Amentoflavone

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  • Identifiers

    CAS number
    1617-53-4

    Molecular formula
    C30H18O10

    SMILES
    C1=CC(=CC=C1C2=CC(=O)C3=C(O2)C(=C(C=C3O)O)C4=C(C=CC(=C4)C5=CC(=O)C6=C(C=C(C=C6O5)O)O)O)O

  • Odor profile

    Fragrance
    Phenolic 56.03%
    Odorless 53.68%
    Burnt 32.72%
    Medicinal 25.0%
    Smoky 21.42%
    Bitter 21.18%
    Spicy 20.51%
    Animal 19.91%
    Savory 19.19%
    Balsamic 19.06%

     

    Flavor
    Bitter 97.11%
    Odorless 23.63%
    Sweet-like 19.77%
    Very strong 19.58%
    Cedarleaf 19.45%
    Nitrile 19.31%
    Indole 19.27%
    Lovage 18.53%
    Rotten 18.53%
    Parsley 18.45%

     

    Odor impact est.
    Odorless

  • Properties

    XLogP3-AA
    5.0

    pKa est.
    9.49 (weak base)

    Molecular weight
    538.5 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    2795°C

    Melting point expt.

    • 300 °C

    Flash point

    • 330.31 ˚C est.

  • Synonyms

    • Amentoflavone
    • 1617-53-4
    • Didemethyl-ginkgetin
    • 3',8''-Biapigenin
    • Amenthoflavone
    • Tridemethylsciadopitysin
    • UNII-9I1VC79L77
    • CHEBI:2631
    • 9I1VC79L77
    • MFCD00017470
    • 8-[5-(5,7-dihydroxy-4-oxochromen-2-yl)-2-hydroxyphenyl]-5,7-dihydroxy-2-(4-hydroxyphenyl)chromen-4-one
    • NSC 295677
    • NSC-295677
    • I3',II8-BIAPIGENIN
    • GINKGETIN, DIDEMETHYL-
    • MLS000574827
    • 4H-1-Benzopyran-4-one, 8-[5-(5,7-dihydroxy-4-oxo-4H-1-benzopyran-2-yl)-2-hydroxyphenyl]-5,7-dihydroxy-2-(4-hydroxyphenyl)-
    • 8-(5-(5,7-Dihydroxy-4-oxo-4H-chromen-2-yl)-2-hydroxyphenyl)-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one
    • DTXSID20167225
    • 8-[5-(5,7-dihydroxy-4-oxo-chromen-2-yl)-2-hydroxy-phenyl]-5,7-dihydroxy-2-(4-hydroxyphenyl)chromen-4-one
    • 3',8-Bi[4',5,7-trihydroxyflavone]
    • SMR000156235
    • 4H-1-Benzopyran-4-one, 8-(5-(5,7-dihydroxy-4-oxo-4H-1-benzopyran-2-yl)-2-hydroxyphenyl)-5,7-dihydroxy-2-(4-hydroxyphenyl)-
    • 8-[5-(5,7-dihydroxy-4-oxo-4H-chromen-2-yl)-2-hydroxyphenyl]-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one
    • 4',5,7-Trihydroxyflavone(3'->8)-4',5,7-trihydroxyflavone
    • 4',4''',5,5'',7,7''-Hexahydroxy-3''',8-biflavone, 8CI
    • 3''',8-BIFLAVONE, 4',4''',5,5'',7,7''-HEXAHYDROXY
    • 3',8-Bi(4',5,7-trihydroxyflavone)
    • 8-(5-(5,7-dihydroxy-4-oxo-4H-1-benzopyran-2-yl)-2-hydroxyphenyl)-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
    • SR-01000721725
    • 8-(5-(5,7-dihydroxy-4-oxochromen-2-yl)-2-hydroxyphenyl)-5,7-dihydroxy-2-(4-hydroxyphenyl)chromen-4-one
    • Amentoflavone (Standard)
    • A1D6Q
    • AMENTOFLAVONE [INCI]
    • BIDD:PXR0028
    • SCHEMBL312563
    • MEGxp0_000924
    • DTXCID1089716
    • HY-N0662R
    • med.21724, Compound 138
    • Amentoflavone, analytical standard
    • BDBM429466
    • HMS2228B12
    • HMS3343J17
    • HMS3885A08
    • BCP13255
    • HY-N0662
    • Amentoflavone, >=99.0% (HPLC)
    • LMPK12040009
    • MFCD20275041
    • NSC295677
    • s3833
    • AKOS015896819
    • CCG-269950
    • CS-4945
    • FA65485
    • NCGC00247542-01
    • NCGC00247542-02
    • AC-34718
    • BS-15502
    • DB-043499
    • A2544
    • NS00074071
    • A11476
    • AO-229/40763433
    • Q4742425
    • SR-01000721725-2
    • SR-01000721725-3
    • 5,5',7,7'-Tetrahydroxy-2,2'-bis(4-hydroxyphenyl)-[3,8'-bi-4H-1-benzopyran]-4,4'-dione
    • 1017-53-4
    • 4H-1-Benzopyran-4-one, 8-[5-(5,7-dihydroxy-4-oxo-4H-1-benzopyran-2-yl)-2-hydroxyphenyl]-5,7-dihydroxy-2-(4-hydroxyphenyl)

  • Applications

    Amentoflavone (CAS 1617-53-4) is a natural biflavonoid with potential applications across several industries. Real-world uses are typically centered on: antioxidant function in cosmetics and personal care; considered a lead compound for pharmacological research and the development of more complex flavonoid derivatives; serves as an intermediate in the synthesis of biflavonoid-related compounds; acts as an antioxidant stabilizer in polymer and plastic formulations; and has been explored in agrochemical research as a natural product lead for prospective agricultural chemistries.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 0.29
    methanol 0.47
    isopropanol 0.13
    water 0.0
    ethyl acetate 0.07
    n-propanol 0.38
    acetone 0.11
    n-butanol 0.18
    acetonitrile 0.02
    DMF 6.71
    toluene 0.01
    isobutanol 0.12
    1,4-dioxane 0.62
    methyl acetate 0.17
    THF 1.92
    2-butanone 0.44
    n-pentanol 0.09
    sec-butanol 0.2
    n-hexane 0.0
    ethylene glycol 0.84
    NMP 7.73
    cyclohexane 0.0
    DMSO 16.15
    n-butyl acetate 0.07
    n-octanol 0.04
    chloroform 0.01
    n-propyl acetate 0.08
    acetic acid 0.76
    dichloromethane 0.01
    cyclohexanone 0.39
    propylene glycol 1.95
    isopropyl acetate 0.04
    DMAc 8.44
    2-ethoxyethanol 2.4
    isopentanol 0.08
    n-heptane 0.0
    ethyl formate 0.16
    1,2-dichloroethane 0.01
    n-hexanol 0.03
    2-methoxyethanol 9.14
    isobutyl acetate 0.02
    tetrachloromethane 0.0
    n-pentyl acetate 0.08
    transcutol 4.2
    n-heptanol 0.04
    ethylbenzene 0.0
    MIBK 0.05
    2-propoxyethanol 2.07
    tert-butanol 0.06
    MTBE 0.03
    2-butoxyethanol 1.03
    propionic acid 0.53
    o-xylene 0.0
    formic acid 1.23
    diethyl ether 0.04
    m-xylene 0.0
    p-xylene 0.0
    chlorobenzene 0.0
    dimethyl carbonate 0.18
    n-octane 0.0
    formamide 1.62
    cyclopentanone 1.09
    2-pentanone 0.14
    anisole 0.03
    cyclopentyl methyl ether 0.1
    gamma-butyrolactone 1.55
    1-methoxy-2-propanol 4.66
    pyridine 0.35
    3-pentanone 0.09
    furfural 1.69
    n-dodecane 0.0
    diethylene glycol 2.6
    diisopropyl ether 0.0
    tert-amyl alcohol 0.12
    acetylacetone 0.2
    n-hexadecane 0.0
    acetophenone 0.07
    methyl propionate 0.22
    isopentyl acetate 0.06
    trichloroethylene 0.03
    n-nonanol 0.05
    cyclohexanol 0.07
    benzyl alcohol 0.1
    2-ethylhexanol 0.02
    isooctanol 0.03
    dipropyl ether 0.05
    1,2-dichlorobenzene 0.0
    ethyl lactate 0.31
    propylene carbonate 0.25
    n-methylformamide 2.03
    2-pentanol 0.06
    n-pentane 0.0
    1-propoxy-2-propanol 1.21
    1-methoxy-2-propyl acetate 0.43
    2-(2-methoxypropoxy) propanol 1.29
    mesitylene 0.0
    ε-caprolactone 0.61
    p-cymene 0.0
    epichlorohydrin 1.04
    1,1,1-trichloroethane 0.0
    2-aminoethanol 1.58
    morpholine-4-carbaldehyde 8.19
    sulfolane 6.58
    2,2,4-trimethylpentane 0.0
    2-methyltetrahydrofuran 0.29
    n-hexyl acetate 0.09
    isooctane 0.0
    2-(2-butoxyethoxy)ethanol 1.68
    sec-butyl acetate 0.04
    tert-butyl acetate 0.05
    decalin 0.0
    glycerin 7.73
    diglyme 3.2
    acrylic acid 0.8
    isopropyl myristate 0.03
    n-butyric acid 0.34
    acetyl acetate 0.03
    di(2-ethylhexyl) phthalate 0.06
    ethyl propionate 0.07
    nitromethane 1.44
    1,2-diethoxyethane 0.23
    benzonitrile 0.02
    trioctyl phosphate 0.05
    1-bromopropane 0.01
    gamma-valerolactone 8.19
    n-decanol 0.03
    triethyl phosphate 0.06
    4-methyl-2-pentanol 0.02
    propionitrile 0.05
    vinylene carbonate 0.22
    1,1,2-trichlorotrifluoroethane 3.06
    DMS 0.1
    cumene 0.0
    2-octanol 0.02
    2-hexanone 0.11
    octyl acetate 0.05
    limonene 0.01
    1,2-dimethoxyethane 2.43
    ethyl orthosilicate 0.05
    tributyl phosphate 0.06
    diacetone alcohol 0.52
    N,N-dimethylaniline 0.03
    acrylonitrile 0.14
    aniline 0.05
    1,3-propanediol 1.87
    bromobenzene 0.0
    dibromomethane 0.0
    1,1,2,2-tetrachloroethane 0.03
    2-methyl-cyclohexyl acetate 0.05
    tetrabutyl urea 0.14
    diisobutyl methanol 0.01
    2-phenylethanol 0.06
    styrene 0.0
    dioctyl adipate 0.1
    dimethyl sulfate 0.69
    ethyl butyrate 0.08
    methyl lactate 1.21
    butyl lactate 0.34
    diethyl carbonate 0.04
    propanediol butyl ether 1.36
    triethyl orthoformate 0.12
    p-tert-butyltoluene 0.0
    methyl 4-tert-butylbenzoate 0.18
    morpholine 1.98
    tert-butylamine 0.01
    n-dodecanol 0.02
    dimethoxymethane 1.35
    ethylene carbonate 0.12
    cyrene 1.52
    2-ethoxyethyl acetate 0.31
    2-ethylhexyl acetate 0.04
    1,2,4-trichlorobenzene 0.01
    4-methylpyridine 0.13
    dibutyl ether 0.04
    2,6-dimethyl-4-heptanol 0.01
    DEF 0.51
    dimethyl isosorbide 1.52
    tetrachloroethylene 0.02
    eugenol 0.31
    triacetin 0.28
    span 80 0.8
    1,4-butanediol 0.36
    1,1-dichloroethane 0.0
    2-methyl-1-pentanol 0.06
    methyl formate 0.94
    2-methyl-1-butanol 0.12
    n-decane 0.0
    butyronitrile 0.04
    3,7-dimethyl-1-octanol 0.02
    1-chlorooctane 0.0
    1-chlorotetradecane 0.0
    n-nonane 0.0
    undecane 0.0
    tert-butylcyclohexane 0.0
    cyclooctane 0.0
    cyclopentanol 0.2
    tetrahydropyran 0.15
    tert-amyl methyl ether 0.05
    2,5,8-trioxanonane 2.04
    1-hexene 0.0
    2-isopropoxyethanol 0.73
    2,2,2-trifluoroethanol 0.21
    methyl butyrate 0.15

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction