Acetic Anhydride

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  • Identifiers

    CAS number
    108-24-7

    Molecular formula
    C4H6O3

    SMILES
    CC(=O)OC(=O)C

    Safety labels

    Flammable
    Flammable

    Corrosive
    Corrosive

    Irritant
    Irritant

  • Odor profile

    Ethereal 44.21%
    Sharp 43.17%
    Pungent 40.57%
    Sour 37.2%
    Fruity 37.12%
    Odorless 36.51%
    Winey 36.42%
    Apple 31.7%
    Rummy 27.12%
    Green 26.63%

    Scent© AI

    Odor threshold>

    • Odor Threshold Low: 0.12 [mmHg]. Odor Threshold High: 0.36 [mmHg]. Detection odor threshold from AIHA (mean <0.14 ppm)
    • 0.13 uL/L
    • Odor Low: 0.56 mg/cu m; Odor High: 1.44 mg/cu m; Sharp odor, sour acid

  • Properties

    XLogP3-AA
    -0.1

    Molecular weight
    102.09 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Melting point expt.

    • -99.6 °F (NTP, 1992)
    • -73.4 °C
    • -73 °C
    • -99 °F

    Boiling point

    • 283.19 °F at 760 mmHg (NTP, 1992)
    • 139.5 °C
    • 137.00 to 140.00 °C. @ 760.00 mm Hg
    • 139 °C
    • 282 °F

    Flash point est.
    36.95 ˚C

    Flash point expt.

    • 121 °F (NTP, 1992)
    • 120 °F (49 °C) Closed cup
    • 49 °C c.c.
    • 120 °F

    Solubility expt.

    • Soluble in cold (greater than or equal to 10mg/ml); Decomposes in hot (NTP, 1992)
    • In water, 120 g/L at 20 °C
    • Slowly soluble in water, forming acetic acid
    • With alcohol forms ethyl acetate; soluble in chloroform, ether
    • Soluble in ethanol, benzene; miscible with ethyl ether; slightly soluble in carbon tetrachloride
    • Miscible with ethanol, ether, acetic acid, and ethyl acetate
    • 120 mg/mL at 20 °C
    • Solubility in water: reaction, releasing heat
    • 12%

  • Synonyms

    • ACETIC ANHYDRIDE
    • Acetyl acetate
    • 108-24-7
    • Acetanhydride
    • Ethanoic anhydride
    • Acetyl anhydride
    • Acetic acid, anhydride
    • Acetyl oxide
    • acetic acid anhydride
    • Acetic oxide
    • Acetyl ether
    • Anhydride acetique
    • Anidride acetica
    • Octowy bezwodnik
    • Azijnzuuranhydride
    • Essigsaeureanhydrid
    • Ethanoic anhydrate
    • Anhydrid kyseliny octove
    • Ac2O
    • ethanoyl ethanoate
    • (CH3CO)2O
    • Caswell No. 003A
    • HSDB 233
    • CCRIS 688
    • Acetic acid, 1,1'-anhydride
    • EINECS 203-564-8
    • UNII-2E48G1QI9Q
    • EPA Pesticide Chemical Code 044007
    • BRN 0385737
    • 2E48G1QI9Q
    • DTXSID0024395
    • CHEBI:36610
    • Acetic anhydride-1,1'-13C2,d6
    • (MeCO)2O
    • DTXCID704395
    • EC 203-564-8
    • 4-02-00-00386 (Beilstein Handbook Reference)
    • MFCD00008705
    • 285977-77-7
    • 285977-78-8
    • ACETIC ANHYDRIDE (II)
    • ACETIC ANHYDRIDE [II]
    • Acetic anhydride-1,1-13C2
    • Octowy bezwodnik [Polish]
    • Azijnzuuranhydride [Dutch]
    • Anidride acetica [Italian]
    • Anhydride acetique [French]
    • Essigsaeureanhydrid [German]
    • Anhydrid kyseliny octove [Czech]
    • UN1715
    • ACETIC ANHYDRIDE (1,1'-13C2, 99%)
    • acetanhydrid
    • aceticanhydride
    • acetic anhydrid
    • actic anhydride
    • diacetyl oxide
    • acetic-anhydride
    • acetic, anhydride
    • AcOAc
    • Acetyltrimethyl-Silane
    • acetic acetic anhydride
    • Acetic anhydride [UN1715] [Corrosive]
    • acetic acid acetyl ester
    • SCHEMBL523
    • Acetic anhydride ACS grade
    • acetic acid-acetic anhydride
    • (Ac)2O
    • Acetic anhydride, >=99%
    • Acetic anhydride, 99.5%
    • Pesticide Code: 044007
    • MLS002454384
    • ACETIC ANHYDRIDE [MI]
    • Acetic anhydride, ACS, 97%
    • ACETIC ANHYDRIDE [HSDB]
    • CHEMBL1305819
    • HMS3039J03
    • BCP20665
    • QDA98078
    • RAA64949
    • Acetic anhydride, JIS special grade
    • ACETIC ANHYDRIDE-13C4, D6
    • Tox21_200278
    • STL264203
    • AKOS015915487
    • UN 1715
    • NCGC00091802-01
    • NCGC00091802-02
    • NCGC00257832-01
    • ACETIC ANHYDRIDE (1,1'-13C2)
    • Acetic anhydride, reagent grade, >=98%
    • BP-24367
    • BP-31054
    • CAS-108-24-7
    • SMR001372001
    • Acetic anhydride [UN1715] [Corrosive]
    • Acetic anhydride, ACS reagent, >=98.0%
    • Acetic anhydride, ReagentPlus(R), >=99%
    • A1668
    • A2036
    • NS00004253
    • Acetic anhydride, p.a., ACS reagent, 97.0%
    • Acetic anhydride, SAJ first grade, >=93.0%
    • A801828
    • Acetic anhydride, Lonza quality, >=99.5% (GC)
    • Q407775
    • Acetic anhydride, for GC derivatization, >=99.0%
    • ACETIC ANHYDRIDE (13C4, 99%; D6, 98%)
    • InChI=1/C4H6O3/c1-3(5)7-4(2)6/h1-2H
    • Acetic anhydride, p.a., ACS reagent, reag. ISO, reag. Ph. Eur., 99.0%
    • Acetic anhydride, puriss. p.a., ACS reagent, reag. ISO, reag. Ph. Eur., >=99% (GC)
    • 203-564-8
    • Capping B1 (40 % acetic anhydride in acetonitrile, for AKTA oligopilottrade mark) NC-0806, GL45 thread emp Biotech GmbH

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 48.57
    methanol 67.88
    isopropanol 36.11
    water 15.04
    ethyl acetate 145.87
    n-propanol 31.33
    acetone 226.29
    n-butanol 25.99
    acetonitrile 141.16
    DMF 458.26
    toluene 45.86
    isobutanol 23.69
    1,4-dioxane 187.22
    methyl acetate 172.97
    THF 288.7
    2-butanone 113.5
    n-pentanol 17.85
    sec-butanol 28.59
    n-hexane 9.06
    ethylene glycol 34.36
    NMP 651.96
    cyclohexane 8.84
    DMSO 370.37
    n-butyl acetate 41.89
    n-octanol 18.09
    chloroform 101.82
    n-propyl acetate 58.95
    acetic acid 199.87
    dichloromethane 140.5
    cyclohexanone 133.95
    propylene glycol 30.59
    isopropyl acetate 82.96
    DMAc 440.47
    2-ethoxyethanol 67.19
    isopentanol 22.9
    n-heptane 4.37
    ethyl formate 102.22
    1,2-dichloroethane 98.03
    n-hexanol 15.32
    2-methoxyethanol 143.51
    isobutyl acetate 33.55
    tetrachloromethane 14.68
    n-pentyl acetate 29.55
    transcutol 129.8
    n-heptanol 9.02
    ethylbenzene 24.07
    MIBK 49.87
    2-propoxyethanol 68.4
    tert-butanol 54.2
    MTBE 54.31
    2-butoxyethanol 26.65
    propionic acid 90.1
    o-xylene 40.12
    formic acid 106.59
    diethyl ether 62.03
    m-xylene 36.85
    p-xylene 34.8
    chlorobenzene 57.9
    dimethyl carbonate 134.5
    n-octane 2.8
    formamide 154.95
    cyclopentanone 247.98
    2-pentanone 90.69
    anisole 81.72
    cyclopentyl methyl ether 114.87
    gamma-butyrolactone 444.4
    1-methoxy-2-propanol 101.76
    pyridine 111.46
    3-pentanone 87.26
    furfural 362.68
    n-dodecane 3.61
    diethylene glycol 68.76
    diisopropyl ether 23.43
    tert-amyl alcohol 41.0
    acetylacetone 231.65
    n-hexadecane 4.04
    acetophenone 82.93
    methyl propionate 148.48
    isopentyl acetate 36.58
    trichloroethylene 173.26
    n-nonanol 16.9
    cyclohexanol 34.07
    benzyl alcohol 41.82
    2-ethylhexanol 13.2
    isooctanol 8.68
    dipropyl ether 29.45
    1,2-dichlorobenzene 65.22
    ethyl lactate 42.56
    propylene carbonate 224.6
    n-methylformamide 171.81
    2-pentanol 20.3
    n-pentane 6.32
    1-propoxy-2-propanol 42.88
    1-methoxy-2-propyl acetate 81.58
    2-(2-methoxypropoxy) propanol 68.31
    mesitylene 25.96
    ε-caprolactone 160.6
    p-cymene 14.54
    epichlorohydrin 284.58
    1,1,1-trichloroethane 84.91
    2-aminoethanol 38.67
    morpholine-4-carbaldehyde 416.48
    sulfolane 478.74
    2,2,4-trimethylpentane 5.0
    2-methyltetrahydrofuran 167.21
    n-hexyl acetate 52.24
    isooctane 3.31
    2-(2-butoxyethoxy)ethanol 57.92
    sec-butyl acetate 42.78
    tert-butyl acetate 86.89
    decalin 9.11
    glycerin 68.11
    diglyme 115.13
    acrylic acid 113.43
    isopropyl myristate 29.0
    n-butyric acid 80.33
    acetyl acetate 163.74
    di(2-ethylhexyl) phthalate 30.6
    ethyl propionate 87.91
    nitromethane 570.93
    1,2-diethoxyethane 48.18
    benzonitrile 58.46
    trioctyl phosphate 18.08
    1-bromopropane 40.58
    gamma-valerolactone 357.74
    n-decanol 13.58
    triethyl phosphate 37.94
    4-methyl-2-pentanol 13.73
    propionitrile 58.06
    vinylene carbonate 205.28
    1,1,2-trichlorotrifluoroethane 158.57
    DMS 115.11
    cumene 20.37
    2-octanol 9.46
    2-hexanone 48.74
    octyl acetate 34.5
    limonene 19.09
    1,2-dimethoxyethane 160.28
    ethyl orthosilicate 31.92
    tributyl phosphate 27.14
    diacetone alcohol 78.43
    N,N-dimethylaniline 67.36
    acrylonitrile 97.6
    aniline 56.03
    1,3-propanediol 49.01
    bromobenzene 51.12
    dibromomethane 75.9
    1,1,2,2-tetrachloroethane 113.02
    2-methyl-cyclohexyl acetate 42.09
    tetrabutyl urea 40.16
    diisobutyl methanol 11.02
    2-phenylethanol 30.07
    styrene 28.98
    dioctyl adipate 50.39
    dimethyl sulfate 303.89
    ethyl butyrate 50.63
    methyl lactate 90.83
    butyl lactate 24.32
    diethyl carbonate 44.33
    propanediol butyl ether 31.42
    triethyl orthoformate 38.74
    p-tert-butyltoluene 15.75
    methyl 4-tert-butylbenzoate 73.25
    morpholine 163.0
    tert-butylamine 31.0
    n-dodecanol 11.67
    dimethoxymethane 211.86
    ethylene carbonate 143.06
    cyrene 89.17
    2-ethoxyethyl acetate 57.07
    2-ethylhexyl acetate 30.77
    1,2,4-trichlorobenzene 83.44
    4-methylpyridine 135.78
    dibutyl ether 28.21
    2,6-dimethyl-4-heptanol 11.02
    DEF 156.28
    dimethyl isosorbide 151.72
    tetrachloroethylene 64.92
    eugenol 55.44
    triacetin 96.89
    span 80 45.93
    1,4-butanediol 18.47
    1,1-dichloroethane 82.08
    2-methyl-1-pentanol 18.22
    methyl formate 191.53
    2-methyl-1-butanol 22.8
    n-decane 5.02
    butyronitrile 45.39
    3,7-dimethyl-1-octanol 19.72
    1-chlorooctane 16.11
    1-chlorotetradecane 9.71
    n-nonane 4.81
    undecane 4.14
    tert-butylcyclohexane 8.74
    cyclooctane 4.48
    cyclopentanol 54.75
    tetrahydropyran 92.04
    tert-amyl methyl ether 53.62
    2,5,8-trioxanonane 105.89
    1-hexene 18.3
    2-isopropoxyethanol 41.84
    2,2,2-trifluoroethanol 114.2
    methyl butyrate 90.66

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction