Anhydroxylitol

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  • Identifiers

    CAS number
    491-19-0

    Molecular formula
    C5H10O4

    SMILES
    C1[C@@H]([C@H]([C@H](O1)CO)O)O

    Safety labels

  • Odor profile

    Fragrance
    Odorless 66.69%
    Sweet 44.84%
    Caramellic 29.59%
    Alcoholic 24.64%
    Woody 19.19%
    Clean 17.64%
    Fishy 16.42%
    Buttery 15.37%
    Milky 15.22%
    Burnt 14.86%

     

    Flavor
    Sweet 83.24%
    Odorless 55.42%
    Bitter 48.51%
    Sweet-like 31.02%
    Caramel 24.24%
    Cauliflower 23.94%
    Alcoholic 23.54%
    Very slight 23.08%
    Vanilla 21.24%
    Soup 21.1%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -1.4

    pKa est.
    5.95 (weak acid)

    Molecular weight
    134.13 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    373°C

    Flash point

    • 169.04 ˚C est.

  • Synonyms

    • 1,4-Anhydro-D-xylitol
    • 491-19-0
    • 53448-53-6
    • (2R,3R,4S)-2-(Hydroxymethyl)tetrahydrofuran-3,4-diol
    • 1,4-Anhydroxylitol
    • Anhydroxylitol
    • D-Xylitol, 1,4-anhydro-
    • Xylitol, 1,4-anhydro-
    • 5KQL0CX6R6
    • XYLITAN
    • EINECS 258-560-9
    • RefChem:558093
    • ANHYDROXYLITOL [INCI]
    • 258-560-9
    • (2R,3R,4S)-2-(hydroxymethyl)oxolane-3,4-diol
    • MFCD27923011
    • 8XWR7NN42F
    • rel-(2R,3R,4S)-2-(Hydroxymethyl)tetrahydrofuran-3,4-diol
    • UNII-5KQL0CX6R6
    • UNII-8XWR7NN42F
    • SCHEMBL532554
    • SCHEMBL608371
    • orb2941862
    • DTXSID70964160
    • KZVAAIRBJJYZOW-VPENINKCSA-N
    • HY-W007174A
    • XH1540
    • (+/-)-1,4-ANHYDROXYLITOL
    • AKOS022173514
    • CS-W007174
    • DS-7326
    • MA16603
    • SY055527
    • DB-130842
    • DB-238159
    • A2635
    • CS-0188768
    • NS00089399
    • D70723
    • 53448-53-6

  • Applications

    Anhydroxylitol (CAS 491-19-0) is used as a diol building block and processing aid in a range of industrial formulations. In polymers and coatings, it can serve as a polyol component for polyurethanes and polyesters, contributing as a plasticizer or reactive diol in crosslinking systems. In cosmetics and personal care, it can function as a humectant and texturizing excipient. In pharmaceutical development, it may be employed as an intermediate or excipient in synthesis and formulation. Its role is typically governed by formulation requirements and regulatory constraints.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 64.1
    methanol 240.71
    isopropanol 22.7
    water 2744.59
    ethyl acetate 8.9
    n-propanol 26.5
    acetone 16.6
    n-butanol 18.16
    acetonitrile 8.81
    DMF 420.92
    toluene 0.72
    isobutanol 13.19
    1,4-dioxane 33.46
    methyl acetate 6.16
    THF 34.62
    2-butanone 6.95
    n-pentanol 7.37
    sec-butanol 13.77
    n-hexane 0.2
    ethylene glycol 566.45
    NMP 201.77
    cyclohexane 0.89
    DMSO 978.14
    n-butyl acetate 3.42
    n-octanol 6.58
    chloroform 5.4
    n-propyl acetate 3.88
    acetic acid 264.62
    dichloromethane 6.61
    cyclohexanone 17.44
    propylene glycol 165.6
    isopropyl acetate 6.5
    DMAc 170.27
    2-ethoxyethanol 108.64
    isopentanol 11.75
    n-heptane 0.99
    ethyl formate 16.79
    1,2-dichloroethane 5.35
    n-hexanol 8.76
    2-methoxyethanol 318.04
    isobutyl acetate 1.96
    tetrachloromethane 3.49
    n-pentyl acetate 3.87
    transcutol 95.32
    n-heptanol 8.66
    ethylbenzene 0.61
    MIBK 7.25
    2-propoxyethanol 60.87
    tert-butanol 26.21
    MTBE 4.24
    2-butoxyethanol 39.69
    propionic acid 48.29
    o-xylene 1.65
    formic acid 2031.48
    diethyl ether 3.9
    m-xylene 1.67
    p-xylene 0.8
    chlorobenzene 1.18
    dimethyl carbonate 14.68
    n-octane 0.52
    formamide 1152.82
    cyclopentanone 27.94
    2-pentanone 9.14
    anisole 3.65
    cyclopentyl methyl ether 10.7
    gamma-butyrolactone 52.91
    1-methoxy-2-propanol 136.51
    pyridine 7.8
    3-pentanone 5.93
    furfural 80.43
    n-dodecane 0.38
    diethylene glycol 192.17
    diisopropyl ether 1.98
    tert-amyl alcohol 18.06
    acetylacetone 22.89
    n-hexadecane 0.4
    acetophenone 6.91
    methyl propionate 12.59
    isopentyl acetate 3.32
    trichloroethylene 9.64
    n-nonanol 5.89
    cyclohexanol 16.08
    benzyl alcohol 9.82
    2-ethylhexanol 4.57
    isooctanol 6.93
    dipropyl ether 4.43
    1,2-dichlorobenzene 2.27
    ethyl lactate 18.09
    propylene carbonate 21.44
    n-methylformamide 249.49
    2-pentanol 8.9
    n-pentane 0.4
    1-propoxy-2-propanol 31.08
    1-methoxy-2-propyl acetate 12.78
    2-(2-methoxypropoxy) propanol 32.32
    mesitylene 1.96
    ε-caprolactone 21.87
    p-cymene 1.96
    epichlorohydrin 29.54
    1,1,1-trichloroethane 2.8
    2-aminoethanol 342.31
    morpholine-4-carbaldehyde 227.25
    sulfolane 168.58
    2,2,4-trimethylpentane 0.47
    2-methyltetrahydrofuran 12.32
    n-hexyl acetate 5.18
    isooctane 0.37
    2-(2-butoxyethoxy)ethanol 43.78
    sec-butyl acetate 2.55
    tert-butyl acetate 8.05
    decalin 0.43
    glycerin 584.52
    diglyme 83.02
    acrylic acid 87.46
    isopropyl myristate 2.55
    n-butyric acid 38.33
    acetyl acetate 9.06
    di(2-ethylhexyl) phthalate 5.4
    ethyl propionate 4.63
    nitromethane 195.04
    1,2-diethoxyethane 6.95
    benzonitrile 4.37
    trioctyl phosphate 4.95
    1-bromopropane 1.13
    gamma-valerolactone 88.79
    n-decanol 4.32
    triethyl phosphate 5.33
    4-methyl-2-pentanol 6.31
    propionitrile 4.62
    vinylene carbonate 21.53
    1,1,2-trichlorotrifluoroethane 145.22
    DMS 6.41
    cumene 0.85
    2-octanol 4.48
    2-hexanone 3.19
    octyl acetate 3.71
    limonene 2.95
    1,2-dimethoxyethane 51.48
    ethyl orthosilicate 4.63
    tributyl phosphate 4.12
    diacetone alcohol 35.23
    N,N-dimethylaniline 4.93
    acrylonitrile 11.15
    aniline 4.79
    1,3-propanediol 260.44
    bromobenzene 0.81
    dibromomethane 2.9
    1,1,2,2-tetrachloroethane 10.24
    2-methyl-cyclohexyl acetate 4.47
    tetrabutyl urea 7.42
    diisobutyl methanol 4.62
    2-phenylethanol 8.47
    styrene 0.59
    dioctyl adipate 5.09
    dimethyl sulfate 59.06
    ethyl butyrate 4.67
    methyl lactate 57.49
    butyl lactate 10.73
    diethyl carbonate 3.05
    propanediol butyl ether 40.86
    triethyl orthoformate 5.29
    p-tert-butyltoluene 2.14
    methyl 4-tert-butylbenzoate 16.52
    morpholine 52.0
    tert-butylamine 7.22
    n-dodecanol 3.26
    dimethoxymethane 66.78
    ethylene carbonate 14.96
    cyrene 54.91
    2-ethoxyethyl acetate 7.52
    2-ethylhexyl acetate 2.34
    1,2,4-trichlorobenzene 2.92
    4-methylpyridine 5.12
    dibutyl ether 2.42
    2,6-dimethyl-4-heptanol 4.62
    DEF 40.27
    dimethyl isosorbide 44.75
    tetrachloroethylene 12.69
    eugenol 23.1
    triacetin 11.87
    span 80 26.4
    1,4-butanediol 87.13
    1,1-dichloroethane 2.11
    2-methyl-1-pentanol 5.85
    methyl formate 119.04
    2-methyl-1-butanol 11.68
    n-decane 0.58
    butyronitrile 4.74
    3,7-dimethyl-1-octanol 5.78
    1-chlorooctane 1.54
    1-chlorotetradecane 0.75
    n-nonane 0.56
    undecane 0.45
    tert-butylcyclohexane 0.36
    cyclooctane 0.65
    cyclopentanol 24.75
    tetrahydropyran 8.58
    tert-amyl methyl ether 5.15
    2,5,8-trioxanonane 65.64
    1-hexene 0.41
    2-isopropoxyethanol 38.35
    2,2,2-trifluoroethanol 269.28
    methyl butyrate 7.06

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction