Amprolium Hydrochloride

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  • Identifiers

    CAS number
    137-88-2

    Molecular formula
    C14H20Cl2N4

    SMILES
    CCCC1=NC=C(C(=N1)N)C[N+]2=CC=CC=C2C.Cl.[Cl-]

    Safety labels

    Irritant
    Irritant

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Animal 44.85%
    Roasted 36.62%
    Nutty 32.64%
    Earthy 31.67%
    Burnt 30.2%
    Musty 27.8%
    Sweet 26.3%
    Fatty 26.11%
    Leathery 25.72%
    Herbal 25.38%

     

    Flavor
    Bitter 58.08%
    Earthy 25.5%
    Roasted 24.7%
    Mild 24.62%
    Green 22.93%
    Tomato leaf 21.63%
    Green pepper 21.58%
    Syrup 21.53%
    Carrot 21.29%
    Musty 21.08%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    6.15 (neutral)

    Molecular weight
    315.2 g/mol

    Flash point

    • 206.06 ˚C est.

  • Synonyms

    • Amprolium hydrochloride
    • 137-88-2
    • Amprolium HCl
    • Mepyrium
    • Thiacoccid
    • Amprol 25
    • Amprolsol vet
    • Corid vet
    • Amprol 25 per cent
    • Corid 20%
    • DTXSID0045547
    • 95CO6N199Q
    • DTXCID8025547
    • NSC523454
    • Pyridinium, 1-((4-amino-2-propyl-5-pyrimidinyl)methyl)-2-methyl-, chloride, monohydrochloride
    • 2-Picolinium, 1-((4-amino-2-propyl-5-pyrimidinyl)methyl)-, chloride, monohydrochloride
    • Hydrochloride, Amprolium
    • RefChem:915770
    • 205-307-5
    • Amprolium (hydrochloride)
    • 1-((4-Amino-2-propylpyrimidin-5-yl)methyl)-2-methylpyridin-1-ium chloride hydrochloride
    • 3053-18-7
    • Pyridinium, 1-[(4-amino-2-propyl-5-pyrimidinyl)methyl]-2-methyl-, chloride, hydrochloride (1:1:1)
    • 1-([4-Amino-2-propyl-5-pyrimidinyl]methyl)-2-methylpyridinium chloride
    • MFCD00078831
    • Anticoccid
    • NSC-755872
    • NCGC00017020-01
    • CAS-137-88-2
    • AMPISOL
    • AMPROLSOL
    • 5-[(2-methylpyridin-1-ium-1-yl)methyl]-2-propylpyrimidin-4-amine;chloride;hydrochloride
    • EINECS 205-307-5
    • NSC 523454
    • UNII-95CO6N199Q
    • 1-(4-Amino-2-n-propyl-5-pyrimidinylmethyl)-2-methylpyridinium Chloride Hydrochloride
    • PYRIDINIUM, 1-((4-AMINO-2-PROPYL-5-PYRIMIDINYL)METHYL)-2-METHYL-, CHLORIDE, HYDROCHLORIDE (1:1:1)
    • Prestwick_880
    • EINECS 221-272-9
    • 1-((4-Amino-2-propyl-5-pyrimidinyl)methyl)-2-methylpyridinium chloride monohydrochloride
    • 1-[(4-Amino-2-propyl-5-pyrimidinyl)methyl]-2-picolinium chloride monohydrochloride
    • Amprolium hydrochloride CRS
    • AMPROLIUM [USP-RS]
    • Amprolium [USP:INN:BAN]
    • MLS002154169
    • SCHEMBL204023
    • SPECTRUM1500124
    • AMPROLIUM [GREEN BOOK]
    • amprolium chloride hydrochloride
    • HY-B0937AR
    • orb1310213
    • CHEMBL1318296
    • SCHEMBL29737311
    • HY-B0937A
    • AMPROLIUM [USP MONOGRAPH]
    • MSK7145
    • PJBQYZZKGNOKNJ-UHFFFAOYSA-M
    • HMS1568A17
    • HMS1920E03
    • Pharmakon1600-01500124
    • Tox21_110740
    • Amprolium (hydrochloride) (Standard)
    • CCG-39883
    • MSK7145-100M
    • NSC755872
    • s4144
    • AKOS015951353
    • MSK7145-1000M
    • Tox21_110740_1
    • CS-5293
    • FA32000
    • Pyridinium, chloride, monohydrochloride
    • 2-Picolinium, 1-((4-amino-2-propyl-5-pyrimidinyl)methyl)-, chloride, hydrochloride
    • AMPROLIUM HYDROCHLORIDE [WHO-DD]
    • NCGC00017020-02
    • NCGC00017020-03
    • NCGC00094589-01
    • NCGC00094589-02
    • NCGC00263460-01
    • 2-Picolinium, chloride, monohydrochloride
    • AS-13051
    • SMR001233467
    • SY052505
    • A2572
    • NS00079171
    • SW197002-3
    • D07571
    • I10002
    • AB00053832_02
    • AMPROLIUM HYDROCHLORIDE FOR VETERINARY USE
    • Q27888479
    • Amprolium hydrochloride Solution in Methanol, 1000ug/mL
    • Amprolium hydrochloride Solution in Methanol, 100ug/mL
    • Amprolium hydrochloride, VETRANAL(TM), analytical standard
    • Amprolium, United States Pharmacopeia (USP) Reference Standard
    • AMPROLIUM HYDROCHLORIDE FOR VETERINARY USE [EP MONOGRAPH]
    • 1-[(4-Amino-2-propyl-5-pyrimidinyl)methyl]-2-methylpyridin-1-ium Chloride Hydrochloride
    • 1-[(4-Amino-2-propyl-5-pyrimidinyl)methyl]-2-methylpyridinium Chloride Hydrochloride
    • 2-Picolinium,1-[(4-amino-2-propyl-5-pyrimidinyl)methyl]-,chloride,hydrochloride
    • 5-[(2-methylpyridin-1-ium-1-yl)methyl]-2-propyl-pyrimidin-4-amine;chloride;hydrochloride
    • 1-[(4-Amino-2-propylpyrimidin-5-yl)methyl]-2-methylpyridin-1-ium chloride--hydrogen chloride (1/1/1)
    • 137-88-2

  • Applications

    Amprolium Hydrochloride (CAS 137-88-2) is primarily used as a coccidiostat in animal health, especially in poultry. It serves as an active pharmaceutical ingredient in veterinary drugs and as a premix component in poultry feeds to prevent and control coccidiosis in broilers and layers. It is commonly formulated in feed premixes and is sometimes combined with other anticoccidials in multi-component products used in poultry production. Its use is governed by local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 64.11
    methanol 106.89
    isopropanol 27.29
    water 5.23
    ethyl acetate 69.99
    n-propanol 48.68
    acetone 89.86
    n-butanol 39.08
    acetonitrile 43.87
    DMF 313.84
    toluene 27.01
    isobutanol 34.58
    1,4-dioxane 62.37
    methyl acetate 47.49
    THF 235.27
    2-butanone 55.37
    n-pentanol 29.38
    sec-butanol 23.56
    n-hexane 0.39
    ethylene glycol 55.14
    NMP 345.87
    cyclohexane 1.45
    DMSO 663.65
    n-butyl acetate 55.31
    n-octanol 2.97
    chloroform 213.3
    n-propyl acetate 29.38
    acetic acid 285.03
    dichloromethane 319.28
    cyclohexanone 170.43
    propylene glycol 74.98
    isopropyl acetate 35.75
    DMAc 260.17
    2-ethoxyethanol 106.43
    isopentanol 37.9
    n-heptane 0.67
    ethyl formate 109.19
    1,2-dichloroethane 144.7
    n-hexanol 28.67
    2-methoxyethanol 308.63
    isobutyl acetate 22.4
    tetrachloromethane 28.71
    n-pentyl acetate 18.49
    transcutol 171.73
    n-heptanol 11.19
    ethylbenzene 5.69
    MIBK 29.95
    2-propoxyethanol 137.19
    tert-butanol 32.74
    MTBE 11.91
    2-butoxyethanol 49.19
    propionic acid 114.59
    o-xylene 14.81
    formic acid 267.2
    diethyl ether 10.36
    m-xylene 19.62
    p-xylene 10.96
    chlorobenzene 63.16
    dimethyl carbonate 61.78
    n-octane 0.21
    formamide 329.83
    cyclopentanone 309.25
    2-pentanone 53.28
    anisole 18.16
    cyclopentyl methyl ether 61.92
    gamma-butyrolactone 411.74
    1-methoxy-2-propanol 179.1
    pyridine 138.79
    3-pentanone 31.16
    furfural 379.68
    n-dodecane 0.18
    diethylene glycol 174.29
    diisopropyl ether 3.28
    tert-amyl alcohol 29.39
    acetylacetone 120.67
    n-hexadecane 0.21
    acetophenone 38.53
    methyl propionate 76.3
    isopentyl acetate 49.54
    trichloroethylene 381.33
    n-nonanol 3.55
    cyclohexanol 40.61
    benzyl alcohol 50.25
    2-ethylhexanol 15.3
    isooctanol 10.24
    dipropyl ether 8.76
    1,2-dichlorobenzene 66.19
    ethyl lactate 33.13
    propylene carbonate 198.88
    n-methylformamide 244.67
    2-pentanol 14.77
    n-pentane 0.46
    1-propoxy-2-propanol 72.3
    1-methoxy-2-propyl acetate 91.32
    2-(2-methoxypropoxy) propanol 38.99
    mesitylene 9.42
    ε-caprolactone 140.49
    p-cymene 8.16
    epichlorohydrin 415.02
    1,1,1-trichloroethane 104.87
    2-aminoethanol 100.71
    morpholine-4-carbaldehyde 249.69
    sulfolane 543.59
    2,2,4-trimethylpentane 0.76
    2-methyltetrahydrofuran 100.11
    n-hexyl acetate 13.24
    isooctane 0.48
    2-(2-butoxyethoxy)ethanol 59.14
    sec-butyl acetate 16.77
    tert-butyl acetate 37.43
    decalin 0.99
    glycerin 174.35
    diglyme 112.8
    acrylic acid 142.52
    isopropyl myristate 5.38
    n-butyric acid 205.05
    acetyl acetate 68.72
    di(2-ethylhexyl) phthalate 19.78
    ethyl propionate 23.98
    nitromethane 447.83
    1,2-diethoxyethane 22.56
    benzonitrile 63.22
    trioctyl phosphate 11.51
    1-bromopropane 28.66
    gamma-valerolactone 405.38
    n-decanol 2.93
    triethyl phosphate 23.46
    4-methyl-2-pentanol 11.72
    propionitrile 35.13
    vinylene carbonate 181.17
    1,1,2-trichlorotrifluoroethane 382.85
    DMS 30.05
    cumene 5.49
    2-octanol 3.83
    2-hexanone 24.26
    octyl acetate 8.01
    limonene 10.03
    1,2-dimethoxyethane 82.16
    ethyl orthosilicate 21.52
    tributyl phosphate 15.33
    diacetone alcohol 76.55
    N,N-dimethylaniline 15.02
    acrylonitrile 75.7
    aniline 68.93
    1,3-propanediol 147.75
    bromobenzene 62.34
    dibromomethane 121.1
    1,1,2,2-tetrachloroethane 252.25
    2-methyl-cyclohexyl acetate 29.83
    tetrabutyl urea 18.48
    diisobutyl methanol 7.83
    2-phenylethanol 47.52
    styrene 7.85
    dioctyl adipate 13.83
    dimethyl sulfate 154.53
    ethyl butyrate 32.67
    methyl lactate 90.11
    butyl lactate 31.44
    diethyl carbonate 27.0
    propanediol butyl ether 35.65
    triethyl orthoformate 25.78
    p-tert-butyltoluene 7.71
    methyl 4-tert-butylbenzoate 36.79
    morpholine 103.46
    tert-butylamine 10.75
    n-dodecanol 2.39
    dimethoxymethane 130.8
    ethylene carbonate 138.86
    cyrene 77.33
    2-ethoxyethyl acetate 41.04
    2-ethylhexyl acetate 32.71
    1,2,4-trichlorobenzene 84.5
    4-methylpyridine 111.43
    dibutyl ether 2.92
    2,6-dimethyl-4-heptanol 7.83
    DEF 87.58
    dimethyl isosorbide 98.62
    tetrachloroethylene 170.14
    eugenol 43.58
    triacetin 27.51
    span 80 33.66
    1,4-butanediol 49.91
    1,1-dichloroethane 82.13
    2-methyl-1-pentanol 31.54
    methyl formate 208.88
    2-methyl-1-butanol 34.49
    n-decane 0.22
    butyronitrile 39.7
    3,7-dimethyl-1-octanol 6.08
    1-chlorooctane 1.57
    1-chlorotetradecane 0.96
    n-nonane 0.17
    undecane 0.19
    tert-butylcyclohexane 0.83
    cyclooctane 0.45
    cyclopentanol 74.0
    tetrahydropyran 44.77
    tert-amyl methyl ether 11.22
    2,5,8-trioxanonane 77.5
    1-hexene 2.28
    2-isopropoxyethanol 49.89
    2,2,2-trifluoroethanol 146.25
    methyl butyrate 42.01

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction