alpha-Lactose monohydrate

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  • Identifiers

    CAS number
    5989-81-1

    Molecular formula
    C12H24O12

    SMILES
    C([C@@H]1[C@@H]([C@@H]([C@H]([C@@H](O1)O[C@@H]2[C@H](O[C@@H]([C@@H]([C@H]2O)O)O)CO)O)O)O)O.O

    Safety labels

  • Odor profile

    Fragrance
    Odorless 72.77%
    Sweet 47.26%
    Alcoholic 22.37%
    Caramellic 22.34%
    Woody 21.23%
    Clean 16.45%
    Vanilla 16.36%
    Milky 15.93%
    Bitter 15.57%
    Cooling 15.48%

     

    Flavor
    Sweet 83.15%
    Odorless 57.11%
    Bitter 45.56%
    Sweet-like 32.23%
    Cauliflower 22.26%
    Very slight 22.14%
    Soup 20.6%
    Alkaline 20.44%
    Fatty 20.4%
    Mentholic 20.03%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    4.04 (weak acid)

    Molecular weight
    360.31 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    2988°C

    Flash point

    • 275.27 ˚C est.

  • Synonyms

    • 5989-81-1
    • alpha-Lactose monohydrate
    • DTXSID1052828
    • alpha-D-Glucopyranose, 4-O-beta-D-galactopyranosyl-, monohydrate
    • RefChem:1076517
    • DTXCID90820517
    • 611-913-4
    • Lactose monohydrate
    • alpha-D-Lactose monohydrate
    • D-Lactose monohydrate
    • 64044-51-5
    • Respitose
    • a-D-Glucopyranose, 4-O-b-D-galactopyranosyl-, monohydrate
    • alpha-lactose hydrate
    • Lactose monohydrate [NF]
    • (2R,3R,4S,5R,6S)-2-(hydroxymethyl)-6-[(2R,3S,4R,5R,6S)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxane-3,4,5-triol;hydrate
    • EWQ57Q8I5X
    • Inhalac 120 (contains b anomer)
    • 4-O-beta-D-Galactopyranosyl-alpha-D-glucose
    • Lactose monohydrate (NF)
    • MFCD00150747
    • lactose hydrate
    • a-Lactose monohydrate
    • |A-lactose monohydrate
    • Microtose
    • Pharmaose
    • Lactopress
    • Lactose, hydrous
    • (2R,3R,4S,5R,6S)-2-(hydroxymethyl)-6-{[(2R,3S,4R,5R,6S)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy}oxane-3,4,5-triol hydrate
    • (2S,3R,4R,5S,6R)-6-(Hydroxymethyl)-5-(((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2,3,4-triol hydrate
    • 66857-12-3
    • Spherolac 100
    • Lactose(Monohydrate)
    • NSC-760401
    • ?-D-Lactose monohydrate
    • 10039-26-6
    • UNII-EWQ57Q8I5X
    • Pharmatose
    • Lactochem
    • Lactohale
    • Wyndale
    • Wynhale
    • Lactose hydrous
    • .alpha.-D-Glucopyranose, 4-O-.beta.-D-galactopyranosyl-, monohydrate
    • Pharmatose dcl ii
    • Supertab 11sd
    • Supertab 14sd
    • Supertab 30gr
    • Supertab 50 odt
    • Supertab 11sd nz
    • Pharmatose dcl 11
    • Lactopress spray dried
    • Lactose fastflo 316
    • |A-Lactose (hydrate)
    • alpha-Lactose (hydrate)
    • LACTOSE,MONOHYDRATE
    • |A-D-Lactose monohydrate
    • alpha -lactose monohydrate
    • Lactose hydrate (JP18)
    • SCHEMBL16787
    • LACTOSE HYDRATE [JAN]
    • LACTOSE, HYDROUS [II]
    • D-Glucose, 4-O-beta-D-galactopyranosyl-, monohydrate
    • orb2278570
    • alpha-D(+)-Lactose monohydrate
    • PHARMATOSE DCL II [II]
    • D-Glucose, 4-O-.beta.-D-galactopyranosyl-, monohydrate
    • LACTOSE MONOHYDRATE [II]
    • MSK3219
    • CHEBI:189432
    • alpha-Lactose, analytical standard
    • 4-O-A-D-Galactopyranosyl-D-glucose
    • LACTOSE MONOHYDRATE [USP-RS]
    • LACTOSE MONOHYDRATE [WHO-IP]
    • AKOS015896871
    • EBC-264041
    • FS-3862
    • HY-W087904
    • NSC 760401
    • OL05009
    • LACTOSE MONOHYDRATE [EP MONOGRAPH]
    • CS-0128727
    • LACTOSUM, MONOHYDRATE [WHO-IP LATIN]
    • NS00099491
    • D03226
    • E80712
    • EN300-1608278
    • /b-D-galactopyranosyl-(1,4)-D-glucose monhydrate
    • F321958
    • 4-O-|A-D-Galactopyranosyl-|A-D-glucopyranose hydrate
    • alpha-4-O-(beta-D-galactopyranosido)-D-glucopyranose
    • Q27277391
    • 4-O-b-D-Galactopyranosyl-a-D-glucopyranose monohydrate
    • alpha-Lactose monohydrate, >=99% total lactose basis (GC)
    • -D-Glucopyranose, 4-O-BATE-D-galactopyranosyl-, hydrate(1:1)
    • Alpha-D(+)-Lactose Monohydrate(Discontinued,See C4X-214913)
    • alpha-D-Glucopyranose, 4-O-beta-D-galactopyranosyl-, hydrate
    • |A-D-Glucopyranose, 4-O-|A-D-galactopyranosyl-, hydrate(1:1)
    • 4-O-beta-D-Galactopyranosyl-alpha-D-glucopyranose--water (1/1)
    • alpha-Lactose monohydrate, BioXtra, >=99% total lactose basis (GC)
    • alpha-Lactose monohydrate, suitable for cell culture, BioReagent
    • .alpha.-D-Glucopyranose, 4-O-.beta.-D-galactopyranosyl-, hydrate (1:1)
    • (2R,3R,4S,5R,6S)-2-(hydroxymethyl)-6-[(2R,3S,4R,5R,6S)-4,5,6-trihydroxy-2-(hydroxymethyl)tetrahydropyran-3-yl]oxy-tetrahydropyran-3,4,5-triol;hydrate
    • 64044-51-5

  • Applications

    alpha-Lactose monohydrate (CAS number: 5989-81-1) is widely used as a pharmaceutical excipient, serving as a diluent and binder in solid dosage forms and as a carrier for dry powder inhalation formulations; in food processing, it acts as a carbohydrate source and bulking agent and is employed as a carrier for spray-dried flavors and aroma compounds to stabilize and deliver them in powders; in animal nutrition, lactose monohydrate serves as an energy source and palatability enhancer in feed for young livestock; in cosmetics/personal care, it can function as a filler and texture enhancer in loose powders and pressed cosmetic formulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 0.86
    methanol 4.65
    isopropanol 0.24
    water 407.99
    ethyl acetate 0.11
    n-propanol 0.35
    acetone 0.22
    n-butanol 0.25
    acetonitrile 0.15
    DMF 36.01
    toluene 0.11
    isobutanol 0.15
    1,4-dioxane 1.12
    methyl acetate 0.11
    THF 0.71
    2-butanone 0.14
    n-pentanol 0.13
    sec-butanol 0.21
    n-hexane 0.03
    ethylene glycol 37.47
    NMP 33.32
    cyclohexane 0.21
    DMSO 156.22
    n-butyl acetate 0.13
    n-octanol 0.31
    chloroform 0.04
    n-propyl acetate 0.06
    acetic acid 7.13
    dichloromethane 0.05
    cyclohexanone 0.65
    propylene glycol 9.66
    isopropyl acetate 0.09
    DMAc 18.0
    2-ethoxyethanol 3.3
    isopentanol 0.15
    n-heptane 0.17
    ethyl formate 0.2
    1,2-dichloroethane 0.08
    n-hexanol 0.31
    2-methoxyethanol 12.38
    isobutyl acetate 0.03
    tetrachloromethane 0.04
    n-pentyl acetate 0.17
    transcutol 7.62
    n-heptanol 0.46
    ethylbenzene 0.05
    MIBK 0.12
    2-propoxyethanol 3.02
    tert-butanol 0.28
    MTBE 0.07
    2-butoxyethanol 2.22
    propionic acid 0.99
    o-xylene 0.21
    formic acid 162.08
    diethyl ether 0.13
    m-xylene 0.13
    p-xylene 0.05
    chlorobenzene 0.03
    dimethyl carbonate 1.16
    n-octane 0.08
    formamide 90.9
    cyclopentanone 0.8
    2-pentanone 0.16
    anisole 0.12
    cyclopentyl methyl ether 0.59
    gamma-butyrolactone 1.47
    1-methoxy-2-propanol 5.73
    pyridine 0.53
    3-pentanone 0.21
    furfural 2.87
    n-dodecane 0.04
    diethylene glycol 15.38
    diisopropyl ether 0.06
    tert-amyl alcohol 0.27
    acetylacetone 0.56
    n-hexadecane 0.04
    acetophenone 0.27
    methyl propionate 0.39
    isopentyl acetate 0.1
    trichloroethylene 0.1
    n-nonanol 0.32
    cyclohexanol 0.76
    benzyl alcohol 0.37
    2-ethylhexanol 0.18
    isooctanol 0.27
    dipropyl ether 0.35
    1,2-dichlorobenzene 0.04
    ethyl lactate 0.81
    propylene carbonate 0.55
    n-methylformamide 8.49
    2-pentanol 0.18
    n-pentane 0.06
    1-propoxy-2-propanol 1.86
    1-methoxy-2-propyl acetate 0.82
    2-(2-methoxypropoxy) propanol 2.41
    mesitylene 0.12
    ε-caprolactone 0.81
    p-cymene 0.13
    epichlorohydrin 0.47
    1,1,1-trichloroethane 0.02
    2-aminoethanol 13.08
    morpholine-4-carbaldehyde 21.62
    sulfolane 14.8
    2,2,4-trimethylpentane 0.02
    2-methyltetrahydrofuran 0.31
    n-hexyl acetate 0.2
    isooctane 0.01
    2-(2-butoxyethoxy)ethanol 3.63
    sec-butyl acetate 0.05
    tert-butyl acetate 0.15
    decalin 0.04
    glycerin 69.9
    diglyme 5.45
    acrylic acid 3.14
    isopropyl myristate 0.1
    n-butyric acid 0.56
    acetyl acetate 0.18
    di(2-ethylhexyl) phthalate 0.22
    ethyl propionate 0.11
    nitromethane 4.36
    1,2-diethoxyethane 0.46
    benzonitrile 0.11
    trioctyl phosphate 0.23
    1-bromopropane 0.03
    gamma-valerolactone 4.03
    n-decanol 0.25
    triethyl phosphate 0.3
    4-methyl-2-pentanol 0.11
    propionitrile 0.09
    vinylene carbonate 0.63
    1,1,2-trichlorotrifluoroethane 6.77
    DMS 0.41
    cumene 0.05
    2-octanol 0.23
    2-hexanone 0.07
    octyl acetate 0.17
    limonene 0.21
    1,2-dimethoxyethane 1.47
    ethyl orthosilicate 0.26
    tributyl phosphate 0.17
    diacetone alcohol 1.17
    N,N-dimethylaniline 0.28
    acrylonitrile 0.26
    aniline 0.38
    1,3-propanediol 6.34
    bromobenzene 0.02
    dibromomethane 0.03
    1,1,2,2-tetrachloroethane 0.15
    2-methyl-cyclohexyl acetate 0.17
    tetrabutyl urea 0.47
    diisobutyl methanol 0.17
    2-phenylethanol 0.42
    styrene 0.04
    dioctyl adipate 0.21
    dimethyl sulfate 5.65
    ethyl butyrate 0.17
    methyl lactate 4.66
    butyl lactate 0.69
    diethyl carbonate 0.14
    propanediol butyl ether 3.54
    triethyl orthoformate 0.31
    p-tert-butyltoluene 0.15
    methyl 4-tert-butylbenzoate 0.99
    morpholine 2.06
    tert-butylamine 0.13
    n-dodecanol 0.19
    dimethoxymethane 3.98
    ethylene carbonate 0.43
    cyrene 5.12
    2-ethoxyethyl acetate 0.39
    2-ethylhexyl acetate 0.09
    1,2,4-trichlorobenzene 0.07
    4-methylpyridine 0.24
    dibutyl ether 0.14
    2,6-dimethyl-4-heptanol 0.17
    DEF 1.73
    dimethyl isosorbide 3.1
    tetrachloroethylene 0.21
    eugenol 1.18
    triacetin 0.69
    span 80 2.47
    1,4-butanediol 2.17
    1,1-dichloroethane 0.02
    2-methyl-1-pentanol 0.09
    methyl formate 3.14
    2-methyl-1-butanol 0.17
    n-decane 0.07
    butyronitrile 0.07
    3,7-dimethyl-1-octanol 0.16
    1-chlorooctane 0.08
    1-chlorotetradecane 0.04
    n-nonane 0.07
    undecane 0.05
    tert-butylcyclohexane 0.02
    cyclooctane 0.15
    cyclopentanol 0.7
    tetrahydropyran 0.34
    tert-amyl methyl ether 0.16
    2,5,8-trioxanonane 5.51
    1-hexene 0.03
    2-isopropoxyethanol 1.07
    2,2,2-trifluoroethanol 8.35
    methyl butyrate 0.14

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction