alpha-Tocopherol succinate

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  • Identifiers

    CAS number
    4345-03-3

    Molecular formula
    C33H54O5

    SMILES
    CC1=C(C(=C(C2=C1O[C@](CC2)(C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)C)OC(=O)CCC(=O)O)C

    Safety labels

  • Odor profile

    Fragrance
    Waxy 37.1%
    Woody 36.31%
    Floral 33.99%
    Odorless 33.28%
    Dry 31.25%
    Musk 31.24%
    Balsamic 30.46%
    Fatty 29.74%
    Animal 29.69%
    Powdery 29.44%

     

    Flavor
    Woody 35.66%
    Bland 31.14%
    Mild 30.23%
    Herbal 27.85%
    Odorless 24.55%
    Faint 20.71%
    Slightly waxy 20.13%
    Parsley 20.12%
    Delicate 20.06%
    Warm 19.9%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    10.2

    pKa est.
    7.51 (neutral)

    Molecular weight
    530.8 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    620°C

    Melting point expt.

    • 169 to 171 °F (NTP, 1992)

    Flash point

    • 218.64 ˚C est.

    Solubility expt.

    • less than 0.1 mg/mL at 64 °F (NTP, 1992)

  • Synonyms

    • 4345-03-3
    • alpha-Tocopheryl succinate
    • alpha-tocopherol succinate
    • (+)-alpha-Tocopheryl succinate
    • d-alpha-Tocopherol acid succinate
    • Covitol 1210
    • alpha-Tocopheryl acid succinate
    • alpha-Vitamin E succinate
    • LU4B53JYVE
    • alpha-Tocopherol, succinate
    • alpha-Tocopherol hemisuccinate
    • 4-oxo-4-[[(2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydrochromen-6-yl]oxy]butanoic acid
    • 6-Chromanol, 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, hydrogen succinate, (+)-
    • Succinic acid, mono(2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-6-chromanyl) ester, (+)-
    • 4-oxo-4-(((2R)-2,5,7,8-tetramethyl-2-((4R,8R)-4,8,12-trimethyltridecyl)-3,4-dihydrochromen-6-yl)oxy)butanoic acid
    • RefChem:555956
    • vitamin e succinate
    • D-alpha-Tocopherol succinate
    • tocopherol succinate
    • D-|A-Tocopherol succinate
    • D-ALPHA-TOCOPHERYL SUCCINATE
    • Vitamin E hemisuccinate
    • Alpha-tocopherol succinate, d-
    • 4-Oxo-4-(((R)-2,5,7,8-tetramethyl-2-((4R,8R)-4,8,12-trimethyltridecyl)chroman-6-yl)oxy)butanoic acid
    • MFCD00072055
    • alpha tocopheryl acid succinate
    • a-Tocopheryl Succinate
    • Vitamine E succinate
    • .alpha.-Tocopherol succinate
    • DTXSID2026151
    • (+)-alpha-Tocopherol acid succinate
    • CV 104
    • 4-oxo-4-{[(2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydro-2H-1-benzopyran-6-yl]oxy}butanoic acid
    • Butanedioic acid,mono[(2R)-3,4-dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-2H-1-benzopyran-6-yl] ester
    • D-alpha tocopheryl acid succinate
    • NCGC00167561-01
    • C33H54O5
    • NSC 173849
    • 4-oxo-4-[(2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]chroman-6-yl]oxy-butanoic acid
    • DTXCID706151
    • 17407-37-3
    • 3-{[(2R)-2-((4R,8R)-4,8,12-trimethyltridecyl)-2,5,7,8-tetramethylchroman-6-yl] oxycarbonyl}propanoic acid
    • Butanedioic acid, 1-((2R)-3,4-dihydro-2,5,7,8-tetramethyl-2-((4R,8R)-4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl) ester
    • Butanedioic acid, mono((2R)-3,4-dihydro-2,5,7,8-tetramethyl-2-((4R,8R)-4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl) ester
    • Tocopheryl succinate
    • d-a-tocopherol succinate
    • CAS-4345-03-3
    • D-.alpha.-Tocopherol succinate
    • D-.alpha.-Tocopheryl succinate
    • CCRIS 4734
    • NSC173849
    • Tocopherol acid succinate, alpha-
    • alpha-Tocopheryl hydrogen succinate
    • Vitamin-E Dragees
    • 4-Oxo-4-({(2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydro-2H-1-benzopyran-6-yl}oxy)butanoic acid
    • Butanedioic acid, mono(3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl) ester, (2R-(2R*(4R*,8R*)))-
    • Butanedioic acid, mono[(2R)-3,4-dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-2H-1-benzopyran-6-yl] ester
    • Vitamin?E?succinate
    • alpha-Tocopherol acid succinate, D-
    • Dal-E
    • EINECS 224-403-8
    • EINECS 241-433-7
    • TOCOPHERYL ACID SUCCINATE,D-ALPHA
    • .ALPHA.-TOCOPHEROL SUCCINATE, D-
    • Tocopherol Succinate RS
    • UNII-LU4B53JYVE
    • D-alpha-tocopheryl-succinate
    • .alpha.-tocopheryl succinate
    • White-e [veterinary] (TN)
    • CHEMBL81421
    • SCHEMBL134422
    • D- alpha -Tocopheryl Succinate
    • orb1944993
    • alpha-Tocopherol, succinate, D-
    • MSK1546
    • .alpha.-tocopheryl succinate, d-
    • CHEBI:135821
    • Tox21_112556
    • Tox21_200568
    • BDBM50458511
    • D-alpha-Tocopheryl hydrogen succinate
    • EBC-27284
    • AKOS015902063
    • Dal-Vita brand of vitamin E succinate
    • Wiedemann brand of vitamin E succinate
    • (+)-.alpha.-Tocopherol acid succinate
    • AC-1132
    • CCG-207945
    • DB14001
    • 2,5,7,8-Tetramethyl-2-(4,8,12-trimethyltridecyl)-6-chromanyl hydrogen succinate, (+)-
    • Mono(2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-6-chromanyl) succinate, (+)-
    • RRR-alpha-Tocopheryl Hydrogen Succinate
    • NCGC00167561-02
    • NCGC00167561-03
    • NCGC00258122-01
    • TOCOPHERYL ACID SUCCINATE [VANDF]
    • 55134-51-5
    • AS-75106
    • Mono(3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl) butanedioate, (2R-(2R*(4R*,8R*)))-
    • ST075423
    • SY130086
    • .ALPHA.-TOCOPHEROL SUCCINATE [MI]
    • RRR-ALPHA-TOCOPHERYL ACID SUCCINATE
    • TOCOPHERYL ACID SUCCINATE [WHO-DD]
    • HY-131553
    • RRR-alpha-Tocopheryl hydrogen succinate CRS
    • CS-0136520
    • NS00045903
    • T2628
    • VITAMIN E (ALPHA-TOCOPHERYL SUCCINATE)
    • C90299
    • D08612
    • SBI-0636756.0001
    • D-ALPHA TOCOFERIL ACID SUCCINATE [MART.]
    • D-alpha-Tocopherol succinate, analytical standard
    • RRR-.ALPHA.-TOCOPHERYL HYDROGEN SUCCINATE
    • C033716
    • EN300-23011947
    • RRR-ALPHA-TOCOPHERYL ACID SUCCINATE [FCC]
    • SR-01000883728
    • TOCOPHERYL ACID SUCCINATE,D-ALPHA [VANDF]
    • SR-01000883728-1
    • BRD-K64636206-001-02-7
    • Melatonine,N-(2-(5-Methoxyindol-3-yl)ethyl)acetaMide
    • Q27283185
    • D-alpha-Tocopherol succinate, semisynthetic, 1210 IU/g
    • Z2216889767
    • 4345-03-3

  • Applications

    alpha-Tocopherol succinate, an ester of alpha-tocopherol with succinic acid, is used in several real-world applications including as a vitamin E source in nutraceutical and pharmaceutical formulations; as an antioxidant stabilizer in cosmetics and personal care products; as an antioxidant additive to polymers and coatings to retard oxidative degradation; as a vitamin E supplement in animal feed; and as an intermediate in the synthesis of other vitamin E derivatives for pharmaceutical or nutraceutical development.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 38.79
    methanol 26.92
    isopropanol 24.43
    water 0.03
    ethyl acetate 56.17
    n-propanol 47.97
    acetone 50.73
    n-butanol 39.4
    acetonitrile 13.06
    DMF 67.11
    toluene 34.02
    isobutanol 36.13
    1,4-dioxane 101.76
    methyl acetate 51.41
    THF 243.24
    2-butanone 97.67
    n-pentanol 62.9
    sec-butanol 46.98
    n-hexane 2.87
    ethylene glycol 1.34
    NMP 130.65
    cyclohexane 3.12
    DMSO 56.86
    n-butyl acetate 69.82
    n-octanol 31.95
    chloroform 191.96
    n-propyl acetate 79.6
    acetic acid 45.56
    dichloromethane 164.26
    cyclohexanone 137.6
    propylene glycol 5.78
    isopropyl acetate 48.64
    DMAc 197.11
    2-ethoxyethanol 109.37
    isopentanol 38.01
    n-heptane 1.94
    ethyl formate 31.88
    1,2-dichloroethane 88.11
    n-hexanol 37.43
    2-methoxyethanol 62.16
    isobutyl acetate 67.32
    tetrachloromethane 24.36
    n-pentyl acetate 100.37
    transcutol 243.6
    n-heptanol 36.39
    ethylbenzene 29.4
    MIBK 46.14
    2-propoxyethanol 97.46
    tert-butanol 28.92
    MTBE 60.43
    2-butoxyethanol 99.86
    propionic acid 34.86
    o-xylene 23.31
    formic acid 9.17
    diethyl ether 38.98
    m-xylene 20.55
    p-xylene 36.61
    chlorobenzene 59.13
    dimethyl carbonate 18.54
    n-octane 1.41
    formamide 16.02
    cyclopentanone 138.76
    2-pentanone 65.8
    anisole 77.6
    cyclopentyl methyl ether 70.08
    gamma-butyrolactone 135.63
    1-methoxy-2-propanol 58.85
    pyridine 103.52
    3-pentanone 52.36
    furfural 99.31
    n-dodecane 1.13
    diethylene glycol 28.94
    diisopropyl ether 12.74
    tert-amyl alcohol 51.2
    acetylacetone 66.26
    n-hexadecane 1.32
    acetophenone 76.97
    methyl propionate 48.07
    isopentyl acetate 79.48
    trichloroethylene 190.66
    n-nonanol 34.44
    cyclohexanol 36.96
    benzyl alcohol 60.53
    2-ethylhexanol 28.54
    isooctanol 35.16
    dipropyl ether 32.04
    1,2-dichlorobenzene 56.39
    ethyl lactate 33.83
    propylene carbonate 70.39
    n-methylformamide 29.57
    2-pentanol 25.41
    n-pentane 1.64
    1-propoxy-2-propanol 70.96
    1-methoxy-2-propyl acetate 84.54
    2-(2-methoxypropoxy) propanol 81.6
    mesitylene 11.76
    ε-caprolactone 151.03
    p-cymene 15.28
    epichlorohydrin 196.48
    1,1,1-trichloroethane 85.97
    2-aminoethanol 10.35
    morpholine-4-carbaldehyde 131.21
    sulfolane 136.21
    2,2,4-trimethylpentane 2.73
    2-methyltetrahydrofuran 154.67
    n-hexyl acetate 96.4
    isooctane 1.39
    2-(2-butoxyethoxy)ethanol 113.7
    sec-butyl acetate 63.95
    tert-butyl acetate 60.73
    decalin 4.11
    glycerin 7.47
    diglyme 187.04
    acrylic acid 23.59
    isopropyl myristate 30.71
    n-butyric acid 63.84
    acetyl acetate 33.95
    di(2-ethylhexyl) phthalate 40.74
    ethyl propionate 54.99
    nitromethane 65.83
    1,2-diethoxyethane 96.57
    benzonitrile 39.03
    trioctyl phosphate 26.29
    1-bromopropane 56.94
    gamma-valerolactone 246.49
    n-decanol 21.45
    triethyl phosphate 32.99
    4-methyl-2-pentanol 18.85
    propionitrile 22.22
    vinylene carbonate 58.19
    1,1,2-trichlorotrifluoroethane 94.72
    DMS 49.12
    cumene 20.67
    2-octanol 28.34
    2-hexanone 94.39
    octyl acetate 44.01
    limonene 19.5
    1,2-dimethoxyethane 149.97
    ethyl orthosilicate 37.53
    tributyl phosphate 28.9
    diacetone alcohol 61.1
    N,N-dimethylaniline 49.25
    acrylonitrile 20.45
    aniline 38.48
    1,3-propanediol 23.38
    bromobenzene 61.16
    dibromomethane 94.77
    1,1,2,2-tetrachloroethane 168.42
    2-methyl-cyclohexyl acetate 66.17
    tetrabutyl urea 40.66
    diisobutyl methanol 14.08
    2-phenylethanol 56.91
    styrene 32.14
    dioctyl adipate 52.23
    dimethyl sulfate 33.22
    ethyl butyrate 57.68
    methyl lactate 20.25
    butyl lactate 66.56
    diethyl carbonate 33.57
    propanediol butyl ether 65.73
    triethyl orthoformate 53.95
    p-tert-butyltoluene 13.71
    methyl 4-tert-butylbenzoate 77.57
    morpholine 145.57
    tert-butylamine 14.87
    n-dodecanol 13.18
    dimethoxymethane 62.58
    ethylene carbonate 53.48
    cyrene 89.26
    2-ethoxyethyl acetate 133.1
    2-ethylhexyl acetate 69.62
    1,2,4-trichlorobenzene 76.77
    4-methylpyridine 103.29
    dibutyl ether 37.16
    2,6-dimethyl-4-heptanol 14.08
    DEF 69.96
    dimethyl isosorbide 144.77
    tetrachloroethylene 92.35
    eugenol 78.24
    triacetin 94.87
    span 80 73.58
    1,4-butanediol 16.78
    1,1-dichloroethane 76.09
    2-methyl-1-pentanol 63.14
    methyl formate 21.22
    2-methyl-1-butanol 46.81
    n-decane 2.54
    butyronitrile 27.6
    3,7-dimethyl-1-octanol 29.52
    1-chlorooctane 18.99
    1-chlorotetradecane 5.31
    n-nonane 2.02
    undecane 1.61
    tert-butylcyclohexane 3.85
    cyclooctane 1.26
    cyclopentanol 41.98
    tetrahydropyran 123.99
    tert-amyl methyl ether 52.75
    2,5,8-trioxanonane 111.5
    1-hexene 19.32
    2-isopropoxyethanol 89.45
    2,2,2-trifluoroethanol 15.07
    methyl butyrate 82.18

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction