Acetamide

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  • Identifiers

    CAS number
    60-35-5

    Molecular formula
    C2H5NO

    SMILES
    CC(=O)N

    Safety labels

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Pungent 36.81%
    Cheesy 36.05%
    Sweet 35.34%
    Meaty 31.47%
    Burnt 31.42%
    Nutty 30.09%
    Fishy 29.54%
    Caramellic 28.12%
    Roasted 27.25%
    Odorless 26.3%

     

    Flavor
    Pungent 38.6%
    Vinegar 31.89%
    Odorless 31.83%
    Sour 29.1%
    Mousy 27.43%
    Sharp 26.49%
    Acidic 26.02%
    Mustard 23.66%
    Soy 23.2%
    Formyl 22.95%

     

    Odor impact est.
    Low

    Odor threshold

    • Recognition: 140-160 mg/cu m

  • Properties

    XLogP3-AA
    -0.9

    pKa est.
    8.73 (weak base)

    Molecular weight
    59.07 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderately slow

    Melting point expt.

    • 180.1 °F (NTP, 1992)
    • 81 °C
    • 81.16 °C
    • 82 - 83 °C
    • 180.1 °F

    Boiling point

    • 430 °F at 760 mmHg (NTP, 1992)
    • 222 °C
    • 222 °C at 760 mm Hg
    • 221.00 to 222.00 °C. @ 760.00 mm Hg
    • 430 °F

    Flash point

    • 60.41 ˚C est.

    Solubility expt.

    • Very soluble (greater than or equal to 100 mg/mL at 72 °F) (NTP, 1992)
    • 2250000 mg/L (at 25 °C)
    • In water, 7.05X10+5 mg/L at 24.5 °C
    • One gram dissolves in 0.5 mL water, 2 mL alcohol, 6 mL pyridine
    • Soluble in chloroform, glycerol, hot benzene
    • Slightly soluble in ether
    • 2250 mg/mL at 25 °C
    • Solubility in water, g/100ml: 200

  • Synonyms

    • acetamide
    • 60-35-5
    • Ethanamide
    • Acetic acid amide
    • Methanecarboxamide
    • Acetimidic acid
    • Ethanimidic acid
    • acetamid
    • Amide C2
    • Amid kyseliny octove
    • Caswell No. 003H
    • Acetimidic acid (VAN)
    • CCRIS 2
    • NCI-C02108
    • CH3CONH2
    • HSDB 4006
    • Amid kyseliny octove [Czech]
    • Essigsaeureamid
    • Ethanamid
    • AI3-02060
    • UNII-8XOE1JSO29
    • EINECS 200-473-5
    • 8XOE1JSO29
    • NSC 25945
    • BRN 1071207
    • DTXSID7020005
    • CHEBI:27856
    • ACETAMIDE [MI]
    • ACETAMIDE [FHFI]
    • ACETAMIDE [HSDB]
    • ACETAMIDE [IARC]
    • MFCD00008023
    • NSC-25945
    • DTXCID505
    • ACETAMIDE [WHO-DD]
    • FEMA NO. 4251
    • CHEBI:49028
    • EC 200-473-5
    • 4-02-00-00399 (Beilstein Handbook Reference)
    • ACETAMIDE (IARC)
    • acetoamide
    • acetamido
    • imidoacetic acid
    • methanecarboxyamide
    • Acetamide, Purified
    • methane, carbamoyl-
    • Acetamido (Spanish)
    • Acetamide, >=98%
    • Lopac-A-0500
    • bmse000825
    • bmse000895
    • Acetamide, sublimed, 99%
    • WLN: ZV1
    • Acetic acid amide;Ethanamide
    • Acetamide, ~99% (GC)
    • Lopac0_000003
    • MLS002153504
    • Acetamide, analytical standard
    • BIDD:ER0566
    • CHEMBL16081
    • Amid kyseliny octove (Polish)
    • GTPL4661
    • Acetamide, crystalline, >=99%
    • Acetamide, >=98.0% (GC)
    • Acetamide, >=99.0% (GC)
    • HMS3260A07
    • Acetamide (6CI,7CI,8CI,9CI)
    • BCP26153
    • HY-Y0946
    • NSC25945
    • STR01066
    • Tox21_300776
    • Tox21_500003
    • s6011
    • STL283915
    • AKOS000118788
    • AKOS015917387
    • CCG-204099
    • DB02736
    • FA32923
    • LP00003
    • SDCCGSBI-0049992.P002
    • CAS-60-35-5
    • NCGC00015030-01
    • NCGC00015030-02
    • NCGC00015030-03
    • NCGC00015030-04
    • NCGC00015030-05
    • NCGC00015030-06
    • NCGC00093530-01
    • NCGC00093530-02
    • NCGC00254680-01
    • NCGC00260688-01
    • SMR000326670
    • DB-342147
    • A0007
    • CS-0015934
    • EU-0100003
    • NS00006888
    • EN300-15608
    • A 0500
    • C06244
    • Q421721
    • SR-01000076247
    • SR-01000076247-1
    • Acetamide, zone-refined, purified by sublimation, 99%
    • Z33546370
    • F1908-0077
    • 02U
    • 200-473-5
    • 74330-92-0

  • Applications

    Acetamide (CAS 60-35-5) is used as a polar, high-boiling solvent and reaction medium in organic synthesis and polymer processing. It also serves as an intermediate and building block for other chemicals, including conversion to acetonitrile by dehydration, and as a precursor for various acetamide derivatives used in pharmaceutical and agrochemical manufacturing. In industrial settings, it finds application as a solvent in coatings, inks, and specialty formulations, and can act as a processing aid in electronics cleaning and related manufacturing applications.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 142.52
    methanol 374.5
    isopropanol 70.24
    water 2330.81
    ethyl acetate 26.07
    n-propanol 65.55
    acetone 96.77
    n-butanol 38.47
    acetonitrile 68.06
    DMF 478.81
    toluene 2.71
    isobutanol 37.94
    1,4-dioxane 56.55
    methyl acetate 49.83
    THF 59.3
    2-butanone 41.95
    n-pentanol 25.68
    sec-butanol 36.6
    n-hexane 2.11
    ethylene glycol 288.13
    NMP 167.37
    cyclohexane 1.18
    DMSO 145.72
    n-butyl acetate 12.78
    n-octanol 14.02
    chloroform 9.41
    n-propyl acetate 16.28
    acetic acid 226.82
    dichloromethane 9.23
    cyclohexanone 27.41
    propylene glycol 205.11
    isopropyl acetate 13.73
    DMAc 314.92
    2-ethoxyethanol 101.22
    isopentanol 22.66
    n-heptane 1.74
    ethyl formate 46.64
    1,2-dichloroethane 6.37
    n-hexanol 20.4
    2-methoxyethanol 227.95
    isobutyl acetate 10.3
    tetrachloromethane 4.47
    n-pentyl acetate 10.39
    transcutol 95.34
    n-heptanol 14.81
    ethylbenzene 1.85
    MIBK 12.31
    2-propoxyethanol 85.24
    tert-butanol 51.93
    MTBE 19.03
    2-butoxyethanol 50.9
    propionic acid 96.24
    o-xylene 3.5
    formic acid 503.24
    diethyl ether 17.15
    m-xylene 3.07
    p-xylene 2.93
    chlorobenzene 3.12
    dimethyl carbonate 41.36
    n-octane 0.8
    formamide 326.23
    cyclopentanone 45.77
    2-pentanone 22.81
    anisole 11.25
    cyclopentyl methyl ether 18.46
    gamma-butyrolactone 59.51
    1-methoxy-2-propanol 122.59
    pyridine 20.7
    3-pentanone 18.8
    furfural 77.1
    n-dodecane 0.74
    diethylene glycol 142.96
    diisopropyl ether 4.36
    tert-amyl alcohol 32.27
    acetylacetone 30.39
    n-hexadecane 0.74
    acetophenone 14.03
    methyl propionate 37.12
    isopentyl acetate 9.41
    trichloroethylene 10.34
    n-nonanol 11.99
    cyclohexanol 19.45
    benzyl alcohol 19.33
    2-ethylhexanol 8.87
    isooctanol 9.85
    dipropyl ether 11.16
    1,2-dichlorobenzene 3.27
    ethyl lactate 30.29
    propylene carbonate 33.11
    n-methylformamide 233.6
    2-pentanol 18.42
    n-pentane 2.08
    1-propoxy-2-propanol 44.86
    1-methoxy-2-propyl acetate 21.55
    2-(2-methoxypropoxy) propanol 40.41
    mesitylene 2.24
    ε-caprolactone 30.48
    p-cymene 2.63
    epichlorohydrin 35.51
    1,1,1-trichloroethane 5.78
    2-aminoethanol 227.64
    morpholine-4-carbaldehyde 176.56
    sulfolane 63.67
    2,2,4-trimethylpentane 1.16
    2-methyltetrahydrofuran 27.17
    n-hexyl acetate 14.73
    isooctane 0.76
    2-(2-butoxyethoxy)ethanol 50.72
    sec-butyl acetate 8.92
    tert-butyl acetate 12.09
    decalin 0.85
    glycerin 324.44
    diglyme 85.44
    acrylic acid 120.14
    isopropyl myristate 5.83
    n-butyric acid 55.01
    acetyl acetate 19.7
    di(2-ethylhexyl) phthalate 11.25
    ethyl propionate 16.44
    nitromethane 231.15
    1,2-diethoxyethane 16.95
    benzonitrile 12.6
    trioctyl phosphate 8.18
    1-bromopropane 3.71
    gamma-valerolactone 93.07
    n-decanol 8.74
    triethyl phosphate 8.69
    4-methyl-2-pentanol 9.86
    propionitrile 29.05
    vinylene carbonate 36.65
    1,1,2-trichlorotrifluoroethane 80.06
    DMS 18.07
    cumene 2.09
    2-octanol 7.83
    2-hexanone 16.11
    octyl acetate 9.85
    limonene 3.72
    1,2-dimethoxyethane 97.54
    ethyl orthosilicate 8.13
    tributyl phosphate 9.23
    diacetone alcohol 31.82
    N,N-dimethylaniline 11.46
    acrylonitrile 47.99
    aniline 14.93
    1,3-propanediol 136.8
    bromobenzene 1.6
    dibromomethane 4.63
    1,1,2,2-tetrachloroethane 9.61
    2-methyl-cyclohexyl acetate 8.79
    tetrabutyl urea 14.11
    diisobutyl methanol 4.8
    2-phenylethanol 15.02
    styrene 2.23
    dioctyl adipate 11.22
    dimethyl sulfate 60.14
    ethyl butyrate 11.14
    methyl lactate 69.9
    butyl lactate 20.57
    diethyl carbonate 9.45
    propanediol butyl ether 58.37
    triethyl orthoformate 10.2
    p-tert-butyltoluene 2.61
    methyl 4-tert-butylbenzoate 19.88
    morpholine 72.78
    tert-butylamine 23.02
    n-dodecanol 6.55
    dimethoxymethane 110.69
    ethylene carbonate 28.5
    cyrene 43.35
    2-ethoxyethyl acetate 17.32
    2-ethylhexyl acetate 7.16
    1,2,4-trichlorobenzene 4.85
    4-methylpyridine 21.29
    dibutyl ether 6.93
    2,6-dimethyl-4-heptanol 4.8
    DEF 49.24
    dimethyl isosorbide 36.97
    tetrachloroethylene 8.9
    eugenol 29.98
    triacetin 23.55
    span 80 35.76
    1,4-butanediol 73.08
    1,1-dichloroethane 7.11
    2-methyl-1-pentanol 15.28
    methyl formate 165.78
    2-methyl-1-butanol 24.59
    n-decane 1.15
    butyronitrile 22.12
    3,7-dimethyl-1-octanol 9.41
    1-chlorooctane 3.03
    1-chlorotetradecane 1.52
    n-nonane 1.07
    undecane 0.89
    tert-butylcyclohexane 1.05
    cyclooctane 0.58
    cyclopentanol 34.42
    tetrahydropyran 21.37
    tert-amyl methyl ether 14.65
    2,5,8-trioxanonane 62.62
    1-hexene 4.8
    2-isopropoxyethanol 49.14
    2,2,2-trifluoroethanol 156.52
    methyl butyrate 21.95

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction