628
    • NS00007511
    • NS00076926
    • T3277
    • D82257
    • 443T682
    • A823897
    • F551324
    • Q27287694
    • Triethyleneglycol-bis-3-(3-tert-butyl-4-hydroxy-5-methyl)propionate
    • triethylene glycol-bis-[3-(3-t-butyl-4-hydroxy-5-methylphenyl)propionate]
    • triethyleneglycol-bis[3-(3-tert-butyl-5-methyl-4-hydroxyphenyl) propionate]
    • TRIETHYLENE GLYCOL BIS(.BETA.-(3-TERT-BUTYL-4-HYDROXY-5-METHYLPHENYL)PROPIONATE)
    • TRIETHYLENE GLYCOL BIS(3-(3-TERT-BUTYL-5-METHYL-4-HYDROXYPHENYL)PROPIONATE)
    • TRIETHYLENE GLYCOL BIS(3-TERT-BUTYL-4-HYDROXY-5-METHYLHYDROCINNAMATE)
    • Triethylene glycol bis(3-tert-butyl-4-hydroxy-5-methylphenyl)propionate, AldrichCPR
    • Triethylene Glycol Bis[3-(3-tert-butyl-4-hydroxy-5-methylphenyl)propionate]
    • [(Ethane-1,2-diyl)bis(oxy)ethane-2,1-diyl] bis[3-(3-tert-butyl-4-hydroxy-5-methylphenyl)propanoate]
    • 2-[2-(2-([3-(3-tert-Butyl-4-hydroxy-5-methylphenyl)propanoyl]oxy)ethoxy)ethoxy]ethyl 3-(3-tert-butyl-4-hydroxy-5-methylphenyl)propanoate #
    • 2-[2-[2-[3-(3-tert-butyl-4-hydroxy-5-methyl-phenyl)propanoyloxy]ethoxy]ethoxy]ethyl 3-(3-tert-butyl-4-hydroxy-5-methyl-phenyl)propanoate
    • 2-[2-[2-[3-(3-tert-butyl-5-methyl-4-oxidanyl-phenyl)propanoyloxy]ethoxy]ethoxy]ethyl 3-(3-tert-butyl-5-methyl-4-oxidanyl-phenyl)propanoate
    • 253-039-2
    • 3-(3-tert-butyl-4-hydroxy-5-methylphenyl)propanoic acid 2-[2-[2-[3-(3-tert-butyl-4-hydroxy-5-methylphenyl)-1-oxopropoxy]ethoxy]ethoxy]ethyl ester
    • BENZENEPROPANOIC ACID, 3,5-BIS(1,1-DIMETHYLETHYL)-4-HYDROXY- , 1,2-ETHANEDIYLBIS(OXY-2,1-ETHANEDIYL) ESTER
    • 36443-68-2

  • Applications

    Antioxidant 245 (CAS 36443-68-2) is a phenolic antioxidant commonly employed as a processing stabilizer and long-term stabilizer to prevent oxidative and thermal degradation of polymer resins and elastomers. It is often used in plastics and rubbers to improve aging resistance during extrusion, molding, and service life; in coatings and printing inks to enhance durability against oxidation; in adhesives and sealants as a stabilizer during cure and in service; and in lubricants and oils to limit oxidation of the base fluids. It may also be considered for electronics encapsulants and related resin systems where oxidative stability is important. Its use is typically governed by formulation needs and applicable regulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 15.69
    methanol 17.41
    isopropanol 8.18
    water 0.04
    ethyl acetate 11.03
    n-propanol 14.96
    acetone 40.43
    n-butanol 8.15
    acetonitrile 8.96
    DMF 85.05
    toluene 4.41
    isobutanol 7.93
    1,4-dioxane 30.85
    methyl acetate 15.03
    THF 112.68
    2-butanone 28.89
    n-pentanol 9.68
    sec-butanol 8.1
    n-hexane 0.38
    ethylene glycol 3.01
    NMP 78.29
    cyclohexane 0.25
    DMSO 141.51
    n-butyl acetate 8.81
    n-octanol 6.16
    chloroform 70.53
    n-propyl acetate 12.16
    acetic acid 31.6
    dichloromethane 61.57
    cyclohexanone 34.5
    propylene glycol 5.89
    isopropyl acetate 7.97
    DMAc 110.57
    2-ethoxyethanol 31.36
    isopentanol 5.17
    n-heptane 0.33
    ethyl formate 14.54
    1,2-dichloroethane 29.53
    n-hexanol 4.96
    2-methoxyethanol 32.66
    isobutyl acetate 8.45
    tetrachloromethane 5.14
    n-pentyl acetate 14.33
    transcutol 38.0
    n-heptanol 6.18
    ethylbenzene 2.96
    MIBK 9.4
    2-propoxyethanol 26.83
    tert-butanol 7.4
    MTBE 6.49
    2-butoxyethanol 22.47
    propionic acid 13.85
    o-xylene 2.79
    formic acid 13.07
    diethyl ether 7.06
    m-xylene 2.48
    p-xylene 4.21
    chlorobenzene 9.72
    dimethyl carbonate 12.37
    n-octane 0.29
    formamide 19.47
    cyclopentanone 70.73
    2-pentanone 17.23
    anisole 9.99
    cyclopentyl methyl ether 14.18
    gamma-butyrolactone 73.08
    1-methoxy-2-propanol 23.83
    pyridine 29.82
    3-pentanone 13.15
    furfural 46.31
    n-dodecane 0.22
    diethylene glycol 15.79
    diisopropyl ether 1.36
    tert-amyl alcohol 7.22
    acetylacetone 28.4
    n-hexadecane 0.25
    acetophenone 15.1
    methyl propionate 15.89
    isopentyl acetate 8.08
    trichloroethylene 70.31
    n-nonanol 6.35
    cyclohexanol 5.08
    benzyl alcohol 11.51
    2-ethylhexanol 3.06
    isooctanol 4.92
    dipropyl ether 6.02
    1,2-dichlorobenzene 10.0
    ethyl lactate 9.43
    propylene carbonate 22.91
    n-methylformamide 32.17
    2-pentanol 3.48
    n-pentane 0.23
    1-propoxy-2-propanol 16.87
    1-methoxy-2-propyl acetate 15.64
    2-(2-methoxypropoxy) propanol 17.18
    mesitylene 1.24
    ε-caprolactone 30.24
    p-cymene 1.81
    epichlorohydrin 83.3
    1,1,1-trichloroethane 18.59
    2-aminoethanol 8.99
    morpholine-4-carbaldehyde 61.94
    sulfolane 103.48
    2,2,4-trimethylpentane 0.21
    2-methyltetrahydrofuran 26.84
    n-hexyl acetate 14.15
    isooctane 0.1
    2-(2-butoxyethoxy)ethanol 21.96
    sec-butyl acetate 6.29
    tert-butyl acetate 9.16
    decalin 0.3
    glycerin 8.87
    diglyme 46.03
    acrylic acid 14.51
    isopropyl myristate 4.57
    n-butyric acid 15.13
    acetyl acetate 9.54
    di(2-ethylhexyl) phthalate 7.07
    ethyl propionate 9.36
    nitromethane 62.89
    1,2-diethoxyethane 15.89
    benzonitrile 9.5
    trioctyl phosphate 5.48
    1-bromopropane 9.71
    gamma-valerolactone 93.76
    n-decanol 3.9
    triethyl phosphate 5.98
    4-methyl-2-pentanol 2.1
    propionitrile 8.46
    vinylene carbonate 23.42
    1,1,2-trichlorotrifluoroethane 56.38
    DMS 12.4
    cumene 2.07
    2-octanol 4.25
    2-hexanone 16.68
    octyl acetate 7.19
    limonene 2.23
    1,2-dimethoxyethane 45.53
    ethyl orthosilicate 5.36
    tributyl phosphate 5.88
    diacetone alcohol 15.32
    N,N-dimethylaniline 7.79
    acrylonitrile 13.39
    aniline 6.92
    1,3-propanediol 10.83
    bromobenzene 9.23
    dibromomethane 31.08
    1,1,2,2-tetrachloroethane 53.86
    2-methyl-cyclohexyl acetate 8.36
    tetrabutyl urea 10.36
    diisobutyl methanol 1.59
    2-phenylethanol 8.75
    styrene 3.3
    dioctyl adipate 9.55
    dimethyl sulfate 32.33
    ethyl butyrate 8.11
    methyl lactate 12.8
    butyl lactate 14.13
    diethyl carbonate 5.36
    propanediol butyl ether 18.61
    triethyl orthoformate 7.74
    p-tert-butyltoluene 1.73
    methyl 4-tert-butylbenzoate 18.96
    morpholine 40.87
    tert-butylamine 2.57
    n-dodecanol 2.32
    dimethoxymethane 47.93
    ethylene carbonate 17.77
    cyrene 26.19
    2-ethoxyethyl acetate 24.4
    2-ethylhexyl acetate 6.65
    1,2,4-trichlorobenzene 13.95
    4-methylpyridine 20.73
    dibutyl ether 5.83
    2,6-dimethyl-4-heptanol 1.59
    DEF 22.42
    dimethyl isosorbide 31.87
    tetrachloroethylene 30.75
    eugenol 16.35
    triacetin 20.81
    span 80 13.97
    1,4-butanediol 7.42
    1,1-dichloroethane 19.59
    2-methyl-1-pentanol 6.29
    methyl formate 28.21
    2-methyl-1-butanol 6.43
    n-decane 0.51
    butyronitrile 7.46
    3,7-dimethyl-1-octanol 4.07
    1-chlorooctane 3.15
    1-chlorotetradecane 0.9
    n-nonane 0.44
    undecane 0.32
    tert-butylcyclohexane 0.3
    cyclooctane 0.11
    cyclopentanol 10.64
    tetrahydropyran 17.35
    tert-amyl methyl ether 6.05
    2,5,8-trioxanonane 26.37
    1-hexene 2.06
    2-isopropoxyethanol 19.14
    2,2,2-trifluoroethanol 14.09
    methyl butyrate 14.09

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction