Acetylglycine

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  • Identifiers

    CAS number
    543-24-8

    Molecular formula
    C4H7NO3

    SMILES
    CC(=O)NCC(=O)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 56.04%
    Savory 34.41%
    Sweet 33.83%
    Meaty 32.96%
    Roasted 24.43%
    Cooked 23.73%
    Burnt 23.63%
    Caramellic 23.21%
    Sour 22.06%
    Milky 21.2%

     

    Flavor
    Odorless 66.62%
    Sour 40.44%
    Acidic 30.35%
    Very mild 29.84%
    Mild 26.83%
    Caramellic 23.55%
    Yeast 23.06%
    Nutty 22.98%
    Musty 21.56%
    Acetoin 21.53%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -1.2

    pKa est.
    7.83 (neutral)

    Molecular weight
    117.1 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    334°C

    Melting point expt.

    • 206 °C
    • 207 - 209 °C

    Flash point

    • 164.01 ˚C est.

    Solubility expt.

    • 26300 mg/L (at 15 °C)
    • 26.3 mg/mL at 15 °C

  • Synonyms

    • N-ACETYLGLYCINE
    • 543-24-8
    • Aceturic acid
    • 2-Acetamidoacetic acid
    • Acetamidoacetic acid
    • Acetylglycine
    • Glycine, N-acetyl-
    • Acetylaminoacetic acid
    • Acetylglycocoll
    • Ethanoylaminoethanoic acid
    • U2UT4677KR
    • acetylaminoacetate
    • NSC-7605
    • DTXSID2043793
    • CHEBI:40410
    • acetylglycinate
    • RefChem:162741
    • DTXCID0023793
    • 208-839-6
    • Ac-Gly-OH
    • ACETYLAMINO-ACETIC ACID
    • (acetylamino)acetic acid
    • N-acetyl-glycine
    • MFCD00004275
    • Acetyl Glycine
    • 2-(Acetylamino)acetic acid
    • NSC 7605
    • Acetyl-glycine
    • aceturate
    • acetamidoacetate
    • 2-acetamidoacetate
    • UNII-U2UT4677KR
    • acetyl-glycin
    • N-acetyl glycine
    • Ac Gly
    • EINECS 208-839-6
    • ethanoylaminoethanoate
    • CH3CONHCH2COOH
    • AI3-17738
    • bmse000610
    • N-acetylglycine sodium salt
    • ACETURIC ACID [MI]
    • N-Acetylglycine (Standard)
    • SCHEMBL5876
    • 15N-acetylglycine a-radical
    • 140907-90-0
    • SCHEMBL426486
    • CHEMBL289004
    • orb1302536
    • SCHEMBL9640328
    • SCHEMBL17966746
    • BDBM82197
    • HY-Y0069R
    • MSK2697
    • NSC7605
    • ALBB-019763
    • BB_SC-13054
    • HY-Y0069
    • AC8343
    • BBL020087
    • EBC-47550
    • s3098
    • SBB036034
    • STK256622
    • AKOS000118774
    • AB00351
    • CS-W020121
    • DB02713
    • FA10861
    • N-Acetylglycine, ReagentPlus(R), 99%
    • NCGC00320093-01
    • AC-24104
    • AS-12785
    • SY013515
    • DB-030111
    • A0093
    • EU-0096429
    • NS00015106
    • ST50646816
    • EN300-18561
    • A-1250
    • AB00374931-02
    • AB00374931-04
    • N-Acetylglycine, Vetec(TM) reagent grade, 98%
    • 10.14272/OKJIRPAQVSHGFK-UHFFFAOYSA-N.1
    • 543A248
    • AB-131/40177771
    • F791624
    • N-Acetylglycine Acetylglycine Acetamidoacetic acid
    • doi:10.14272/OKJIRPAQVSHGFK-UHFFFAOYSA-N.1
    • Q15634040
    • Z85886676
    • 19FC14B9-9BF4-46B1-9A63-D3B6CFB535ED
    • F0921-6976
    • Acetamidoacetic acid; Aceturic acid; Aceturic acid; Acetamidoacetic acid
    • InChI=1/C4H7NO3/c1-3(6)5-2-4(7)8/h2H2,1H3,(H,5,6)(H,7,8
    • 543-24-8

  • Applications

    Acetylglycine (CAS 543-24-8) is primarily used as an intermediate in pharmaceutical manufacturing and general organic synthesis, serving as a building block for acetylated glycine derivatives and related amino-acid-based compounds. It is commonly evaluated as a precursor in peptide and amino-acid chemistry and may be employed in polymer or materials development as a specialty building block. In formulations, it can function as a chelating agent and as a buffering or stabilizing component for metal-containing systems. It may also find use as a starting material for agrochemical or other fine-chemical syntheses.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 8.95
    methanol 20.54
    isopropanol 5.08
    water 41.75
    ethyl acetate 0.77
    n-propanol 4.57
    acetone 1.42
    n-butanol 3.47
    acetonitrile 0.79
    DMF 70.15
    toluene 0.2
    isobutanol 2.89
    1,4-dioxane 1.79
    methyl acetate 1.54
    THF 5.2
    2-butanone 1.26
    n-pentanol 2.56
    sec-butanol 3.62
    n-hexane 0.17
    ethylene glycol 20.41
    NMP 37.73
    cyclohexane 0.07
    DMSO 53.31
    n-butyl acetate 1.35
    n-octanol 1.77
    chloroform 1.07
    n-propyl acetate 0.95
    acetic acid 7.26
    dichloromethane 1.77
    cyclohexanone 2.28
    propylene glycol 17.57
    isopropyl acetate 0.57
    DMAc 44.33
    2-ethoxyethanol 13.38
    isopentanol 3.07
    n-heptane 0.14
    ethyl formate 25.72
    1,2-dichloroethane 0.98
    n-hexanol 2.0
    2-methoxyethanol 36.71
    isobutyl acetate 0.62
    tetrachloromethane 0.46
    n-pentyl acetate 1.13
    transcutol 12.18
    n-heptanol 1.74
    ethylbenzene 0.34
    MIBK 0.88
    2-propoxyethanol 9.98
    tert-butanol 5.84
    MTBE 1.22
    2-butoxyethanol 7.67
    propionic acid 4.47
    o-xylene 0.44
    formic acid 50.11
    diethyl ether 0.48
    m-xylene 0.3
    p-xylene 0.5
    chlorobenzene 0.32
    dimethyl carbonate 2.4
    n-octane 0.09
    formamide 34.88
    cyclopentanone 3.65
    2-pentanone 0.87
    anisole 1.44
    cyclopentyl methyl ether 1.05
    gamma-butyrolactone 8.25
    1-methoxy-2-propanol 14.66
    pyridine 1.43
    3-pentanone 0.54
    furfural 30.05
    n-dodecane 0.09
    diethylene glycol 21.69
    diisopropyl ether 0.18
    tert-amyl alcohol 5.02
    acetylacetone 1.68
    n-hexadecane 0.09
    acetophenone 2.02
    methyl propionate 1.27
    isopentyl acetate 1.52
    trichloroethylene 1.29
    n-nonanol 1.6
    cyclohexanol 1.55
    benzyl alcohol 3.05
    2-ethylhexanol 1.24
    isooctanol 1.38
    dipropyl ether 0.66
    1,2-dichlorobenzene 0.61
    ethyl lactate 3.82
    propylene carbonate 7.28
    n-methylformamide 34.36
    2-pentanol 1.4
    n-pentane 0.11
    1-propoxy-2-propanol 5.84
    1-methoxy-2-propyl acetate 2.22
    2-(2-methoxypropoxy) propanol 10.16
    mesitylene 0.28
    ε-caprolactone 3.86
    p-cymene 0.45
    epichlorohydrin 5.42
    1,1,1-trichloroethane 0.47
    2-aminoethanol 22.36
    morpholine-4-carbaldehyde 31.87
    sulfolane 18.65
    2,2,4-trimethylpentane 0.09
    2-methyltetrahydrofuran 1.96
    n-hexyl acetate 1.62
    isooctane 0.06
    2-(2-butoxyethoxy)ethanol 9.63
    sec-butyl acetate 0.52
    tert-butyl acetate 0.82
    decalin 0.09
    glycerin 43.55
    diglyme 18.75
    acrylic acid 6.19
    isopropyl myristate 0.73
    n-butyric acid 4.66
    acetyl acetate 0.77
    di(2-ethylhexyl) phthalate 2.36
    ethyl propionate 1.02
    nitromethane 10.68
    1,2-diethoxyethane 1.47
    benzonitrile 1.91
    trioctyl phosphate 1.55
    1-bromopropane 0.56
    gamma-valerolactone 14.89
    n-decanol 1.2
    triethyl phosphate 2.06
    4-methyl-2-pentanol 1.08
    propionitrile 1.2
    vinylene carbonate 9.39
    1,1,2-trichlorotrifluoroethane 14.52
    DMS 1.52
    cumene 0.42
    2-octanol 1.12
    2-hexanone 1.06
    octyl acetate 1.08
    limonene 0.47
    1,2-dimethoxyethane 20.55
    ethyl orthosilicate 1.81
    tributyl phosphate 1.77
    diacetone alcohol 3.83
    N,N-dimethylaniline 2.41
    acrylonitrile 2.38
    aniline 0.89
    1,3-propanediol 19.2
    bromobenzene 0.23
    dibromomethane 0.82
    1,1,2,2-tetrachloroethane 1.46
    2-methyl-cyclohexyl acetate 1.46
    tetrabutyl urea 3.63
    diisobutyl methanol 0.88
    2-phenylethanol 2.06
    styrene 0.31
    dioctyl adipate 1.55
    dimethyl sulfate 8.61
    ethyl butyrate 1.28
    methyl lactate 7.45
    butyl lactate 3.58
    diethyl carbonate 1.5
    propanediol butyl ether 10.96
    triethyl orthoformate 1.68
    p-tert-butyltoluene 0.44
    methyl 4-tert-butylbenzoate 4.26
    morpholine 3.69
    tert-butylamine 2.58
    n-dodecanol 0.9
    dimethoxymethane 9.8
    ethylene carbonate 5.69
    cyrene 11.78
    2-ethoxyethyl acetate 1.68
    2-ethylhexyl acetate 1.1
    1,2,4-trichlorobenzene 0.72
    4-methylpyridine 2.44
    dibutyl ether 0.81
    2,6-dimethyl-4-heptanol 0.88
    DEF 5.21
    dimethyl isosorbide 12.26
    tetrachloroethylene 1.09
    eugenol 7.04
    triacetin 2.13
    span 80 5.45
    1,4-butanediol 8.9
    1,1-dichloroethane 0.52
    2-methyl-1-pentanol 2.37
    methyl formate 35.62
    2-methyl-1-butanol 2.89
    n-decane 0.13
    butyronitrile 1.86
    3,7-dimethyl-1-octanol 1.59
    1-chlorooctane 0.38
    1-chlorotetradecane 0.2
    n-nonane 0.12
    undecane 0.1
    tert-butylcyclohexane 0.12
    cyclooctane 0.04
    cyclopentanol 2.81
    tetrahydropyran 0.81
    tert-amyl methyl ether 1.19
    2,5,8-trioxanonane 15.59
    1-hexene 0.42
    2-isopropoxyethanol 5.04
    2,2,2-trifluoroethanol 7.61
    methyl butyrate 2.67

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction