Amphetamine

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  • Identifiers

    CAS number
    300-62-9

    Molecular formula
    C9H13N

    SMILES
    CC(CC1=CC=CC=C1)N

    Safety labels

    Flammable
    Flammable

    Acute Toxic
    Acute Toxic

  • Odor profile

    Fragrance
    Fishy 56.29%
    Cheesy 38.07%
    Animal 32.21%
    Ripe 31.79%
    Meaty 26.24%
    Burnt 21.79%
    Citrus 21.09%
    Floral 20.94%
    Savory 20.46%
    Grapefruit 19.61%

     

    Flavor
    Fishy 29.84%
    Ammoniacal 27.8%
    Meaty 26.34%
    Mild 24.3%
    Sulfurous 22.73%
    Skunky 20.14%
    Glue 20.05%
    Creosote 19.64%
    Bloody 19.56%
    Penetrating 19.55%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    1.8

    pKa est.
    5.71 (weak acid)

    Molecular weight
    135.21 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderately fast

    Melting point expt.

    • -98 ºC
    • 25 °C

    Boiling point

    • 392 to 397 °F at 760 mmHg (EPA, 1998)
    • 64.7 ºC at 760 mm Hg
    • 200-203 °C at 760 mm Hg

    Flash point

    • 90.6 ˚C est.
    • 80 °F (EPA, 1998)

    Solubility expt.

    • Moderate solubility
    • Sparingly soluble in water (1:50)
    • Slightly soluble in water
    • Readily sol in acids
    • Slightly soluble inethyl ether; soluble in ethanol and chloroform
    • 1.74e+00 g/L

  • Synonyms

    • AMPHETAMINE
    • Amfetamine
    • 1-phenylpropan-2-amine
    • dl-Amphetamine
    • Desoxynorephedrine
    • Norephedrane
    • 300-62-9
    • 1-Phenyl-2-aminopropane
    • Elastonon
    • Fenopromin
    • Phenedrine
    • alpha-Methylphenethylamine
    • beta-Aminopropylbenzene
    • Propisamine
    • Psychedrine
    • Raphetamine
    • Rhinalator
    • Simpatedrin
    • Sympatedrine
    • Actedron
    • Allodene
    • Anorexide
    • Anorexine
    • Benzebar
    • Benzolone
    • Isoamyne
    • Mecodrin
    • Novydrine
    • Oktedrin
    • Ortedrine
    • Percomon
    • Profamina
    • Simpatina
    • Sympamine
    • Weckamine
    • Adipan
    • Finam
    • Isomyn
    • 1-Methyl-2-phenylethylamine
    • 1-Phenyl-2-propylamine
    • Protioamphetamine
    • amfetaminum
    • alpha-Methylbenzeneethaneamine
    • 3-Phenyl-2-propylamine
    • Anfetamina
    • Fenylo-izopropylaminyl
    • (Phenylisopropyl)amine
    • dl-alpha-Methylphenethylamine
    • 1-Phenyl-2-propanamine
    • 2-Amino-1-phenylpropane
    • (+-)-Benzedrine
    • racemic-Desoxynor-ephedrine
    • Amfetamin
    • Amfetamina
    • Amphetamin
    • Dyanavel
    • dl-Benzedrine
    • beta-Phenylisopropylamin
    • Adzenys ER
    • Amphetamine, dl-
    • 1-Phenyl-2-amino-propan
    • (+-)-alpha-Methylphenylethylamine
    • beta-Phenylisopropylamine
    • rac-Amphetamine
    • (+-)-alpha-Methylphenethylamine
    • HSDB 3287
    • .beta.-Aminopropylbenzene
    • Amfetaminum [INN-Latin]
    • Amfetamina [INN-Spanish]
    • (+-)-alpha-Methylbenzeneethanamine
    • (+/-)-Desoxynorephedrine
    • Benzeneethanamine, .alpha.-methyl-
    • UNII-CK833KGX7E
    • 60-15-1
    • EINECS 200-458-3
    • EINECS 206-096-2
    • CK833KGX7E
    • dl-1-Phenyl-2-aminopropane
    • Adzenys XR-ODT
    • NSC 27159
    • NSC-27159
    • Phenethylamine, alpha-methyl-
    • .alpha.-Methylbenzeneethanamine
    • Phenethylamine, alpha-methyl-, (+-)-
    • Norephedrine, deoxy-
    • 3-AMINO-1-PROPYLBENZENE
    • Benzeneethanamine, alpha-methyl-, (+-)-
    • AI3-02438
    • 1-Phenylpropan-2-amin
    • alpha-Methylphenylethylamine
    • Dexedrine
    • CHEBI:2679
    • DTXSID4022600
    • Amfetamine (INN)
    • NSC27159
    • Dexacaps
    • NT-0201
    • AMFETAMINE [INN]
    • Amfetaminum (INN-Latin)
    • Amfetamina (INN-Spanish)
    • Phenethylamine, .alpha.-methyl-, (.+/-.)-
    • AMFETAMINE (MART.)
    • AMFETAMINE [MART.]
    • Benzeneethanamine, .alpha.-methyl-, (.+/-.)-
    • Amfetamina [Italian]
    • Anfetamina [Spanish]
    • DEA No. 1100
    • Amfetamine [INN:BAN]
    • Desoxynorephedrin
    • Adderall XR
    • Dyanavel XR
    • beta-Aminopropylbenzene (VAN)
    • DELCOBESE
    • Fenylo-izopropylaminyl [Polish]
    • Benzeneethanamine, alpha-methyl-
    • 1-Phenyl-2-aminopropane (VAN)
    • beta-Phenylisopropylamin [German]
    • 1-Phenyl-2-amino-propan [German]
    • beta-phenyl-isopropylamine
    • alpha-Methylbenzeneethanamine
    • amphetaminium
    • (+)-.alpha.-Methylphenethylamine
    • Adderal
    • Adzenys
    • Isoamycin
    • amphetamine-
    • NSC73713
    • Amfetamin (TN)

  • Applications

    Amphetamine (CAS 300-62-9) is primarily used as an active pharmaceutical ingredient (API) for the treatment of ADHD and narcolepsy under strict regulatory control; it also serves as a building block for the synthesis of CNS-active compounds in medicinal chemistry research and is used as an analytical reference standard in laboratories for chromatographic and chemical analyses, with full regulatory compliance; in drug discovery research and development, it may also function as a structural scaffold for CNS-derived derivatives.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 455.14
    methanol 472.96
    isopropanol 287.92
    water 2.44
    ethyl acetate 174.9
    n-propanol 326.94
    acetone 446.38
    n-butanol 299.22
    acetonitrile 342.51
    DMF 535.81
    toluene 79.61
    isobutanol 210.66
    1,4-dioxane 400.36
    methyl acetate 166.86
    THF 673.62
    2-butanone 221.97
    n-pentanol 177.32
    sec-butanol 168.18
    n-hexane 30.9
    ethylene glycol 138.05
    NMP 333.6
    cyclohexane 46.27
    DMSO 904.95
    n-butyl acetate 271.1
    n-octanol 93.35
    chloroform 455.03
    n-propyl acetate 109.21
    acetic acid 414.83
    dichloromethane 377.97
    cyclohexanone 359.97
    propylene glycol 187.44
    isopropyl acetate 93.09
    DMAc 234.65
    2-ethoxyethanol 186.99
    isopentanol 191.79
    n-heptane 81.28
    ethyl formate 179.52
    1,2-dichloroethane 206.24
    n-hexanol 448.61
    2-methoxyethanol 418.92
    isobutyl acetate 76.39
    tetrachloromethane 84.7
    n-pentyl acetate 70.19
    transcutol 326.37
    n-heptanol 120.01
    ethylbenzene 33.09
    MIBK 104.26
    2-propoxyethanol 466.31
    tert-butanol 287.19
    MTBE 139.04
    2-butoxyethanol 161.28
    propionic acid 248.23
    o-xylene 49.9
    formic acid 126.22
    diethyl ether 171.08
    m-xylene 60.77
    p-xylene 40.93
    chlorobenzene 115.21
    dimethyl carbonate 88.39
    n-octane 15.13
    formamide 136.6
    cyclopentanone 508.4
    2-pentanone 207.32
    anisole 90.81
    cyclopentyl methyl ether 257.16
    gamma-butyrolactone 485.65
    1-methoxy-2-propanol 293.08
    pyridine 252.7
    3-pentanone 138.53
    furfural 340.32
    n-dodecane 11.4
    diethylene glycol 321.98
    diisopropyl ether 46.52
    tert-amyl alcohol 147.39
    acetylacetone 192.94
    n-hexadecane 12.37
    acetophenone 81.39
    methyl propionate 171.72
    isopentyl acetate 180.93
    trichloroethylene 348.7
    n-nonanol 77.16
    cyclohexanol 192.09
    benzyl alcohol 89.13
    2-ethylhexanol 198.99
    isooctanol 76.36
    dipropyl ether 274.01
    1,2-dichlorobenzene 93.71
    ethyl lactate 72.79
    propylene carbonate 255.31
    n-methylformamide 289.74
    2-pentanol 142.07
    n-pentane 30.68
    1-propoxy-2-propanol 330.35
    1-methoxy-2-propyl acetate 196.19
    2-(2-methoxypropoxy) propanol 113.36
    mesitylene 38.22
    ε-caprolactone 231.92
    p-cymene 50.29
    epichlorohydrin 345.21
    1,1,1-trichloroethane 169.34
    2-aminoethanol 241.54
    morpholine-4-carbaldehyde 325.12
    sulfolane 571.77
    2,2,4-trimethylpentane 14.6
    2-methyltetrahydrofuran 346.45
    n-hexyl acetate 97.73
    isooctane 14.89
    2-(2-butoxyethoxy)ethanol 166.14
    sec-butyl acetate 55.35
    tert-butyl acetate 97.36
    decalin 18.72
    glycerin 216.03
    diglyme 290.61
    acrylic acid 212.07
    isopropyl myristate 44.81
    n-butyric acid 375.24
    acetyl acetate 118.94
    di(2-ethylhexyl) phthalate 57.9
    ethyl propionate 88.17
    nitromethane 498.84
    1,2-diethoxyethane 154.73
    benzonitrile 124.67
    trioctyl phosphate 50.07
    1-bromopropane 151.83
    gamma-valerolactone 475.87
    n-decanol 62.08
    triethyl phosphate 64.3
    4-methyl-2-pentanol 77.06
    propionitrile 223.87
    vinylene carbonate 219.16
    1,1,2-trichlorotrifluoroethane 286.01
    DMS 71.53
    cumene 29.27
    2-octanol 59.04
    2-hexanone 129.36
    octyl acetate 62.35
    limonene 93.13
    1,2-dimethoxyethane 305.5
    ethyl orthosilicate 64.33
    tributyl phosphate 53.7
    diacetone alcohol 147.29
    N,N-dimethylaniline 62.01
    acrylonitrile 233.17
    aniline 127.23
    1,3-propanediol 259.31
    bromobenzene 107.72
    dibromomethane 261.64
    1,1,2,2-tetrachloroethane 271.74
    2-methyl-cyclohexyl acetate 102.41
    tetrabutyl urea 75.37
    diisobutyl methanol 92.98
    2-phenylethanol 130.87
    styrene 45.53
    dioctyl adipate 69.58
    dimethyl sulfate 138.29
    ethyl butyrate 152.49
    methyl lactate 113.68
    butyl lactate 75.54
    diethyl carbonate 90.01
    propanediol butyl ether 129.97
    triethyl orthoformate 109.43
    p-tert-butyltoluene 51.77
    methyl 4-tert-butylbenzoate 87.92
    morpholine 434.12
    tert-butylamine 162.58
    n-dodecanol 52.1
    dimethoxymethane 308.8
    ethylene carbonate 185.53
    cyrene 115.88
    2-ethoxyethyl acetate 89.16
    2-ethylhexyl acetate 129.73
    1,2,4-trichlorobenzene 104.92
    4-methylpyridine 205.12
    dibutyl ether 90.59
    2,6-dimethyl-4-heptanol 92.98
    DEF 195.38
    dimethyl isosorbide 203.44
    tetrachloroethylene 184.15
    eugenol 90.62
    triacetin 91.49
    span 80 133.6
    1,4-butanediol 109.33
    1,1-dichloroethane 201.79
    2-methyl-1-pentanol 110.28
    methyl formate 230.26
    2-methyl-1-butanol 166.93
    n-decane 18.12
    butyronitrile 265.72
    3,7-dimethyl-1-octanol 81.88
    1-chlorooctane 53.8
    1-chlorotetradecane 24.34
    n-nonane 18.17
    undecane 13.75
    tert-butylcyclohexane 19.21
    cyclooctane 17.78
    cyclopentanol 262.9
    tetrahydropyran 393.61
    tert-amyl methyl ether 93.69
    2,5,8-trioxanonane 203.07
    1-hexene 77.07
    2-isopropoxyethanol 117.28
    2,2,2-trifluoroethanol 99.56
    methyl butyrate 125.22

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction