Amitraz

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  • Identifiers

    CAS number
    33089-61-1

    Molecular formula
    C19H23N3

    SMILES
    CC1=CC(=C(C=C1)N=CN(C)C=NC2=C(C=C(C=C2)C)C)C

    Safety labels

  • Odor profile

    Fragrance
    Floral 39.74%
    Fresh 33.88%
    Green 32.29%
    Citrus 31.7%
    Sweet 30.82%
    Spicy 25.41%
    Animal 25.38%
    Neroli 24.61%
    Roasted 24.42%
    Fatty 23.87%

     

    Flavor
    Bitter 51.01%
    Odorless 21.29%
    Nitrile 20.91%
    Very strong 19.92%
    Broom 19.9%
    Heather 19.89%
    Oriental 19.63%
    Genet 19.58%
    Indole 19.48%
    Cedarleaf 19.44%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    5.5

    pKa est.
    5.51 (weak acid)

    Molecular weight
    293.4 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    463°C

    Flash point

    • 183.1 ˚C est.

  • Synonyms

    • AMITRAZ
    • 33089-61-1
    • Mitac
    • Triazid
    • Acarac
    • Azaform
    • Taktic
    • BAAM
    • Ectodex
    • Edrizar
    • Mitaban
    • Fumilat A
    • Azadieno
    • Amitraz estrella
    • Amitraze
    • Amitrazum
    • U-36059
    • Upjohn U-36059
    • Boots BTS 27419
    • BTS-27419
    • ENT 27967
    • Certifect
    • Triatix
    • Triatox
    • Ovasyn
    • 1,5-Di(2,4-dimethylphenyl)-3-methyl-1,3,5-triazapenta-1,4-diene
    • BTS 27,419
    • NSC 324552
    • N-Methylbis(2,4-xylyliminomethyl)amine
    • N-Methyl-N'-2,4-xylyl-N-(N-2,4-xylylformimidoyl)formamidine
    • N,N-Bis(2,4-xylyliminomethyl)methylamine
    • U-36,059
    • N,N-Di-(2,4-xylyliminomethyl)methylamine
    • R.D. 27419
    • 2-Methyl-1,3-di(2,4-xylylimino)-2-azapropane
    • NSC-324552
    • N,N'-((Methylimino)dimethylidyne)di-2,4-xylidine
    • 2,4-Xylidine, N,N'-(methyliminodimethylidyne)bis-
    • N,N'-((Methylimino)dimethylidyne)bis(2,4-xylidine)
    • Acadrex
    • Bumetran
    • Istambul
    • Mtiaban
    • Maitac
    • Tudy
    • N'-(2,4-dimethylphenyl)-N-{[(2,4-dimethylphenyl)imino]methyl}-N-methylmethanimidamide
    • DTXSID5023871
    • Bipin
    • 33IAH5017S
    • N,N'-(methyliminodimethylidyne)bis-2,4-xylidine
    • Amitraz 10 microg/mL in Cyclohexane
    • MFCD00069396
    • Methanimidamide, N'-(2,4-dimethylphenyl)-N-(((2,4-dimethylphenyl)imino)methyl)-N-methyl-
    • N'-(2,4-Dimethylphenyl)-N-(((2,4-dimethylphenyl)imino)methyl)-N-methylmethanimidamide
    • N'-(2,4-dimethylphenyl)-N-[(2,4-dimethylphenyl)iminomethyl]-N-methylmethanimidamide
    • Amitraz 100 microg/mL in Acetonitrile
    • NCGC00094572-01
    • Formamidine, N-methyl-N'-2,4-xylyl-N-(N-2,4-xylylformimidoyl)-
    • Methanimidamide, N'-(2,4-dimethylphenyl)-N-[[(2,4-dimethylphenyl)imino]methyl]-N-methyl-
    • Amitraze [French]
    • U-36-059
    • DTXCID403871
    • Mitaban (Veterinary)
    • Caswell No. 374A
    • Amitrazum [INN-Latin]
    • OMS 1820
    • N'-(2,4-Dimethylphenyl)-N-[[(2,4-dimethylphenyl)imino]methyl]-N-methyl-methanimidamide
    • N-Methyl-bis(2,4-xylyliminomethyl)amine
    • BTS 27419
    • N-Methylbis-(2,4-xylyliminomethyl)-amine
    • CAS-33089-61-1
    • CCRIS 1552
    • U 36059
    • HSDB 6939
    • EINECS 251-375-4
    • EPA Pesticide Chemical Code 106201
    • BRN 2946590
    • N-Methyl-bis(2,4-xylyliminomethyl)amin
    • UNII-33IAH5017S
    • AI3-27967
    • 1,5-Bis(2,4-dimethylphenyl)-3-methyl-1,3,5-triazapenta-1,4-diene
    • Amitraz [USAN:USP:INN:BAN]
    • (E)-N'-(2,4-dimethylphenyl)-N-{[(2,4-dimethylphenyl)imino]methyl}-N-methylmethanimidamide
    • N'-(2,4-Dimethylphenyl)-N-([(2,4-dimethylphenyl)imino]methyl)-N-methylimidoformamide
    • N-(2,4-Dimethylphenyl)-N-[[(2,4-dimethylphenyl)imino]methyl]-N-methyl-methaniminamide
    • N,4-xylidine]
    • Amitraz (Standard)
    • Amitraz (USP/INN)
    • AMITRAZ [HSDB]
    • AMITRAZ [USAN]
    • AMITRAZ [INN]
    • AMITRAZ [MI]
    • AMITRAZ [MART.]
    • Spectrum2_001243
    • Spectrum3_001944
    • AMITRAZ [USP-RS]
    • SCHEMBL37309
    • AMITRAZ [GREEN BOOK]
    • BSPBio_003544
    • SPECTRUM1505299
    • SPBio_001146
    • CHEBI:2665
    • orb1307965
    • SCHEMBL1765794
    • AMITRAZ [USP MONOGRAPH]
    • CHEMBL1365675
    • SCHEMBL13346111
    • SCHEMBL19312984
    • SCHEMBL29370387
    • HY-B1111R
    • KBio3_002829
    • HMS1922B10
    • HMS2093O18
    • HMS3885O17
    • HMS5081B14
    • HMS6018H13
    • Pharmakon1600-01505299
    • HY-B1111
    • MSK20367
    • Tox21_111299
    • Tox21_201357
    • Tox21_300930
    • 1,5-Di-(2,4-dimethylphenyl)-3-methyl-1,3,5-triazapenta-1,4-diene
    • CCG-39116
    • EBC-04350
    • EBC-06997
    • EBC-12735
    • 33089-61-1

  • Applications

    Amitraz is used primarily as an acaricide and insecticide in veterinary and agricultural settings. In veterinary medicine, it is formulated as topical dips or solutions to treat demodectic mange in dogs and to control ectoparasites. In livestock production, it is applied as dips, sprays, or pour-on formulations to reduce parasitic infestations on cattle, sheep and other animals. In apiculture, amitraz-based products are used to manage Varroa destructor mites in honeybee colonies. It also appears in professional pest-control formulations for on-animal and on-farm applications, subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 35.85
    methanol 27.57
    isopropanol 22.41
    water 0.06
    ethyl acetate 167.79
    n-propanol 38.37
    acetone 121.85
    n-butanol 45.72
    acetonitrile 51.75
    DMF 179.81
    toluene 256.27
    isobutanol 32.88
    1,4-dioxane 237.25
    methyl acetate 139.41
    THF 637.83
    2-butanone 163.98
    n-pentanol 50.37
    sec-butanol 36.33
    n-hexane 27.77
    ethylene glycol 3.48
    NMP 277.35
    cyclohexane 34.41
    DMSO 112.76
    n-butyl acetate 146.31
    n-octanol 25.11
    chloroform 904.25
    n-propyl acetate 120.61
    acetic acid 60.49
    dichloromethane 929.39
    cyclohexanone 246.61
    propylene glycol 8.45
    isopropyl acetate 97.92
    DMAc 256.77
    2-ethoxyethanol 75.76
    isopentanol 44.37
    n-heptane 20.92
    ethyl formate 102.96
    1,2-dichloroethane 437.85
    n-hexanol 62.2
    2-methoxyethanol 74.18
    isobutyl acetate 88.52
    tetrachloromethane 104.27
    n-pentyl acetate 79.03
    transcutol 156.04
    n-heptanol 34.93
    ethylbenzene 100.44
    MIBK 88.44
    2-propoxyethanol 104.94
    tert-butanol 36.83
    MTBE 96.2
    2-butoxyethanol 64.39
    propionic acid 48.73
    o-xylene 113.03
    formic acid 16.46
    diethyl ether 137.59
    m-xylene 124.88
    p-xylene 126.59
    chlorobenzene 293.44
    dimethyl carbonate 86.93
    n-octane 7.34
    formamide 29.88
    cyclopentanone 383.22
    2-pentanone 143.45
    anisole 163.62
    cyclopentyl methyl ether 256.47
    gamma-butyrolactone 396.36
    1-methoxy-2-propanol 61.49
    pyridine 332.93
    3-pentanone 152.3
    furfural 303.29
    n-dodecane 4.18
    diethylene glycol 39.12
    diisopropyl ether 44.71
    tert-amyl alcohol 47.47
    acetylacetone 146.34
    n-hexadecane 5.01
    acetophenone 142.25
    methyl propionate 149.16
    isopentyl acetate 122.35
    trichloroethylene 839.74
    n-nonanol 28.22
    cyclohexanol 60.27
    benzyl alcohol 99.67
    2-ethylhexanol 60.96
    isooctanol 31.89
    dipropyl ether 110.92
    1,2-dichlorobenzene 227.54
    ethyl lactate 46.7
    propylene carbonate 206.87
    n-methylformamide 62.66
    2-pentanol 35.04
    n-pentane 17.53
    1-propoxy-2-propanol 77.81
    1-methoxy-2-propyl acetate 133.21
    2-(2-methoxypropoxy) propanol 63.67
    mesitylene 63.22
    ε-caprolactone 212.83
    p-cymene 52.21
    epichlorohydrin 573.36
    1,1,1-trichloroethane 355.17
    2-aminoethanol 11.92
    morpholine-4-carbaldehyde 218.5
    sulfolane 344.06
    2,2,4-trimethylpentane 12.67
    2-methyltetrahydrofuran 334.25
    n-hexyl acetate 85.66
    isooctane 7.36
    2-(2-butoxyethoxy)ethanol 77.19
    sec-butyl acetate 88.33
    tert-butyl acetate 99.18
    decalin 22.35
    glycerin 11.8
    diglyme 168.27
    acrylic acid 45.64
    isopropyl myristate 36.5
    n-butyric acid 86.31
    acetyl acetate 108.03
    di(2-ethylhexyl) phthalate 43.23
    ethyl propionate 114.94
    nitromethane 131.48
    1,2-diethoxyethane 116.05
    benzonitrile 120.92
    trioctyl phosphate 26.87
    1-bromopropane 246.79
    gamma-valerolactone 337.45
    n-decanol 22.39
    triethyl phosphate 63.3
    4-methyl-2-pentanol 28.45
    propionitrile 63.09
    vinylene carbonate 195.85
    1,1,2-trichlorotrifluoroethane 200.98
    DMS 92.19
    cumene 62.18
    2-octanol 22.87
    2-hexanone 115.49
    octyl acetate 48.08
    limonene 68.99
    1,2-dimethoxyethane 172.79
    ethyl orthosilicate 65.93
    tributyl phosphate 35.29
    diacetone alcohol 77.79
    N,N-dimethylaniline 109.32
    acrylonitrile 74.21
    aniline 156.86
    1,3-propanediol 22.21
    bromobenzene 370.29
    dibromomethane 573.38
    1,1,2,2-tetrachloroethane 595.69
    2-methyl-cyclohexyl acetate 100.8
    tetrabutyl urea 45.23
    diisobutyl methanol 34.01
    2-phenylethanol 105.06
    styrene 128.96
    dioctyl adipate 58.3
    dimethyl sulfate 123.94
    ethyl butyrate 127.31
    methyl lactate 42.07
    butyl lactate 48.69
    diethyl carbonate 82.81
    propanediol butyl ether 33.65
    triethyl orthoformate 91.95
    p-tert-butyltoluene 48.67
    methyl 4-tert-butylbenzoate 90.1
    morpholine 236.03
    tert-butylamine 28.6
    n-dodecanol 17.28
    dimethoxymethane 177.35
    ethylene carbonate 151.59
    cyrene 105.04
    2-ethoxyethyl acetate 109.78
    2-ethylhexyl acetate 112.38
    1,2,4-trichlorobenzene 263.95
    4-methylpyridine 302.06
    dibutyl ether 56.57
    2,6-dimethyl-4-heptanol 34.01
    DEF 161.43
    dimethyl isosorbide 168.67
    tetrachloroethylene 328.83
    eugenol 82.24
    triacetin 81.58
    span 80 53.26
    1,4-butanediol 14.71
    1,1-dichloroethane 346.18
    2-methyl-1-pentanol 56.37
    methyl formate 72.37
    2-methyl-1-butanol 48.39
    n-decane 7.9
    butyronitrile 84.74
    3,7-dimethyl-1-octanol 32.32
    1-chlorooctane 37.81
    1-chlorotetradecane 13.95
    n-nonane 7.45
    undecane 5.56
    tert-butylcyclohexane 20.45
    cyclooctane 14.11
    cyclopentanol 67.17
    tetrahydropyran 266.78
    tert-amyl methyl ether 94.22
    2,5,8-trioxanonane 107.26
    1-hexene 81.95
    2-isopropoxyethanol 60.44
    2,2,2-trifluoroethanol 28.57
    methyl butyrate 144.71

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction